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TVVLAVFGVPVAKSLSPSGFSDPGSESAHASALLTGKFGQGDVQMLILVSSDDGIDSPRARDVGTEVVKR LDQDPHVTDVSSPWTAPPAAAADLVSRDRTAGLIVAGITGTEAEQQTYARQISEDVSGDRDGVSVRTGGT AMVNVQITEHSQRDLLVMESLAIPLSFLVLVWVFGGLVAAALPVAIGGMAILGALAVLRLVTLVTDVSIF ALNLATAMGLALAIDYTLLMLSRYRDELAAGADRPDAIRRTVSTAGRTVLFSATTVALSMAAMVLFPMHF LKSFAYAGVATVAFAAAAAVVVTPAALMLLGDRLDALDVHRLARRILRRPEPTPTPVQRRFWYRCATTVM RRALPLGLAVVVLLLVLGAPFLGVKWGFPDERVLPPSASSHQVGDQLRRDFADNTDTAVTVVVPDSAGLS PADLSAYAAELSRVPDVPAVSAPTGTFVDGARAGPPSAPAGEKDDSVFLTVASTAPLFSDASETQLDRLH AVAGPGGREVLMTGTAQVNRDSVDAITSKLPIVLGLIAVIMFALLFLLTGSIVVPLKALVLNMLSLTAAF GALVWIFQDGHLSGLGTTPTGTLVANMPVLLFCIAFGLSMDYEVFLVSRIREFWLETGDSDESVALGIAH TGRVITAAALIMSISFAALIAASVSFMRMFGLGLTLAVLVDATLVRMVLVPAFMHLMGGLNWWAPGWLRR VHERLGFTEAPSVNPEVTPPERISSP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_1197 | - | - | 100% (727) | hypothetical protein Mvan_1197 |
M. vanbaalenii PYR-1 | Mvan_4573 | - | 0.0 | 66.89% (746) | MMPL domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_1577 | - | 0.0 | 63.60% (717) | polyprenyl synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1177 | mmpL13 | 0.0 | 66.53% (723) | transmembrane transport protein MmpL13 |
M. gilvum PYR-GCK | Mflv_5139 | - | 0.0 | 84.38% (736) | MMPL domain-containing protein |
M. tuberculosis H37Rv | Rv1146 | mmpL13b | 1e-167 | 69.04% (436) | transmembrane transport protein MmpL13B |
M. leprae Br4923 | MLBr_02620 | - | 4e-97 | 31.76% (743) | hypothetical protein MLBr_02620 |
M. abscessus ATCC 19977 | MAB_1287 | - | 0.0 | 55.74% (714) | MmpL family membrane protein |
M. marinum M | MMAR_4305 | mmpL13 | 0.0 | 66.67% (729) | transmembrane transport protein MmpL13 |
M. avium 104 | MAV_1287 | - | 0.0 | 66.99% (727) | mmpL protein |
M. smegmatis MC2 155 | MSMEG_5178 | - | 0.0 | 67.32% (716) | integral membrane protein |
M. thermoresistible (build 8) | TH_1538 | - | 0.0 | 62.14% (729) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL13B |
M. ulcerans Agy99 | MUL_0989 | mmpL13 | 0.0 | 66.12% (729) | transmembrane transport protein MmpL13 |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_1197|M.vanbaalenii_PYR-1 -----------------------MTVVLAVFGVPVAKSLSPSGFSDPGSE Mflv_5139|M.gilvum_PYR-GCK ----------------------MLTVALGVFGIPVAQSLSPSGFSDPGSQ Mb1177|M.bovis_AF2122/97 -MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSE Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSPGGFQDPNAE MUL_0989|M.ulcerans_Agy99 -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSRGGFQDPNAE MAV_1287|M.avium_104 -MLQKIARVAIAAPRRIIALGVLVFLAAAVFGIPVAKSLSPGGFQDPDSE MSMEG_5178|M.smegmatis_MC2_155 -MLQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAE TH_1538|M.thermoresistible__bu -MLETLARRIVAAPRRVLALVVLVIVGAAMFGLPVAGSLSAGGFRDPHSE MAB_1287|M.abscessus_ATCC_1997 MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSE MLBr_02620|M.leprae_Br4923 -MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQ Mvan_1197|M.vanbaalenii_PYR-1 SAHASALLTGKFGQGDVQMLILVSSDD---GIDSPRARDVGTEVVKRLDQ Mflv_5139|M.gilvum_PYR-GCK SAHAAALLTDTFGQGDVQMLIVVSSPD---GIDDPRVRDVGTDIVDLLTA Mb1177|M.bovis_AF2122/97 SARAIEVLTDKFGQSGQKMLIVVTAAA---GADSPPAREVGTDIVEVLRR Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M SARAIKVLADKFGQSGQQMLILVTAPG---GVGTERARAVGTDIVAELNH MUL_0989|M.ulcerans_Agy99 SARAIKVLADKFGQSGQQMLILVTAPG---GVGTERARAVGTDIVAELNH MAV_1287|M.avium_104 SARAIGVLTDKFGQSGQQMLILVTAPG---GSNSDPARRVGTELVEQLQR MSMEG_5178|M.smegmatis_MC2_155 SARATQLLADKFHRGDMQLVIAVTAEAPGGRADGGRAREVGTEIVSELKA TH_1538|M.thermoresistible__bu SAQASALLAERFDQTDMQLLVTVSSSA---GVYGEAARRVGTEIVAALEA MAB_1287|M.abscessus_ATCC_1997 SAYVTKALRDKFDISDQSLVFMLTSEQ---GVKSPQMRAVAADLERQLKD MLBr_02620|M.leprae_Br4923 SVKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQR Mvan_1197|M.vanbaalenii_PYR-1 --DPHVTDVSSPWTAP---PAAAADLVSRDRTAGLIVAGITGTEAEQQTY Mflv_5139|M.gilvum_PYR-GCK --DPHVAEVSSPWTSP---PGAAADLVSRDRTAGLVVAGITGDEAEQQTY Mb1177|M.bovis_AF2122/97 --SPLVYNVTSPWTVP---PTAAADLLSTDGKSGLIVVNVKGGENDAQNH Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M --SPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN MUL_0989|M.ulcerans_Agy99 --SPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN MAV_1287|M.avium_104 --SPLVYNVSSPWTAP---PQASADLVSRDGKSGLIVVNLKGGENFVQNN MSMEG_5178|M.smegmatis_MC2_155 --SPYVTEVTSAWTAP---PSAAAALVSKDARTGLIVAGLNGGENGAQQH TH_1538|M.thermoresistible__bu --SPQVAGVQSPWTVP---PGAGDRLVSEDATAGLIVAPIRGNETESSDI MAB_1287|M.abscessus_ATCC_1997 --SGVVINLTSAWTAP---PQVAEELLGADGKAGLIVAGLTGGENDAQKH MLBr_02620|M.leprae_Br4923 NNSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILN Mvan_1197|M.vanbaalenii_PYR-1 ARQISEDVSGDRDGVSVRTGGTAMVNVQITEHSQRDLLVMESLAIPLSFL Mflv_5139|M.gilvum_PYR-GCK AKDISDRVTRDRDGITVRTGGTAMVNVQITEQSQRDLLMMEGLAIPLSFL Mb1177|M.bovis_AF2122/97 AQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL MUL_0989|M.ulcerans_Agy99 AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL MAV_1287|M.avium_104 AQTLADQFVHDRDGVTVRAGGAAMQYAQINTQNQADLLVMEMIALPLSFL MSMEG_5178|M.smegmatis_MC2_155 AKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFV TH_1538|M.thermoresistible__bu ARQLAAAVGSDRDRVNVRAGGPALVNAQIDTQTEHDLLVMEAIAIPLSFV MAB_1287|M.abscessus_ATCC_1997 AAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFV MLBr_02620|M.leprae_Br4923 NYKAIAPDLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEVLALPLVAV Mvan_1197|M.vanbaalenii_PYR-1 VLVWVFGGLVAAALPVAIGGMAILGALAVLRLVTLVTDVSIFALNLATAM Mflv_5139|M.gilvum_PYR-GCK VLVWVFGGLVAAALPVAIGGMAIVGALAVLRLVTFTTDVSIFALNLATAM Mb1177|M.bovis_AF2122/97 VLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL MUL_0989|M.ulcerans_Agy99 VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL MAV_1287|M.avium_104 VLIWVFGGLLAAALPMALGALAVVGSMSVLRLITFTTEVSIFALNLSTAL MSMEG_5178|M.smegmatis_MC2_155 VLVWVFGGLLAAALPLAVGGFAILGSLAVLRLFTMVTDVSIFALNLTVAM TH_1538|M.thermoresistible__bu VLVWVFGGLLAAALPLAVGVLAIVGSMAVLRTFTMFTEVSVFALNLSIAM MAB_1287|M.abscessus_ATCC_1997 VLVWIFGGLYAALLPLVVGVFSIVGAMSILRGLTYVTDVSVFALNLAVAM MLBr_02620|M.leprae_Br4923 VLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFFAQPVVSLI Mvan_1197|M.vanbaalenii_PYR-1 GLALAIDYTLLMLSRYRDELAAGADRPDAIRRTVSTAGRTVLFSATTVAL Mflv_5139|M.gilvum_PYR-GCK GLALAIDYTLLILSRYRDELAAGASRPDAIARTMATAGRTVIFSATTVAL Mb1177|M.bovis_AF2122/97 GLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL MUL_0989|M.ulcerans_Agy99 GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL MAV_1287|M.avium_104 GLALAIDYTLLIVSRYRDELAEGHDRDQALIRTMATSGRTVLFSAVTVAL MSMEG_5178|M.smegmatis_MC2_155 GLALAIDYTLLIISRFRDELAEGADRETALVRTMMTAGRTVLFSAMTVAL TH_1538|M.thermoresistible__bu GLALAIDYTLLLLNRYRDELAEGCSREQAVIRTMTSAGRTVIFSAVIVAT MAB_1287|M.abscessus_ATCC_1997 GLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAGRTVLFSALTVAL MLBr_02620|M.leprae_Br4923 GLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVTFSAVLIAA Mvan_1197|M.vanbaalenii_PYR-1 SMAAMVLFPMHFLKSFAYAGVATVAFAAAAAVVVTPAALMLLGDRLDALD Mflv_5139|M.gilvum_PYR-GCK SMAVMVLFPMHFLKSFAYAGVATVAFAAAAAVIVTPAALALLGDRLDSLD Mb1177|M.bovis_AF2122/97 SMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALD Rv1146|M.tuberculosis_H37Rv --------------------MATVAFVATASIVITPAAIVLLGPRLDALD MMAR_4305|M.marinum_M SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN MUL_0989|M.ulcerans_Agy99 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN MAV_1287|M.avium_104 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGDRLDALD MSMEG_5178|M.smegmatis_MC2_155 SMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYD TH_1538|M.thermoresistible__bu SMVPLALFPMYFLRSFAYAGVGVVAFALCAALVITPAAITVLGARLDSWD MAB_1287|M.abscessus_ATCC_1997 ALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALD MLBr_02620|M.leprae_Br4923 SGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAILAKHVDALG :..* . :: : ** : :*. ::*: . Mvan_1197|M.vanbaalenii_PYR-1 VHRLARRILRRP-----------------EPTPTPVQRRFWYRCATTVMR Mflv_5139|M.gilvum_PYR-GCK VHRLARRVLRRP-----------------EPVPVPVEQRFWYRCATTVMR Mb1177|M.bovis_AF2122/97 VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR Rv1146|M.tuberculosis_H37Rv VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR MMAR_4305|M.marinum_M VRRLARRMLGRP-----------------EPQHKPVDQLFWYRSTKFVMR MUL_0989|M.ulcerans_Agy99 VRRLARRMLGRP-----------------KPQHKPVDQLFWYRSTKFVMR MAV_1287|M.avium_104 VRRLLRRALRRA-----------------QPVRKPVEQLFWYRSSKFVMR MSMEG_5178|M.smegmatis_MC2_155 VRRFFRRVFGRP-----------------EPEPKPVEQGFWYRTAKAAMR TH_1538|M.thermoresistible__bu IRRLIRRLMRRTP-------------AAAEPAPRAVCGSKWYRWAKAVMR MAB_1287|M.abscessus_ATCC_1997 VRRLIRRVLGRP-----------------EPVAKDVTQSFWYRTTKRVMA MLBr_02620|M.leprae_Br4923 VRTLFRVPLLRNWRMSHACLNWLADRLQKTKTREEVEAGFWGKLVNFVMK :: : * : * * * : . .* Mvan_1197|M.vanbaalenii_PYR-1 RALPLGLAVVVLLLVLGAPFLGVKWGFPDERVLPPSASSHQVGDQLRRDF Mflv_5139|M.gilvum_PYR-GCK RALPLGTVVVVLLLVLGAPFLGVKWGFPDERVLPRSASAHQVGDQLRAEF Mb1177|M.bovis_AF2122/97 RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF Rv1146|M.tuberculosis_H37Rv RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF MMAR_4305|M.marinum_M RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF MUL_0989|M.ulcerans_Agy99 RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF MAV_1287|M.avium_104 RWAPVGLIVVGLLLLLGLPFFSVKWGFPDDRVLPRSASAHQVGDRLRSGF MSMEG_5178|M.smegmatis_MC2_155 RAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGDEMRTNF TH_1538|M.thermoresistible__bu HWLVAGLAVTVVLLLLGAPFLGVRWGFPDERVLPRSASAHQVGHELRTNF MAB_1287|M.abscessus_ATCC_1997 RAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNEMRRNF MLBr_02620|M.leprae_Br4923 RPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPNNAVRQSQEHFDQLF : . : :::* *: . :* .:: ** . : :* . : * Mvan_1197|M.vanbaalenii_PYR-1 ---ADNTDTAVTVVVPDSAGLSPADLSAYAAELSRVPDVPAVSAPTGTFV Mflv_5139|M.gilvum_PYR-GCK TGTANNVDTGVAVVVPDSAGLSPADLSAYAAALSQVPDVPAVSAPTGTFV Mb1177|M.bovis_AF2122/97 ---GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFV Rv1146|M.tuberculosis_H37Rv ---GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFV MMAR_4305|M.marinum_M ---AHDLAMAVPVVVPDVRGLVPADLDGYAADLSRVPDVASVTAPSGTFV MUL_0989|M.ulcerans_Agy99 ---AHDLAMAVPVVVPDVHGLVPADLDGYAADLSRVPDVASVTAPSGTFV MAV_1287|M.avium_104 ---AHDSATSVPVVIPDAAGLSPADLDDYAAALSRVPDVSAVSAPGGTFT MSMEG_5178|M.smegmatis_MC2_155 ---AVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDV TH_1538|M.thermoresistible__bu ---ATDSASDVTVVLPDAPGLTADELAGYAARLSEVTDVAWVSAPAGTFV MAB_1287|M.abscessus_ATCC_1997 N---NNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFI MLBr_02620|M.leprae_Br4923 P----GYRTNPLTLVIQTSNHQPVTDQEIADIRSKAMAISGFIEPDNNYV . : . * *. : . * . Mvan_1197|M.vanbaalenii_PYR-1 DGARAGPPSAPAGEKDDSVFLTVASTAPLFSDASETQLDRLHAVAGPGGR Mflv_5139|M.gilvum_PYR-GCK DGAQAGPPSAPAGERDGSTFLTVTSTAPLFSDASETQLDRLHEVPGPGGR Mb1177|M.bovis_AF2122/97 DGSWVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGR Rv1146|M.tuberculosis_H37Rv DGSWVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGR MMAR_4305|M.marinum_M NGSRVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGR MUL_0989|M.ulcerans_Agy99 NGSRVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGR MAV_1287|M.avium_104 GGTRVGPPAGATGLGDGSAFLTVSSTAPLFSTANDVQLKRLHEVPGPAGR MSMEG_5178|M.smegmatis_MC2_155 QGRHVGPPSAATGIGDGSAFLTVGSDAPLFSDASEAQLDALHAVAAHA-- TH_1538|M.thermoresistible__bu RGRSVGPPSAPTGIADGSAFVTVGSVAPLFSDDSLEQLNDIRAVPAPGGT MAB_1287|M.abscessus_ATCC_1997 RGMKVGPSASATGIKNDTALFTVQTAAKPYTEAAERQLDAIHALPGPADV MLBr_02620|M.leprae_Br4923 NMWQERTVAPGASKDPS---VRVLQNGLINPNDASKKINELRSITPPKGL . :. . . * . . ::. :: :. Mvan_1197|M.vanbaalenii_PYR-1 EVLMTGTAQVNRDSVDAITSKLPIVLGLIAVIMFALLFLLTGSIVVPLKA Mflv_5139|M.gilvum_PYR-GCK DVQMTGTAQINRDSVDAITSRLPLVLGLIAIIMFALLFLLTGSVVVPLKA Mb1177|M.bovis_AF2122/97 SVVMAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKA Rv1146|M.tuberculosis_H37Rv SVVMAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKA MMAR_4305|M.marinum_M TVEMAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKA MUL_0989|M.ulcerans_Agy99 TVEMAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKA MAV_1287|M.avium_104 SVEMGGVAQVNRDSVDAVTDRLPLVLGLMAAITFVLLFLLTGSVLLPAKA MSMEG_5178|M.smegmatis_MC2_155 EVQFTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFLLTGSVVLPLKA TH_1538|M.thermoresistible__bu AVQLTGTAQINHDIVVAVTSRLTVVLTVIALTTLVWLFLLTGSIVLPIKA MAB_1287|M.abscessus_ATCC_1997 LVRIGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLFLLTGSVVLPIKA MLBr_02620|M.leprae_Br4923 TVSVGGTPALEQDSIHSLVAQAPLMVIMLITTTMLLMFLAFGSFVLPIKA * . * . :::* .:. : .::: :: :** **.::* ** Mvan_1197|M.vanbaalenii_PYR-1 LVLNMLSLTAAFGALVWIFQDGHLSGLGTTPTGTLVANMPVLLFCIAFGL Mflv_5139|M.gilvum_PYR-GCK LVLNMLSLTAAFGALVWIFQDGHLSGLGTTPTGTLVANMPVLLFCIAFGL Mb1177|M.bovis_AF2122/97 LVCNVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGL Rv1146|M.tuberculosis_H37Rv LVCNVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGL MMAR_4305|M.marinum_M LICNVLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGL MUL_0989|M.ulcerans_Agy99 LICNVLSLTAAFGALVWIFQDGHLGALGTIPSGTLVANMPVLLFCIAFGL MAV_1287|M.avium_104 LACNFLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGL MSMEG_5178|M.smegmatis_MC2_155 LVLNVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGL TH_1538|M.thermoresistible__bu LVLNALSLTAAFGALVWIFQDGHLGALGTTPSGTMAVTMPALLLCVAFGI MAB_1287|M.abscessus_ATCC_1997 LVLNVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGL MLBr_02620|M.leprae_Br4923 AVMSALTLGSTMGILTWIFVDGHLSKWLNFTPTPLMVVIIALVVAVGYGL . *:* :::* * *** :**:. . . .: . : *:..:.:*: Mvan_1197|M.vanbaalenii_PYR-1 SMDYEVFLVSRIREFWLETGD--------------SDESVALGIAHTGRV Mflv_5139|M.gilvum_PYR-GCK SMDYEVFLVSRIREFRLQGHGG----DTAGRKLSANDESVALGIAHTGRV Mb1177|M.bovis_AF2122/97 SMDYEVFLVSRIREYWLESGAARPARRSVAEVHAANDESVALGVARTGRV Rv1146|M.tuberculosis_H37Rv SMDYEVFLVSRIREYWLESGAARPARRSVAEVHAANDESVALGVARTGRV MMAR_4305|M.marinum_M SMDYEVFLVARIREYWLASGAARPATPSPAQAHAANDESVALGLARTGRV MUL_0989|M.ulcerans_Agy99 SMDYEVFLVARIREYWLASGAAGPATPSPAQAHAANDESVALGLARTGRV MAV_1287|M.avium_104 SMDYEVFLLSRIREYWLASGAARPARPTPKRAHAANDESVALGVARTGRV MSMEG_5178|M.smegmatis_MC2_155 SMDYEVFLVSRIREFWLQSDQSR----------AANEESVALGLAHTGRV TH_1538|M.thermoresistible__bu SMDYEVFLIARIREHWLASSRT----------AAANDEAVALGVARTARV MAB_1287|M.abscessus_ATCC_1997 SMDYEVFLISRIREYWMASGRTR----------ADNDEAVALGVARTGRV MLBr_02620|M.leprae_Br4923 ATDYEVFLVSRMVEARAESMST--------------QEAVRIGTASTGRL : ******::*: * :*:* :* * *.*: Mvan_1197|M.vanbaalenii_PYR-1 ITAAALIMSISFAALIAASVSFMRMFGLGLTLAVLVDATLVRMVLVPAFM Mflv_5139|M.gilvum_PYR-GCK ITAAALIMSISFAALIAANVSFMRMFGLGLTLAVLVDATLVRMVLVPAFM Mb1177|M.bovis_AF2122/97 ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVPAFM Rv1146|M.tuberculosis_H37Rv ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVPAFM MMAR_4305|M.marinum_M ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVLVPAFM MUL_0989|M.ulcerans_Agy99 ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAMAADATLVRMVLVPAFM MAV_1287|M.avium_104 ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVFADATLVRMVVVPAFM MSMEG_5178|M.smegmatis_MC2_155 ITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDATLVRMLLVPAFM TH_1538|M.thermoresistible__bu ITAAALIMSISFAALIGAQVSFMRMIGLGLMVAVLVDATLVRLILVPAFM MAB_1287|M.abscessus_ATCC_1997 VTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDATIIRMLLVPSFM MLBr_02620|M.leprae_Br4923 ITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVM :*****:::: .::: : : :*: :. ** *: ***::*:.:**:.* Mvan_1197|M.vanbaalenii_PYR-1 HLMGGLNWWAPGWLRRVHERLGFTEAP---SVNPEVTPP-------ERIS Mflv_5139|M.gilvum_PYR-GCK HLMGGVNWWAPRFLTRIHRRLGFSDDP---PTHQRAHPT-------EQTE Mb1177|M.bovis_AF2122/97 HVTGRWNWWAPRPLAWLHERFGVSEAA--EPVSRRRSHAGGLGKIAGRSD Rv1146|M.tuberculosis_H37Rv HVTGRWNWWAPRPLAWLHERFGVSEAA--EPVSRRRSHAGGLGKIAGRSD MMAR_4305|M.marinum_M HVMGRWNWWAPKPLVWLHQRFGISETG--AVGDADAAAT----EAADRRD MUL_0989|M.ulcerans_Agy99 HVMGRWNWWAPKPLVWLHQRFGISETG--AVGGADAAAT----EAADRRD MAV_1287|M.avium_104 HVMGRWNWWAPKPLAWLHDRFGISEAADEEPRLRACPRTRRIRRIARRRG MSMEG_5178|M.smegmatis_MC2_155 RVMGRWNWWAPAPLARLHERIGFSESG--LPPDPKPQPAS-----VGMTQ TH_1538|M.thermoresistible__bu HVMGRANWWAPAPLARWHDRFGIREAADAPDRPRSDPAPTPXXXDASVRK MAB_1287|M.abscessus_ATCC_1997 RLLGRFNWWAPKPLVTLHERIGFSD------------------------- MLBr_02620|M.leprae_Br4923 KLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGRPVRPPVTAAS :: * **** : *:*. : Mvan_1197|M.vanbaalenii_PYR-1 SP------------------------------------------------ Mflv_5139|M.gilvum_PYR-GCK QVPS---------------------------------------------- Mb1177|M.bovis_AF2122/97 GQT---------IPAS-----------LTRNG------------------ Rv1146|M.tuberculosis_H37Rv GQT---------IPAS-----------LTRNG------------------ MMAR_4305|M.marinum_M RPT---------IPAA-----------LSGRG------------------ MUL_0989|M.ulcerans_Agy99 RPT---------IPAA-----------LSGRG------------------ MAV_1287|M.avium_104 RRTGAQHRLTAVRPTARRVWRSDPILRLIRGGRCTQA------------- MSMEG_5178|M.smegmatis_MC2_155 SG------------------------------------------------ TH_1538|M.thermoresistible__bu GPAPSSISRDPAVPAYVPDRPRTRSACRCSR------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 LAAPASRVPRGPTHPATLEPSQRARSGLASRPQIKRPQELPSGASTARIQ Mvan_1197|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5139|M.gilvum_PYR-GCK -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 MRPSQSVEATTTRLSVPGNAPTTAAVSSSQGVQAVPLAATRHPLPTPSPA Mvan_1197|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5139|M.gilvum_PYR-GCK -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 SGQTRAMPVPANRSSDNASETAEPTTALPIMRPQDNDSEVATEKLNALGQ Mvan_1197|M.vanbaalenii_PYR-1 --------------------------- Mflv_5139|M.gilvum_PYR-GCK --------------------------- Mb1177|M.bovis_AF2122/97 --------------------------- Rv1146|M.tuberculosis_H37Rv --------------------------- MMAR_4305|M.marinum_M --------------------------- MUL_0989|M.ulcerans_Agy99 --------------------------- MAV_1287|M.avium_104 --------------------------- MSMEG_5178|M.smegmatis_MC2_155 --------------------------- TH_1538|M.thermoresistible__bu --------------------------- MAB_1287|M.abscessus_ATCC_1997 --------------------------- MLBr_02620|M.leprae_Br4923 GDNSRQHRRATGGGISAQDLLRREGRL