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LQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAESARATQLLADKFHRGDMQLVIA VTAEAPGGRADGGRAREVGTEIVSELKASPYVTEVTSAWTAPPSAAAALVSKDARTGLIVAGLNGGENGA QQHAKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFVVLVWVFGGLLAAALPLA VGGFAILGSLAVLRLFTMVTDVSIFALNLTVAMGLALAIDYTLLIISRFRDELAEGADRETALVRTMMTA GRTVLFSAMTVALSMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYDVRRFFRR VFGRPEPEPKPVEQGFWYRTAKAAMRRAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGD EMRTNFAVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDVQGRHVGPPSAATGIGDG SAFLTVGSDAPLFSDASEAQLDALHAVAAHAEVQFTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFL LTGSVVLPLKALVLNVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGLSMDYEVFLV SRIREFWLQSDQSRAANEESVALGLAHTGRVITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDAT LVRMLLVPAFMRVMGRWNWWAPAPLARLHERIGFSESGLPPDPKPQPASVGMTQSG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5178 | - | - | 100% (757) | integral membrane protein |
M. smegmatis MC2 155 | MSMEG_0250 | - | 5e-99 | 32.28% (759) | membrane protein, MmpL family protein |
M. smegmatis MC2 155 | MSMEG_0241 | - | 1e-69 | 28.22% (762) | MmpL11 protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1177 | mmpL13 | 0.0 | 67.46% (753) | transmembrane transport protein MmpL13 |
M. gilvum PYR-GCK | Mflv_2131 | - | 0.0 | 74.59% (740) | MMPL domain-containing protein |
M. tuberculosis H37Rv | Rv1146 | mmpL13b | 1e-168 | 69.25% (439) | transmembrane transport protein MmpL13B |
M. leprae Br4923 | MLBr_02620 | - | 6e-94 | 31.20% (766) | hypothetical protein MLBr_02620 |
M. abscessus ATCC 19977 | MAB_1287 | - | 0.0 | 61.03% (739) | MmpL family membrane protein |
M. marinum M | MMAR_4305 | mmpL13 | 0.0 | 69.00% (758) | transmembrane transport protein MmpL13 |
M. avium 104 | MAV_1287 | - | 0.0 | 68.27% (750) | mmpL protein |
M. thermoresistible (build 8) | TH_1538 | - | 0.0 | 62.83% (756) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL13B |
M. ulcerans Agy99 | MUL_0989 | mmpL13 | 0.0 | 68.83% (754) | transmembrane transport protein MmpL13 |
M. vanbaalenii PYR-1 | Mvan_4573 | - | 0.0 | 75.79% (756) | MMPL domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_2131|M.gilvum_PYR-GCK -MLHRIARLAIAAPRRVLMAALLVAIACGVFGIPVVTHLSAGGFQDPTSE Mvan_4573|M.vanbaalenii_PYR-1 -MLHRIALLAIAAPRRVLVVALLIMVGCGIFGAPVAKHLSAGGFQDPTSE MSMEG_5178|M.smegmatis_MC2_155 -MLQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAE Mb1177|M.bovis_AF2122/97 -MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSE Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -MLQKIARVAIAAPRRIIALGVLVFLAAAVFGIPVAKSLSPGGFQDPDSE MMAR_4305|M.marinum_M -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSPGGFQDPNAE MUL_0989|M.ulcerans_Agy99 -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSRGGFQDPNAE TH_1538|M.thermoresistible__bu -MLETLARRIVAAPRRVLALVVLVIVGAAMFGLPVAGSLSAGGFRDPHSE MAB_1287|M.abscessus_ATCC_1997 MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSE MLBr_02620|M.leprae_Br4923 -MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQ Mflv_2131|M.gilvum_PYR-GCK SARATQMLVDTFGQGDMELILAVTSD---DGAQSPAARDVGVELVERLS- Mvan_4573|M.vanbaalenii_PYR-1 SARATQLLVDKFDQGDMELLISITDDNSADGANSPAARAVGTDLADRLA- MSMEG_5178|M.smegmatis_MC2_155 SARATQLLADKFHRGDMQLVIAVTAEAPGGRADGGRAREVGTEIVSELK- Mb1177|M.bovis_AF2122/97 SARAIEVLTDKFGQSGQKMLIVVTAA---AGADSPPAREVGTDIVEVLR- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 SARAIGVLTDKFGQSGQQMLILVTAP---GGSNSDPARRVGTELVEQLQ- MMAR_4305|M.marinum_M SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- MUL_0989|M.ulcerans_Agy99 SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- TH_1538|M.thermoresistible__bu SAQASALLAERFDQTDMQLLVTVSSS---AGVYGEAARRVGTEIVAALE- MAB_1287|M.abscessus_ATCC_1997 SAYVTKALRDKFDISDQSLVFMLTSE---QGVKSPQMRAVAADLERQLK- MLBr_02620|M.leprae_Br4923 SVKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQR Mflv_2131|M.gilvum_PYR-GCK -DSPHVAAITSAWTSP---PSAAPALISEDGRTGLIVAGITGGESGAQKL Mvan_4573|M.vanbaalenii_PYR-1 -ASPHVGAVTSAWTAP---PSAAPALVSEDGRTGLIIAGITGGESEAQKH MSMEG_5178|M.smegmatis_MC2_155 -ASPYVTEVTSAWTAP---PSAAAALVSKDARTGLIVAGLNGGENGAQQH Mb1177|M.bovis_AF2122/97 -RSPLVYNVTSPWTVP---PTAAADLLSTDGKSGLIVVNVKGGENDAQNH Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -RSPLVYNVSSPWTAP---PQASADLVSRDGKSGLIVVNLKGGENFVQNN MMAR_4305|M.marinum_M -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN MUL_0989|M.ulcerans_Agy99 -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN TH_1538|M.thermoresistible__bu -ASPQVAGVQSPWTVP---PGAGDRLVSEDATAGLIVAPIRGNETESSDI MAB_1287|M.abscessus_ATCC_1997 -DSGVVINLTSAWTAP---PQVAEELLGADGKAGLIVAGLTGGENDAQKH MLBr_02620|M.leprae_Br4923 NNSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILN Mflv_2131|M.gilvum_PYR-GCK AKALTDELVYDRDGVTVRAGGAAMTYVQINTQTEKDLLLMESIAIPLSFV Mvan_4573|M.vanbaalenii_PYR-1 AKTLTDELVRDRDGVTVRAGGVAMTYVQINTQSEKDLLMMESIAIPLSFV MSMEG_5178|M.smegmatis_MC2_155 AKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFV Mb1177|M.bovis_AF2122/97 AQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 AQTLADQFVHDRDGVTVRAGGAAMQYAQINTQNQADLLVMEMIALPLSFL MMAR_4305|M.marinum_M AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL MUL_0989|M.ulcerans_Agy99 AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL TH_1538|M.thermoresistible__bu ARQLAAAVGSDRDRVNVRAGGPALVNAQIDTQTEHDLLVMEAIAIPLSFV MAB_1287|M.abscessus_ATCC_1997 AAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFV MLBr_02620|M.leprae_Br4923 NYKAIAPDLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEVLALPLVAV Mflv_2131|M.gilvum_PYR-GCK VLVWVFGGLLAAALPLAVGVFAILGSMAVLRGFTLVTDVSIFALNLSIAM Mvan_4573|M.vanbaalenii_PYR-1 VLVWVFGGLLAAALPLAVGAFAILGSMAVLRAVTLVTDVSIFALNLSIAM MSMEG_5178|M.smegmatis_MC2_155 VLVWVFGGLLAAALPLAVGGFAILGSLAVLRLFTMVTDVSIFALNLTVAM Mb1177|M.bovis_AF2122/97 VLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 VLIWVFGGLLAAALPMALGALAVVGSMSVLRLITFTTEVSIFALNLSTAL MMAR_4305|M.marinum_M VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL MUL_0989|M.ulcerans_Agy99 VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL TH_1538|M.thermoresistible__bu VLVWVFGGLLAAALPLAVGVLAIVGSMAVLRTFTMFTEVSVFALNLSIAM MAB_1287|M.abscessus_ATCC_1997 VLVWIFGGLYAALLPLVVGVFSIVGAMSILRGLTYVTDVSVFALNLAVAM MLBr_02620|M.leprae_Br4923 VLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFFAQPVVSLI Mflv_2131|M.gilvum_PYR-GCK GLALAIDYTLLIISRYRDELADGHDRDTALLRTMTTAGRTVVFSATTVAL Mvan_4573|M.vanbaalenii_PYR-1 GLALAIDYTLLIISRYRDELAEGHDRDSALVRTMMTAGRTVLFSALTVAL MSMEG_5178|M.smegmatis_MC2_155 GLALAIDYTLLIISRFRDELAEGADRETALVRTMMTAGRTVLFSAMTVAL Mb1177|M.bovis_AF2122/97 GLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 GLALAIDYTLLIVSRYRDELAEGHDRDQALIRTMATSGRTVLFSAVTVAL MMAR_4305|M.marinum_M GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL MUL_0989|M.ulcerans_Agy99 GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL TH_1538|M.thermoresistible__bu GLALAIDYTLLLLNRYRDELAEGCSREQAVIRTMTSAGRTVIFSAVIVAT MAB_1287|M.abscessus_ATCC_1997 GLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAGRTVLFSALTVAL MLBr_02620|M.leprae_Br4923 GLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVTFSAVLIAA Mflv_2131|M.gilvum_PYR-GCK SMVAMVLFPMYFLKSFAYAGIAVVSFAALAAIVVTPAAIALAGDRLDALD Mvan_4573|M.vanbaalenii_PYR-1 SMVAMVLFPMYFLKSFAYAGIAVVGFAAVAAIVVAPAAIVLAGARLDSMD MSMEG_5178|M.smegmatis_MC2_155 SMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYD Mb1177|M.bovis_AF2122/97 SMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALD Rv1146|M.tuberculosis_H37Rv --------------------MATVAFVATASIVITPAAIVLLGPRLDALD MAV_1287|M.avium_104 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGDRLDALD MMAR_4305|M.marinum_M SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN MUL_0989|M.ulcerans_Agy99 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN TH_1538|M.thermoresistible__bu SMVPLALFPMYFLRSFAYAGVGVVAFALCAALVITPAAITVLGARLDSWD MAB_1287|M.abscessus_ATCC_1997 ALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALD MLBr_02620|M.leprae_Br4923 SGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAILAKHVDALG :..* . ::.: ** :.: . ::*: . Mflv_2131|M.gilvum_PYR-GCK VRRLVRRILGRP-----------------DPVAKPVEQNFWYRSTTFVMR Mvan_4573|M.vanbaalenii_PYR-1 VRRLVRRVLGRP-----------------EPVAKPVEQMFWYRSTKFVMR MSMEG_5178|M.smegmatis_MC2_155 VRRFFRRVFGRP-----------------EPEPKPVEQGFWYRTAKAAMR Mb1177|M.bovis_AF2122/97 VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR Rv1146|M.tuberculosis_H37Rv VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR MAV_1287|M.avium_104 VRRLLRRALRRA-----------------QPVRKPVEQLFWYRSSKFVMR MMAR_4305|M.marinum_M VRRLARRMLGRP-----------------EPQHKPVDQLFWYRSTKFVMR MUL_0989|M.ulcerans_Agy99 VRRLARRMLGRP-----------------KPQHKPVDQLFWYRSTKFVMR TH_1538|M.thermoresistible__bu IRRLIRRLMRRTP-------------AAAEPAPRAVCGSKWYRWAKAVMR MAB_1287|M.abscessus_ATCC_1997 VRRLIRRVLGRP-----------------EPVAKDVTQSFWYRTTKRVMA MLBr_02620|M.leprae_Br4923 VRTLFRVPLLRNWRMSHACLNWLADRLQKTKTREEVEAGFWGKLVNFVMK :* : * : * . * * : . .* Mflv_2131|M.gilvum_PYR-GCK RSIPIGGVVVVLLVLLGAPFLGATWGFPDDRVLPETASARQIGDELRQDF Mvan_4573|M.vanbaalenii_PYR-1 RSIPIGVVVVTLLLLLGAPFLGANWGFPDDRVLPQSASARQVGDELRTDF MSMEG_5178|M.smegmatis_MC2_155 RAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGDEMRTNF Mb1177|M.bovis_AF2122/97 RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF Rv1146|M.tuberculosis_H37Rv RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF MAV_1287|M.avium_104 RWAPVGLIVVGLLLLLGLPFFSVKWGFPDDRVLPRSASAHQVGDRLRSGF MMAR_4305|M.marinum_M RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF MUL_0989|M.ulcerans_Agy99 RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF TH_1538|M.thermoresistible__bu HWLVAGLAVTVVLLLLGAPFLGVRWGFPDERVLPRSASAHQVGHELRTNF MAB_1287|M.abscessus_ATCC_1997 RAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNEMRRNF MLBr_02620|M.leprae_Br4923 RPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPNNAVRQSQEHFDQLF : . : :::* *: . :* .:: ** . : :* . : * Mflv_2131|M.gilvum_PYR-GCK AVDSSTNVVVVLPDADGISREDFDAYAIALSGVADVSSVSAPSGTFIGGA Mvan_4573|M.vanbaalenii_PYR-1 AVDSSANVVVVLPDAEGLGPDALDGYAAELSRVQDVSSVSAPGGTFVDGA MSMEG_5178|M.smegmatis_MC2_155 AVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDVQGR Mb1177|M.bovis_AF2122/97 GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS Rv1146|M.tuberculosis_H37Rv GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS MAV_1287|M.avium_104 AHDSATSVPVVIPDAAGLSPADLDDYAAALSRVPDVSAVSAPGGTFTGGT MMAR_4305|M.marinum_M AHDLAMAVPVVVPDVRGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS MUL_0989|M.ulcerans_Agy99 AHDLAMAVPVVVPDVHGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS TH_1538|M.thermoresistible__bu ATDSASDVTVVLPDAPGLTADELAGYAARLSEVTDVAWVSAPAGTFVRGR MAB_1287|M.abscessus_ATCC_1997 NNNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFIRGM MLBr_02620|M.leprae_Br4923 PGYRTNPLTLVIQTSN-HQPVTDQEIADIRSKAMAISGFIEPDNNYVN-- : : :: * * : . * . Mflv_2131|M.gilvum_PYR-GCK RAGPPSAATGSADGSAFLTIGSRAPLFTDASEVQLDRLHAIAPPGDRQVL Mvan_4573|M.vanbaalenii_PYR-1 KAGPPSAATGIAEGSAFLTIGSTAPLFTDASETQLDRLHDVAPPEGRDVL MSMEG_5178|M.smegmatis_MC2_155 HVGPPSAATGIGDGSAFLTVGSDAPLFSDASEAQLDALHAVAAH--AEVQ Mb1177|M.bovis_AF2122/97 WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV Rv1146|M.tuberculosis_H37Rv WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV MAV_1287|M.avium_104 RVGPPAGATGLGDGSAFLTVSSTAPLFSTANDVQLKRLHEVPGPAGRSVE MMAR_4305|M.marinum_M RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE MUL_0989|M.ulcerans_Agy99 RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE TH_1538|M.thermoresistible__bu SVGPPSAPTGIADGSAFVTVGSVAPLFSDDSLEQLNDIRAVPAPGGTAVQ MAB_1287|M.abscessus_ATCC_1997 KVGPSASATGIKNDTALFTVQTAAKPYTEAAERQLDAIHALPGPADVLVR MLBr_02620|M.leprae_Br4923 -MWQERTVAPGASKDPSVRVLQNGLINPNDASKKINELRSITPPKGLTVS : . . . : . . ::. :: :. * Mflv_2131|M.gilvum_PYR-GCK LTGLAQINRDSADAITSRLPLVLAVIAAITFVLLFVLTGSVVLPLKALVL Mvan_4573|M.vanbaalenii_PYR-1 LTGLAQINRDSADAITSRLPTVLAVIAAITFVLLFLLTGSVVLPLKALVL MSMEG_5178|M.smegmatis_MC2_155 FTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFLLTGSVVLPLKALVL Mb1177|M.bovis_AF2122/97 MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC Rv1146|M.tuberculosis_H37Rv MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC MAV_1287|M.avium_104 MGGVAQVNRDSVDAVTDRLPLVLGLMAAITFVLLFLLTGSVLLPAKALAC MMAR_4305|M.marinum_M MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC MUL_0989|M.ulcerans_Agy99 MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC TH_1538|M.thermoresistible__bu LTGTAQINHDIVVAVTSRLTVVLTVIALTTLVWLFLLTGSIVLPIKALVL MAB_1287|M.abscessus_ATCC_1997 IGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLFLLTGSVVLPIKALVL MLBr_02620|M.leprae_Br4923 VGGTPALEQDSIHSLVAQAPLMVIMLITTTMLLMFLAFGSFVLPIKAAVM . * . :::* .:. : . :: :: * : :*: **.:** ** Mflv_2131|M.gilvum_PYR-GCK NVLSLTAAFGALVWIFQEGHLGALGTTPTGTLVATMPVLLFCIAFGLSMD Mvan_4573|M.vanbaalenii_PYR-1 NVLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANMPVLLFCIAFGLSMD MSMEG_5178|M.smegmatis_MC2_155 NVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGLSMD Mb1177|M.bovis_AF2122/97 NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD Rv1146|M.tuberculosis_H37Rv NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD MAV_1287|M.avium_104 NFLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MMAR_4305|M.marinum_M NVLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MUL_0989|M.ulcerans_Agy99 NVLSLTAAFGALVWIFQDGHLGALGTIPSGTLVANMPVLLFCIAFGLSMD TH_1538|M.thermoresistible__bu NALSLTAAFGALVWIFQDGHLGALGTTPSGTMAVTMPALLLCVAFGISMD MAB_1287|M.abscessus_ATCC_1997 NVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGLSMD MLBr_02620|M.leprae_Br4923 SALTLGSTMGILTWIFVDGHLSKWLNFTPTPLMVVIIALVVAVGYGLATD . *:* :::* * *** :**:. . . .: . : *:..:.:*:: * Mflv_2131|M.gilvum_PYR-GCK YEVFLVSRIREYWLETG--------------------ENGRSVALGLART Mvan_4573|M.vanbaalenii_PYR-1 YEVFLVSRIREYWLASGGAGADSSTAHQRSDDLAPHVRSDESVALGLART MSMEG_5178|M.smegmatis_MC2_155 YEVFLVSRIREFWLQSDQS----------------RAANEESVALGLAHT Mb1177|M.bovis_AF2122/97 YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART Rv1146|M.tuberculosis_H37Rv YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART MAV_1287|M.avium_104 YEVFLLSRIREYWLASGAAR------PARPTPKRAHAANDESVALGVART MMAR_4305|M.marinum_M YEVFLVARIREYWLASGAAR------PATPSPAQAHAANDESVALGLART MUL_0989|M.ulcerans_Agy99 YEVFLVARIREYWLASGAAG------PATPSPAQAHAANDESVALGLART TH_1538|M.thermoresistible__bu YEVFLIARIREHWLASSRTA----------------AANDEAVALGVART MAB_1287|M.abscessus_ATCC_1997 YEVFLISRIREYWMASGRTR----------------ADNDEAVALGVART MLBr_02620|M.leprae_Br4923 YEVFLVSRMVEARAESMSTQ--------------------EAVRIGTAST *****::*: * : .:* :* * * Mflv_2131|M.gilvum_PYR-GCK GRVVTAAALVMSISFAALIAAQVSFMRMFGGGLTLAVLVDATLVRMLLVP Mvan_4573|M.vanbaalenii_PYR-1 GRVVTAAALLMSISFAALIAAKVAFMRMFGVGLTLAILADATLVRMLLVP MSMEG_5178|M.smegmatis_MC2_155 GRVITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDATLVRMLLVP Mb1177|M.bovis_AF2122/97 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP Rv1146|M.tuberculosis_H37Rv GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP MAV_1287|M.avium_104 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVFADATLVRMVVVP MMAR_4305|M.marinum_M GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVLVP MUL_0989|M.ulcerans_Agy99 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAMAADATLVRMVLVP TH_1538|M.thermoresistible__bu ARVITAAALIMSISFAALIGAQVSFMRMIGLGLMVAVLVDATLVRLILVP MAB_1287|M.abscessus_ATCC_1997 GRVVTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDATIIRMLLVP MLBr_02620|M.leprae_Br4923 GRLITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVP .*::*****:::: .::: :.: :*: :. ** *: ***::*:.:** Mflv_2131|M.gilvum_PYR-GCK AFMHLLGRWNWWAPPPLARLHARIGVSETVP------------------- Mvan_4573|M.vanbaalenii_PYR-1 AFMHVLGRWNWWAPKPLARLHERIGFSETLDDSSDSPP----------RS MSMEG_5178|M.smegmatis_MC2_155 AFMRVMGRWNWWAPAPLARLHERIGFSESGLPPDPKP------------- Mb1177|M.bovis_AF2122/97 AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG Rv1146|M.tuberculosis_H37Rv AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG MAV_1287|M.avium_104 AFMHVMGRWNWWAPKPLAWLHDRFGISEAADEEPRLRACPRTRRIRRIAR MMAR_4305|M.marinum_M AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGDADAAATEA------AD MUL_0989|M.ulcerans_Agy99 AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGGADAAATEA------AD TH_1538|M.thermoresistible__bu AFMHVMGRANWWAPAPLARWHDRFGIREAADAPDRPRSDPAPTPXXXDAS MAB_1287|M.abscessus_ATCC_1997 SFMRLLGRFNWWAPKPLVTLHERIGFSD---------------------- MLBr_02620|M.leprae_Br4923 SVMKLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGRPVRPPVT :.*:: * **** : *:*. : Mflv_2131|M.gilvum_PYR-GCK -QRV---------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 RQHVATG-----------------------NEHG---------------- MSMEG_5178|M.smegmatis_MC2_155 -QPASVG-----------------------MTQSG--------------- Mb1177|M.bovis_AF2122/97 RSDGQT---------IPAS-----------LTRNG--------------- Rv1146|M.tuberculosis_H37Rv RSDGQT---------IPAS-----------LTRNG--------------- MAV_1287|M.avium_104 RRGRRTGAQHRLTAVRPTARRVWRSDPILRLIRGGRCTQA---------- MMAR_4305|M.marinum_M RRDRPT---------IPAA-----------LSGRG--------------- MUL_0989|M.ulcerans_Agy99 RRDRPT---------IPAA-----------LSGRG--------------- TH_1538|M.thermoresistible__bu VRKGPAPSSISRDPAVPAYVPDRP------RTRSACRCSR---------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 AASLAAPASRVPRGPTHPATLEPSQRARSGLASRPQIKRPQELPSGASTA Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 RIQMRPSQSVEATTTRLSVPGNAPTTAAVSSSQGVQAVPLAATRHPLPTP Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 SPASGQTRAMPVPANRSSDNASETAEPTTALPIMRPQDNDSEVATEKLNA Mflv_2131|M.gilvum_PYR-GCK ------------------------------ Mvan_4573|M.vanbaalenii_PYR-1 ------------------------------ MSMEG_5178|M.smegmatis_MC2_155 ------------------------------ Mb1177|M.bovis_AF2122/97 ------------------------------ Rv1146|M.tuberculosis_H37Rv ------------------------------ MAV_1287|M.avium_104 ------------------------------ MMAR_4305|M.marinum_M ------------------------------ MUL_0989|M.ulcerans_Agy99 ------------------------------ TH_1538|M.thermoresistible__bu ------------------------------ MAB_1287|M.abscessus_ATCC_1997 ------------------------------ MLBr_02620|M.leprae_Br4923 LGQGDNSRQHRRATGGGISAQDLLRREGRL