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MNHTGKHTATDVTGVSETALLTLLVRATEARRPDSLIDDPMAIHLVDSIDFDFAKFGYVRRQDMSLRALA FDKQTRRYLRDHPKATVVALAEGLQTSFYRLDAQGPDVGHDFRWLTVDLPPMIELRRKLLPASDRVQMLA QSALDFSWMDRVPTDDGDVNQAGDDGDVNQAGDDGDVDQAGADGVFITAEGLLMYLQPEESMALITECAA RFPGGRMMFDLPPSAFAPLVRRGFRASLRYRVPPMPFTLSPAEAADLVNTVPGVRAVHDVPAEHARGRIL NALLWTAQRVPLLDPVRPMFTLLEFG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4568 | - | - | 100% (306) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 7e-86 | 55.23% (306) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 2e-22 | 29.28% (263) | O-methyltransferase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 2e-85 | 58.50% (294) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_2136 | - | 1e-127 | 75.82% (306) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 3e-86 | 58.84% (294) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1295c | - | 4e-66 | 48.99% (298) | O-methyltransferase OMT |
| M. marinum M | MMAR_4300 | omt_2 | 2e-90 | 58.64% (295) | O-methyltransferase Omt_2 |
| M. avium 104 | MAV_2991 | - | 9e-22 | 28.87% (284) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 1e-107 | 66.22% (299) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 1e-113 | 68.98% (303) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 2e-73 | 52.74% (292) | O-methyltransferase Omt |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4568|M.vanbaalenii_PYR-1 --------MNHTGKHTATDVTGVSETALLTLLVRATEARRPDSLIDDPMA
Mflv_2136|M.gilvum_PYR-GCK --------MSPTDKHSA-DLTGVSETALMTLLVRATEARRPDSLIDDPMA
TH_0460|M.thermoresistible__bu ---------VSSGPLAKPELTGVSETALLTLLVRATEARRPDGIIDDPMA
MSMEG_5173|M.smegmatis_MC2_155 -------MTTDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMA
Mb1184c|M.bovis_AF2122/97 ------MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMA
Rv1153c|M.tuberculosis_H37Rv ------MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMA
MMAR_4300|M.marinum_M ------MTPADEFAQQKVALTGVSETALLTLNARAAEARRRDPIIEDPMA
MUL_3020|M.ulcerans_Agy99 -------MGHSDNNVNAGMLGGVSETALLTLNGRAHQAAKPNPIIDDPMA
MAB_1295c|M.abscessus_ATCC_199 MTESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLA
MAV_2991|M.avium_104 ------MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAA
.*. * * ** *. :: : :: *. *
Mvan_4568|M.vanbaalenii_PYR-1 IHLVDSIDFDFAKFG-----YVRRQDMSLRALAFDKQTRRYLRDHPKATV
Mflv_2136|M.gilvum_PYR-GCK VKLVDSLDFDRAKFG-----FVRRQDMAVRALVFDKWTRRYLVDHPRATV
TH_0460|M.thermoresistible__bu VRLVDSIDFDFAKFG-----PSRRQDMALRAKAFDTATRRYLRAHPKATV
MSMEG_5173|M.smegmatis_MC2_155 VQLVDSIDFDFAKFG-----HSHRQDMALRSLIFDRATSDYLRDHPKATV
Mb1184c|M.bovis_AF2122/97 VALVESIDFGFAKFG-----PTG-QGFALRARAFDMAAQHYLDQHPAATV
Rv1153c|M.tuberculosis_H37Rv VALVESIDFDFAKFG-----PTG-QGFALRARAFDMAAQHYLDQHPAATV
MMAR_4300|M.marinum_M VRLVDSIDFDFAKFG-----PTR-QDIALRALAFDTRALAYLNKHPSATV
MUL_3020|M.ulcerans_Agy99 IKLVESNDFDFEKFG-----RRG-QEMALRSLAVDRCEIAYLTKHPGATV
MAB_1295c|M.abscessus_ATCC_199 AELFDAIEYDYRKFG-----RPS-QTHALRALAFDTQARVYLATHPRAAI
MAV_2991|M.avium_104 AEAVDRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVV
.: :. :: ::*: .* :* ** *.:
Mvan_4568|M.vanbaalenii_PYR-1 VALAEGLQTSFYRLDAQGPDVGHDFRWLTVDLPPMIELRRKLLPASDRVQ
Mflv_2136|M.gilvum_PYR-GCK VALAEGLQTSFYRLDSGPESVGHDFRWLTVDLPPMIDLRTKLLPPSDRVR
TH_0460|M.thermoresistible__bu VALAEGLQTSFFRLN--AADVGDEFRWVTVDLAPVIELRRQLLPADDRVT
MSMEG_5173|M.smegmatis_MC2_155 VALAEGLQTSFYRLN--EAGVGDQFCWLTVDLPPMVEIRNKLLPPSDRVR
Mb1184c|M.bovis_AF2122/97 VALAEGLQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVS
Rv1153c|M.tuberculosis_H37Rv VALAEGLQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVS
MMAR_4300|M.marinum_M VALAEGLQTSFWRLD--SALPGKKFRWLTVDLPPIIDIRKRLLPNSPRVS
MUL_3020|M.ulcerans_Agy99 VAHAEGFQTGFWRVS--NALPDTQFRWVSLDLEPVMELRRRLLPDSARVT
MAB_1295c|M.abscessus_ATCC_199 VALAEGMQTSFWRLG--GADATAQFTWYSVDLPPVMELRNQLLPNDERIV
MAV_2991|M.avium_104 LHLGCGLDGRAFRVS-----VPPSLSWFDVDQPSVIGLRRRLYDDTENYR
: . *:: :*:. .: * :* .:: :* :* .
Mvan_4568|M.vanbaalenii_PYR-1 MLAQSALDFSWMDRVPTDDGDVNQAGDDGDVNQAGDDGDVDQAGADGVFI
Mflv_2136|M.gilvum_PYR-GCK TLAQSALDFSWMDQVDTSEG---------------------------VFI
TH_0460|M.thermoresistible__bu MLAQSALDYSWMDRIDTSEG---------------------------VFI
MSMEG_5173|M.smegmatis_MC2_155 TCAQSALDYSWMDQVDDSEG---------------------------VFI
Mb1184c|M.bovis_AF2122/97 VCAQSALDYSWMDSVDPAGG---------------------------VFI
Rv1153c|M.tuberculosis_H37Rv VCAQSALDYSWMDSVDPAGG---------------------------VFI
MMAR_4300|M.marinum_M VCAQSALDYGWMDSVDTSGG---------------------------VFI
MUL_3020|M.ulcerans_Agy99 NLAQSALDYTWMDKVDSCAA---------------------------VFI
MAB_1295c|M.abscessus_ATCC_199 KLAQSALDLSWMDQVDASGG---------------------------AFI
MAV_2991|M.avium_104 MIGSSVTELQWLDEVPAGRP---------------------------TLM
..*. : *:* : .::
Mvan_4568|M.vanbaalenii_PYR-1 TAEGLLMYLQPEESMALITECAARFPGGRMMFDLPPSAFAPLVRRGFRAS
Mflv_2136|M.gilvum_PYR-GCK TAEGLLMYLQPAEAMSLITECAARFPGGQMIFDLPPSAFAFLVGRGVRAS
TH_0460|M.thermoresistible__bu TAEGLLMYLQPDEAMGLIRECARRFPGGQMMFDLPPSFFAWLTRRGFRTS
MSMEG_5173|M.smegmatis_MC2_155 TAEGLLMYLQPEESMGLIKECARRFPGGQMIFDLPPSWFAAWARKGMRTS
Mb1184c|M.bovis_AF2122/97 TAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTS
Rv1153c|M.tuberculosis_H37Rv TAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTS
MMAR_4300|M.marinum_M TAEGLLMYLEPDQALDLIAQCAKRFPGAQMLFDLPPRWFSLFTRLGMRTS
MUL_3020|M.ulcerans_Agy99 TAEGLLMYPQPNQAMELISQCAKRFAGGQMFFDLPPTIVKRVAPKGMRAS
MAB_1295c|M.abscessus_ATCC_199 TAEGLLMYLQPEESLGLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLS
MAV_2991|M.avium_104 VAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFDTLSALAPLLSKVFTRGI
.******* . : *: *.*..* ** . :
Mvan_4568|M.vanbaalenii_PYR-1 LRYRVPPMPFTLSPAEAADLVNTVPGVRAVHDVPAEHARGRILNALLWTA
Mflv_2136|M.gilvum_PYR-GCK LRYRVPPMPFSLTIAEAADLVNTVPGVRAVHDLPAEHARGRLINALLWTA
TH_0460|M.thermoresistible__bu LRYKVPPMPFTLSPEQAADLVNTVPGVQAVHDVPIPRGRGVLVNTLIWAA
MSMEG_5173|M.smegmatis_MC2_155 RRYRVPPMPFSLSPAEVADLVNTVPGVRVVHDLPFPPARGKFMRTVVWGV
Mb1184c|M.bovis_AF2122/97 LRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTV
Rv1153c|M.tuberculosis_H37Rv LRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTV
MMAR_4300|M.marinum_M IRYKIPPMPFSLSVAQAADLVNTIPGIRAVRDVQLPAGRGLMFNAALSTV
MUL_3020|M.ulcerans_Agy99 RRYRVPPMPFSLSVNQLARLVDTVPGIRAVHDVPMPEGRGLFFRTLYPAL
MAB_1295c|M.abscessus_ATCC_199 DRYVAPPMPFALTPDEGEALIS-IPGVVTAIDIPLHRGRGIWKFVNSKRL
MAV_2991|M.avium_104 ITWGIR---------DARRIADWNPRLRFLEQSPALAGYQRIPSTVVRSI
: : : . * : : .
Mvan_4568|M.vanbaalenii_PYR-1 QRVPLLDPVRPMFTLLEFG-------
Mflv_2136|M.gilvum_PYR-GCK QRVPLLDPIRPMFTLLEFG-------
TH_0460|M.thermoresistible__bu QRTPLFDNVRGTYTLLEFGPPNSAST
MSMEG_5173|M.smegmatis_MC2_155 QRLPLFDPIRPVMALLEFG-------
Mb1184c|M.bovis_AF2122/97 YRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv YRLPVFDPLRPCLTLLEFSRPARG--
MMAR_4300|M.marinum_M YRLPALDSLRPCLTLLEFG-------
MUL_3020|M.ulcerans_Agy99 WRFPPIKPFRGAYVLLEFD-------
MAB_1295c|M.abscessus_ATCC_199 DRG-FLRRTRPSMTLLQFG-------
MAV_2991|M.avium_104 YRLTWLTGGRGYDVLNRFEY------
* : * .* .*