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MIDFTDLVDPEHGWVSPQIYTDPEIYERELQHVFGRSWLFLAHDSQLPKPGSFLQTYMGEDPVLVVRQRD GSVRAFLNQCRHRGMRICRSEAGVSKAFTCTYHGWSYDLAGNLINVPLEERAYHSSIDKKEWGAMKVPRV ANYRGFYFGTWSEETPEFDAYLGDMAFYFDAIVDRFDSGLEFVKGTTKWVIDCNWKFASEQFASDMYHTQ SAHASALLALTDDPNPIGPLNDPNVPGRQFSGNGHGSGGYFLPAPVVKTPEMTDTMFEWFKSREEEMVAR IGADRLSKVSITHNTIFPNFSWLGAHSTMRVWHPRGPGQIEVWAWTYVPKDAPPKVKNEIRELTQRTFSP AGSFETDDGENWTEIQQVLRGSQARRNRLHTAMGVGYEERDAFGLPGLGNDVYSETAARGFYRHWLDMLT GKPWSEIQKWTPNGNHGELRDEGVTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4415 | - | - | 100% (446) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0533 | - | 2e-73 | 35.19% (449) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0546 | - | 2e-72 | 35.55% (422) | ring hydroxylating dioxygenase, alpha subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 4e-19 | 29.33% (225) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0632 | - | 4e-75 | 35.92% (451) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 1e-18 | 28.89% (225) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 1e-102 | 43.93% (428) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_4422 | - | 5e-22 | 31.55% (206) | dioxygenase |
| M. avium 104 | MAV_3509 | - | 3e-55 | 30.36% (448) | phthalate dioxygenase large subunit |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 1e-40 | 29.22% (373) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2967 | - | 8e-34 | 38.12% (202) | PUTATIVE putative Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 7e-15 | 30.70% (215) | ring-hydroxylating dioxygenase, large terminal subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 ----------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSEL
Rv3161c|M.tuberculosis_H37Rv ----------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSEL
Mvan_4415|M.vanbaalenii_PYR-1 -----------------------MIDFTDLVDPE--HGWVSPQIYTDPEI
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSH--GGLLDRVIFTDGEL
Mflv_0632|M.gilvum_PYR-GCK ------------MTLKMSTSGGSDTTARSLVDVD--RGEISREIFTDASI
MAV_3509|M.avium_104 -------------------MAGPDGGLLGVLENVR-RGMIPAHIYNDPEL
MSMEG_1908|M.smegmatis_MC2_155 -----------MTTHLSPDHLENVLADAVIEDPAAGVYRANRRIFTDDEI
TH_2967|M.thermoresistible__bu ----------------------------MPVFPTSDGSRIPYEVYSSQAV
MMAR_4422|M.marinum_M --------------------------MTAVRQPSALLPTLGGAYYTSAAV
MUL_3820|M.ulcerans_Agy99 ---------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDR
:..
Mb3186c|M.bovis_AF2122/97 WQLERERIFNR-SWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLH
Rv3161c|M.tuberculosis_H37Rv WQLERERIFNR-SWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLH
Mvan_4415|M.vanbaalenii_PYR-1 YERELQHVFGR-SWLFLAHDSQLPKPGSFLQTYMGEDPVLVVRQRDGSVR
MAB_4370c|M.abscessus_ATCC_199 YRQELRRVFAP-SWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRRIR
Mflv_0632|M.gilvum_PYR-GCK FNRELEYLFPR-SWLFVGHASQVSAPGQFFSSRMGSDPVLLTRDAQGGVN
MAV_3509|M.avium_104 FALEKRRLFAR-AWTFVGHESEIPHDGDYMVRRVLDDSFIITRGSDGRVR
MSMEG_1908|M.smegmatis_MC2_155 FELEMKHIFEG-NWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGDLH
TH_2967|M.thermoresistible__bu YDREQERLFRGPIWNFLALEAELPNPFDFKSTFVGDTPVVVTRDGEGRLA
MMAR_4422|M.marinum_M FAAEQQHVFES-MWFCVVRAADLNEPGQFKAVQVGRESVLLVRGRDRRLR
MUL_3820|M.ulcerans_Agy99 HERDRAMVLDS--PQLVGYSSELPGPDTYRTKTIMGRSILLTRAADRAVR
: :: : :. : : ..:: : :
Mb3186c|M.bovis_AF2122/97 ALSPICRHRLMLMVEPGAG-RIDTLTCQYHLWRYGLDGRLRG--------
Rv3161c|M.tuberculosis_H37Rv ALSPICRHRLMLMVEPGAG-RIDTLTCQYHLWRYGLDGRLRG--------
Mvan_4415|M.vanbaalenii_PYR-1 AFLNQCRHRGMRICRSEAG-VSKAFTCTYHGWSYDLAGNLIN-------V
MAB_4370c|M.abscessus_ATCC_199 AFLNSCRHRGARVCRADYG-VTRGFTCTYHGWAYDLEGKLIS-------V
Mflv_0632|M.gilvum_PYR-GCK VLLNSCRHRGMAVCRYDEG-RALQFTCPYHGWSYSMDGSLVSTPGDLHGV
MAV_3509|M.avium_104 ALFNMCLHRGMQVCRAELG-NASNFRCPYHGWTYRNDGRLTG------LP
MSMEG_1908|M.smegmatis_MC2_155 CLINACAHRGAMICRRKTD-NRTTLTCPFHGWTFRNDGTLLKVK------
TH_2967|M.thermoresistible__bu AWVNRCAHRGATVCREQTG-NTRSHVCVYHQWSYNAAGDLEGVP---FRR
MMAR_4422|M.marinum_M AFLNICRHRGALLCTEPEGQVRRNLRCPYHSWTYGLDGTLIAAP------
MUL_3820|M.ulcerans_Agy99 AFDNVCLHRQSRVAT-GCG-TALRFTCPYHGWTYDNGGRLVG--------
* ** : . * :* * : * *
Mb3186c|M.bovis_AF2122/97 -APHMAANLDFNRR-ECRLPQFA-VATWNGLVW--------INLDADAEP
Rv3161c|M.tuberculosis_H37Rv -APHMAANLDFNRR-ECRLPQFA-VATWNGLVW--------INLDADAEP
Mvan_4415|M.vanbaalenii_PYR-1 PLEERAYHSSIDKK-EWGAMKVPRVANYRGFYFGTWSEET-PEFDAYLGD
MAB_4370c|M.abscessus_ATCC_199 PNEE-GYPDSFSTD-DWGLVEVPHVDSYHGLIFGTWNPAP-VGLRESLGD
Mflv_0632|M.gilvum_PYR-GCK PQQGMAYGNGLDKA-AWGLVRAAKVHNYKGLVFACWDPSA-PEFDEYVGD
MAV_3509|M.avium_104 FHREAYGGDDGFVK-DQTLLPAPNFAGYNGLLFISLDPAA-PPLQDFLGD
MSMEG_1908|M.smegmatis_MC2_155 DPDGAGYPDTFNSNGSHNMTNVARFEGYRGFLFGSLNPDV-LPLTEHLGD
TH_2967|M.thermoresistible__bu GANGTGMPKSFDPT--QNGLQKLRVESYRGLVFGTFDEAT-PDLLAYLGN
MMAR_4422|M.marinum_M NIAELTDTDGASIDRHRYGLVAVALREWLGYAWVCLAEDP-PSFEDDVVG
MUL_3820|M.ulcerans_Agy99 -LPGREGFPGIAVG--SDGLTELPATEFAGFLWVSLHPAARLDVPAHLGP
: * : .
Mb3186c|M.bovis_AF2122/97 IAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAEN-GHENYHVLG
Rv3161c|M.tuberculosis_H37Rv IAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAEN-GHENYHVLG
Mvan_4415|M.vanbaalenii_PYR-1 MAFYFDAIVDRFD---SGLEFVKGTTKWVIDCNWKFASEQFASDMYHTQS
MAB_4370c|M.abscessus_ATCC_199 MAWYMDAMLDHDS---EGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNM
Mflv_0632|M.gilvum_PYR-GCK FHHWLDNLSDAFDGTEGGTEVFRGVQKWRIKSNWKFVSENFLGDTYHGAT
MAV_3509|M.avium_104 FRFYLDYYTRQSA----GGVELRGPQRWRIRANWKIGAENFAGDMYHTPH
MSMEG_1908|M.smegmatis_MC2_155 TTTVIDMLVDQSP---DGLEVLRGASTYTYDGNWKVQAEN-GADGYHVTA
TH_2967|M.thermoresistible__bu QTPGLDRIFHKPI-------EYLGCTRQRIRGNWKLYLEN-VRDGYHASL
MMAR_4422|M.marinum_M SVTARLGDVSAIDTYRIEALQVGRRVSYDVAANWKLIVEN-FMECYHCAT
MUL_3820|M.ulcerans_Agy99 LAGELQSWG-------IGRWSPLGEKVLGSPIDWKLATDT-FAENYHFAT
:**. : : **
Mb3186c|M.bovis_AF2122/97 LHRQTLEPFVP--------------------------------GGGD---
Rv3161c|M.tuberculosis_H37Rv LHRQTLEPFVP--------------------------------GGGD---
Mvan_4415|M.vanbaalenii_PYR-1 AHASALLALTDDPNPIGPLND-PNVPGRQFSG--------NGHGSGGYFL
MAB_4370c|M.abscessus_ATCC_199 SHASALMVMA--PQGKAPKDEIVHRTGRQYVDP-------NGHGAG----
Mflv_0632|M.gilvum_PYR-GCK THASVEQVGIG-PGGRNSRRHGERQDQGGFSKGRVKTSFRMGHGASDNLA
MAV_3509|M.avium_104 THASIVDIGLFREPKAQKRKDGATYWAHR------------GGGTTYKLP
MSMEG_1908|M.smegmatis_MC2_155 THWNYAATTSRRTCGESKNDTKALDAGSWGKS----------GGGYWSFP
TH_2967|M.thermoresistible__bu LHAFHSTFNLVRSGQRVKIVVGDTHEVHN-------------CGDLFYTE
MMAR_4422|M.marinum_M IHPELTRVIPEFARGQAAQRS---------------------VGRGAEFG
MUL_3820|M.ulcerans_Agy99 VHRRTFATIAR---------------------------------------
*
Mb3186c|M.bovis_AF2122/97 -LDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKS----NLVVLWTFPNS
Rv3161c|M.tuberculosis_H37Rv -LDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKS----NLVVLWTFPNS
Mvan_4415|M.vanbaalenii_PYR-1 PAPVVKTPEMTDTMFEWFKSREEEMVARIGADRLS-KV-SITHNTIFPNF
MAB_4370c|M.abscessus_ATCC_199 -FPVHPKNRFDARVVHQWTDYG-ALRERLGEARVQGPL-TNGHATVFPNL
Mflv_0632|M.gilvum_PYR-GCK YEIPYPEFAEEPALSEYFSQAWAVRKERLQAQGRQ-LG-GRGPATMFPNM
MAV_3509|M.avium_104 PGGFEERMRYVGYPDEMIGRIKQVWTPRQQRVVGEDGF-MVSAATCFPNL
MSMEG_1908|M.smegmatis_MC2_155 HGHLCLWTWAANPQDRPLWDRLDELKARFGDAKGEFMVKGSRNLCLYPNV
TH_2967|M.thermoresistible__bu DPTKGAAYANVTSFKEGLRLENPELVENWQEFDEIITN---HLQCIFPQL
MMAR_4422|M.marinum_M SAVAGFTVDGRAGFTALPGIRPEQDRRYFAITVKP-----TVFINLVPDH
MUL_3820|M.ulcerans_Agy99 -SNCTVFDSYGPHHRLIFPLNTILELENVPEGQWDPFHHMVVIYALFPNV
*:
Mb3186c|M.bovis_AF2122/97 ALAI--------------------------AGERVVWFGFIPQS------
Rv3161c|M.tuberculosis_H37Rv ALAI--------------------------AGERVVWFGFIPQS------
Mvan_4415|M.vanbaalenii_PYR-1 SWLG-AHST-------------MRVWHPRGPGQIEVWAWTYVPKDAPPKV
MAB_4370c|M.abscessus_ATCC_199 SYLP-VNGS-------------VRIWHPKGPDKMEVWAWTIVDRSMPEEV
Mflv_0632|M.gilvum_PYR-GCK SFSAGFPRT-------------ILVSHPISPTETEVWRWYLIDKNAPDDV
MAV_3509|M.avium_104 SFVHNWPKVRDGRDDETLPFISIRLWQPISENETEVCSWFAVDSAAPAHY
MSMEG_1908|M.smegmatis_MC2_155 YVMDQFSTQ-------------IRHFRPIAPDKTEVTIYCIAPKGESAAA
TH_2967|M.thermoresistible__bu VVMQIQNVLA------------VRNVLPKGVDEFELIFNFFGYADDTPEM
MMAR_4422|M.marinum_M AIIH-------------------RMFPIAADRTIVECDWLYAPEVAAAG-
MUL_3820|M.ulcerans_Agy99 VLSV-------------------------TIANGELFRIYPGDRPGS---
Mb3186c|M.bovis_AF2122/97 -------IDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLE
Rv3161c|M.tuberculosis_H37Rv -------IDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLE
Mvan_4415|M.vanbaalenii_PYR-1 KNEIRELTQRTFSPAGSFETDDGENWTEIQQVLRGSQARRNRLHTAMGVG
MAB_4370c|M.abscessus_ATCC_199 RDAQRLYNLRTFGPTGIFEQDDGENWSEVQSISRGFVTNSVALNYQMGLD
Mflv_0632|M.gilvum_PYR-GCK RDWLRRYYMRYSGPGGMTEQDDMENWNYATQASQGVIARRYPYNYQQGLD
MAV_3509|M.avium_104 KQDSYKAYLMCFGSTGMFEQDDVENWVSLTTTAGGSMARRLLLNSRMGLY
MSMEG_1908|M.smegmatis_MC2_155 RAHRIRQYEDFFNASGMATPDDLEEFRSCQLTFR---AQAAPWNDMSRGA
TH_2967|M.thermoresistible__bu RRHR-IAQFNLVGPAGLISMEDGEAIELVQRATAVGPAGEAIALMALEAD
MMAR_4422|M.marinum_M ---------DIAHSVELFHRVNEQDFDACQRTQPAMSSRAYRTGGVLVPA
MUL_3820|M.ulcerans_Agy99 ---------SITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDYRLA
Mb3186c|M.bovis_AF2122/97 AVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS-------
Rv3161c|M.tuberculosis_H37Rv AVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS-------
Mvan_4415|M.vanbaalenii_PYR-1 YEERDAFGLPGLGNDVYS-ETAARGFYRHWLDMLTGKPWSEIQKWTPNGN
MAB_4370c|M.abscessus_ATCC_199 SEREDGR-HPGLTSELYS-DAAGRSFYARWRDLMNTKAWHEEHV------
Mflv_0632|M.gilvum_PYR-GCK METPSALDQAVHSHHPIAGEVNARAFYRRWAEFTDNLSWPQLIELAKSDE
MAV_3509|M.avium_104 DD--GRPVVEALAPSAFHGPGRAQVGYNEHNQRALLAMWADYLQEGDACE
MSMEG_1908|M.smegmatis_MC2_155 QHWLSGPDPVAESLGMHGIVSSGLRNEDEGLYPVQHGYWLETLRRAVTSN
TH_2967|M.thermoresistible__bu EEHRNQHPISEDAIRRFWVGYQKLMGL-----------------------
MMAR_4422|M.marinum_M EHHIAEFHQWVIARIGTPAVTG----------------------------
MUL_3820|M.ulcerans_Agy99 ETLQTNLESGARQRLVFGRNEPGLQHRHITWAQALETPG-----------
Mb3186c|M.bovis_AF2122/97 -----------
Rv3161c|M.tuberculosis_H37Rv -----------
Mvan_4415|M.vanbaalenii_PYR-1 HGELRDEGVTA
MAB_4370c|M.abscessus_ATCC_199 -----------
Mflv_0632|M.gilvum_PYR-GCK RAARS------
MAV_3509|M.avium_104 NR---------
MSMEG_1908|M.smegmatis_MC2_155 PTEH-------
TH_2967|M.thermoresistible__bu -----------
MMAR_4422|M.marinum_M -----------
MUL_3820|M.ulcerans_Agy99 -----------