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DWLDNQVVLVTGGGSGLGRSLVERFIDEGAQVGVLELNEEKAAAIAARWGDRVCSVVGDATSYADNERAV QATVAAFGKLDTLVGNAGLWDFGTPLEQLKPEQISPAFDEIFGLNVKGYLLGARAALAELRETRGSIIFT VSNAGFWPGGGGPLYTASKHAVVGLVKQLAYELCPEVRVNGVAPGGMPSDLRGPRALDLQETAFDSLPVD ELVQRLSPLEAPIHAEDYTGHYVLLASRANGSTATGSVHNCDGGVGVAGRKLTEKVRAELFGRGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4412 | - | - | 100% (276) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0544 | - | 7e-71 | 54.20% (262) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0466 | - | 7e-47 | 44.19% (258) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 6e-23 | 33.33% (264) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0621 | - | 6e-71 | 54.20% (262) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 6e-23 | 33.33% (264) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-13 | 26.59% (252) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4365c | - | 5e-63 | 48.30% (265) | putative dihydrodiol dehydrogenase |
| M. marinum M | MMAR_4765 | - | 2e-25 | 32.45% (265) | short chain dehydrogenase |
| M. avium 104 | MAV_3512 | - | 4e-45 | 43.30% (261) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4859 | - | 1e-24 | 31.84% (267) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3420 | - | 4e-24 | 32.10% (271) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 1e-25 | 32.83% (265) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 -----------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAK
Rv2002|M.tuberculosis_H37Rv -----------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAK
MMAR_4765|M.marinum_M -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MUL_0336|M.ulcerans_Agy99 -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MSMEG_4859|M.smegmatis_MC2_155 ------------------MSELAGRVAVVTGGASGLGEGLVRRFVAEGAQ
TH_3420|M.thermoresistible__bu --------------VTERAGELAGKVAVVTGGAAGLGAGLARRFVAEGAK
Mvan_4412|M.vanbaalenii_PYR-1 ------------------MDWLDNQVVLVTGGGSGLGRSLVERFIDEGAQ
Mflv_0621|M.gilvum_PYR-GCK MGRCRATRALRITGGTIVLSWLTGQVALVTGGAAGIGLAVVERFLAEGAC
MAB_4365c|M.abscessus_ATCC_199 -----------MSG-----GWLGGYVALITGGGSGIGRAVTERYLAEGAS
MAV_3512|M.avium_104 -----------MTG------WLDGKRALVVGAGSGIGRAVVDAFAAEGAK
MLBr_01807|M.leprae_Br4923 ---MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHR
: . :: *. *:* . . :*
Mb2025|M.bovis_AF2122/97 VVFGDILDEEGKAVAAELAD--AARYVHLDVTQPAQWTAAVDTAVTAFGG
Rv2002|M.tuberculosis_H37Rv VVFGDILDEEGKAVAAELAD--AARYVHLDVTQPAQWTAAVDTAVTAFGG
MMAR_4765|M.marinum_M VVIADVEEERGESLAAALGA--DAMFCRTDVSQPEQVAAVVAAAVENFGG
MUL_0336|M.ulcerans_Agy99 VVIADVEEERGESLAAALGA--DAMFCRTDVSQPEQVAAVVAAAVDNFGG
MSMEG_4859|M.smegmatis_MC2_155 VMIGDVDKDRGTALAEELGA--HTEFLTTDVADQEQVAALVSAGVERFGG
TH_3420|M.thermoresistible__bu VLIGDVDTGNGAKLAAELGA--DAEFVEADVADLDQVSGLVSTAVERFGG
Mvan_4412|M.vanbaalenii_PYR-1 VGVLELNEEKAAAIAARWGD--RVCSVVGDATSYADNERAVQATVAAFGK
Mflv_0621|M.gilvum_PYR-GCK VGVLDRSEGDLATIGNADG---RLIAVTGDVTSYADNVMAVRETVDAFGK
MAB_4365c|M.abscessus_ATCC_199 VTIVGHRPEQLDRVHAESSAPDRLHTVVADTRESDQLHDAVVQTVSRFGQ
MAV_3512|M.avium_104 VAALERDSDKCDRLRRQLP---EVAVAEGDATTREANERAVALAVDTFGG
MLBr_01807|M.leprae_Br4923 VAVTHR----ASVVPDWFFG------VECDVTDNDAIGAAFKAVEEHQGP
* : *. . *
Mb2025|M.bovis_AF2122/97 LHVLVNNAGILNIG-----TIEDYALTEWQRILDVNLTGVFLGIRAVVKP
Rv2002|M.tuberculosis_H37Rv LHVLVNNAGILNIG-----TIEDYALTEWQRILDVNLTGVFLGIRAVVKP
MMAR_4765|M.marinum_M LHVMVNNAGVSGVMH---RRFLDDDLADFHRVMAVNVLGVMAGTRDAARH
MUL_0336|M.ulcerans_Agy99 LHVMVNNAGVSGAMH---RRFLDDDLADFHRVMAVNVLGVMAGTRDAARH
MSMEG_4859|M.smegmatis_MC2_155 LHVMVNNAGVSGTMH---RRFLDDDLADFHKVMGVNVLGVMAGTREAARY
TH_3420|M.thermoresistible__bu LHVMVNNAGISGTMH---RSLLDDDLADFDRVMRINVRAVMAGTRDAARH
Mvan_4412|M.vanbaalenii_PYR-1 LDTLVGNAGLWDFGTPLEQLKPEQISPAFDEIFGLNVKGYLLGARAALAE
Mflv_0621|M.gilvum_PYR-GCK LDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPE
MAB_4365c|M.abscessus_ATCC_199 LDTLVANAGVWDYQRPLTRLTASELTASFHEVFSVNVKGYLLAAEAAWRE
MAV_3512|M.avium_104 LDTLVNCVGVFDFYRGVADIDAGALADAFDEMFRTNVLSHLQSVKAALPA
MLBr_01807|M.leprae_Br4923 VEVLVANAGITSDML-----IMRMSEEQFQKVIDVNLTGVFRVAKLASRN
:..:* .*: . :..:: *: . : . .
Mb2025|M.bovis_AF2122/97 MKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGI
Rv2002|M.tuberculosis_H37Rv MKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGI
MMAR_4765|M.marinum_M MAAHGGGSIVNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEI
MUL_0336|M.ulcerans_Agy99 MAAHGGGSIVNLTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYEI
MSMEG_4859|M.smegmatis_MC2_155 MADNGGGSILNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHHEI
TH_3420|M.thermoresistible__bu MAEHGGGSIINLTSIGGIQAGGGVQTYRASKAAVIQFTKSAAIELAHHEI
Mvan_4412|M.vanbaalenii_PYR-1 LRETRG-SIIFTVSNAGFWPGGGGPLYTASKHAVVGLVKQLAYELCP-EV
Mflv_0621|M.gilvum_PYR-GCK LLKSDGPSMIFTVSNSGFYAAGGGPLYTASKHAVVGVVRELAYELAP-KI
MAB_4365c|M.abscessus_ATCC_199 LVKTRG-SIIMTLSNASFYVNGGGPIYTASKHACLGLMRELAFELAP-KV
MAV_3512|M.avium_104 LRAAGASSIVLTESASSFYPGRGGVLYVSSKFAVRGLVSALAHELAP-GI
MLBr_01807|M.leprae_Br4923 MIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSI
: : * .: . * ::* . . * ** :
Mb2025|M.bovis_AF2122/97 RVNSIHPGLVK-TPMT-------DWVPEDIFQT----------ALGRAA-
Rv2002|M.tuberculosis_H37Rv RVNSIHPGLVK-TPMT-------DWVPEDIFQT----------ALGRAA-
MMAR_4765|M.marinum_M RVNAIAPGNIP-TPLLASSAAGMDQEQVERFTAQIRQTMREDRPLKREG-
MUL_0336|M.ulcerans_Agy99 RVNAIAPGNIP-TPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREG-
MSMEG_4859|M.smegmatis_MC2_155 RVNAIAPGNIR-TAIVAKSASEEDRQRIEEFEANIRAQMRADRPLKREG-
TH_3420|M.thermoresistible__bu RVNALAPGNIR-TAIVRKSATGADLERLERFEARIRQQMRDDRPLKREG-
Mvan_4412|M.vanbaalenii_PYR-1 RVNGVAPGGMP-SDLRGPRALDLQETAFDSLP---VDELVQRLSPLEAP-
Mflv_0621|M.gilvum_PYR-GCK RVNGVAPGGTV-TGLRGIEDLGQGQDVLSSVPG--IADIMSTTNPLQYA-
MAB_4365c|M.abscessus_ATCC_199 RVNGVACGGMN-TDLRGPEALSLADRSISTSFAKRGHDASAPLIPLHDSS
MAV_3512|M.avium_104 RVNGVAPGGTLGTDLRGLASLRLQGTRLDDAPD--RAAEVAARTPLRVA-
MLBr_01807|M.leprae_Br4923 TANVVAPGFID-TEMTRAMDSKYQEAALQAIPLG------------RIG-
.* : * : : . .
Mb2025|M.bovis_AF2122/97 -EPVEVSNLVVYLAS-DESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQ
Rv2002|M.tuberculosis_H37Rv -EPVEVSNLVVYLAS-DESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQ
MMAR_4765|M.marinum_M -TPEDIAEAALYFAG-ERSRYVTGTVLPVDGGTVAG------KVIRRSR-
MUL_0336|M.ulcerans_Agy99 -TPEDIAEAALYFAG-ERSRYVTGTVLPVDGGTVAG------KVIRRSR-
MSMEG_4859|M.smegmatis_MC2_155 -TVEDVAEAALYFAT-DRSRYVTGTVLPIDGGTVAG------KVIVRKEK
TH_3420|M.thermoresistible__bu -TVEDVAEAALYFAG-DRSRYVTGTVLPIDGGTVAG------KVIARKSH
Mvan_4412|M.vanbaalenii_PYR-1 IHAEDYTGHYVLLASRANGSTATGSVHNCDGGVGVAGRKLTEKVRAELFG
Mflv_0621|M.gilvum_PYR-GCK QQPADHAGLYLLLASADNSRAVTGVVINSDGGLGVRG--LNQPSGGTELA
MAB_4365c|M.abscessus_ATCC_199 TDPADFTGPYVLLASREQSGPITGEAIAIDGGIGVRG--FVKPAGGEHL-
MAV_3512|M.avium_104 LSGADHAWSFVFLAS-DRSRGITGETVRPDGGFGLGT-----PR------
MLBr_01807|M.leprae_Br4923 -AVEEIAGAVSFLAS-EDAGYISGAVIPVDGGLGMGH-------------
: : :* . :* ***
Mb2025|M.bovis_AF2122/97 PEWVT------
Rv2002|M.tuberculosis_H37Rv PEWVT------
MMAR_4765|M.marinum_M -----------
MUL_0336|M.ulcerans_Agy99 -----------
MSMEG_4859|M.smegmatis_MC2_155 R----------
TH_3420|M.thermoresistible__bu AE---------
Mvan_4412|M.vanbaalenii_PYR-1 RGA--------
Mflv_0621|M.gilvum_PYR-GCK TGAMRIDVGST
MAB_4365c|M.abscessus_ATCC_199 -----------
MAV_3512|M.avium_104 -----------
MLBr_01807|M.leprae_Br4923 -----------