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GRCRATRALRITGGTIVLSWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRL IAVTGDVTSYADNVMAVRETVDAFGKLDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGA RAAVPELLKSDGPSMIFTVSNSGFYAAGGGPLYTASKHAVVGVVRELAYELAPKIRVNGVAPGGTVTGLR GIEDLGQGQDVLSSVPGIADIMSTTNPLQYAQQPADHAGLYLLLASADNSRAVTGVVINSDGGLGVRGLN QPSGGTELATGAMRIDVGST*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0621 | - | - | 100% (301) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0539 | - | e-168 | 99.67% (301) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0682 | - | 3e-51 | 44.57% (258) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 2e-22 | 31.68% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 2e-22 | 31.68% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-15 | 30.28% (251) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4365c | - | 1e-60 | 48.36% (275) | putative dihydrodiol dehydrogenase |
| M. marinum M | MMAR_4765 | - | 6e-28 | 37.12% (264) | short chain dehydrogenase |
| M. avium 104 | MAV_3512 | - | 5e-49 | 43.02% (258) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4859 | - | 3e-24 | 35.00% (260) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3420 | - | 1e-25 | 36.68% (259) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 2e-28 | 38.02% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0544 | - | 1e-167 | 99.00% (301) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0621|M.gilvum_PYR-GCK MGRCRATRALRITGGTIVLSWLTGQVALVTGGAAGIGLAVVERFLAEGAC
Mvan_0544|M.vanbaalenii_PYR-1 MGRCRATRALRITGGTIVLSWLTGQVALVTGGAAGIGLAVVERFLAEGAC
MAB_4365c|M.abscessus_ATCC_199 -----------MSGG-----WLGGYVALITGGGSGIGRAVTERYLAEGAS
MAV_3512|M.avium_104 -----------MTG------WLDGKRALVVGAGSGIGRAVVDAFAAEGAK
MMAR_4765|M.marinum_M -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MUL_0336|M.ulcerans_Agy99 -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MSMEG_4859|M.smegmatis_MC2_155 ------------------MSELAGRVAVVTGGASGLGEGLVRRFVAEGAQ
TH_3420|M.thermoresistible__bu --------------VTERAGELAGKVAVVTGGAAGLGAGLARRFVAEGAK
Mb2788c|M.bovis_AF2122/97 ----------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAH
Rv2766c|M.tuberculosis_H37Rv ----------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAH
MLBr_01807|M.leprae_Br4923 ---MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHR
: . ::.*. *:* . . * *
Mflv_0621|M.gilvum_PYR-GCK VGVLDRSEGDLATIG---NADGRLIAVTGDVTSYADNVMAVRETVDAFGK
Mvan_0544|M.vanbaalenii_PYR-1 VGVLDRSEGDLATIG---NADGRLIAVTGDVTSYADNVTAVRETVDAFGK
MAB_4365c|M.abscessus_ATCC_199 VTIVGHRPEQLDRVHAESSAPDRLHTVVADTRESDQLHDAVVQTVSRFGQ
MAV_3512|M.avium_104 VAALERDSDKCDRLR---RQLPEVAVAEGDATTREANERAVALAVDTFGG
MMAR_4765|M.marinum_M VVIADVEEERGESLA--AALGADAMFCRTDVSQPEQVAAVVAAAVENFGG
MUL_0336|M.ulcerans_Agy99 VVIADVEEERGESLA--AALGADAMFCRTDVSQPEQVAAVVAAAVDNFGG
MSMEG_4859|M.smegmatis_MC2_155 VMIGDVDKDRGTALA--EELGAHTEFLTTDVADQEQVAALVSAGVERFGG
TH_3420|M.thermoresistible__bu VLIGDVDTGNGAKLA--AELGADAEFVEADVADLDQVSGLVSTAVERFGG
Mb2788c|M.bovis_AF2122/97 VVLTARRQE--AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFGS
Rv2766c|M.tuberculosis_H37Rv VVLTARRQE--AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFGS
MLBr_01807|M.leprae_Br4923 VAVTHR----------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGP
* .. . . *
Mflv_0621|M.gilvum_PYR-GCK LDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPE
Mvan_0544|M.vanbaalenii_PYR-1 LDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPE
MAB_4365c|M.abscessus_ATCC_199 LDTLVANAGVWDYQRPLTRLTASELTASFHEVFSVNVKGYLLAAEAAWRE
MAV_3512|M.avium_104 LDTLVNCVGVFDFYRGVADIDAGALADAFDEMFRTNVLSHLQSVKAALPA
MMAR_4765|M.marinum_M LHVMVNNAGVSG---VMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARH
MUL_0336|M.ulcerans_Agy99 LHVMVNNAGVSG---AMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARH
MSMEG_4859|M.smegmatis_MC2_155 LHVMVNNAGVSG---TMHRRFLDDDLADFHKVMGVNVLGVMAGTREAARY
TH_3420|M.thermoresistible__bu LHVMVNNAGISG---TMHRSLLDDDLADFDRVMRINVRAVMAGTRDAARH
Mb2788c|M.bovis_AF2122/97 VDILINNAGTNPAYGPLLEQDH----ARFAKIFDVNLWAPLMWTSLVVTA
Rv2766c|M.tuberculosis_H37Rv VDILINNAGTNPAYGPLLEQDH----ARFAKIFDVNLWAPLMWTSLVVTA
MLBr_01807|M.leprae_Br4923 VEVLVANAGITSDM-LIMRMSE----EQFQKVIDVNLTGVFRVAKLASRN
:. :: .* : * .:: *: . : . .
Mflv_0621|M.gilvum_PYR-GCK LLKSDGPSMIFTVSNSGFYAAGGGPLYTASKHAVVGVVRELAYELAP-KI
Mvan_0544|M.vanbaalenii_PYR-1 LLKSDGPSMIFTVSNSGFYASGGGPLYTASKHAVVGVVRELAYELAP-KI
MAB_4365c|M.abscessus_ATCC_199 LVKTRG-SIIMTLSNASFYVNGGGPIYTASKHACLGLMRELAFELAP-KV
MAV_3512|M.avium_104 LRAAGASSIVLTESASSFYPGRGGVLYVSSKFAVRGLVSALAHELAP-GI
MMAR_4765|M.marinum_M MAAHGGGSIVNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEI
MUL_0336|M.ulcerans_Agy99 MAAHGGGSIVNLTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYEI
MSMEG_4859|M.smegmatis_MC2_155 MADNGGGSILNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHHEI
TH_3420|M.thermoresistible__bu MAEHGGGSIINLTSIGGIQAGGGVQTYRASKAAVIQFTKSAAIELAHHEI
Mb2788c|M.bovis_AF2122/97 WMGEHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-I
Rv2766c|M.tuberculosis_H37Rv WMGEHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-I
MLBr_01807|M.leprae_Br4923 MIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSI
: * .: . * ::* . . * **. :
Mflv_0621|M.gilvum_PYR-GCK RVNGVAPGGTV-TGLRGIEDLGQGQDVLSS--VPGIADIMSTTNPLQY-A
Mvan_0544|M.vanbaalenii_PYR-1 RVNGVAPGGTV-TGLRGIEDLGQGQDVLSS--VPGIADIMSTTNPLQY-A
MAB_4365c|M.abscessus_ATCC_199 RVNGVACGGMN-TDLRGPEALSLADRSISTSFAKRGHDASAPLIPLHDSS
MAV_3512|M.avium_104 RVNGVAPGGTLGTDLRGLASLRLQGTRLDD--APDRAAEVAARTPLRV-A
MMAR_4765|M.marinum_M RVNAIAPGNIP-TPLLASSAAGMDQEQVER-FTAQIRQTMREDRPLKR--
MUL_0336|M.ulcerans_Agy99 RVNAIAPGNIP-TPLLASSAAGLDQEQVER-FTAQIRQTMREDRPLKR--
MSMEG_4859|M.smegmatis_MC2_155 RVNAIAPGNIR-TAIVAKSASEEDRQRIEE-FEANIRAQMRADRPLKR--
TH_3420|M.thermoresistible__bu RVNALAPGNIR-TAIVRKSATGADLERLER-FEARIRQQMRDDRPLKR--
Mb2788c|M.bovis_AF2122/97 RVNAICPGVVR--------------TRLAEALWKDHEDPLAATIALGR--
Rv2766c|M.tuberculosis_H37Rv RVNAICPGVVR--------------TRLAEALWKDHEDPLAATIALGR--
MLBr_01807|M.leprae_Br4923 TANVVAPGFID--------------TEMTRAMDSKYQEAALQAIPLGR--
.* :. * : .*
Mflv_0621|M.gilvum_PYR-GCK QQPADHAGLYLLLASADNSRAVTGVVINSDGGLGVRGLNQPSGGTELATG
Mvan_0544|M.vanbaalenii_PYR-1 QQPADHAGLYLLLASADNSRAVTGVVINSDGGLGVRGLNQPSGGLELATG
MAB_4365c|M.abscessus_ATCC_199 TDPADFTGPYVLLASREQSGPITGEAIAIDGGIGVRGFVKPAGGEHL---
MAV_3512|M.avium_104 LSGADHAWSFVFLAS-DRSRGITGETVRPDGGFGLG---TPR--------
MMAR_4765|M.marinum_M EGTPEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR-------
MUL_0336|M.ulcerans_Agy99 EGTPEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR-------
MSMEG_4859|M.smegmatis_MC2_155 EGTVEDVAEAALYFATDRSRYVTGTVLPIDGGTVAGKVIVRKEKR-----
TH_3420|M.thermoresistible__bu EGTVEDVAEAALYFAGDRSRYVTGTVLPIDGGTVAGKVIARKSHAE----
Mb2788c|M.bovis_AF2122/97 IGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH-
Rv2766c|M.tuberculosis_H37Rv IGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH-
MLBr_01807|M.leprae_Br4923 IGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-------------
: : ::* .: ***
Mflv_0621|M.gilvum_PYR-GCK AMRIDVGST
Mvan_0544|M.vanbaalenii_PYR-1 AMRIDVGST
MAB_4365c|M.abscessus_ATCC_199 ---------
MAV_3512|M.avium_104 ---------
MMAR_4765|M.marinum_M ---------
MUL_0336|M.ulcerans_Agy99 ---------
MSMEG_4859|M.smegmatis_MC2_155 ---------
TH_3420|M.thermoresistible__bu ---------
Mb2788c|M.bovis_AF2122/97 ---------
Rv2766c|M.tuberculosis_H37Rv ---------
MLBr_01807|M.leprae_Br4923 ---------