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SGGWLGGYVALITGGGSGIGRAVTERYLAEGASVTIVGHRPEQLDRVHAESSAPDRLHTVVADTRESDQL HDAVVQTVSRFGQLDTLVANAGVWDYQRPLTRLTASELTASFHEVFSVNVKGYLLAAEAAWRELVKTRGS IIMTLSNASFYVNGGGPIYTASKHACLGLMRELAFELAPKVRVNGVACGGMNTDLRGPEALSLADRSIST SFAKRGHDASAPLIPLHDSSTDPADFTGPYVLLASREQSGPITGEAIAIDGGIGVRGFVKPAGGEHL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4365c | - | - | 100% (278) | putative dihydrodiol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0952 | - | 2e-21 | 33.72% (258) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0073c | - | 2e-21 | 31.06% (264) | putative short chain dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 2e-21 | 30.60% (281) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_0621 | - | 1e-60 | 48.36% (275) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 2e-21 | 30.60% (281) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-17 | 29.57% (257) | 3-oxoacyl- |
| M. marinum M | MMAR_4765 | - | 2e-22 | 31.92% (260) | short chain dehydrogenase |
| M. avium 104 | MAV_3512 | - | 1e-36 | 39.85% (266) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0269 | - | 2e-22 | 30.92% (262) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3169 | - | 4e-23 | 36.04% (222) | PUTATIVE carveol dehydrogenase |
| M. ulcerans Agy99 | MUL_0336 | - | 5e-23 | 32.31% (260) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4412 | - | 7e-63 | 48.30% (265) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2788c|M.bovis_AF2122/97 ----------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAH
Rv2766c|M.tuberculosis_H37Rv ----------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAH
MLBr_01807|M.leprae_Br4923 ---MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHR
MMAR_4765|M.marinum_M -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MUL_0336|M.ulcerans_Agy99 -----------------MVDELAGKIAIVTGGASGIGRATVARFIAEGAR
MSMEG_0269|M.smegmatis_MC2_155 -----------------MFTSLEGRSAIVTGGSKGIGRGIAETFANAGVD
Mflv_0621|M.gilvum_PYR-GCK MGRCRATRALRITGGTIVLSWLTGQVALVTGGAAGIGLAVVERFLAEGAC
Mvan_4412|M.vanbaalenii_PYR-1 ------------------MDWLDNQVVLVTGGGSGLGRSLVERFIDEGAQ
MAB_4365c|M.abscessus_ATCC_199 -----------MSG-----GWLGGYVALITGGGSGIGRAVTERYLAEGAS
MAV_3512|M.avium_104 -----------MTG------WLDGKRALVVGAGSGIGRAVVDAFAAEGAK
TH_3169|M.thermoresistible__bu -----------------MTGRLAGRVAFITGAARGQGRAHAVRMAAEGAD
: . ::.*. * * . . *
Mb2788c|M.bovis_AF2122/97 VVLTARR-------------QEAADEAAAQVG---DRALGVGAHAVDEDA
Rv2766c|M.tuberculosis_H37Rv VVLTARR-------------QEAADEAAAQVG---DRALGVGAHAVDEDA
MLBr_01807|M.leprae_Br4923 VAVTHR---------------------ASVVP---DWFFGVECDVTDNDA
MMAR_4765|M.marinum_M VVIADVE-------------EERGESLAAALG---ADAMFCRTDVSQPEQ
MUL_0336|M.ulcerans_Agy99 VVIADVE-------------EERGESLAAALG---ADAMFCRTDVSQPEQ
MSMEG_0269|M.smegmatis_MC2_155 VVITGRN-------------QDDLDRTVADLSGTRGKVTAVRADVTDPED
Mflv_0621|M.gilvum_PYR-GCK VGVLDRS-------------EGDLATIGNADG----RLIAVTGDVTSYAD
Mvan_4412|M.vanbaalenii_PYR-1 VGVLELN-------------EEKAAAIAARWGD---RVCSVVGDATSYAD
MAB_4365c|M.abscessus_ATCC_199 VTIVGHR-------------PEQLDRVHAESSAP-DRLHTVVADTRESDQ
MAV_3512|M.avium_104 VAALERD-------------SDKCDRLRRQLP----EVAVAEGDATTREA
TH_3169|M.thermoresistible__bu IIAVDIAGKLPDCVPYEPATPEDLDETVRLVTATGRRIHAAVADTRDLDG
: ..
Mb2788c|M.bovis_AF2122/97 ARRCVDLTLERFGSVDILINNAGTNPAYG-PLLEQD---HARFAKIFDVN
Rv2766c|M.tuberculosis_H37Rv ARRCVDLTLERFGSVDILINNAGTNPAYG-PLLEQD---HARFAKIFDVN
MLBr_01807|M.leprae_Br4923 IGAAFKAVEEHQGPVEVLVANAGITSDM--LIMRMS---EEQFQKVIDVN
MMAR_4765|M.marinum_M VAAVVAAAVENFGGLHVMVNNAGVSGVMHRRFLDDD---LADFHRVMAVN
MUL_0336|M.ulcerans_Agy99 VAAVVAAAVDNFGGLHVMVNNAGVSGAMHRRFLDDD---LADFHRVMAVN
MSMEG_0269|M.smegmatis_MC2_155 ARRTVAETVSRHGGLDIVCANAGIFPSG--RLEDLT---PDDIEQVLGVN
Mflv_0621|M.gilvum_PYR-GCK NVMAVRETVDAFGKLDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVN
Mvan_4412|M.vanbaalenii_PYR-1 NERAVQATVAAFGKLDTLVGNAGLWDFGTPLEQLKPEQISPAFDEIFGLN
MAB_4365c|M.abscessus_ATCC_199 LHDAVVQTVSRFGQLDTLVANAGVWDYQRPLTRLTASELTASFHEVFSVN
MAV_3512|M.avium_104 NERAVALAVDTFGGLDTLVNCVGVFDFYRGVADIDAGALADAFDEMFRTN
TH_3169|M.thermoresistible__bu LREAVDAGVAALGRLDVIVANAGICAPQTWDAITPA-----DFRDVMDIN
. * :. . .* : :: *
Mb2788c|M.bovis_AF2122/97 LWAPLMWTSLVVTAWMG-EHGGAVVNTASIGG-MHQSPAMGMYNATKAAL
Rv2766c|M.tuberculosis_H37Rv LWAPLMWTSLVVTAWMG-EHGGAVVNTASIGG-MHQSPAMGMYNATKAAL
MLBr_01807|M.leprae_Br4923 LTGVFRVAKLASRNMIK-QRFGRYIFMGSVVG-LSGVPGQANYAASKSGL
MMAR_4765|M.marinum_M VLGVMAGTRDAARHMAA-HGGGSIVNLTSIGG-IQAGGGVMTYRASKAAV
MUL_0336|M.ulcerans_Agy99 VLGVMAGTRDAARHMAA-HGGGSIVNLTSIGG-IQAGGGVMTYRASKGAV
MSMEG_0269|M.smegmatis_MC2_155 FKGTVYIVQAALQALTA-SGHGRVVVTSSITGPITGYPGWSHYGASKAAQ
Mflv_0621|M.gilvum_PYR-GCK VKGYLLGARAAVPELLK-SDGPSMIFTVSNSG-FYAAGGGPLYTASKHAV
Mvan_4412|M.vanbaalenii_PYR-1 VKGYLLGARAALAELRE-TRG-SIIFTVSNAG-FWPGGGGPLYTASKHAV
MAB_4365c|M.abscessus_ATCC_199 VKGYLLAAEAAWRELVK-TRG-SIIMTLSNAS-FYVNGGGPIYTASKHAC
MAV_3512|M.avium_104 VLSHLQSVKAALPALRA-AGASSIVLTESASS-FYPGRGGVLYVSSKFAV
TH_3169|M.thermoresistible__bu VTGTWNTVMAGARHIIDGRRGGSIILISSLAG-MKLQPFMVHYTTSKHAV
. . . : * . : * ::* .
Mb2788c|M.bovis_AF2122/97 IHVTKQLALELSPR-IRVNAICPGVVR-TRLAE----ALWKDHEDPLAAT
Rv2766c|M.tuberculosis_H37Rv IHVTKQLALELSPR-IRVNAICPGVVR-TRLAE----ALWKDHEDPLAAT
MLBr_01807|M.leprae_Br4923 IGMARSLARELGSRSITANVVAPGFID-TEMTR----AMDSKYQEAALQA
MMAR_4765|M.marinum_M IQFTKSAAIELAHYEIRVNAIAPGNIP-TPLLASSAAGMDQEQVERFTAQ
MUL_0336|M.ulcerans_Agy99 IQFTKSAAIELAHYEIRVNAIAPGNIP-TPLLASSAAGLDQEQVERFTAQ
MSMEG_0269|M.smegmatis_MC2_155 LGFLRTAAMELAPKKITINAVLPGNIM-TEGLD----EMGQDYLDQMASA
Mflv_0621|M.gilvum_PYR-GCK VGVVRELAYELAPK-IRVNGVAPGGTV-TGLRGIEDLGQGQDVLSSVPG-
Mvan_4412|M.vanbaalenii_PYR-1 VGLVKQLAYELCPE-VRVNGVAPGGMP-SDLRGPRALDLQETAFDSLP--
MAB_4365c|M.abscessus_ATCC_199 LGLMRELAFELAPK-VRVNGVACGGMN-TDLRGPEALSLADRSISTSFAK
MAV_3512|M.avium_104 RGLVSALAHELAPG-IRVNGVAPGGTLGTDLRGLASLRLQGTRLDDAPD-
TH_3169|M.thermoresistible__bu AGMARAFAAELGRHRIRVNSLHPGAVATDMGGGEMVSALAATGESNPPLT
. * ** : * : * .
Mb2788c|M.bovis_AF2122/97 I--------ALGRIG--EPADIASAVAFLVS-DAASWITGETMIIDGGLL
Rv2766c|M.tuberculosis_H37Rv I--------ALGRIG--EPADIASAVAFLVS-DAASWITGETMIIDGGLL
MLBr_01807|M.leprae_Br4923 I--------PLGRIG--AVEEIAGAVSFLAS-EDAGYISGAVIPVDGGLG
MMAR_4765|M.marinum_M IRQTMREDRPLKREG--TPEDIAEAALYFAG-ERSRYVTGTVLPVDGGTV
MUL_0336|M.ulcerans_Agy99 IRQTMREDRPLKREG--TPEDIAEAALYFAG-ERSRYVTGTVLPVDGGTV
MSMEG_0269|M.smegmatis_MC2_155 I--------PAGRLG--SVADIGNAALFFAT-DEAAYVTGQTLVVDGGQV
Mflv_0621|M.gilvum_PYR-GCK -IADIMSTTNPLQYA-QQPADHAGLYLLLASADNSRAVTGVVINSDGGLG
Mvan_4412|M.vanbaalenii_PYR-1 -VDELVQRLSPLEAP-IHAEDYTGHYVLLASRANGSTATGSVHNCDGGVG
MAB_4365c|M.abscessus_ATCC_199 RGHDASAPLIPLHDSSTDPADFTGPYVLLASREQSGPITGEAIAIDGGIG
MAV_3512|M.avium_104 -RAAEVAARTPLRVA-LSGADHAWSFVFLAS-DRSRGITGETVRPDGGFG
TH_3169|M.thermoresistible__bu QMIT-----PFLPDWIAQVDDIADAAVWLAS-DESRFVTAAKIPVDMGSS
: :. . :. * *
Mb2788c|M.bovis_AF2122/97 LGNALGFRAAPSTEH------------
Rv2766c|M.tuberculosis_H37Rv LGNALGFRAAPSTEH------------
MLBr_01807|M.leprae_Br4923 MGH------------------------
MMAR_4765|M.marinum_M AGKVIRRSR------------------
MUL_0336|M.ulcerans_Agy99 AGKVIRRSR------------------
MSMEG_0269|M.smegmatis_MC2_155 LPESHLAIAEL----------------
Mflv_0621|M.gilvum_PYR-GCK VRG--LNQPSGGTELATGAMRIDVGST
Mvan_4412|M.vanbaalenii_PYR-1 VAGRKLTEKVRAELFGRGA--------
MAB_4365c|M.abscessus_ATCC_199 VRG--FVKPAGGEHL------------
MAV_3512|M.avium_104 LGT-----PR-----------------
TH_3169|M.thermoresistible__bu QF-------------------------