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MTGWLDGKRALVVGAGSGIGRAVVDAFAAEGAKVAALERDSDKCDRLRRQLPEVAVAEGDATTREANERA VALAVDTFGGLDTLVNCVGVFDFYRGVADIDAGALADAFDEMFRTNVLSHLQSVKAALPALRAAGASSIV LTESASSFYPGRGGVLYVSSKFAVRGLVSALAHELAPGIRVNGVAPGGTLGTDLRGLASLRLQGTRLDDA PDRAAEVAARTPLRVALSGADHAWSFVFLASDRSRGITGETVRPDGGFGLGTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3512 | - | - | 100% (264) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. avium 104 | MAV_0886 | - | 5e-24 | 33.08% (260) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_3019 | - | 1e-21 | 34.85% (264) | carveol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 8e-22 | 30.77% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_0682 | - | 1e-109 | 74.90% (263) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 9e-22 | 30.77% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01094 | - | 1e-14 | 29.63% (189) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4365c | - | 1e-36 | 39.85% (266) | putative dihydrodiol dehydrogenase |
| M. marinum M | MMAR_0402 | - | 9e-23 | 35.34% (266) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5204 | - | 5e-23 | 32.20% (264) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3893 | - | 4e-23 | 32.44% (262) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 2e-22 | 33.85% (257) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0466 | - | 1e-108 | 74.52% (263) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2788c|M.bovis_AF2122/97 --MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEA
Rv2766c|M.tuberculosis_H37Rv --MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEA
MSMEG_5204|M.smegmatis_MC2_155 MNNHSTRLEGRTALVTGATGGLGVAIASSLAANGAHVVITGRDAARGDAV
TH_3893|M.thermoresistible__bu ---MDFDLNGKRALVTGSSSGIGAGIVETLAAEGVSVVVHGRNAERAEAV
Mflv_0682|M.gilvum_PYR-GCK --MTG-WLAGKRALIVGAGSGIGRATVDAFLNEDARVAVLEYDSGKCATL
Mvan_0466|M.vanbaalenii_PYR-1 --MTG-WLAGKRALIVGGGSGIGRATVDAFLNEDARVAVLEYDSGKCATL
MAV_3512|M.avium_104 --MTG-WLDGKRALVVGAGSGIGRAVVDAFAAEGAKVAALERDSDKCDRL
MAB_4365c|M.abscessus_ATCC_199 --MSGGWLGGYVALITGGGSGIGRAVTERYLAEGASVTIVGHRPEQLDRV
MMAR_0402|M.marinum_M --MTG---GGRVALVTGAAGGQGWAIVQRLRAEGHSVAACDLRADRLDAL
MUL_0336|M.ulcerans_Agy99 ---MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERGESL
MLBr_01094|M.leprae_Br4923 --MEG--FAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQT
* *::.*. * * . . . :.
Mb2788c|M.bovis_AF2122/97 AAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFG-SVDILINNAG--
Rv2766c|M.tuberculosis_H37Rv AAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFG-SVDILINNAG--
MSMEG_5204|M.smegmatis_MC2_155 VAGIRSAGGRVDLVAADLAAGEDEVRRLARRAVEVAGGHIDILVNNAGLW
TH_3893|M.thermoresistible__bu ADRIRADGGTAATAVGDLATEDGAAQVADTAAAAFSG--IDILVNNAGGS
Mflv_0682|M.gilvum_PYR-GCK RQQ--LPD---VPVIEGDGTTRTANDEAVQVAVDAFG-GLDTLVNCVGIF
Mvan_0466|M.vanbaalenii_PYR-1 RHQ--LPD---VPVIEGDGTTRTANDEAVQVAVDAFG-GLDTLVNCVGIF
MAV_3512|M.avium_104 RRQ--LPE---VAVAEGDATTREANERAVALAVDTFG-GLDTLVNCVGVF
MAB_4365c|M.abscessus_ATCC_199 HAESSAPDR--LHTVVADTRESDQLHDAVVQTVSRFG-QLDTLVANAGVW
MMAR_0402|M.marinum_M VAES-GDDA--VISLALDVTDEAQWQEAVERAVTRFG-ALTALINNAGVL
MUL_0336|M.ulcerans_Agy99 AAALGAD----AMFCRTDVSQPEQVAAVVAAAVDNFG-GLHVMVNNAG--
MLBr_01094|M.leprae_Br4923 EGQLKAIGAS-ARTDRLDVTEREAFLTYADVVHENFG-KVNQIYNNAG-I
. * : : .*
Mb2788c|M.bovis_AF2122/97 TNPAYGPLLEQDH--ARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVN
Rv2766c|M.tuberculosis_H37Rv TNPAYGPLLEQDH--ARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVN
MSMEG_5204|M.smegmatis_MC2_155 GMP--EATSAVSE--PDLLASFRTNVIAPFLLTGALAPAMAERGHGAVVN
TH_3893|M.thermoresistible__bu SETGIQSWFALPV--SEWGVTYQRNVMSAGYLIHALVPAMKESGWGRIIQ
Mflv_0682|M.gilvum_PYR-GCK DFYRRIQDIPAERIDQAFDEMFRINVLSHIHSVKAAVPALMGQDGASIVL
Mvan_0466|M.vanbaalenii_PYR-1 DFYRRIQDIPAERIDQAFDEMFRINVLSHIHSVKAAVPALMGQDGASIVL
MAV_3512|M.avium_104 DFYRGVADIDAGALADAFDEMFRTNVLSHLQSVKAALPALRAAGASSIVL
MAB_4365c|M.abscessus_ATCC_199 DYQRPLTRLTASELTASFHEVFSVNVKGYLLAAEAAWRELVKTRG-SIIM
MMAR_0402|M.marinum_M HRAALVDETAAG-----FESAWRVNCLGAFLGMRAALGALSAAEGPVIVN
MUL_0336|M.ulcerans_Agy99 -VSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVN
MLBr_01094|M.leprae_Br4923 AFTGDVEVSHFKD----IERVMDVDYWGVVNGTKAFLPYLISSGDGHVIN
: . ::
Mb2788c|M.bovis_AF2122/97 TASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR---IRVNAICPGV
Rv2766c|M.tuberculosis_H37Rv TASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR---IRVNAICPGV
MSMEG_5204|M.smegmatis_MC2_155 VGSITGFIGGDRAALYSSTKAAVHSLTKSWAVEYGPQG--VRVNAVAPGP
TH_3893|M.thermoresistible__bu IASAAGIIPTSGQPDYGPSKAAMINMSMGLSKALAGTG--ITVNTVMPGM
Mflv_0682|M.gilvum_PYR-GCK TESASSFYPGRGGLLYVASKFAVRGVVTALAHELAPR---IRVNGVAPGG
Mvan_0466|M.vanbaalenii_PYR-1 TESASSFYPGRGGLLYVASKFAVRGVVTALAHELAPR---IRVNGVAPGG
MAV_3512|M.avium_104 TESASSFYPGRGGVLYVSSKFAVRGLVSALAHELAPG---IRVNGVAPGG
MAB_4365c|M.abscessus_ATCC_199 TLSNASFYVNGGGPIYTASKHACLGLMRELAFELAPK---VRVNGVACGG
MMAR_0402|M.marinum_M ICSTGAIRPFPHHCAYGAAKWALRGLTQTAAAELAPAG--IRVNAVFPGP
MUL_0336|M.ulcerans_Agy99 LTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYE--IRVNAIAPGN
MLBr_01094|M.leprae_Br4923 ISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGG
* .: * .:* * . . : *. : *
Mb2788c|M.bovis_AF2122/97 VRTRLAEALWKDHEDPLAAT----------------IALGRIGEPADIAS
Rv2766c|M.tuberculosis_H37Rv VRTRLAEALWKDHEDPLAAT----------------IALGRIGEPADIAS
MSMEG_5204|M.smegmatis_MC2_155 IATERVLEAADHVSGVLAR-----------------IPSRRMSTPEEVAA
TH_3893|M.thermoresistible__bu IMTEGLRDFLRTFADHRGWGDDLDKAADYILKG-TGQTVHRIGQVSDVAY
Mflv_0682|M.gilvum_PYR-GCK TLNTDLRGLDSLDLGARRLDAAPDRARELAAR--TPLGVALSG-EDHAWS
Mvan_0466|M.vanbaalenii_PYR-1 TLNTDLRGLDSLDLGARRLDAAPDRARELAAR--TPLGVALSG-EDHAWS
MAV_3512|M.avium_104 TLGTDLRGLASLRLQGTRLDDAPDRAAEVAAR--TPLRVALSG-ADHAWS
MAB_4365c|M.abscessus_ATCC_199 -MNTDLRGPEALSLADRSISTSFAKRGHDASAPLIPLHDSSTDPADFTGP
MMAR_0402|M.marinum_M IATSMLDEPTQARLAAVSMFGRLGRPAEVADA------------------
MUL_0336|M.ulcerans_Agy99 IPTPLLASSAAGLDQEQVERFTAQIRQTMRED----RPLKREGTPEDIAE
MLBr_01094|M.leprae_Br4923 IKTAIARNATAAEGLDVSKIASRFDTWVAHTS---PQHAARIILKAVRKK
Mb2788c|M.bovis_AF2122/97 AVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH--
Rv2766c|M.tuberculosis_H37Rv AVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH--
MSMEG_5204|M.smegmatis_MC2_155 AVVFLAGDEAANIHGAILSVDGGWAAA---------------
TH_3893|M.thermoresistible__bu AVAFLASPRADFLNGINLHLDGGATQSIY-------------
Mflv_0682|M.gilvum_PYR-GCK YVFLASHRSRG-LTGETIHPDGGFSLG---PPPQRN------
Mvan_0466|M.vanbaalenii_PYR-1 YVFLASHRSRG-LTGETIHPDGGFSLG---PPPQRN------
MAV_3512|M.avium_104 FVFLASDRSRG-ITGETVRPDGGFGLG---TPR---------
MAB_4365c|M.abscessus_ATCC_199 YVLLASREQSGPITGEAIAIDGGIGVRGFVKPAGGEHL----
MMAR_0402|M.marinum_M -VAFLVSENSSFITGSELVVDGGQCLQ---VP----------
MUL_0336|M.ulcerans_Agy99 AALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR--------
MLBr_01094|M.leprae_Br4923 KARVLVGPDAK-VANVVVRFSGGAGYQRLFAQVASRLILNQR
. : . : .**