For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RWVLDQPELKLTLKSGAAGVGREINLALTTELADPAQWLSGGELVLTTGIGLPKSSRDRRRYLRSLDENN VAALGFGTGLTFDEVPPELVSTADELGMPLLEIPLRTPFAAVVKAVSTRIAELEYDAVLRASRAQPRITR AIVNGGVQAVTAELGRSLRASVVVLDPGGTVVASHPRNLDVATVNLVRGALSPGASAGVQQLDPGITVSQ QAIGVGGTSYGVLAVVSKTPLTFVDQVLLGHTNSLLALDFDKPSRLQEAQRRLNGQALGLLLGDERNLGP VWAQLGQAADARGRIRVLVVDAESQTALVRVLPAVTRDMESAGYPVFAHTGERQLTVVLPGAETADFARR LFGDVDARIKKGLRAGLSGAHPVGRLADAVQNARLAASVAERGGTPLEFTSLAGSALLSFGASREVLVAV ANATLEPIVEHDAVHGSELMTSLRAYLEANGHWESAATVVGVHRHTLRKRIETVQSLLACDLDIARVRAE LLLAMLTGTPGTGN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4202c | - | - | 100% (505) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_0825 | - | 3e-58 | 32.94% (510) | peptidase |
| M. abscessus ATCC 19977 | MAB_4347 | - | 2e-14 | 24.28% (519) | putative regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 8e-07 | 28.31% (219) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0356 | - | 8e-17 | 24.71% (510) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv1186c | - | 8e-07 | 28.31% (219) | hypothetical protein Rv1186c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4951 | - | 5e-05 | 25.69% (218) | hypothetical protein MMAR_4951 |
| M. avium 104 | MAV_1987 | - | 7e-09 | 28.83% (163) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 9e-55 | 33.54% (495) | regulatory protein |
| M. thermoresistible (build 8) | TH_2137 | - | 6e-06 | 23.81% (315) | putative DNA-binding protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 4e-46 | 30.31% (508) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6688|M.smegmatis_MC2_155 -----MITARGLAQVESLGLSLLAGAQGADREIAWAHANELRDPTPYLAG
Mvan_1854|M.vanbaalenii_PYR-1 -----MITARSLCQDENLGLTLVAGAQAADRPIAWAHAIELADPTPYLAG
Mb1218c|M.bovis_AF2122/97 MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVRLGLAA
Rv1186c|M.tuberculosis_H37Rv MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVRLGLAA
MAV_1987|M.avium_104 ----MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETPEDRP----
TH_2137|M.thermoresistible__bu ----VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENAGGLR----
MAB_4202c|M.abscessus_ATCC_199 --------MRWVLDQPELKLTLKSGAAGVGREINLALTTELADPAQWLSG
Mflv_0356|M.gilvum_PYR-GCK --MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTLLQG
MMAR_4951|M.marinum_M ---------------------MQTCATQLARDIVDRYQSELP--------
. : :
MSMEG_6688|M.smegmatis_MC2_155 GELVMTTGINIGAGAGEQRDYVARLSAAGIAALAVDTGTTLQEVPAAVLA
Mvan_1854|M.vanbaalenii_PYR-1 GELVMTTGINIGADAAAQADYVARLAAAGTAALAVDTGTTLTAVPAGVLA
Mb1218c|M.bovis_AF2122/97 AAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGAVR
Rv1186c|M.tuberculosis_H37Rv AAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGAVR
MAV_1987|M.avium_104 --VVGDVLLAVGAGSLDEAVRWAASAR----AAVVVLRDDETPMTFDGVT
TH_2137|M.thermoresistible__bu --VTGDVLLAVGAESVAEAVRWAETAQ----AVVVLTRAG-PDASRSCSD
MAB_4202c|M.abscessus_ATCC_199 GELVLTTGIGLPKSSRDRRRYLRSLDENNVAALGFGTGLTFDEVPPELVS
Mflv_0356|M.gilvum_PYR-GCK GELVLTTGAAMARS---PRTYLRGLAEAGAVGVVVEVGAVVPEVPPGVGG
MMAR_4951|M.marinum_M ------------------------------------------SIVPDPPA
MSMEG_6688|M.smegmatis_MC2_155 AGDELGLPVLEVPASTPFIAIARVVIDAVKADELSAVQRMVDQQQVLARA
Mvan_1854|M.vanbaalenii_PYR-1 AGDEHGVPVLRVPASTPFIAIARVVIDAVKADQLESVQRVVDQQEVLARA
Mb1218c|M.bovis_AF2122/97 AGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQSLA
Rv1186c|M.tuberculosis_H37Rv AGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQSLA
MAV_1987|M.avium_104 DVGAVLVIDPTVSWSAVAAVVYGLVLEG--RETESGRGPTDLFALADSLA
TH_2137|M.thermoresistible__bu GAVAVLTVEPEVSWSELAAVVYGLVLEG--RETESGRGPTDLFALADNLA
MAB_4202c|M.abscessus_ATCC_199 TADELGMPLLEIPLRTPFAAVVKAVSTRIAELEYDAVLRASRAQPRITRA
Mflv_0356|M.gilvum_PYR-GCK IAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDRRVHETFTDL
MMAR_4951|M.marinum_M VADQLASVEASVRQIAECIDSGEGPRLLDLTPATAAIGRSG-VQRNIALN
MSMEG_6688|M.smegmatis_MC2_155 TLRGG-IPAVVNALAECLSATVVVADIEGR----ILATRG-AADQQLVEV
Mvan_1854|M.vanbaalenii_PYR-1 TLRGG-IPGVVGALAECLSAVVVAVSTDGR----DLAAGG-TADPQLISA
Mb1218c|M.bovis_AF2122/97 DRIHG-MISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIGQ
Rv1186c|M.tuberculosis_H37Rv DRIHG-MISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIGQ
MAV_1987|M.avium_104 DGIGN-PVVIQDRHLGVLAYS-RLAQADPALVETVLQRQTPEPLRALLEA
TH_2137|M.thermoresistible__bu DAVGG-PVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRRLFEQ
MAB_4202c|M.abscessus_ATCC_199 IVNGG-VQAVTAELGRSLRASVVVLDPGGT------VVASHPRNLDVATV
Mflv_0356|M.gilvum_PYR-GCK SMKRASLSGIVDAAAKLLGEHVVLED---------LSHQALVASTGIPAD
MMAR_4951|M.marinum_M DLFRS-------------------------------VRMAQERTWQWLFD
MSMEG_6688|M.smegmatis_MC2_155 LEASRRAGARAQAGVVADADGYVTVQTLRAAQPVR-----------GHLA
Mvan_1854|M.vanbaalenii_PYR-1 LSEAVGQARNRGAAVIPDGDALLTIQRLRAAQAVR-----------GYLV
Mb1218c|M.bovis_AF2122/97 WGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAGTIW
Rv1186c|M.tuberculosis_H37Rv WGIFDALRPGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAGTIW
MAV_1987|M.avium_104 RGVFAHLQVADEPLFVAEDAERGLSGRMVVAVRAG-------AELIGSVW
TH_2137|M.thermoresistible__bu LGVSEHLAAGDDPLFIAARPGHDLTGRTVIAVRAG-------RELLGSVW
MAB_4202c|M.abscessus_ATCC_199 NLVRGALSPGASAGVQQLDPGITVSQQAIGVGGTS----------YGVLA
Mflv_0356|M.gilvum_PYR-GCK LLTDWARRSRRSPGGGAGAEPWSATDVGPRFEQWG------------RLV
MMAR_4951|M.marinum_M RITASSAATDHDRALDLATNWLFGYVDVVLIRAER---------------
MSMEG_6688|M.smegmatis_MC2_155 VRTEQPMSNSQRLLVAHAVSLISIELEKPARVVDAEDRLRSAVTRDILSG
Mvan_1854|M.vanbaalenii_PYR-1 VRSAGPLSDSGRLLVSHAVSLISIALEKPARVQDAEQRLRSAVTRELLGG
Mb1218c|M.bovis_AF2122/97 VQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGLAEL
Rv1186c|M.tuberculosis_H37Rv VQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGLAEL
MAV_1987|M.avium_104 VACEAPLQPAALRALADGARTVALHLLRSRASADLERQVESELVIRLLEG
TH_2137|M.thermoresistible__bu VVTPEPLDDGRRRALADGARTVALHLLRSRASADLERQVESDLVLRLLEG
MAB_4202c|M.abscessus_ATCC_199 VVSKTPLTFVDQVLLGHTNSLLALDFDKPSRLQEAQRRLNGQALGLLLGD
Mflv_0356|M.gilvum_PYR-GCK VPYAPADATRAATVLERAAAALAMHRMVEQNRTGLQHQAQSGLIDDVLRG
MMAR_4951|M.marinum_M LYEVEREAWLTGAAAARAAAVEDILTEREDDAQRASTRLRYDVNRHHVGV
: .
MSMEG_6688|M.smegmatis_MC2_155 T----GTTDSAVLRYLGFQPDDEVVVLLLTGFT-------------PLLT
Mvan_1854|M.vanbaalenii_PYR-1 R----GAVDDGLLRYFGFTPDGDVVVSVLHGIG-------------PVLA
Mb1218c|M.bovis_AF2122/97 NATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAV------RHVRL
Rv1186c|M.tuberculosis_H37Rv NATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAV------RHVRL
MAV_1987|M.avium_104 -----TADAATVASRLDLAHNG-LRVVAVQAFVGADRDA-------PLLL
TH_2137|M.thermoresistible__bu -----TSDAAGAAARLGLPQEA-LRIIAVRARSGVDRQG-------PLLL
MAB_4202c|M.abscessus_ATCC_199 E-----RNLGPVWAQLGQAADARGRIRVLVVDAESQT---------ALVR
Mflv_0356|M.gilvum_PYR-GCK RVVD-DRDAAARAQALGLRSNAQYLPVVVRVARPAEIDDPVAGHRRNVAV
MMAR_4951|M.marinum_M SVWR-DVTQDACAGPVTLTEALTQLTRAIAAQS--------------VLA
. . :
MSMEG_6688|M.smegmatis_MC2_155 AQDDLGQRLAPAGSYLMTSTGD-EFAIIVHAARRRR-VY-AAVEEFGRVT
Mvan_1854|M.vanbaalenii_PYR-1 AEEELSRPLADTGPYLMAATGT-EIVIVLPADGSR-----ARIRTLLRGR
Mb1218c|M.bovis_AF2122/97 VDVMALSASAFRHDAQVAANGS-RIYVLLPQTTTG-----RAVTSWVRGT
Rv1186c|M.tuberculosis_H37Rv VDVMALSASAFRHDAQVAANGS-RIYVLLPQTTTG-----RAVTSWVRGT
MAV_1987|M.avium_104 AFERATTGFGWSRPGRSALAGN-SVYAVLPADEAS-----TARR-WVGAL
TH_2137|M.thermoresistible__bu AFEHATTGFGWSRAGRSALAGD-TVYTVLPADHAA-----TARR-WVEGL
MAB_4202c|M.abscessus_ATCC_199 VLPAVTRDMESAGYPVFAHTGERQLTVVLPGAETAD-FARRLFGDVDARI
Mflv_0356|M.gilvum_PYR-GCK LDAVAHTVNACGHTGLFSLRGDGEVGAVLSLKDSRTRSVDQALGALARRI
MMAR_4951|M.marinum_M HPAGSKAIAGWLSRPQAFTAAELDVANICSGIHLP--------QDVRVAI
. . :
MSMEG_6688|M.smegmatis_MC2_155 GRTVRGGASQPVRLADAVVGAEQARIAAHSNSRRNITEFTEVKVFGTLLG
Mvan_1854|M.vanbaalenii_PYR-1 G-APGGGSSRVVPMADVGTGLEQARVAAHS-SVGEFTEYADLGPLAAVLD
Mb1218c|M.bovis_AF2122/97 ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVT
Rv1186c|M.tuberculosis_H37Rv ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVT
MAV_1987|M.avium_104 RAALPERL--TMIAGISG-VAEVGDLAAARQEADECLALHEMSPAAPPP-
TH_2137|M.thermoresistible__bu QAALPSEV--TVSAGISG-IADHTELPDARREADECLALHDALHDARPDT
MAB_4202c|M.abscessus_ATCC_199 KKGLRAGLSGAHPVGRLADAVQNARLAASVAERGGTPLEFTSLAGSALLS
Mflv_0356|M.gilvum_PYR-GCK HTEIRRVDGSDRVVVTLGPSARNVTDAIAGLAEAIDTAEVALSLRGDVRD
MMAR_4951|M.marinum_M GEPGWGISGFRRTHVEASHAQRFVSLLGDRAEVVTCYRNVAVAALAGTDR
MSMEG_6688|M.smegmatis_MC2_155 -------------GRSTAELRVLAQPIEPLLAGGD---------------
Mvan_1854|M.vanbaalenii_PYR-1 -------------GRTSRELRFLAAVLDPLAGNDE---------------
Mb1218c|M.bovis_AF2122/97 -------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQDP
Rv1186c|M.tuberculosis_H37Rv -------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQDP
MAV_1987|M.avium_104 -------------AYDESWDDILLQRLRAAARSGRAPTRGPVADLGRHDR
TH_2137|M.thermoresistible__bu GSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAALHEHDL
MAB_4202c|M.abscessus_ATCC_199 FG-----------ASREVLVAVANATLEPIVEHDAVHG------------
Mflv_0356|M.gilvum_PYR-GCK FY-----------RTSDIRLRGLISLLRDDPRIRRFAETELRALLAHDAG
MMAR_4951|M.marinum_M -------------GHAVAFVRRVLGPLAANDEGTYR--------------
:
MSMEG_6688|M.smegmatis_MC2_155 ----ELIDALTAFLRHNGQLEAAASELQIHRHTMRNRMRRISDLLADDLG
Mvan_1854|M.vanbaalenii_PYR-1 ----DLIATLAAFLRHNGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLT
Mb1218c|M.bovis_AF2122/97 ----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLG
Rv1186c|M.tuberculosis_H37Rv ----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLG
MAV_1987|M.avium_104 ANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLD
TH_2137|M.thermoresistible__bu RHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQLDLQ
MAB_4202c|M.abscessus_ATCC_199 ---SELMTSLRAYLEANGHWESAATVVGVHRHTLRKRIETVQSLLACDLD
Mflv_0356|M.gilvum_PYR-GCK -AEPSNISVLREYLRLAGNKSALAERLHMSRPALYKRLRGIEDALGVDLD
MMAR_4951|M.marinum_M -----IAATLAVYLEENRSPAKAAQRLGVHPNTVSYRVHQAEELLGRTID
* :* . : : :: *:. :
MSMEG_6688|M.smegmatis_MC2_155 TADTRAQLWLAIRAWQLLVSRERPGLS---
Mvan_1854|M.vanbaalenii_PYR-1 SADSRAQLWLALRAFQLLENRRAPAGRCDS
Mb1218c|M.bovis_AF2122/97 DPDVRLLFSLGLRAMERTA-----------
Rv1186c|M.tuberculosis_H37Rv DPDVRLLFSLGLRAMERTA-----------
MAV_1987|M.avium_104 DSKKRLAMMIELAAIHTD------------
TH_2137|M.thermoresistible__bu DPDKRLAMMIELAAIEGPPILSG-------
MAB_4202c|M.abscessus_ATCC_199 IARVRAELLLAMLTGTPGTGN---------
Mflv_0356|M.gilvum_PYR-GCK DGESMTSLHVAVMVLDSLTGSG--------
MMAR_4951|M.marinum_M IGALDLSVALALLPAMRAMTQRSGGEL---
. : :