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KPLQERNLAVIGAIGVGVTAGVVLAALQYDKLPVFSGGERYSAYFTEASGLQPGADVQVAGHKVGKVSDI NLDGGRVLVNFEIGENIAIGDRSEAAIKTNSLLGLKVLEVTPRGADSLAQPIPIDRTTPAYQLPDALGDL SSTISNLNTTSLNDSLATLAAEFADTPDDLKNAVEGVMRFSATLNSRDQQLRDLLANARSASTVLADRTD QVVTLIEHSAALLAQLRVEREALDDISGNISDLTEQLSALIDEHRTSLRPALEKLSGVMALIDNRRDKVQ ESLKLLHPFMLSLGESVSAGPFFKPYITNLLPGQFIQPFIEAAFSDLGLDPNVLLPSQLSDPQTGQPATP ALPVPYPRTGQAGDPHLTLPDAITGNPGDQRYPYREPRPAPSPGGPPPGPPAGTTPAGSAPAPPQSPEPG SPIETGGPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4397 | - | - | 100% (430) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | e-151 | 62.44% (434) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0515 | - | e-146 | 60.71% (420) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 5e-59 | 32.88% (438) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-147 | 60.14% (439) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-142 | 61.04% (403) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-54 | 30.87% (447) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 1e-55 | 36.13% (346) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-148 | 60.56% (426) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-143 | 58.58% (437) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-145 | 59.08% (435) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4453 | - | 1e-144 | 58.60% (430) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-145 | 59.62% (426) | MCE-family protein, Mce3C_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4453|M.thermoresistible__bu VCTEMKPFAERNKRVMGAVGIGVGTIIIAGALQYDNLPVVSSDTRYSAYF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Mflv_2103|M.gilvum_PYR-GCK ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
Mvan_4397|M.vanbaalenii_PYR-1 ----MKPLQERNLAVIGAIGVGVTAGVVLAALQYDKLPVFSGGERYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
* : : * . : : . : :*. . *
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4453|M.thermoresistible__bu AESGGLRAGAAVQVSGMRVGKVSAVELDGPHVRVEFRVRPNIRLGELSEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
Mvan_4397|M.vanbaalenii_PYR-1 TEASGLQPGADVQVAGHKVGKVSDINLDGGRVLVNFEIGENIAIGDRSEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNT-IGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-IGTASRL
:::.** . * ::* ** *. : : * : : * : :* :
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
TH_4453|M.thermoresistible__bu AIKTKSLLGAKILDITSRGEGRLSA--SIPVERTVSPYELPDALGDLAST
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK AIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSAT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
Mvan_4397|M.vanbaalenii_PYR-1 AIKTNSLLGLKVLEVTPRGADSLAQ--PIPIDRTTPAYQLPDALGDLSST
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
.*: :** * :.: . * :*: :: ..* .*: :
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4453|M.thermoresistible__bu IAGLDTAGVSESLATLAETFENTPAEVQAAVRGVTRFSESLGRRDQQLRQ
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
Mvan_4397|M.vanbaalenii_PYR-1 ISNLNTTSLNDSLATLAAEFADTPDDLKNAVEGVMRFSATLNSRDQQLRD
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* .:: . : .. *: ** :: ::. ** :
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4453|M.thermoresistible__bu LLENARKATGVLGERSQQIAALVRDSNALLVQLRTESAALDQLSANISAL
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
Mvan_4397|M.vanbaalenii_PYR-1 LLANARSASTVLADRTDQVVTLIEHSAALLAQLRVEREALDDISGNISDL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: :* ..: :*. * :: *: . :: : . *:. : :
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4453|M.thermoresistible__bu AQQVSGFISENHDTLSPALEKLNGVLTIVENRKEQVQDALHLAQGYHTRL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
Mvan_4397|M.vanbaalenii_PYR-1 TEQLSALIDEHRTSLRPALEKLSGVMALIDNRRDKVQESLKLLHPFMLSL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
*: :: :: : :::* : : ::: : .:: : :
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4453|M.thermoresistible__bu GEAVSSGPFFNSYVANLLPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mvan_4397|M.vanbaalenii_PYR-1 GESVSAGPFFKPYITNLLPGQFIQPFIEAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *: : .: * : ... *
Rv1968|M.tuberculosis_H37Rv ----------------------LTDPPTGQPGTP----------------
MSMEG_0348|M.smegmatis_MC2_155 ----------------------LVDPPVGQPGTP----------------
TH_4453|M.thermoresistible__bu ----------------------LNDPQVGQPGTP----------------
MMAR_4053|M.marinum_M ----------------------RTDPPIGQPGTP----------------
MUL_3920|M.ulcerans_Agy99 ----------------------RTDPPIGQPGTP----------------
Mflv_2103|M.gilvum_PYR-GCK ----------------------RSDPQVGQPGTP----------------
MAV_2534|M.avium_104 ----------------------RADPQVGQPATP----------------
Mvan_4397|M.vanbaalenii_PYR-1 ----------------------LSDPQTGQPATP----------------
MAB_4151c|M.abscessus_ATCC_199 -----------------------------QPGKL----------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
*.
Rv1968|M.tuberculosis_H37Rv -------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP-------
MSMEG_0348|M.smegmatis_MC2_155 -------------ALPVPYPRTGQGGEPRLNLPDAITGNPGDP-------
TH_4453|M.thermoresistible__bu -------------AAPVPYPRTGQGGGPRLTLPDAITGNPGDP-------
MMAR_4053|M.marinum_M -------------PLPLPFPRTGQGGEPHLKLPDAITGNPDDP-------
MUL_3920|M.ulcerans_Agy99 -------------PLPLPFPRTGQGGEPHRKLPDAITGNPDDP-------
Mflv_2103|M.gilvum_PYR-GCK -------------AMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPGI
MAV_2534|M.avium_104 -------------PLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPGA
Mvan_4397|M.vanbaalenii_PYR-1 -------------ALPVPYPRTGQAGDPHLTLPDAITGNPGDQ-------
MAB_4151c|M.abscessus_ATCC_199 -------------PASLSDYLNGLIGERQIMRPKSP--------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
. . . * * *
Rv1968|M.tuberculosis_H37Rv -------RYPYRPEPPAPPPGGPPPGPPAQ-------------------Q
MSMEG_0348|M.smegmatis_MC2_155 -------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVPA
TH_4453|M.thermoresistible__bu -------RYPYREPLPAPPPGGPPPGPPAAIPPVPVREPVFVPAPN-EVS
MMAR_4053|M.marinum_M -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
MUL_3920|M.ulcerans_Agy99 -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
Mflv_2103|M.gilvum_PYR-GCK PLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVPA
MAV_2534|M.avium_104 ASSGP-GCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------APL
Mvan_4397|M.vanbaalenii_PYR-1 -------RYPYREPRPAPSPGGPPPGPPAGTTPAGSAP----------AP
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
Rv1968|M.tuberculosis_H37Rv PGDQP--------------------------
MSMEG_0348|M.smegmatis_MC2_155 PGEPT--TPIPAGEGR---------------
TH_4453|M.thermoresistible__bu AGEPD--TPEIDGESQ---------------
MMAR_4053|M.marinum_M PGEVS--APQTAGAGR---------------
MUL_3920|M.ulcerans_Agy99 PGEVS--APQTAGAGR---------------
Mflv_2103|M.gilvum_PYR-GCK PGEAPPLVPVPGEGTR---------------
MAV_2534|M.avium_104 PGPAQ---PGEGGEGR---------------
Mvan_4397|M.vanbaalenii_PYR-1 PQSPEPGSPIETGGPT---------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------------
Mb0177|M.bovis_AF2122/97 PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN