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M. vanbaalenii PYR-1 Mvan_4397 (-)

annotation: virulence factor Mce family protein
coordinates: 4718463 - 4719755
length: 430

KPLQERNLAVIGAIGVGVTAGVVLAALQYDKLPVFSGGERYSAYFTEASGLQPGADVQVAGHKVGKVSDI
NLDGGRVLVNFEIGENIAIGDRSEAAIKTNSLLGLKVLEVTPRGADSLAQPIPIDRTTPAYQLPDALGDL
SSTISNLNTTSLNDSLATLAAEFADTPDDLKNAVEGVMRFSATLNSRDQQLRDLLANARSASTVLADRTD
QVVTLIEHSAALLAQLRVEREALDDISGNISDLTEQLSALIDEHRTSLRPALEKLSGVMALIDNRRDKVQ
ESLKLLHPFMLSLGESVSAGPFFKPYITNLLPGQFIQPFIEAAFSDLGLDPNVLLPSQLSDPQTGQPATP
ALPVPYPRTGQAGDPHLTLPDAITGNPGDQRYPYREPRPAPSPGGPPPGPPAGTTPAGSAPAPPQSPEPG
SPIETGGPT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4397--100% (430)virulence factor Mce family protein
M. vanbaalenii PYR-1Mvan_0365-e-15162.44% (434) virulence factor Mce family protein
M. vanbaalenii PYR-1Mvan_0515-e-14660.71% (420) virulence factor Mce family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0177mce1C5e-5932.88% (438) MCE-family protein MCE1C
M. gilvum PYR-GCKMflv_2103-1e-14760.14% (439) virulence factor Mce family protein
M. tuberculosis H37RvRv1968mce3C1e-14261.04% (403) MCE-family protein MCE3C
M. leprae Br4923MLBr_02591mce1C2e-5430.87% (447) putative secreted protein
M. abscessus ATCC 19977MAB_4151c-1e-5536.13% (346) MCE-family protein
M. marinum MMMAR_4053mce3C_11e-14860.56% (426) MCE-family protein, Mce3C_1
M. avium 104MAV_2534-1e-14358.58% (437) virulence factor Mce family protein
M. smegmatis MC2 155MSMEG_0348-1e-14559.08% (435) mce-family protein mce3c
M. thermoresistible (build 8)TH_4453-1e-14458.60% (430) PUTATIVE virulence factor Mce family protein
M. ulcerans Agy99MUL_3920mce3C_11e-14559.62% (426) MCE-family protein, Mce3C_1

CLUSTAL 2.0.9 multiple sequence alignment


Rv1968|M.tuberculosis_H37Rv         ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155      MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4453|M.thermoresistible__bu      VCTEMKPFAERNKRVMGAVGIGVGTIIIAGALQYDNLPVVSSDTRYSAYF
MMAR_4053|M.marinum_M               ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99           ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Mflv_2103|M.gilvum_PYR-GCK          ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
MAV_2534|M.avium_104                ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
Mvan_4397|M.vanbaalenii_PYR-1       ----MKPLQERNLAVIGAIGVGVTAGVVLAALQYDKLPVFSGGERYSAYF
MAB_4151c|M.abscessus_ATCC_199      MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97            ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923          ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
                                        *  :   :    * . :     :   .  :  :*.        . *

Rv1968|M.tuberculosis_H37Rv         ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155      ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4453|M.thermoresistible__bu      AESGGLRAGAAVQVSGMRVGKVSAVELDGPHVRVEFRVRPNIRLGELSEA
MMAR_4053|M.marinum_M               ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99           ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK          AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
MAV_2534|M.avium_104                AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
Mvan_4397|M.vanbaalenii_PYR-1       TEASGLQPGADVQVAGHKVGKVSDINLDGGRVLVNFEIGENIAIGDRSEA
MAB_4151c|M.abscessus_ATCC_199      ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97            TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNT-IGTESRL
MLBr_02591|M.leprae_Br4923          TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-IGTASRL
                                    :::.**  .  * ::*  ** *. : : *  : : * :     :*  :  

Rv1968|M.tuberculosis_H37Rv         AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155      AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
TH_4453|M.thermoresistible__bu      AIKTKSLLGAKILDITSRGEGRLSA--SIPVERTVSPYELPDALGDLAST
MMAR_4053|M.marinum_M               AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99           AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK          AIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSAT
MAV_2534|M.avium_104                AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
Mvan_4397|M.vanbaalenii_PYR-1       AIKTNSLLGLKVLEVTPRGADSLAQ--PIPIDRTTPAYQLPDALGDLSST
MAB_4151c|M.abscessus_ATCC_199      AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97            AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923          GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
                                    .*:   :** * :.: . *         :*: :: ..*   .*: :    

Rv1968|M.tuberculosis_H37Rv         ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155      VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4453|M.thermoresistible__bu      IAGLDTAGVSESLATLAETFENTPAEVQAAVRGVTRFSESLGRRDQQLRQ
MMAR_4053|M.marinum_M               ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99           ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK          ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
MAV_2534|M.avium_104                ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
Mvan_4397|M.vanbaalenii_PYR-1       ISNLNTTSLNDSLATLAAEFADTPDDLKNAVEGVMRFSATLNSRDQQLRD
MAB_4151c|M.abscessus_ATCC_199      AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97            ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923          ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
                                      . .   :. :* .::  .  :  ..  *: **  :: ::. **  :  

Rv1968|M.tuberculosis_H37Rv         LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155      LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4453|M.thermoresistible__bu      LLENARKATGVLGERSQQIAALVRDSNALLVQLRTESAALDQLSANISAL
MMAR_4053|M.marinum_M               LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99           LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK          LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
MAV_2534|M.avium_104                LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
Mvan_4397|M.vanbaalenii_PYR-1       LLANARSASTVLADRTDQVVTLIEHSAALLAQLRVEREALDDISGNISDL
MAB_4151c|M.abscessus_ATCC_199      LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97            LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923          LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
                                    *: :* ..: :*. *  ::  *: .   ::  :  .  *:. :   :   

Rv1968|M.tuberculosis_H37Rv         AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155      ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4453|M.thermoresistible__bu      AQQVSGFISENHDTLSPALEKLNGVLTIVENRKEQVQDALHLAQGYHTRL
MMAR_4053|M.marinum_M               GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99           GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK          SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
MAV_2534|M.avium_104                ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
Mvan_4397|M.vanbaalenii_PYR-1       TEQLSALIDEHRTSLRPALEKLSGVMALIDNRRDKVQESLKLLHPFMLSL
MAB_4151c|M.abscessus_ATCC_199      SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97            SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923          AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
                                      *:  :: ::   :   :::*  :   : :::  : .::     :   :

Rv1968|M.tuberculosis_H37Rv         GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155      GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4453|M.thermoresistible__bu      GEAVSSGPFFNSYVANLLPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MMAR_4053|M.marinum_M               GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99           GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK          GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104                GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mvan_4397|M.vanbaalenii_PYR-1       GESVSAGPFFKPYITNLLPGQFIQPFIEAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199      GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97            GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923          NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
                                    .* ..:** *:  : .: *  :    ... *                   

Rv1968|M.tuberculosis_H37Rv         ----------------------LTDPPTGQPGTP----------------
MSMEG_0348|M.smegmatis_MC2_155      ----------------------LVDPPVGQPGTP----------------
TH_4453|M.thermoresistible__bu      ----------------------LNDPQVGQPGTP----------------
MMAR_4053|M.marinum_M               ----------------------RTDPPIGQPGTP----------------
MUL_3920|M.ulcerans_Agy99           ----------------------RTDPPIGQPGTP----------------
Mflv_2103|M.gilvum_PYR-GCK          ----------------------RSDPQVGQPGTP----------------
MAV_2534|M.avium_104                ----------------------RADPQVGQPATP----------------
Mvan_4397|M.vanbaalenii_PYR-1       ----------------------LSDPQTGQPATP----------------
MAB_4151c|M.abscessus_ATCC_199      -----------------------------QPGKL----------------
Mb0177|M.bovis_AF2122/97            RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923          RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
                                                                  *.                  

Rv1968|M.tuberculosis_H37Rv         -------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP-------
MSMEG_0348|M.smegmatis_MC2_155      -------------ALPVPYPRTGQGGEPRLNLPDAITGNPGDP-------
TH_4453|M.thermoresistible__bu      -------------AAPVPYPRTGQGGGPRLTLPDAITGNPGDP-------
MMAR_4053|M.marinum_M               -------------PLPLPFPRTGQGGEPHLKLPDAITGNPDDP-------
MUL_3920|M.ulcerans_Agy99           -------------PLPLPFPRTGQGGEPHRKLPDAITGNPDDP-------
Mflv_2103|M.gilvum_PYR-GCK          -------------AMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPGI
MAV_2534|M.avium_104                -------------PLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPGA
Mvan_4397|M.vanbaalenii_PYR-1       -------------ALPVPYPRTGQAGDPHLTLPDAITGNPGDQ-------
MAB_4151c|M.abscessus_ATCC_199      -------------PASLSDYLNGLIGERQIMRPKSP--------------
Mb0177|M.bovis_AF2122/97            -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923          TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
                                                 . . .    *  *      *                 

Rv1968|M.tuberculosis_H37Rv         -------RYPYRPEPPAPPPGGPPPGPPAQ-------------------Q
MSMEG_0348|M.smegmatis_MC2_155      -------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVPA
TH_4453|M.thermoresistible__bu      -------RYPYREPLPAPPPGGPPPGPPAAIPPVPVREPVFVPAPN-EVS
MMAR_4053|M.marinum_M               -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
MUL_3920|M.ulcerans_Agy99           -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
Mflv_2103|M.gilvum_PYR-GCK          PLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVPA
MAV_2534|M.avium_104                ASSGP-GCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------APL
Mvan_4397|M.vanbaalenii_PYR-1       -------RYPYREPRPAPSPGGPPPGPPAGTTPAGSAP----------AP
MAB_4151c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0177|M.bovis_AF2122/97            GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923          GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
                                                                                      

Rv1968|M.tuberculosis_H37Rv         PGDQP--------------------------
MSMEG_0348|M.smegmatis_MC2_155      PGEPT--TPIPAGEGR---------------
TH_4453|M.thermoresistible__bu      AGEPD--TPEIDGESQ---------------
MMAR_4053|M.marinum_M               PGEVS--APQTAGAGR---------------
MUL_3920|M.ulcerans_Agy99           PGEVS--APQTAGAGR---------------
Mflv_2103|M.gilvum_PYR-GCK          PGEAPPLVPVPGEGTR---------------
MAV_2534|M.avium_104                PGPAQ---PGEGGEGR---------------
Mvan_4397|M.vanbaalenii_PYR-1       PQSPEPGSPIETGGPT---------------
MAB_4151c|M.abscessus_ATCC_199      -------------------------------
Mb0177|M.bovis_AF2122/97            PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923          SAPHEPREQLSAPLINPGGTGGSGGAGGSRN