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PFEPRPSHPRQRRTQHMNSTDGAESLLAPLTAAEWGDDEYAAFGALLGLPGEKVPRAGSGHAADPLKFDI IGLLARHPKMARRFLTFNGWLLQCGELPLRLRELAILRIAHTRRSAFFWGEHTKVATEGGVPEADIARLA EGNEAFTGADRLVLDATDELLHDGHAEPATWHRLTDELGTHQAMELIFVVGTYAMLAMAFDTWRLPPPAG SASLPEPPAGVPPGGGTH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4316 | - | - | 100% (229) | carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_4212 | - | 1e-25 | 37.02% (181) | carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_4181 | - | 2e-24 | 35.36% (181) | carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1558 | - | 2e-14 | 31.06% (161) | hypothetical protein Mb1558 |
| M. gilvum PYR-GCK | Mflv_2330 | - | 1e-92 | 83.16% (196) | carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv1531 | - | 2e-14 | 31.06% (161) | hypothetical protein Rv1531 |
| M. leprae Br4923 | MLBr_02465 | - | 4e-08 | 27.74% (137) | hypothetical protein MLBr_02465 |
| M. abscessus ATCC 19977 | MAB_2040c | - | 1e-11 | 27.95% (161) | hypothetical protein MAB_2040c |
| M. marinum M | MMAR_4743 | - | 2e-25 | 37.85% (177) | hypothetical protein MMAR_4743 |
| M. avium 104 | MAV_3958 | pcaC | 9e-26 | 33.69% (187) | hypothetical protein MAV_3958 |
| M. smegmatis MC2 155 | MSMEG_6536 | - | 4e-26 | 37.70% (191) | carboxymuconolactone decarboxylase |
| M. thermoresistible (build 8) | TH_2018 | - | 2e-27 | 37.63% (186) | carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_4533 | - | 5e-07 | 27.17% (184) | hypothetical protein MUL_4533 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1558|M.bovis_AF2122/97 ------------------------MTTS-RVPLLPVDEAKAAADEAGV--
Rv1531|M.tuberculosis_H37Rv ------------------------MTTS-RVPLLPVDEAKAAADEAGV--
MAB_2040c|M.abscessus_ATCC_199 ------------------------MTMAERVPMLDREQAQLRAAECGL--
Mvan_4316|M.vanbaalenii_PYR-1 MPFEPRPSHPRQRRTQHMNSTDGAESLLAPLTAAEWGDDEYAAFGALLGL
Mflv_2330|M.gilvum_PYR-GCK --------------------MTADEPLLAPLAAEEWGDDEYAAFGALLGL
MMAR_4743|M.marinum_M -------------------------MRLPPLPADQWDEAVQRSLSVIL--
TH_2018|M.thermoresistible__bu -------------------------VRLAPLPAEQWDDEVLSALAVML--
MAV_3958|M.avium_104 -----------------MAASDRHPQRLTPLPADEWDEDTRAALASLI--
MSMEG_6536|M.smegmatis_MC2_155 --------------------------MLPPLPAEDWDDAARDALASVV--
MLBr_02465|M.leprae_Br4923 ------------------MSGGTGTGPVGRIPPGSLRQLGPINWVIAKLA
MUL_4533|M.ulcerans_Agy99 ------------------MTG----DQVARIPSGGIRQLGPVNWALAKLA
:. :
Mb1558|M.bovis_AF2122/97 PDYMAEL------------SIFQVLLNHPRLARTFNDLLATMLWHGTLDS
Rv1531|M.tuberculosis_H37Rv PDYMAEL------------SIFQVLLNHPRLARTFNDLLATMLWHGTLDS
MAB_2040c|M.abscessus_ATCC_199 PEELAEL------------SVFRVALHQPRVAVALYGLLDALLFRGSLDA
Mvan_4316|M.vanbaalenii_PYR-1 PGEKVPRAGSGHAADPLKFDIIGLLARHPKMARRFLTFNGWLLQCGELPL
Mflv_2330|M.gilvum_PYR-GCK PGEKVPRAGSGHDADPLKFDIIGLLARHPKMARRFLTFNGWLLQRGELPL
MMAR_4743|M.marinum_M PAQRCNPRDAG--------NALSTFANHPALAKAFLRFNTHLLFASTLPA
TH_2018|M.thermoresistible__bu PEERRNPDGAG--------TALSTLVRHPRLTKAFLRFSNHLLFRSTLPP
MAV_3958|M.avium_104 PAERANPVGAG--------NVLSTLVRHPDLTAAYLPFNAYLLTRSTLSP
MSMEG_6536|M.smegmatis_MC2_155 PPERRDADGVG--------NALGVLVRHPELARHFLQFNNYLQRDSLLPE
MLBr_02465|M.leprae_Br4923 ASLLRTS----------EMHLFTILGQRQLLFWAWLIYGGRLLR-GKLPR
MUL_4533|M.ulcerans_Agy99 ARSVRAP----------EMHLFTALGYRQYLFWTWAIYSGRLLH-GRLPR
. : : : : . *
Mb1558|M.bovis_AF2122/97 RLRELVIMRIGWLTDCDYEWTQHWRVASGLGVSADDLLGVRDWQGYNGFG
Rv1531|M.tuberculosis_H37Rv RLRELVIMRIGWLTDCDYEWTQHWRVASGLGVSADDLLGVRDWQGYNGFG
MAB_2040c|M.abscessus_ATCC_199 RLRELVILRIGWITGSEYEWTQHWRIATLLGVPERDLLAVRDWQNSESLG
Mvan_4316|M.vanbaalenii_PYR-1 RLRELAILRIAHTRRSAFFWGEHTKVATEGGVPEADIARLAEGN--EAFT
Mflv_2330|M.gilvum_PYR-GCK RLRELAILRVAVTRRSEFFWGEHAKVALEGGVSEDDINRLAGDI--EGFS
MMAR_4743|M.marinum_M RVRELAILRVAHRRACAYEWTHHVALAEQAGISGDEIAAVRRG---EATD
TH_2018|M.thermoresistible__bu RLRELAVLRVAHRRSCDYEWAHHVFIGKAEGLTDDDIAGVQRG---AVDD
MAV_3958|M.avium_104 RIREVALLRVVHRSKCGYLWSHHLPIARRAGLSESDIDDIRRG---RCAD
MSMEG_6536|M.smegmatis_MC2_155 RIRELVILRTAYRAGCVYEWGHHAAMGLLAGLTVDDVESARSG---SAAD
MLBr_02465|M.leprae_Br4923 VDTELVILRVAHLRTCEYELQHHRRMARKRGLDTKIQAMIFAWPDVPTGA
MUL_4533|M.ulcerans_Agy99 IDTELVILRVAHLRSCEYELQHHRRMARAAGLDAHAQATIFAWPDAPQGD
*:.::* . : .* :. *:
Mb1558|M.bovis_AF2122/97 P-------AEQAVLAATDDVVREGAVSAQSWSACERELHCDKVVLIELVT
Rv1531|M.tuberculosis_H37Rv P-------AEQAVLAATDDVVREGAVSAQSWSACERELHCDKVVLIELVT
MAB_2040c|M.abscessus_ATCC_199 P-------VERAVLAATDDVVRDGVISEENWAGCQKAFNSDHAVLVELVG
Mvan_4316|M.vanbaalenii_PYR-1 G-------ADRLVLDATDELLHDGHAEPATWHRLTDELGTHQ--AMELIF
Mflv_2330|M.gilvum_PYR-GCK G-------VDRVILEVTDELLRDGRAEPDSWHRLVDELDTHQ--AMELVF
MMAR_4743|M.marinum_M D-------FERAVLTGVDELDENSELSDQTWAALGEHLDDRQ--RMDYVF
TH_2018|M.thermoresistible__bu P-------FDQAVLDAVDELEEHYRISDATWATLGARLDERQ--LMDLVF
MAV_3958|M.avium_104 P-------TDAAVVRAVDELTGESTLSRQTWDRLCELFTQRQ--CMDLIF
MSMEG_6536|M.smegmatis_MC2_155 E-------FDQTVLDATDELVAGAQLSPETWTRLGRWLDDRQ--RMDLMF
MLBr_02465|M.leprae_Br4923 G----LSVRQQALLAATDEFVKDRKITSSSWQQLETHLDRRR--LIEFCM
MUL_4533|M.ulcerans_Agy99 GPRRVLSSRQQALLTATDELIKNRSVTPATWEQLEIHLNRRR--LIEFCL
: :: .*:. .* : : ::
Mb1558|M.bovis_AF2122/97 VISAWRMVASILHSLEVPLEDGVSSWPPDGLSPR------
Rv1531|M.tuberculosis_H37Rv VISAWRMVASILHSLEVPLEDGVSSWPPDGLSPR------
MAB_2040c|M.abscessus_ATCC_199 AIANWRLFSILLRSLNIPLESGTDGWPPDGRAPRRRD---
Mvan_4316|M.vanbaalenii_PYR-1 VVGTYAMLAMAFDTWRLPPPAGSASLPEPPAGVPPGGGTH
Mflv_2330|M.gilvum_PYR-GCK VVGTYAMLAMAFDTWRLAPPAGSAPLPEPPS---------
MMAR_4743|M.marinum_M TVGCYALLAMAFNTFGVQLEELEQDRAER-----------
TH_2018|M.thermoresistible__bu TVGCYGLMAMAYNTFGITPETGR-----------------
MAV_3958|M.avium_104 TIGGYLLLALAVNTFGVQEEEETR----------------
MSMEG_6536|M.smegmatis_MC2_155 TVGGYLTLAMALNTFEVQLEEGAGRPEFYAPVGTAR----
MLBr_02465|M.leprae_Br4923 LISQYDGLAATISSLDIPLDNSC-----------------
MUL_4533|M.ulcerans_Agy99 LATQYDALAATITALGVPLDNPR-----------------
: .: : :