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MTTPSLPSADELGAEVRDWLRDNWTPLPKNTDPWASSPERIAWLEKVLDAGYAVPTYPAEWFGRGYPNKL ANVIGQEFAAIKAPGSRQDKYNIPANTVLALGTGKLREDLLRDFLVERARTCLLYSEPGAGSDLASVRTT AVRQGDHWVVNGQKVWTSGAQTADYALLLARTDWDVPKHKGLSLFIMPMNQAGIEVRPLVQITGESHFNE VFISDATVSDDYLLGGEGNGWRALQTALAYERSIMGDSGRGSRNRKADSLIDLAREHGVLDDSAVRHQLA SVLAMRELNRLNNARAKASTTQGTSSSIMSLGKLAMSRILHTEAAMKTQIIGAEALLAGPDNPVADDVNF LALNAFFTSIGGGTDQIQRNIIGERVLGLPKEPEADRDIPFRQARRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4313 | - | - | 100% (397) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0394 | - | 3e-56 | 37.40% (369) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4006 | - | 8e-56 | 36.87% (358) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 5e-54 | 34.91% (401) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2334 | - | 1e-167 | 71.00% (400) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 5e-54 | 34.91% (401) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-21 | 25.99% (377) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3122 | - | 1e-55 | 38.80% (366) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_2862 | fadE17 | 8e-58 | 36.16% (401) | acyl-CoA dehydrogenase FadE17 |
| M. avium 104 | MAV_1878 | - | 3e-54 | 36.06% (391) | acyl-CoA dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_1904 | - | 0.0 | 78.03% (396) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2799 | - | 1e-114 | 52.30% (392) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 6e-57 | 37.12% (361) | acyl-CoA dehydrogenase FadE17 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4313|M.vanbaalenii_PYR-1 ---MTTPSLPSADELGAEVRDWLRDNWT-----PLPKNTDPWASSPERIA
MSMEG_1904|M.smegmatis_MC2_155 ---MTN-ELPTPEELAAEVREWLAQNWK-----GLPKQTDPWVSTPERIA
Mflv_2334|M.gilvum_PYR-GCK ---MSDNNLPSAEDLRTEVREWLAENWTG---VTLPKSDDPWVSSPERIA
TH_2799|M.thermoresistible__bu ---MSE---LTDDQVRTEVREWLAANWK---------------PGMDRAE
MAB_3122|M.abscessus_ATCC_1997 MPVTSSEPSSAGSNALHTSGSSQRDRVAA---AAHEVLAKHPPATTPVTD
Mb1969c|M.bovis_AF2122/97 ---MDVSYPPEAEAFRDRIREFVAEHLPPG--WPGPGALPPHEREEFARH
Rv1934c|M.tuberculosis_H37Rv ---MDVSYPPEAEAFRDRIREFVAEHLPPG--WPGPGALPPHEREEFARH
MMAR_2862|M.marinum_M ---MDVAYPPEAEEFRERVRAFLDEHLPCG--WSGPGALAVQDRKAFAAR
MUL_2892|M.ulcerans_Agy99 ----------------------MDEHLPCG--WSGPGALAVQDRKAFAAR
MAV_1878|M.avium_104 ---MEYGMRPELAEFRAEVRAFVAEHAPAIPPRAGVRSAENDAEFKALQE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mvan_4313|M.vanbaalenii_PYR-1 WLEKVLDAGYAVPTYPAEWFGRG-YPNKLANVIGQEFAAIKAPGSRQD--
MSMEG_1904|M.smegmatis_MC2_155 WLEKVVDAGYAVPSYPKQWWGRE-YPHKLASVIEKEFRAVRAPGSRLD--
Mflv_2334|M.gilvum_PYR-GCK WLEKVVAAGYGAPTYPTEWYGRA-YPNKLAKVIAEEFRAVGAPGACQD--
TH_2799|M.thermoresistible__bu WARLVFEAGWAVPSWEPQWYGRG-LTDPQSRIVAAEFAAVGAPGTGHD--
MAB_3122|M.abscessus_ATCC_1997 LLGAVYDAGLAWVHFPVGLGGLD-APPALQAVSDTILRAAGVPDPLFVNV
Mb1969c|M.bovis_AF2122/97 WRRALAGAGLVAVSWPTEYGGGG-LSPMEQVVLAEEFARAGAPERAENDL
Rv1934c|M.tuberculosis_H37Rv WRRALAGAGLVAVSWPTEYGGGG-LSPMEQVVLAEEFARAGAPERAENDL
MMAR_2862|M.marinum_M WRQLLVAAGLIAVSWPKEYGGGG-YSPVEQVVLAEEFARAGAPEREENDL
MUL_2892|M.ulcerans_Agy99 WRQLLVAAGLIAVSWPKEYGGGG-YSPVEQVVLAEEFARAGAPEREENDL
MAV_1878|M.avium_104 WTGRLFEAGYVGADWPVEFGGRGDFTPEHSIIVGEELARAQAPSAQSG--
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIP--
: :* * : . ..
Mvan_4313|M.vanbaalenii_PYR-1 -KYNIPANTVLALGTGKLREDLLRDFLVERARTCLLYSEPGAGSDLASVR
MSMEG_1904|M.smegmatis_MC2_155 -KYSIPANTILMFGNDTIKQHLLYEFLTERSRTCLLYSEPGAGSDLAAVR
Mflv_2334|M.gilvum_PYR-GCK -RFSIPANTSLAFGTEQLKADLLHEFLTENSRTCLLYSEPGAGSDLAGVR
TH_2799|M.thermoresistible__bu -RANLFACTLHDLGTEEQKRRLIPPSIRGETRWCLLYSEPGAGSDLAGLR
MAB_3122|M.abscessus_ATCC_1997 IGYGMAAPTVLAHGQPELIRRILRPLFTGEELWCQLFSEPGAGSDLAGLA
Mb1969c|M.bovis_AF2122/97 LGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVR
Rv1934c|M.tuberculosis_H37Rv LGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVR
MMAR_2862|M.marinum_M FGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPEAGSDLASVR
MUL_2892|M.ulcerans_Agy99 FGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPEAGSDLASVR
MAV_1878|M.avium_104 --SVLASHALIHYGTDEQRRRHLPEIRGGRELWCQLFSEPGAGSDLASLR
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
: * : . ** **** *.:
Mvan_4313|M.vanbaalenii_PYR-1 TTAVRQGDHWVVNGQKVWTSGAQTADYALLLARTDWDVPKHKGLSLFIMP
MSMEG_1904|M.smegmatis_MC2_155 TTAVRDGDEWMVNGQKVWTSGAATSEYALLIARTDWDVPKHKGLSFFVIP
Mflv_2334|M.gilvum_PYR-GCK TTAVRDGDQWIINGQKVWTSGAQTSQYALLIARTDWDVPKHKGITFFIVP
TH_2799|M.thermoresistible__bu TRAERDGDEWVINGQKVWTSFAQTADYGLLVARTDWDVPKHKGISFFMLP
MAB_3122|M.abscessus_ATCC_1997 TRAVRDGDEWVINGQKVWTSGAHQARWALLVARSNPDVAKHRGLTYFVVD
Mb1969c|M.bovis_AF2122/97 TRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFLLVP
Rv1934c|M.tuberculosis_H37Rv TRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFLLVP
MMAR_2862|M.marinum_M TRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKHQGLSLLLVP
MUL_2892|M.ulcerans_Agy99 TRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKHQGLSLLLVP
MAV_1878|M.avium_104 TRAVRHGDTYTIDGQKVWTTDGHWARYGYLLARTDPDAPKHKGISAFILD
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN-GISAFIVH
* . .** : ::* * * : . : : ::* :: : *:: :::
Mvan_4313|M.vanbaalenii_PYR-1 MNQAGIEVRPLVQITGE--SHFNEVFISDATVSDDYLLGGEGNGWRALQT
MSMEG_1904|M.smegmatis_MC2_155 MKQPGIEVRPLVQITGE--SHFNEVFITDARVSDEYLVGGEGNGWRVLQT
Mflv_2334|M.gilvum_PYR-GCK MKQPGIEIRPLVQITGD--SHFNEVFITDATVPDAYVVGGVGNGWRVLQT
TH_2799|M.thermoresistible__bu MKQPGIEVRPIHQITGE--SEFNEVFITDARCPAENMVGRPGEGWSVLQV
MAB_3122|M.abscessus_ATCC_1997 MTDPGVEVRPLRQMTGD--AEFNEVYLTDVRIPDAHRLGNEGDGWRVSMT
Mb1969c|M.bovis_AF2122/97 MDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRVGDGWSTAMT
Rv1934c|M.tuberculosis_H37Rv MDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAGNVVGRVGDGWSTAMT
MMAR_2862|M.marinum_M MDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVANVVGEVGSGWTAAMS
MUL_2892|M.ulcerans_Agy99 MDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVANVVGEVGSGWTAAMS
MAV_1878|M.avium_104 MSAPGVSVRPLRELTGT--SDFNEVFFDGVEVPADAMIGAPGQGWAIANA
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
.. : * : * : .*::: :* * *:
Mvan_4313|M.vanbaalenii_PYR-1 ALAYERSIMGDSGRGSRNR---------KADSLIDLAR-----EHGVLDD
MSMEG_1904|M.smegmatis_MC2_155 ALAYERSIMGDSGRGSRNKS--------KADSLVELAR-----EHGRLDD
Mflv_2334|M.gilvum_PYR-GCK ALAVERSIMGSGTSLHRKQS--------RGNSLVEMAR-----AHGKLDD
TH_2799|M.thermoresistible__bu ALGYERRLMGDLARTSKASRKPKDDPAQQRNALVEMAR-----EAGRLDD
MAB_3122|M.abscessus_ATCC_1997 TLMNERSALGGAFDHGRGGG--------SIGNALNLWK-----QRPDLHT
Mb1969c|M.bovis_AF2122/97 LLGFERGSHIATAAIDFERD---------LQRLCELAR-----DRGLHTD
Rv1934c|M.tuberculosis_H37Rv LLGFERGSHIATAAIDFERD---------LQRLCELAR-----DRGLHTD
MMAR_2862|M.marinum_M LLGFERGAQATTGAIDFARD---------LSRLCDLAR-----ARGLDSD
MUL_2892|M.ulcerans_Agy99 LLGFERGAQATTGAIDFARD---------LSRLCDLAR-----ARGLDSD
MAV_1878|M.avium_104 TLAHERTNVGGIVVKLRLAI----------DALIDLARRVTIDGGPAIDS
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGA---------LDAAIVYTKDRKQFGESISTF
* * :
Mvan_4313|M.vanbaalenii_PYR-1 SAVRHQLASVLAMRELNRLNNARAKASTTQG--TSSSIMSLGKLAMSRIL
MSMEG_1904|M.smegmatis_MC2_155 PAIRKELANVLALRELNRLNNARAKASAGQG--TSTSIMSLGKLAMSHIL
Mflv_2334|M.gilvum_PYR-GCK SAIRKSLADVLALRELNNLNNARAKAEAKQG--TASPVMSLGKLATSGIL
TH_2799|M.thermoresistible__bu PYIRQRIARMDEFAAVNRWNTQRSKATRDKV--ESLTLQALGKIAMSRIL
MAB_3122|M.abscessus_ATCC_1997 PELRAKLTNLFVRSEGNRYGTQMRIAAQGDA--PMGPEGSIGKLMGAELN
Mb1969c|M.bovis_AF2122/97 PRVRDGLAWCYARVQIMRYRGYRDLTLALTGR-PPGAEAAITKVIWSEYF
Rv1934c|M.tuberculosis_H37Rv PRVRDGLAWCYARVQIMRYRGYRDLTLALTGR-PPGAEAAITKVIWSEYF
MMAR_2862|M.marinum_M PRIRDRLAWCYSRTQIMRYRGYRSLTWALNGL-LPGAEAAISKVIWSEYF
MUL_2892|M.ulcerans_Agy99 PRIRDRLAWCYSRTQIMRYRGYCSLTWALNGV-LPGAEAAISKVIWSEYF
MAV_1878|M.avium_104 DRVRDRIGQFSAEVEALSALTYANLTRWLRGR-ERMHDAAMGKLMFSEIN
MLBr_00737|M.leprae_Br4923 QSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIA
:: : : : * :
Mvan_4313|M.vanbaalenii_PYR-1 HTEAAMKTQIIGAEALLAG-------PDNPVADDVN------FLALNAFF
MSMEG_1904|M.smegmatis_MC2_155 HSEARLKTEIIGAEALLAG-------PENPEADDIN------FLTLNAFF
Mflv_2334|M.gilvum_PYR-GCK HAEARLKTDIIGADALLAG-------PDNAEADEVN------FLTLNAFF
TH_2799|M.thermoresistible__bu HETARVQTEIVGAESMLAG-------PDHPIGDGVT------FRTLNAYF
MAB_3122|M.abscessus_ATCC_1997 QQIYDFCVELLGIEATLYASYDMRRVVEDDRRADTM------WAFLRSKA
Mb1969c|M.bovis_AF2122/97 RRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARA
Rv1934c|M.tuberculosis_H37Rv RRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARA
MMAR_2862|M.marinum_M QRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELLYARA
MUL_2892|M.ulcerans_Agy99 QRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELLYARA
MAV_1878|M.avium_104 LEMAAFAVELAGEAGVLVE-------GDDNVLDGGR----WQDEWLYARA
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGGAGYTSD---------FPVERFMR----------DAKI
.:: * . :
Mvan_4313|M.vanbaalenii_PYR-1 TSIGGGTDQIQRNIIGERVLGLPKEPEADRDIPFRQARRS
MSMEG_1904|M.smegmatis_MC2_155 TSIGGGTDQVQRNIIGERVLGLPKEPEVDRDIPFREARRS
Mflv_2334|M.gilvum_PYR-GCK TSIGGGTDQIQRNIIGERVLGLPKEPEVDREIPFRDIRKN
TH_2799|M.thermoresistible__bu TSIGGGTDQVQRNIVGERVLGLPKEPDPYRDQPFRDLPH-
MAB_3122|M.abscessus_ATCC_1997 NTIEGGTSDVMRNIIGERVLGLPGDIRVDTDKAWKDVPRG
Mb1969c|M.bovis_AF2122/97 ATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC--------
Rv1934c|M.tuberculosis_H37Rv ATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC--------
MMAR_2862|M.marinum_M ATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH--------
MUL_2892|M.ulcerans_Agy99 ATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH--------
MAV_1878|M.avium_104 YTIAGGSSEIMRNLIAERGLGLPRD---------------
MLBr_00737|M.leprae_Br4923 TQIYEGTNQIQRVVMSRALLR-------------------
* *:.:: * ::.. *