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TNELPTPEELAAEVREWLAQNWKGLPKQTDPWVSTPERIAWLEKVVDAGYAVPSYPKQWWGREYPHKLAS VIEKEFRAVRAPGSRLDKYSIPANTILMFGNDTIKQHLLYEFLTERSRTCLLYSEPGAGSDLAAVRTTAV RDGDEWMVNGQKVWTSGAATSEYALLIARTDWDVPKHKGLSFFVIPMKQPGIEVRPLVQITGESHFNEVF ITDARVSDEYLVGGEGNGWRVLQTALAYERSIMGDSGRGSRNKSKADSLVELAREHGRLDDPAIRKELAN VLALRELNRLNNARAKASAGQGTSTSIMSLGKLAMSHILHSEARLKTEIIGAEALLAGPENPEADDINFL TLNAFFTSIGGGTDQVQRNIIGERVLGLPKEPEVDRDIPFREARRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1904 | - | - | 100% (397) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6584 | - | 3e-58 | 37.98% (366) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2992 | - | 1e-52 | 31.68% (404) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 4e-57 | 36.70% (406) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2334 | - | 1e-177 | 75.31% (397) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 4e-57 | 36.70% (406) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-17 | 23.30% (339) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3122 | - | 3e-65 | 37.69% (398) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1953 | fadE34_1 | 4e-58 | 38.81% (371) | acyl-CoA dehydrogenase FadE34_1 |
| M. avium 104 | MAV_0601 | - | 2e-57 | 36.72% (384) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2799 | - | 1e-120 | 54.94% (395) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 8e-57 | 37.67% (361) | acyl-CoA dehydrogenase FadE17 |
| M. vanbaalenii PYR-1 | Mvan_4313 | - | 0.0 | 78.03% (396) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 ---------------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGAL-
Rv1934c|M.tuberculosis_H37Rv ---------------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGAL-
MUL_2892|M.ulcerans_Agy99 ----------------------------------MDEHLPCGWSGPGAL-
MAV_0601|M.avium_104 --------------------MQDVEEFRAEVRSWLADNLVGEFAALKGLG
MSMEG_1904|M.smegmatis_MC2_155 ---------------MTN-ELPTPEELAAEVREWLAQNWK-------GLP
Mvan_4313|M.vanbaalenii_PYR-1 ---------------MTTPSLPSADELGAEVRDWLRDNWT-------PLP
Mflv_2334|M.gilvum_PYR-GCK ---------------MSDNNLPSAEDLRTEVREWLAENWTG-----VTLP
TH_2799|M.thermoresistible__bu ---------------MSE---LTDDQVRTEVREWLAANWK----------
MAB_3122|M.abscessus_ATCC_1997 MPVTSSEPSSAGSNALHTSGSSQRDRVAAAAHEVLAKHPP----------
MMAR_1953|M.marinum_M --------------------MTAADDLQSRVQTLLDAHPP----------
MLBr_00737|M.leprae_Br4923 -----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP---------
.
Mb1969c|M.bovis_AF2122/97 -PPHEREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEF
Rv1934c|M.tuberculosis_H37Rv -PPHEREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEF
MUL_2892|M.ulcerans_Agy99 -AVQDRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEF
MAV_0601|M.avium_104 GPGREHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEY
MSMEG_1904|M.smegmatis_MC2_155 KQTDPWVSTPERIAWLEKVVDAGYAVPSYPKQWWGREYPHKLASVIEKEF
Mvan_4313|M.vanbaalenii_PYR-1 KNTDPWASSPERIAWLEKVLDAGYAVPTYPAEWFGRGYPNKLANVIGQEF
Mflv_2334|M.gilvum_PYR-GCK KSDDPWVSSPERIAWLEKVVAAGYGAPTYPTEWYGRAYPNKLAKVIAEEF
TH_2799|M.thermoresistible__bu -------PGMDRAEWARLVFEAGWAVPSWEPQWYGRGLTDPQSRIVAAEF
MAB_3122|M.abscessus_ATCC_1997 -------ATTPVTDLLGAVYDAGLAWVHFPVGLGGLDAPPALQAVSDTIL
MMAR_1953|M.marinum_M -------ATSDPREFLGARFDAGLAWVHFPVGFGGLDLPHTYQAQVDKQL
MLBr_00737|M.leprae_Br4923 HAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEV
:* *
Mb1969c|M.bovis_AF2122/97 ARAGAPER-AENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQG
Rv1934c|M.tuberculosis_H37Rv ARAGAPER-AENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQG
MUL_2892|M.ulcerans_Agy99 ARAGAPER-EENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQG
MAV_0601|M.avium_104 ARADAPDK-VNH--FGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQG
MSMEG_1904|M.smegmatis_MC2_155 RAVRAPGS----RLDKYSIPANTILMFGNDTIKQHLLYEFLTERSRTCLL
Mvan_4313|M.vanbaalenii_PYR-1 AAIKAPGS----RQDKYNIPANTVLALGTGKLREDLLRDFLVERARTCLL
Mflv_2334|M.gilvum_PYR-GCK RAVGAPGA----CQDRFSIPANTSLAFGTEQLKADLLHEFLTENSRTCLL
TH_2799|M.thermoresistible__bu AAVGAPGT----GHDRANLFACTLHDLGTEEQKRRLIPPSIRGETRWCLL
MAB_3122|M.abscessus_ATCC_1997 RAAGVPDP-LFVNVIGYGMAAPTVLAHGQPELIRRILRPLFTGEELWCQL
MMAR_1953|M.marinum_M AAAGAPPAGGGRNIIGIGMAAPTIAAFGTAEQKQKFLRPLFTGEHLYCQL
MLBr_00737|M.leprae_Br4923 ARVDASAS---LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYA
.. : * .: .
Mb1969c|M.bovis_AF2122/97 FSEPEAGSDLASVRTRGVLDGD---EWVINGHKIWTSAGTTANWIFLLAR
Rv1934c|M.tuberculosis_H37Rv FSEPEAGSDLASVRTRGVLDGD---EWVINGHKIWTSAGTTANWIFLLAR
MUL_2892|M.ulcerans_Agy99 FSEPEAGSDLASVRTRAVLDGD---QWVINGQKIWTSAGSTANWIFVLAR
MAV_0601|M.avium_104 YSEPGAGSDLANVSTTAELDGD---QWVINGQKVWTSLAHLSQWCFVVAR
MSMEG_1904|M.smegmatis_MC2_155 YSEPGAGSDLAAVRTTAVRDGD---EWMVNGQKVWTSGAATSEYALLIAR
Mvan_4313|M.vanbaalenii_PYR-1 YSEPGAGSDLASVRTTAVRQGD---HWVVNGQKVWTSGAQTADYALLLAR
Mflv_2334|M.gilvum_PYR-GCK YSEPGAGSDLAGVRTTAVRDGD---QWIINGQKVWTSGAQTSQYALLIAR
TH_2799|M.thermoresistible__bu YSEPGAGSDLAGLRTRAERDGD---EWVINGQKVWTSFAQTADYGLLVAR
MAB_3122|M.abscessus_ATCC_1997 FSEPGAGSDLAGLATRAVRDGD---EWVINGQKVWTSGAHQARWALLVAR
MMAR_1953|M.marinum_M FSEPGAGSDLAAAATRAVRDPHRPLDWIVNGQKVWTSMAQHAQMAILVAR
MLBr_00737|M.leprae_Br4923 LSEREAGSDAASMRTRAKADGD---DWILNGFKCWITNGGKSTWYTVMAV
** **** * * . : . .*::** * * : . : ::*
Mb1969c|M.bovis_AF2122/97 TDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTS
Rv1934c|M.tuberculosis_H37Rv TDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTS
MUL_2892|M.ulcerans_Agy99 TDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTG
MAV_0601|M.avium_104 TEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTD
MSMEG_1904|M.smegmatis_MC2_155 TDWDVPKHKGLSFFVIPMKQPGIEVRPLVQITGE--SHFNEVFITDARVS
Mvan_4313|M.vanbaalenii_PYR-1 TDWDVPKHKGLSLFIMPMNQAGIEVRPLVQITGE--SHFNEVFISDATVS
Mflv_2334|M.gilvum_PYR-GCK TDWDVPKHKGITFFIVPMKQPGIEIRPLVQITGD--SHFNEVFITDATVP
TH_2799|M.thermoresistible__bu TDWDVPKHKGISFFMLPMKQPGIEVRPIHQITGE--SEFNEVFITDARCP
MAB_3122|M.abscessus_ATCC_1997 SNPDVAKHRGLTYFVVDMTDPGVEVRPLRQMTGD--AEFNEVYLTDVRIP
MMAR_1953|M.marinum_M TDPDVPKHAGLTYFLCDMTQPGIDIRPLRQITGE--AEFNEVFLTDIRVP
MLBr_00737|M.leprae_Br4923 TDPD-KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIP
:: *:: :: : .. : * : * : .*::: .
Mb1969c|M.bovis_AF2122/97 AGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERD---------LQRL
Rv1934c|M.tuberculosis_H37Rv AGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERD---------LQRL
MUL_2892|M.ulcerans_Agy99 VANVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARD---------LSRL
MAV_0601|M.avium_104 ASMVVGQPGDGWRVAMGTLTFERGVSTLGQQIRYARE---------LSNL
MSMEG_1904|M.smegmatis_MC2_155 DEYLVGGEGNGWRVLQTALAYERSIMGDSGRGSRNKS--------KADSL
Mvan_4313|M.vanbaalenii_PYR-1 DDYLLGGEGNGWRALQTALAYERSIMGDSGRGSRNR---------KADSL
Mflv_2334|M.gilvum_PYR-GCK DAYVVGGVGNGWRVLQTALAVERSIMGSGTSLHRKQS--------RGNSL
TH_2799|M.thermoresistible__bu AENMVGRPGEGWSVLQVALGYERRLMGDLARTSKASRKPKDDPAQQRNAL
MAB_3122|M.abscessus_ATCC_1997 DAHRLGNEGDGWRVSMTTLMNERSALGGAFDHGRGGG--------SIGNA
MMAR_1953|M.marinum_M DANRLGPEGGGWRVATTTLNNERVAIGSRTGVPREGG--------MIGKV
MLBr_00737|M.leprae_Br4923 GDRIIGEPGTGFKTALATLDHTRPTIG-AQAVGIAQG--------ALDAA
:* * *: . * *
Mb1969c|M.bovis_AF2122/97 CELARDRGLHTD-----PRVRDGLAWCYARVQIMRYRGYRDLTLALTGRP
Rv1934c|M.tuberculosis_H37Rv CELARDRGLHTD-----PRVRDGLAWCYARVQIMRYRGYRDLTLALTGRP
MUL_2892|M.ulcerans_Agy99 CDLARARGLDSD-----PRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVL
MAV_0601|M.avium_104 AELARRNGAADD-----PFIRERLTRAWTGLRAMRSYALATMDVEQPG--
MSMEG_1904|M.smegmatis_MC2_155 VELAREHGRLDD-----PAIRKELANVLALRELNRLNNARAKASAGQGTS
Mvan_4313|M.vanbaalenii_PYR-1 IDLAREHGVLDD-----SAVRHQLASVLAMRELNRLNNARAKASTTQGTS
Mflv_2334|M.gilvum_PYR-GCK VEMARAHGKLDD-----SAIRKSLADVLALRELNNLNNARAKAEAKQGTA
TH_2799|M.thermoresistible__bu VEMAREAGRLDD-----PYIRQRIARMDEFAAVNRWNTQRSKATRDKVES
MAB_3122|M.abscessus_ATCC_1997 LNLWKQRPDLHT-----PELRAKLTNLFVRSEGNRYG-TQMRIAAQGDAP
MMAR_1953|M.marinum_M TEAWRAEPALRN-----PAMHDDMMRLWVEAEVLRLAGERLRQQAASGQP
MLBr_00737|M.leprae_Br4923 IVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEP
: :: : .
Mb1969c|M.bovis_AF2122/97 -PGAEAAITKVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAG
Rv1934c|M.tuberculosis_H37Rv -PGAEAAITKVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAG
MUL_2892|M.ulcerans_Agy99 -PGAEAAISKVIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAG
MAV_0601|M.avium_104 ----QDNVSKLLWANWHRALGELAMDVIGKPGMT-----------MPDG-
MSMEG_1904|M.smegmatis_MC2_155 --TSIMSLGKLAMSHILHSEARLKTEIIGAEALLAG--------PENPEA
Mvan_4313|M.vanbaalenii_PYR-1 --SSIMSLGKLAMSRILHTEAAMKTQIIGAEALLAG--------PDNPVA
Mflv_2334|M.gilvum_PYR-GCK --SPVMSLGKLATSGILHAEARLKTDIIGADALLAG--------PDNAEA
TH_2799|M.thermoresistible__bu --LTLQALGKIAMSRILHETARVQTEIVGAESMLAG--------PDHPIG
MAB_3122|M.abscessus_ATCC_1997 -MGPEGSIGKLMGAELNQQIYDFCVELLGIEATLYASYDMRR-VVEDDRR
MMAR_1953|M.marinum_M --GPEGAGMKVAFARLAQQISGFELELHPESGLQYDDWTLRRPDTVDLTG
MLBr_00737|M.leprae_Br4923 DLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSD--------------
* : :: .
Mb1969c|M.bovis_AF2122/97 TPNSPACWMDELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC-
Rv1934c|M.tuberculosis_H37Rv TPNSPACWMDELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC-
MUL_2892|M.ulcerans_Agy99 TANSPACWMDELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH-
MAV_0601|M.avium_104 ---EFDEWQRLFLFTRADTIYGGSNEIQRNIIAERVLGLPREVKG-----
MSMEG_1904|M.smegmatis_MC2_155 -----DDINFLTLNAFFTSIGGGTDQVQRNIIGERVLGLPKEPEVDRDIP
Mvan_4313|M.vanbaalenii_PYR-1 -----DDVNFLALNAFFTSIGGGTDQIQRNIIGERVLGLPKEPEADRDIP
Mflv_2334|M.gilvum_PYR-GCK -----DEVNFLTLNAFFTSIGGGTDQIQRNIIGERVLGLPKEPEVDREIP
TH_2799|M.thermoresistible__bu -----DGVTFRTLNAYFTSIGGGTDQVQRNIVGERVLGLPKEPDPYRDQP
MAB_3122|M.abscessus_ATCC_1997 -----ADTMWAFLRSKANTIEGGTSDVMRNIIGERVLGLPGDIRVDTDKA
MMAR_1953|M.marinum_M -----RGPGYRYLRARGNSIEGGTSEILRNTISERVLGLPGEHRVDKTLA
MLBr_00737|M.leprae_Br4923 -----FPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------------
: * *:.:: * :.. :*
Mb1969c|M.bovis_AF2122/97 -------
Rv1934c|M.tuberculosis_H37Rv -------
MUL_2892|M.ulcerans_Agy99 -------
MAV_0601|M.avium_104 -------
MSMEG_1904|M.smegmatis_MC2_155 FREARRS
Mvan_4313|M.vanbaalenii_PYR-1 FRQARRS
Mflv_2334|M.gilvum_PYR-GCK FRDIRKN
TH_2799|M.thermoresistible__bu FRDLPH-
MAB_3122|M.abscessus_ATCC_1997 WKDVPRG
MMAR_1953|M.marinum_M WKDLDR-
MLBr_00737|M.leprae_Br4923 -------