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LDEHLPCGWSGPGALAVQDRKAFAARWRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAGAPER EENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPEAGSDLASVRTRAVLDGDQWVINGQ KIWTSAGSTANWIFVLARTDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGHSLFNEVFFADARTGVANV VGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARARGLDSDPRIRDRLAWCYSRTQIMRYRG YCSLTWALNGVLPGAEAAISKVIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWM DELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | - | 100% (390) | acyl-CoA dehydrogenase FadE17 |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 4e-83 | 45.26% (380) | acyl-CoA dehydrogenase FadE30 |
| M. ulcerans Agy99 | MUL_3681 | fadE17_1 | 5e-58 | 39.43% (350) | acyl-CoA dehydrogenase FadE17_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 1e-180 | 78.55% (387) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_1481 | - | 4e-81 | 44.62% (381) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 1e-180 | 78.55% (387) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-26 | 29.66% (381) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 1e-84 | 45.79% (380) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_2862 | fadE17 | 0.0 | 99.23% (390) | acyl-CoA dehydrogenase FadE17 |
| M. avium 104 | MAV_0601 | - | 2e-84 | 45.38% (379) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6012 | - | 5e-79 | 43.81% (388) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4263 | - | 2e-81 | 44.50% (382) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_4006 | - | 1e-173 | 77.14% (385) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2892|M.ulcerans_Agy99 ------------------------------MDEHLPCGWSGPGALAV--Q
MMAR_2862|M.marinum_M -----------MDVAYPPEAEEFRERVRAFLDEHLPCGWSGPGALAV--Q
Mb1969c|M.bovis_AF2122/97 -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
Rv1934c|M.tuberculosis_H37Rv -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
Mvan_4006|M.vanbaalenii_PYR-1 -----------MDVDYPPQAEAFRDRIRALLAEHLPPDWSGGGALAP--E
Mflv_1481|M.gilvum_PYR-GCK ----------------MIEVQKFRAEVRDWLAENLVGDFAALKGLGGPGR
MSMEG_6012|M.smegmatis_MC2_155 ----------------MIEVQEFRAEVRQWLADNLVGDFAALKGLGGPGR
TH_4263|M.thermoresistible__bu ----------------VIEVHEFRAEVRQWLADNLVGEYAALKGLGGPGR
MAV_0601|M.avium_104 ----------------MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MLBr_00737|M.leprae_Br4923 --------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVD
MUL_2892|M.ulcerans_Agy99 DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MMAR_2862|M.marinum_M DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
Mb1969c|M.bovis_AF2122/97 EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Mvan_4006|M.vanbaalenii_PYR-1 ERAAVARR--WRQSLAAAGLVAVSWPKAYGGAGLSVIEQVVLDEEFARAG
Mflv_1481|M.gilvum_PYR-GCK EHEAFEERLAWNQHLAAAGLTCLGWPEEHGGRGLSVAHRVAFYEEYAKAN
MSMEG_6012|M.smegmatis_MC2_155 EHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSVAHRVAFYEEYARAN
TH_4263|M.thermoresistible__bu EHEAFEERLEWNRKLAAAGLTCLGWPVEHGGRGLSVAHRVAFYEEYALAN
MAV_0601|M.avium_104 EHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MLBr_00737|M.leprae_Br4923 QRARFPEEA--LAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
:: . . * :* .: * :** * . ** * .
MUL_2892|M.ulcerans_Agy99 APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MMAR_2862|M.marinum_M APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Mvan_4006|M.vanbaalenii_PYR-1 APERAENDLLGIQLLGNTLIALGTEEQKRHFLPRILSAEDRWCQGFSEPE
Mflv_1481|M.gilvum_PYR-GCK APDKVNH--LGEELLGPTLIAYGTPEQQQRFLPRILDVTELWSQGYSEPG
MSMEG_6012|M.smegmatis_MC2_155 APDKVNH--FGEELLGPTLIEYGTPEQQKRFLPKILDVTELWCQGYSEPN
TH_4263|M.thermoresistible__bu APAKVNH--LGEELLGPTLIEYGTPEQQQRFLPRILDVTELWAQGYSEPG
MAV_0601|M.avium_104 APDKVNH--FGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPG
MAB_0597|M.abscessus_ATCC_1997 APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
*. : ** *: :::.** : . . **
MUL_2892|M.ulcerans_Agy99 AGSDLASVRTRAVLDGDQ----------WVINGQKIWTSAGSTANWIFVL
MMAR_2862|M.marinum_M AGSDLASVRTRAVLDGDQ----------WVINGQKIWTSAGSTANWIFVL
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLDGDE----------WVINGHKIWTSAGTTANWIFLL
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLDGDE----------WVINGHKIWTSAGTTANWIFLL
Mvan_4006|M.vanbaalenii_PYR-1 AGSDLASVRTRAVLDDDE----------WVINGQKIWTSAGPTANWIFVL
Mflv_1481|M.gilvum_PYR-GCK AGSDLANVSTTATLDGDE----------WVINGQKVWTSLAHWAQWCFVV
MSMEG_6012|M.smegmatis_MC2_155 AGSDLANVSTTAELVGDAEASGATGNQYWVINGQKVWTSLAHWAQWCFVV
TH_4263|M.thermoresistible__bu AGSDLANVSTTAVLDGDQ----------WVINGQKVWTSLAHWAQWCFVV
MAV_0601|M.avium_104 AGSDLANVSTTAELDGDQ----------WVINGQKVWTSLAHLSQWCFVV
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLDGGD----------WVINGQKVWTSLALQSQWCFVV
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDD----------WILNGFKCWITNGGKSTWYTVM
**** *.: * . .. *::** * * : . : * ::
MUL_2892|M.ulcerans_Agy99 ARTDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADAR
MMAR_2862|M.marinum_M ARTDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADAR
Mb1969c|M.bovis_AF2122/97 ARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDAR
Rv1934c|M.tuberculosis_H37Rv ARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDAR
Mvan_4006|M.vanbaalenii_PYR-1 ARTDTEAPKHKGLSLLLVPIDQPGVVVRPIVNAAGH--ASFSEVFFTDAR
Mflv_1481|M.gilvum_PYR-GCK ARTEKGSKRHAGLSYLLVPLQQPGVEIRPIIQLTGD--SEFNEVFFDDAR
MSMEG_6012|M.smegmatis_MC2_155 ARTEKGSKRHAGLSYLLVPLDQPGVEIRPINQLTGD--SEFNEVFFDDAR
TH_4263|M.thermoresistible__bu ARTERGSKRHHGLSYLLVPLDQPGVEIRPIVQLTGD--SEFNEVFFDNAR
MAV_0601|M.avium_104 ARTEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDAR
MAB_0597|M.abscessus_ATCC_1997 ARTEPGSSRHKGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNAR
MLBr_00737|M.leprae_Br4923 AVTDP-DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCR
* *: *:* ::* :: .. : * : * : .*::: ..*
MUL_2892|M.ulcerans_Agy99 TGVANVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARAR
MMAR_2862|M.marinum_M TGVANVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARAR
Mb1969c|M.bovis_AF2122/97 TSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR
Rv1934c|M.tuberculosis_H37Rv TSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR
Mvan_4006|M.vanbaalenii_PYR-1 TPAVNVVGRVGDGWPAAMTVLGFERGSQVTTAAINFGREMDRLRELARDR
Mflv_1481|M.gilvum_PYR-GCK TAADLVVGEPGDGWRVAMGTLTFERGVSTLGQQIRYAREHSNLVELAEKT
MSMEG_6012|M.smegmatis_MC2_155 TEAGLVVGQPGDGWRVAMGTLTFERGVSTLGQQIRYAREHSNLVELAKRT
TH_4263|M.thermoresistible__bu TDASMVVGEPGDGWRVAMGTLTFERGVSTLGQQIQYRRELEGVVELAKRT
MAV_0601|M.avium_104 TDASMVVGQPGDGWRVAMGTLTFERGVSTLGQQIRYARELSNLAELARRN
MAB_0597|M.abscessus_ATCC_1997 TSADLVVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSN
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
::*. * *: .*: * . * . :.
MUL_2892|M.ulcerans_Agy99 GLDSDPRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVLPGAEAAISKVIW
MMAR_2862|M.marinum_M GLDSDPRIRDRLAWCYSRTQIMRYRGYRSLTWALNGLLPGAEAAISKVIW
Mb1969c|M.bovis_AF2122/97 GLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIW
Rv1934c|M.tuberculosis_H37Rv GLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIW
Mvan_4006|M.vanbaalenii_PYR-1 GLHTDARIRDGLAWCYSRVQIMRFQGYRGLTSLLAGQRPGREAAISKVVW
Mflv_1481|M.gilvum_PYR-GCK GAADDPLIRERLVRSWAGLKAMRSYALATMDVEKPG-----QDNISKLLW
MSMEG_6012|M.smegmatis_MC2_155 GAADDPLIRERLVQSWTGLQAMRSYALATMDVEQPG-----QDNVSKLLW
TH_4263|M.thermoresistible__bu GAIDDPLIRERLTRSWVGLRTMRSYALATMDDERPG-----QDNISKLLW
MAV_0601|M.avium_104 GAADDPFIRERLTRAWTGLRAMRSYALATMDVEQPG-----QDNVSKLLW
MAB_0597|M.abscessus_ATCC_1997 GAADDPAIRERLAQAYVGMRTMRAYALATMDEERPG-----QDNVSKLLW
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FIS
:. *: . : . : : .:
MUL_2892|M.ulcerans_Agy99 SEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELL
MMAR_2862|M.marinum_M SEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELL
Mb1969c|M.bovis_AF2122/97 SEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELL
Rv1934c|M.tuberculosis_H37Rv SEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELL
Mvan_4006|M.vanbaalenii_PYR-1 SEFFRRYTELAVEILGLEALSPAGPGNGEALIVPEPGTPNSAACWMDELL
Mflv_1481|M.gilvum_PYR-GCK ANWHRELGEIAMDIEGAAGLTLPD---------------GEFSEWQRLYL
MSMEG_6012|M.smegmatis_MC2_155 ANWHRELGEIAMDVQGMAGLTLEN---------------GEFDEWQRLYL
TH_4263|M.thermoresistible__bu ANWHRELGEIAMDVVGMAGLTLTD---------------GDFDEWQRLYL
MAV_0601|M.avium_104 ANWHRALGELAMDVIGKPGMTMPD---------------GEFDEWQRLFL
MAB_0597|M.abscessus_ATCC_1997 ANWHRDLGELAMEIIGTSTLLTNA---------------GEMDEWQRLFL
MLBr_00737|M.leprae_Br4923 AASKCFASDIAMEVTTDAVQLFGGAG------------YTSDFPVERFMR
: ::*::: .
MUL_2892|M.ulcerans_Agy99 YARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH----------
MMAR_2862|M.marinum_M YARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH----------
Mb1969c|M.bovis_AF2122/97 YARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----------
Rv1934c|M.tuberculosis_H37Rv YARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----------
Mvan_4006|M.vanbaalenii_PYR-1 YARASTIYAGSSQIQRNVIGEQLLGLPREPRVPAGRVPEPAGRGSN
Mflv_1481|M.gilvum_PYR-GCK FSRSDTIYGGSNEIQRNIIAERVLGLPREARH--------------
MSMEG_6012|M.smegmatis_MC2_155 FSRADTIYGGSNEIQRNIIAERVLGLPREVKG--------------
TH_4263|M.thermoresistible__bu FSRSDTIYGGSNEIQRNIIAERVLGLPREPKG--------------
MAV_0601|M.avium_104 FTRADTIYGGSNEIQRNIIAERVLGLPREVKG--------------
MAB_0597|M.abscessus_ATCC_1997 FSRADTIYGGSNEIQRNIISERVLGLPREAR---------------
MLBr_00737|M.leprae_Br4923 DAKITQIYEGTNQIQRVVMSRALLR---------------------
:: ** *:.:*** ::.. :*