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M. gilvum PYR-GCK Mflv_2334 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 2433304 - 2434506
length: 400

SDNNLPSAEDLRTEVREWLAENWTGVTLPKSDDPWVSSPERIAWLEKVVAAGYGAPTYPTEWYGRAYPNK
LAKVIAEEFRAVGAPGACQDRFSIPANTSLAFGTEQLKADLLHEFLTENSRTCLLYSEPGAGSDLAGVRT
TAVRDGDQWIINGQKVWTSGAQTSQYALLIARTDWDVPKHKGITFFIVPMKQPGIEIRPLVQITGDSHFN
EVFITDATVPDAYVVGGVGNGWRVLQTALAVERSIMGSGTSLHRKQSRGNSLVEMARAHGKLDDSAIRKS
LADVLALRELNNLNNARAKAEAKQGTASPVMSLGKLATSGILHAEARLKTDIIGADALLAGPDNAEADEV
NFLTLNAFFTSIGGGTDQIQRNIIGERVLGLPKEPEVDREIPFRDIRKN*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_2334 - - 100% (400) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1481 - 1e-58 38.90% (383) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_0344 - 3e-55 38.33% (300) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3590c fadE30 2e-58 38.24% (387) acyl-CoA dehydrogenase FADE30
M. tuberculosis H37Rv Rv3560c fadE30 3e-58 38.24% (387) acyl-CoA dehydrogenase FADE30
M. leprae Br4923 MLBr_00737 fadE25 1e-19 26.82% (343) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0597 - 8e-61 39.07% (389) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_2862 fadE17 6e-61 38.71% (403) acyl-CoA dehydrogenase FadE17
M. avium 104 MAV_0601 - 1e-60 39.02% (387) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_1904 - 1e-177 75.31% (397) acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_2799 - 1e-114 52.78% (396) PUTATIVE acyl-CoA dehydrogenase
M. ulcerans Agy99 MUL_2892 fadE17 2e-58 39.89% (361) acyl-CoA dehydrogenase FadE17
M. vanbaalenii PYR-1 Mvan_4313 - 1e-167 71.00% (400) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3590c|M.bovis_AF2122/97           --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
Rv3560c|M.tuberculosis_H37Rv        --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
MAV_0601|M.avium_104                --------------MQDV--EEFRAEVRSWLADNLVGEFAALKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997      MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MMAR_2862|M.marinum_M               -----------MDVAYPPEAEEFRERVRAFLDEHLPCGWSGPGALAVQDR
MUL_2892|M.ulcerans_Agy99           ------------------------------MDEHLPCGWSGPGALAVQDR
MSMEG_1904|M.smegmatis_MC2_155      -----------MTN-ELPTPEELAAEVREWLAQNWK-------GLPKQTD
Mvan_4313|M.vanbaalenii_PYR-1       -----------MTTPSLPSADELGAEVRDWLRDNWT-------PLPKNTD
Mflv_2334|M.gilvum_PYR-GCK          -----------MSDNNLPSAEDLRTEVREWLAENWTG-----VTLPKSDD
TH_2799|M.thermoresistible__bu      -----------MSE---LTDDQVRTEVREWLAANWK--------------
MLBr_00737|M.leprae_Br4923          ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
                                                                                      

Mb3590c|M.bovis_AF2122/97           EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
Rv3560c|M.tuberculosis_H37Rv        EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
MAV_0601|M.avium_104                EHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997      EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MMAR_2862|M.marinum_M               --KAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MUL_2892|M.ulcerans_Agy99           --KAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MSMEG_1904|M.smegmatis_MC2_155      PWVSTPERIAWLEKVVDAGYAVPSYPKQWWGREYPHKLASVIEKEFRAVR
Mvan_4313|M.vanbaalenii_PYR-1       PWASSPERIAWLEKVLDAGYAVPTYPAEWFGRGYPNKLANVIGQEFAAIK
Mflv_2334|M.gilvum_PYR-GCK          PWVSSPERIAWLEKVVAAGYGAPTYPTEWYGRAYPNKLAKVIAEEFRAVG
TH_2799|M.thermoresistible__bu      ---PGMDRAEWARLVFEAGWAVPSWEPQWYGRGLTDPQSRIVAAEFAAVG
MLBr_00737|M.leprae_Br4923          VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
                                                  :  :*        :  *          .  *     

Mb3590c|M.bovis_AF2122/97           APDKVNH--FGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPG
Rv3560c|M.tuberculosis_H37Rv        APDKVNH--FGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPG
MAV_0601|M.avium_104                APDKVNH--FGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPG
MAB_0597|M.abscessus_ATCC_1997      APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MMAR_2862|M.marinum_M               APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MUL_2892|M.ulcerans_Agy99           APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MSMEG_1904|M.smegmatis_MC2_155      APGSRLD---KYSIPANTILMFGNDTIKQHLLYEFLTERSRTCLLYSEPG
Mvan_4313|M.vanbaalenii_PYR-1       APGSRQD---KYNIPANTVLALGTGKLREDLLRDFLVERARTCLLYSEPG
Mflv_2334|M.gilvum_PYR-GCK          APGACQD---RFSIPANTSLAFGTEQLKADLLHEFLTENSRTCLLYSEPG
TH_2799|M.thermoresistible__bu      APGTGHD---RANLFACTLHDLGTEEQKRRLIPPSIRGETRWCLLYSEPG
MLBr_00737|M.leprae_Br4923          ASASLIP--AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSERE
                                    *.          .:        *.   :  .:          .   **  

Mb3590c|M.bovis_AF2122/97           AGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQRH
Rv3560c|M.tuberculosis_H37Rv        AGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQRH
MAV_0601|M.avium_104                AGSDLANVSTTAELDGDQWVINGQKVWTSLAHLSQWCFVVARTEKGSKRH
MAB_0597|M.abscessus_ATCC_1997      AGSDLANVSTSAVLDGGDWVINGQKVWTSLALQSQWCFVVARTEPGSSRH
MMAR_2862|M.marinum_M               AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MUL_2892|M.ulcerans_Agy99           AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MSMEG_1904|M.smegmatis_MC2_155      AGSDLAAVRTTAVRDGDEWMVNGQKVWTSGAATSEYALLIARTDWDVPKH
Mvan_4313|M.vanbaalenii_PYR-1       AGSDLASVRTTAVRQGDHWVVNGQKVWTSGAQTADYALLLARTDWDVPKH
Mflv_2334|M.gilvum_PYR-GCK          AGSDLAGVRTTAVRDGDQWIINGQKVWTSGAQTSQYALLIARTDWDVPKH
TH_2799|M.thermoresistible__bu      AGSDLAGLRTRAERDGDEWVINGQKVWTSFAQTADYGLLVARTDWDVPKH
MLBr_00737|M.leprae_Br4923          AGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD-KGA
                                    **** * : * *  :*..*::** * * : .  : :  ::* *:      

Mb3590c|M.bovis_AF2122/97           AGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVVGAP
Rv3560c|M.tuberculosis_H37Rv        AGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVVGAP
MAV_0601|M.avium_104                AGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDASMVVGQP
MAB_0597|M.abscessus_ATCC_1997      KGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTSADLVVGEP
MMAR_2862|M.marinum_M               QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVANVVGEV
MUL_2892|M.ulcerans_Agy99           QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVANVVGEV
MSMEG_1904|M.smegmatis_MC2_155      KGLSFFVIPMKQPGIEVRPLVQITGE--SHFNEVFITDARVSDEYLVGGE
Mvan_4313|M.vanbaalenii_PYR-1       KGLSLFIMPMNQAGIEVRPLVQITGE--SHFNEVFISDATVSDDYLLGGE
Mflv_2334|M.gilvum_PYR-GCK          KGITFFIVPMKQPGIEIRPLVQITGD--SHFNEVFITDATVPDAYVVGGV
TH_2799|M.thermoresistible__bu      KGISFFMLPMKQPGIEVRPIHQITGE--SEFNEVFITDARCPAENMVGRP
MLBr_00737|M.leprae_Br4923          NGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEP
                                     *:: :::  .: .. : *  :  *   :  .*::: ..      ::*  

Mb3590c|M.bovis_AF2122/97           GDGWRVAMATLTFERGVSTLGQQIVYAR---------ELSNLVELARRTA
Rv3560c|M.tuberculosis_H37Rv        GDGWRVAMATLTFERGVSTLGQQIVYAR---------ELSNLVELARRTA
MAV_0601|M.avium_104                GDGWRVAMGTLTFERGVSTLGQQIRYAR---------ELSNLAELARRNG
MAB_0597|M.abscessus_ATCC_1997      GDGWRVAMGTLTFERGVSTLGNQITYAR---------ELSRLAELAKSNG
MMAR_2862|M.marinum_M               GSGWTAAMSLLGFERGAQATTGAIDFAR---------DLSRLCDLARARG
MUL_2892|M.ulcerans_Agy99           GSGWTAAMSLLGFERGAQATTGAIDFAR---------DLSRLCDLARARG
MSMEG_1904|M.smegmatis_MC2_155      GNGWRVLQTALAYERSIMGDSGRGSRNKS--------KADSLVELAREHG
Mvan_4313|M.vanbaalenii_PYR-1       GNGWRALQTALAYERSIMGDSGRGSRNR---------KADSLIDLAREHG
Mflv_2334|M.gilvum_PYR-GCK          GNGWRVLQTALAVERSIMGSGTSLHRKQS--------RGNSLVEMARAHG
TH_2799|M.thermoresistible__bu      GEGWSVLQVALGYERRLMGDLARTSKASRKPKDDPAQQRNALVEMAREAG
MLBr_00737|M.leprae_Br4923          GTGFKTALATLDHTRPTIGAQAVGIAQG---------ALDAAIVYTKDRK
                                    * *: .    *   *                        .     ::   

Mb3590c|M.bovis_AF2122/97           AADDPLIRERLTRAWTGLRAMR--SYALATMEGPAVEQPGQDNVSKLLWA
Rv3560c|M.tuberculosis_H37Rv        AADDPLIRERLTRAWTGLRAMR--SYALATMEGPAVEQPGQDNVSKLLWA
MAV_0601|M.avium_104                AADDPFIRERLTRAWTGLRAMR--SYALATMD---VEQPGQDNVSKLLWA
MAB_0597|M.abscessus_ATCC_1997      AADDPAIRERLAQAYVGMRTMR--AYALATMD---EERPGQDNVSKLLWA
MMAR_2862|M.marinum_M               LDSDPRIRDRLAWCYSRTQIMRYRGYRSLTWALNGLLPGAEAAISKVIWS
MUL_2892|M.ulcerans_Agy99           LDSDPRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVLPGAEAAISKVIWS
MSMEG_1904|M.smegmatis_MC2_155      RLDDPAIRKELANVLALRELNR-LNNARAKASAGQGTSTSIMSLGKLAMS
Mvan_4313|M.vanbaalenii_PYR-1       VLDDSAVRHQLASVLAMRELNR-LNNARAKASTTQGTSSSIMSLGKLAMS
Mflv_2334|M.gilvum_PYR-GCK          KLDDSAIRKSLADVLALRELNN-LNNARAKAEAKQGTASPVMSLGKLATS
TH_2799|M.thermoresistible__bu      RLDDPYIRQRIARMDEFAAVNR-WNTQRSKATRDKVESLTLQALGKIAMS
MLBr_00737|M.leprae_Br4923          QFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAA
                                      .:.                .                     :. :  :

Mb3590c|M.bovis_AF2122/97           NWHRNLGELAMDVIGKPGMTMP---------------DGEFDEWQRLYLF
Rv3560c|M.tuberculosis_H37Rv        NWHRNLGELAMDVIGKPGMTMP---------------DGEFDEWQRLYLF
MAV_0601|M.avium_104                NWHRALGELAMDVIGKPGMTMP---------------DGEFDEWQRLFLF
MAB_0597|M.abscessus_ATCC_1997      NWHRDLGELAMEIIGTSTLLTN---------------AGEMDEWQRLFLF
MMAR_2862|M.marinum_M               EYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELLY
MUL_2892|M.ulcerans_Agy99           EYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELLY
MSMEG_1904|M.smegmatis_MC2_155      HILHSEARLKTEIIGAEALLAGP-------------ENPEADDINFLTLN
Mvan_4313|M.vanbaalenii_PYR-1       RILHTEAAMKTQIIGAEALLAGP-------------DNPVADDVNFLALN
Mflv_2334|M.gilvum_PYR-GCK          GILHAEARLKTDIIGADALLAGP-------------DNAEADEVNFLTLN
TH_2799|M.thermoresistible__bu      RILHETARVQTEIVGAESMLAGP-------------DHPIGDGVTFRTLN
MLBr_00737|M.leprae_Br4923          SKCFASDIAMEVTTDAVQLFGGAG-------------YTSDFPVERFMRD
                                                  .   :                               

Mb3590c|M.bovis_AF2122/97           TRADTIYGGSNEIQRNIIAERVLGLPREAKG------------
Rv3560c|M.tuberculosis_H37Rv        TRADTIYGGSNEIQRNIIAERVLGLPREAKG------------
MAV_0601|M.avium_104                TRADTIYGGSNEIQRNIIAERVLGLPREVKG------------
MAB_0597|M.abscessus_ATCC_1997      SRADTIYGGSNEIQRNIISERVLGLPREAR-------------
MMAR_2862|M.marinum_M               ARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH--------
MUL_2892|M.ulcerans_Agy99           ARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH--------
MSMEG_1904|M.smegmatis_MC2_155      AFFTSIGGGTDQVQRNIIGERVLGLPKEPEVDRDIPFREARRS
Mvan_4313|M.vanbaalenii_PYR-1       AFFTSIGGGTDQIQRNIIGERVLGLPKEPEADRDIPFRQARRS
Mflv_2334|M.gilvum_PYR-GCK          AFFTSIGGGTDQIQRNIIGERVLGLPKEPEVDREIPFRDIRKN
TH_2799|M.thermoresistible__bu      AYFTSIGGGTDQVQRNIVGERVLGLPKEPDPYRDQPFRDLPH-
MLBr_00737|M.leprae_Br4923          AKITQIYEGTNQIQRVVMSRALLR-------------------
                                    :    *  *:.::** ::.. :*

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_2334	-	-	100% (400)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1481	-	1e-58	38.90% (383)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_0344	-	3e-55	38.33% (300)	acyl-CoA dehydrogenase domain-containing protein