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VDVDYPPQAEAFRDRIRALLAEHLPPDWSGGGALAPEERAAVARRWRQSLAAAGLVAVSWPKAYGGAGLS VIEQVVLDEEFARAGAPERAENDLLGIQLLGNTLIALGTEEQKRHFLPRILSAEDRWCQGFSEPEAGSDL ASVRTRAVLDDDEWVINGQKIWTSAGPTANWIFVLARTDTEAPKHKGLSLLLVPIDQPGVVVRPIVNAAG HASFSEVFFTDARTPAVNVVGRVGDGWPAAMTVLGFERGSQVTTAAINFGREMDRLRELARDRGLHTDAR IRDGLAWCYSRVQIMRFQGYRGLTSLLAGQRPGREAAISKVVWSEFFRRYTELAVEILGLEALSPAGPGN GEALIVPEPGTPNSAACWMDELLYARASTIYAGSSQIQRNVIGEQLLGLPREPRVPAGRVPEPAGRGSN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4006 | - | - | 100% (419) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5285 | - | 2e-82 | 42.18% (403) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4254 | - | 6e-64 | 36.87% (396) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 0.0 | 79.95% (404) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_1481 | - | 9e-86 | 44.14% (401) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 0.0 | 79.95% (404) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-27 | 28.08% (406) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 2e-86 | 45.20% (396) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_2862 | fadE17 | 0.0 | 77.23% (404) | acyl-CoA dehydrogenase FadE17 |
| M. avium 104 | MAV_0601 | - | 1e-87 | 44.47% (398) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6012 | - | 8e-83 | 43.03% (409) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4263 | - | 3e-85 | 43.14% (401) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 1e-173 | 77.14% (385) | acyl-CoA dehydrogenase FadE17 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
Rv1934c|M.tuberculosis_H37Rv -----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPP--H
MMAR_2862|M.marinum_M -----------MDVAYPPEAEEFRERVRAFLDEHLPCGWSGPGALAV--Q
MUL_2892|M.ulcerans_Agy99 ------------------------------MDEHLPCGWSGPGALAV--Q
Mvan_4006|M.vanbaalenii_PYR-1 -----------MDVDYPPQAEAFRDRIRALLAEHLPPDWSGGGALAP--E
Mflv_1481|M.gilvum_PYR-GCK ----------------MIEVQKFRAEVRDWLAENLVGDFAALKGLGGPGR
MSMEG_6012|M.smegmatis_MC2_155 ----------------MIEVQEFRAEVRQWLADNLVGDFAALKGLGGPGR
TH_4263|M.thermoresistible__bu ----------------VIEVHEFRAEVRQWLADNLVGEYAALKGLGGPGR
MAV_0601|M.avium_104 ----------------MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MLBr_00737|M.leprae_Br4923 --------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVD
Mb1969c|M.bovis_AF2122/97 EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MMAR_2862|M.marinum_M DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MUL_2892|M.ulcerans_Agy99 DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
Mvan_4006|M.vanbaalenii_PYR-1 ERAAVARR--WRQSLAAAGLVAVSWPKAYGGAGLSVIEQVVLDEEFARAG
Mflv_1481|M.gilvum_PYR-GCK EHEAFEERLAWNQHLAAAGLTCLGWPEEHGGRGLSVAHRVAFYEEYAKAN
MSMEG_6012|M.smegmatis_MC2_155 EHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSVAHRVAFYEEYARAN
TH_4263|M.thermoresistible__bu EHEAFEERLEWNRKLAAAGLTCLGWPVEHGGRGLSVAHRVAFYEEYALAN
MAV_0601|M.avium_104 EHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MLBr_00737|M.leprae_Br4923 QRARFPEEA--LAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
:: . . * :* .: * :** * . ** * .
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MMAR_2862|M.marinum_M APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MUL_2892|M.ulcerans_Agy99 APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
Mvan_4006|M.vanbaalenii_PYR-1 APERAENDLLGIQLLGNTLIALGTEEQKRHFLPRILSAEDRWCQGFSEPE
Mflv_1481|M.gilvum_PYR-GCK APDKVNH--LGEELLGPTLIAYGTPEQQQRFLPRILDVTELWSQGYSEPG
MSMEG_6012|M.smegmatis_MC2_155 APDKVNH--FGEELLGPTLIEYGTPEQQKRFLPKILDVTELWCQGYSEPN
TH_4263|M.thermoresistible__bu APAKVNH--LGEELLGPTLIEYGTPEQQQRFLPRILDVTELWAQGYSEPG
MAV_0601|M.avium_104 APDKVNH--FGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPG
MAB_0597|M.abscessus_ATCC_1997 APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
*. : ** *: :::.** : . . **
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLDGDE----------WVINGHKIWTSAGTTANWIFLL
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLDGDE----------WVINGHKIWTSAGTTANWIFLL
MMAR_2862|M.marinum_M AGSDLASVRTRAVLDGDQ----------WVINGQKIWTSAGSTANWIFVL
MUL_2892|M.ulcerans_Agy99 AGSDLASVRTRAVLDGDQ----------WVINGQKIWTSAGSTANWIFVL
Mvan_4006|M.vanbaalenii_PYR-1 AGSDLASVRTRAVLDDDE----------WVINGQKIWTSAGPTANWIFVL
Mflv_1481|M.gilvum_PYR-GCK AGSDLANVSTTATLDGDE----------WVINGQKVWTSLAHWAQWCFVV
MSMEG_6012|M.smegmatis_MC2_155 AGSDLANVSTTAELVGDAEASGATGNQYWVINGQKVWTSLAHWAQWCFVV
TH_4263|M.thermoresistible__bu AGSDLANVSTTAVLDGDQ----------WVINGQKVWTSLAHWAQWCFVV
MAV_0601|M.avium_104 AGSDLANVSTTAELDGDQ----------WVINGQKVWTSLAHLSQWCFVV
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLDGGD----------WVINGQKVWTSLALQSQWCFVV
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDD----------WILNGFKCWITNGGKSTWYTVM
**** *.: * . .. *::** * * : . : * ::
Mb1969c|M.bovis_AF2122/97 ARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDAR
Rv1934c|M.tuberculosis_H37Rv ARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDAR
MMAR_2862|M.marinum_M ARTDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADAR
MUL_2892|M.ulcerans_Agy99 ARTDPVAPKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADAR
Mvan_4006|M.vanbaalenii_PYR-1 ARTDTEAPKHKGLSLLLVPIDQPGVVVRPIVNAAGH--ASFSEVFFTDAR
Mflv_1481|M.gilvum_PYR-GCK ARTEKGSKRHAGLSYLLVPLQQPGVEIRPIIQLTGD--SEFNEVFFDDAR
MSMEG_6012|M.smegmatis_MC2_155 ARTEKGSKRHAGLSYLLVPLDQPGVEIRPINQLTGD--SEFNEVFFDDAR
TH_4263|M.thermoresistible__bu ARTERGSKRHHGLSYLLVPLDQPGVEIRPIVQLTGD--SEFNEVFFDNAR
MAV_0601|M.avium_104 ARTEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDAR
MAB_0597|M.abscessus_ATCC_1997 ARTEPGSSRHKGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNAR
MLBr_00737|M.leprae_Br4923 AVTDP-DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCR
* *: *:* ::* :: .. : * : * : .*::: ..*
Mb1969c|M.bovis_AF2122/97 TSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR
Rv1934c|M.tuberculosis_H37Rv TSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR
MMAR_2862|M.marinum_M TGVANVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARAR
MUL_2892|M.ulcerans_Agy99 TGVANVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARAR
Mvan_4006|M.vanbaalenii_PYR-1 TPAVNVVGRVGDGWPAAMTVLGFERGSQVTTAAINFGREMDRLRELARDR
Mflv_1481|M.gilvum_PYR-GCK TAADLVVGEPGDGWRVAMGTLTFERGVSTLGQQIRYAREHSNLVELAEKT
MSMEG_6012|M.smegmatis_MC2_155 TEAGLVVGQPGDGWRVAMGTLTFERGVSTLGQQIRYAREHSNLVELAKRT
TH_4263|M.thermoresistible__bu TDASMVVGEPGDGWRVAMGTLTFERGVSTLGQQIQYRRELEGVVELAKRT
MAV_0601|M.avium_104 TDASMVVGQPGDGWRVAMGTLTFERGVSTLGQQIRYARELSNLAELARRN
MAB_0597|M.abscessus_ATCC_1997 TSADLVVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSN
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
::*. * *: .*: * . * . :.
Mb1969c|M.bovis_AF2122/97 GLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIW
Rv1934c|M.tuberculosis_H37Rv GLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIW
MMAR_2862|M.marinum_M GLDSDPRIRDRLAWCYSRTQIMRYRGYRSLTWALNGLLPGAEAAISKVIW
MUL_2892|M.ulcerans_Agy99 GLDSDPRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVLPGAEAAISKVIW
Mvan_4006|M.vanbaalenii_PYR-1 GLHTDARIRDGLAWCYSRVQIMRFQGYRGLTSLLAGQRPGREAAISKVVW
Mflv_1481|M.gilvum_PYR-GCK GAADDPLIRERLVRSWAGLKAMRSYALATMDVEKPG-----QDNISKLLW
MSMEG_6012|M.smegmatis_MC2_155 GAADDPLIRERLVQSWTGLQAMRSYALATMDVEQPG-----QDNVSKLLW
TH_4263|M.thermoresistible__bu GAIDDPLIRERLTRSWVGLRTMRSYALATMDDERPG-----QDNISKLLW
MAV_0601|M.avium_104 GAADDPFIRERLTRAWTGLRAMRSYALATMDVEQPG-----QDNVSKLLW
MAB_0597|M.abscessus_ATCC_1997 GAADDPAIRERLAQAYVGMRTMRAYALATMDEERPG-----QDNVSKLLW
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FIS
:. *: . : . : : .:
Mb1969c|M.bovis_AF2122/97 SEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELL
Rv1934c|M.tuberculosis_H37Rv SEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELL
MMAR_2862|M.marinum_M SEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELL
MUL_2892|M.ulcerans_Agy99 SEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELL
Mvan_4006|M.vanbaalenii_PYR-1 SEFFRRYTELAVEILGLEALSPAGPGNGEALIVPEPGTPNSAACWMDELL
Mflv_1481|M.gilvum_PYR-GCK ANWHRELGEIAMDIEGAAGLTLPD---------------GEFSEWQRLYL
MSMEG_6012|M.smegmatis_MC2_155 ANWHRELGEIAMDVQGMAGLTLEN---------------GEFDEWQRLYL
TH_4263|M.thermoresistible__bu ANWHRELGEIAMDVVGMAGLTLTD---------------GDFDEWQRLYL
MAV_0601|M.avium_104 ANWHRALGELAMDVIGKPGMTMPD---------------GEFDEWQRLFL
MAB_0597|M.abscessus_ATCC_1997 ANWHRDLGELAMEIIGTSTLLTNA---------------GEMDEWQRLFL
MLBr_00737|M.leprae_Br4923 AASKCFASDIAMEVTTDAVQLFGGAG------------YTSDFPVERFMR
: ::*::: .
Mb1969c|M.bovis_AF2122/97 YARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----------
Rv1934c|M.tuberculosis_H37Rv YARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----------
MMAR_2862|M.marinum_M YARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH----------
MUL_2892|M.ulcerans_Agy99 YARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH----------
Mvan_4006|M.vanbaalenii_PYR-1 YARASTIYAGSSQIQRNVIGEQLLGLPREPRVPAGRVPEPAGRGSN
Mflv_1481|M.gilvum_PYR-GCK FSRSDTIYGGSNEIQRNIIAERVLGLPREARH--------------
MSMEG_6012|M.smegmatis_MC2_155 FSRADTIYGGSNEIQRNIIAERVLGLPREVKG--------------
TH_4263|M.thermoresistible__bu FSRSDTIYGGSNEIQRNIIAERVLGLPREPKG--------------
MAV_0601|M.avium_104 FTRADTIYGGSNEIQRNIIAERVLGLPREVKG--------------
MAB_0597|M.abscessus_ATCC_1997 FSRADTIYGGSNEIQRNIISERVLGLPREAR---------------
MLBr_00737|M.leprae_Br4923 DAKITQIYEGTNQIQRVVMSRALLR---------------------
:: ** *:.:*** ::.. :*