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SSSQPSAAPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGDFARDYDDVVNGPGGLAAHFVWS NRGKESVTLNTKTAGGLDLLHRLLDRADAFVSNLAPGATARLGVAPADLAARHPRVIPVEIDGYGPGGPL SHKRAYDLLVQAESGSCAVTGYPGMPAKPGPAVADFSTGLYAAISILALLYGRARHPGSAPAPSVELSLF DVMTDVMGYALTYTQHSGIDQEPLGVGSPAVAPYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLAD DPRFATNSDRCAHRQILEEAIGSWCAQHDLAEIQKTADAAGIGNSRYNLPSEVVVHPHLAARDRWRTVAT PKGDIQALRPPPVISDFEQPMGAIPGLGEHTDAVLTEIGVTPDELRQLRADGAIGPAYRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4208 | - | - | 100% (411) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | 5e-44 | 32.25% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1895 | - | 1e-43 | 30.60% (415) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 9e-37 | 30.79% (393) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_2443 | - | 0.0 | 89.05% (411) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 7e-37 | 30.79% (393) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 3e-38 | 28.89% (405) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1267 | - | 4e-39 | 31.82% (396) | acyl-CoA transferase |
| M. avium 104 | MAV_1892 | - | 3e-90 | 44.92% (394) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_4834 | - | 0.0 | 78.30% (401) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_2496 | - | 0.0 | 74.63% (410) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_2621 | - | 1e-38 | 31.57% (396) | acyl-CoA transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4208|M.vanbaalenii_PYR-1 MSSSQP-SAAPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGD
Mflv_2443|M.gilvum_PYR-GCK MTASQ--SAGPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGD
MSMEG_4834|M.smegmatis_MC2_155 MPKDTPEKSGPLAGFTVVALEQAVSAPMCTRVLADFGARVIKVENPKGGD
TH_2496|M.thermoresistible__bu MAESEHADPAPLAGITVVALEQAVSAPMCTRVLADFGARVIKVENPDGGD
MAV_1892|M.avium_104 --------MGPLSGVTVVSLEQAVAAPYATRQLADLGARVIKVERPDGGD
Mb3300|M.bovis_AF2122/97 --MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGE
Rv3272|M.tuberculosis_H37Rv --MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGE
MMAR_1267|M.marinum_M --MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEAP-GGE
MUL_2621|M.ulcerans_Agy99 --MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVEAP-GGE
MAB_4651c|M.abscessus_ATCC_199 -------MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPD
.* *. *: : ::.* . : * *:**.::*:* * . :
Mvan_4208|M.vanbaalenii_PYR-1 FARDYDDVVNGPGGLAAHFVWSNRGKESVTLNTKTAGGLDLLHRLLDRAD
Mflv_2443|M.gilvum_PYR-GCK FARAYDDVVNGPGGLAAHFVWSNRGKESVTLNTKSPAGLEVLHRLLDRAD
MSMEG_4834|M.smegmatis_MC2_155 FARDYDDVVLGPGGLAAHFVWANRGKESITLDLKTPGGMDVLHKLLDTAD
TH_2496|M.thermoresistible__bu FARHYDDVVKG---QAAHFVWANRGKESVTLNLKSEAGMAVLHRLLDEAD
MAV_1892|M.avium_104 FARGYDHSVHGD---SSYFVWLNRGKESLTLDLKTLEGQRILRQLLANSD
Mb3300|M.bovis_AF2122/97 AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
Rv3272|M.tuberculosis_H37Rv AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
MMAR_1267|M.marinum_M AARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRLADTAD
MUL_2621|M.ulcerans_Agy99 AARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRLADTAD
MAB_4651c|M.abscessus_ATCC_199 PLRTWGQAEVDG--HHVFWTVHARNKKAITLDLRTEAGRALFLDLVDKSD
* .: *.*:::::: : . : * :*
Mvan_4208|M.vanbaalenii_PYR-1 AFVSNLAPGATARLGVAPADLAARHPRVIPVEIDGYGPGGPLSHKRAYDL
Mflv_2443|M.gilvum_PYR-GCK AFVSNLAPGATARLGLSPADLAERHPQVIPVEIDGYGPGGPISHKRAYDL
MSMEG_4834|M.smegmatis_MC2_155 ALVSNLAPGAMARMGLAPADLAERHPQVIPVEIDGYGSGGPLSHKRAYDL
TH_2496|M.thermoresistible__bu VLVSNLAPGALARMGLAADDLKTSHPRVLPVQIDGYGAGGPISHKRAYDL
MAV_1892|M.avium_104 VLVQNLGPGATTRLSLDATTLTPEYPRLIVCDITGYGGTGPWRDRKAYDL
Mb3300|M.bovis_AF2122/97 VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
Rv3272|M.tuberculosis_H37Rv VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
MMAR_1267|M.marinum_M VVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTRPGVDL
MUL_2621|M.ulcerans_Agy99 VVLEGFRPGVMERMGLGPEDLRARNPKLIYARLSAFGGNGPHGTRPGVDL
MAB_4651c|M.abscessus_ATCC_199 VIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYAS
..:. : **. : .: * :: : .:* ** : .
Mvan_4208|M.vanbaalenii_PYR-1 LVQAESGSCAVTGYP-GMPAKPGPAVADFSTGLYAAISILALLYGRARH-
Mflv_2443|M.gilvum_PYR-GCK LVQAESGSCAVTGYP-GMPAKPGPAVADFTSGLYAAMSIVSLLYGRATR-
MSMEG_4834|M.smegmatis_MC2_155 LVQAESGACAVTGHP-DMPAKPGPPVADISTGLYAALSIMALLIGRLRR-
TH_2496|M.thermoresistible__bu LIQAESGACAVTGYP-GMPAKPGPPVADISTGLYAALSVMALLYGRDRRD
MAV_1892|M.avium_104 LVQAEAGLLSVTGSG-DEVARTGVSIADIAAGMFAFSGILTALYVRATT-
Mb3300|M.bovis_AF2122/97 VVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERN-
Rv3272|M.tuberculosis_H37Rv VVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERN-
MMAR_1267|M.marinum_M MVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALLNRERH-
MUL_2621|M.ulcerans_Agy99 MVAAEAGMTTGMPTPDGKPQIIPFQLVDNASGHVLAQAVLAALLNRERH-
MAB_4651c|M.abscessus_ATCC_199 VAEAASGLRHLNGFPGGPPPRMALSIGDTLAGMFAAQGALAALYRRTVT-
: * :* . : * :* . :: * *
Mvan_4208|M.vanbaalenii_PYR-1 -PGSAPAPSVELSLFDVMTDVMGYALTYTQHSGIDQEPLGVGSP------
Mflv_2443|M.gilvum_PYR-GCK -PEPGPAPHVELSLFDVMTDVMGYALTYTQHSGIDQEPLGVGSP------
MSMEG_4834|M.smegmatis_MC2_155 -PENGAAPAVAVSLFDTMTDIMGYPLTYTQHSGVDQQPLGMSSP------
TH_2496|M.thermoresistible__bu RATPGPVPAVAVSLFDTMTDIMGYQLTYTQHSGVDQQPLGMSSP------
MAV_1892|M.avium_104 ----GDVRPVSVSLFESLVELVSQPAYYAHYGGTAPPRTGARHA------
Mb3300|M.bovis_AF2122/97 ----GVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPK-PEPAPKAKRR
Rv3272|M.tuberculosis_H37Rv ----GVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPK-PEPAPKAKRR
MMAR_1267|M.marinum_M ----GVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGARR
MUL_2621|M.ulcerans_Agy99 ----GVADTVRVAMYDVAVGLQANQLTMHLNRPSSDAPKRPEQTPAGARR
MAB_4651c|M.abscessus_ATCC_199 ----GRGQVVDAALTESCLAVQESTIPDYDVGRVVRGPSGTRLEG-----
. * :: : :
Mvan_4208|M.vanbaalenii_PYR-1 -----AVAPYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLADDPRF
Mflv_2443|M.gilvum_PYR-GCK -----AVAPYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLADDPRF
MSMEG_4834|M.smegmatis_MC2_155 -----AVAPYGAFSTRDGQTVVLGTTNDREWQRLAREIIDRPDLADDPRF
TH_2496|M.thermoresistible__bu -----AVAPYGAFRTRDGQTVVLGTTNDREWQRLARDIIERPDLADDPAY
MAV_1892|M.avium_104 -----TIAPYGPFTAGDGGTVLLAVQNQREWRRLCDEVLATPGLCEDPRF
Mb3300|M.bovis_AF2122/97 KGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLC-YLIGRPDLVEDQRF
Rv3272|M.tuberculosis_H37Rv KGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLC-YLIGRPDLVEDQRF
MMAR_1267|M.marinum_M KRVAFATQPSDAFRAADG-YLLISAYVPKHWQRLC-EIIGRPDLLDDERF
MUL_2621|M.ulcerans_Agy99 KRVAFATQPSDAFRAADG-YLLISAYVPKHWQRLC-EIIGQPDLLDDERF
MAB_4651c|M.abscessus_ATCC_199 ------IAPSNIYQSADGSWVVIAANQDTVFRRLC-EAMGRPELSSDARF
* . : : ** :::.. ::::. : * * .* :
Mvan_4208|M.vanbaalenii_PYR-1 ATNSDRCAHRQILEEAIGSWCAQHDLAEIQKTADAAGIGNSRYNLPSEVV
Mflv_2443|M.gilvum_PYR-GCK ATNPGRCANRDVLEEAIGAWCARHDLAEIQDKADRAGIGNSRYNLPSEVI
MSMEG_4834|M.smegmatis_MC2_155 ATNSDRCAHRDVLNEAIGTWCAQHDLAEIQQIADEAGIGNSRFNRPSEVI
TH_2496|M.thermoresistible__bu ATNSDRVRHRDVLNEAIAAWCARHDLAHIQKTADDAGIGNSRYNLPSEVV
MAV_1892|M.avium_104 VTNPDRVTHRDELEAIIHAAIASMTADELAHRLEAAGIANARMNDVETLW
Mb3300|M.bovis_AF2122/97 AEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVV
Rv3272|M.tuberculosis_H37Rv AEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVV
MMAR_1267|M.marinum_M IDQRARAINYAELTEELESALAAKTAAQWVELLHEGGLMACLAYTWKQVV
MUL_2621|M.ulcerans_Agy99 IDQRARAINYAELTEELESALAAKTAAQWVELLHEGGLMACLAYTWKQVV
MAB_4651c|M.abscessus_ATCC_199 ANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVV
: * : * : * . . *: :
Mvan_4208|M.vanbaalenii_PYR-1 VHPHLAARDRWRTVATPKGDIQALRPPPVISDFEQPMGA----IPGLGEH
Mflv_2443|M.gilvum_PYR-GCK AHPHLVARDRWRTVATPKGDIQALRPPPVISDFEQPMGA----IPGLGEH
MSMEG_4834|M.smegmatis_MC2_155 AHQHLKDRDRWRQVATPKGEIAALLPPPVIAGYEMPMGA----VPGLGEH
TH_2496|M.thermoresistible__bu AHPHLSARDRWRPVDTPNGQITALRPPPVIEGFEQPMGP----VPGLGQH
MAV_1892|M.avium_104 SHPVLAGRDRWREVRAPGGAIEALLPPATLRDVEPQLGD----VPGLAAH
Mb3300|M.bovis_AF2122/97 DTPLFAESDLTLEVGRGADTITVIRTPARYASFRAVVTD----PPPTAGE
Rv3272|M.tuberculosis_H37Rv DTPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTD----PPPTAGE
MMAR_1267|M.marinum_M TTPLFAENELALQVGSGDDAVTVIRTPARYSSFSAVLAE----PPAATGE
MUL_2621|M.ulcerans_Agy99 TTPLFAENELALQVDSGDDAVTVIRTPARYSSFSAVLAD----PPPATGE
MAB_4651c|M.abscessus_ATCC_199 QDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQD
: : .: . . .
Mvan_4208|M.vanbaalenii_PYR-1 TDAVLT-EIGVTPDELRQLRADGAIGPAYRG-------
Mflv_2443|M.gilvum_PYR-GCK TDAVLT-EFGVSAEELAQLRAEGAIGPAYRG-------
MSMEG_4834|M.smegmatis_MC2_155 TDHILA-DIGLSAEEIASLREQGAVGPAMQTRSEQSHA
TH_2496|M.thermoresistible__bu TDAVLSGLLGMTDDEIAALREQGAIGPAYN--------
MAV_1892|M.avium_104 SRMILR-ELGYTNEAIADLVRSGVTTVASDH-------
Mb3300|M.bovis_AF2122/97 HNAVFLARP-----------------------------
Rv3272|M.tuberculosis_H37Rv HNAVFLARP-----------------------------
MMAR_1267|M.marinum_M HNETLLGES-----------------------------
MUL_2621|M.ulcerans_Agy99 HNETLLGES-----------------------------
MAB_4651c|M.abscessus_ATCC_199 NDDVYVGLLGKSAQDIERLRAEGVL-------------