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MGVLDGVRVLDYGRFIAAPWCAALLADMGADVIRVEKREGGEDRWVQSVAEGGEGGTFLQCNRNKRSLTL DSTTDEGKEITRKLVAGADIVVANMPAAGMRSSGLDYETLRAVKPDIILASATAYGEGGPYSDRIGFDGA GQVMSGAVYRQGLPDQPIRTVVPYADFGTALTLTIGVMMALFHRDRTGQGQHVEGALLPTALMLSNAFLI ERELLGTDKPRMGNRGTSVAPCDLYRTRDDGWVLLQVAGPPMFKRWCRLVGRPELFDDPRFANDDLRWQH GDVLNDIMAQWCADKTKAEVLERLEAAKLPAAPMHSTQEVLDDPHVQAMGFLQRVPFPGAPRDVPIIETP FRMSATPGQIRRRAPLLGEHTDEILGEIGYTGDQVARLRDRQVI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | - | 100% (394) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_4229 | - | 4e-55 | 34.14% (413) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1895 | - | 5e-52 | 32.26% (403) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1897 | - | 1e-39 | 29.10% (402) | hypothetical protein Mb1897 |
| M. gilvum PYR-GCK | Mflv_4365 | - | 0.0 | 88.55% (393) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv1866 | - | 2e-39 | 29.10% (402) | hypothetical protein Rv1866 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 3e-50 | 30.64% (408) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 1e-53 | 33.08% (399) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_0341 | - | 2e-55 | 34.01% (397) | caib/baif family protein |
| M. smegmatis MC2 155 | MSMEG_6294 | - | 1e-54 | 34.60% (396) | caib/baif family protein |
| M. thermoresistible (build 8) | TH_3339 | - | 2e-57 | 32.32% (396) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 2e-53 | 33.08% (399) | hypothetical protein MUL_2446 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 MVTRLLADLGADVLKVQPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Rv1866|M.tuberculosis_H37Rv MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Rv1866|M.tuberculosis_H37Rv NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Rv1866|M.tuberculosis_H37Rv SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Rv1866|M.tuberculosis_H37Rv AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Rv1866|M.tuberculosis_H37Rv RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Rv1866|M.tuberculosis_H37Rv DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Rv1866|M.tuberculosis_H37Rv SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Mvan_1979|M.vanbaalenii_PYR-1 ---------------------MGVLDGVRVLDYGRFIAAPWCAALLADMG
Mflv_4365|M.gilvum_PYR-GCK --------------------MTGVLDGIRVLDYGRFIAAPWCSALLADMG
MAV_0341|M.avium_104 -------------MLD----------GLRVLDLATLAAAPLVATYLGEFG
MSMEG_6294|M.smegmatis_MC2_155 -------------MFDTTSAQPPPLRGVRVVDGATIYAGPMIATLLGDFG
MMAR_1494|M.marinum_M ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MUL_2446|M.ulcerans_Agy99 ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MAB_4651c|M.abscessus_ATCC_199 --------------------MTGALDGIRVLELGTLIAGPFAGRLLGDMG
TH_3339|M.thermoresistible__bu --------MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLG
Mb1897|M.bovis_AF2122/97 QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
Rv1866|M.tuberculosis_H37Rv QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
*:*::: . : *. . :.::*
Mvan_1979|M.vanbaalenii_PYR-1 ADVIRVEKREGGEDRWVQSVAE-GGEGGTFLQCNRNKRSLTLDSTTDEGK
Mflv_4365|M.gilvum_PYR-GCK ADVIRVEKREGGEDRWVQSIAD-SGEGGTFLQCNRNKRSLTLDTTTAEGR
MAV_0341|M.avium_104 ADVIKVEEPRHGDPIRGWGNQR-DGVGLMWKSISRNKKSITLDLRSADGQ
MSMEG_6294|M.smegmatis_MC2_155 ADVIKVEHP-HGDGLRQWEWRK-DGESLWWALVGRNKRDISLSLSDPRGA
MMAR_1494|M.marinum_M ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MUL_2446|M.ulcerans_Agy99 ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MAB_4651c|M.abscessus_ATCC_199 AEVLKIEPPGAPDPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGR
TH_3339|M.thermoresistible__bu ADVVKIEDPGKGDPLRQWGQNRPKGQSLWFSIVGRNKRSVTINLREPRGQ
Mb1897|M.bovis_AF2122/97 AEVIKVESADHPDGLRQTRVGDAMSES--FAWTHRNHLALGLDLRNSEGK
Rv1866|M.tuberculosis_H37Rv AEVIKVESADHPDGLRQTRVGDAMSES--FAWTHRNHLALGLDLRNSEGK
*:*:::* : . : **: : :. *
Mvan_1979|M.vanbaalenii_PYR-1 EITRKLVAGADIVVANMPAAGMRSSGLDYETLRAVKPDIILASATAYGEG
Mflv_4365|M.gilvum_PYR-GCK EVTRKLVAGADIVVANMPAVGMRTSGLDYDTLRTIKPDIILASATAYGEG
MAV_0341|M.avium_104 QLVRRLVEHADVAIFNTRPQTLRKWGLDYESLRAVNERLVMLHITGYGLS
MSMEG_6294|M.smegmatis_MC2_155 DVMRRLLADADVFIENFRPGTLEKWGLDPEDLIAANPKLVVVRVSGFGQT
MMAR_1494|M.marinum_M ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MUL_2446|M.ulcerans_Agy99 ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MAB_4651c|M.abscessus_ATCC_199 ALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQT
TH_3339|M.thermoresistible__bu ELVRQLVAEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQD
Mb1897|M.bovis_AF2122/97 AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
Rv1866|M.tuberculosis_H37Rv AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
: *: :* . * . : .:. . * : ::: :.:*
Mvan_1979|M.vanbaalenii_PYR-1 GPYSDRIGFDGAGQVMSGAVYRQGLPD-QPIRTVVPYADF-------GTA
Mflv_4365|M.gilvum_PYR-GCK GPYSDRIGFDGAGQVMSGAVYRQGLPD-QPIRTVVPYADF-------GTA
MAV_0341|M.avium_104 GPKSERPGFGTLGEAMSGFAHITGQAGAPPTLPPFMLADG-------VAS
MSMEG_6294|M.smegmatis_MC2_155 GPYRSRPGFGTIAEAMSGFADTNGAADGPPVLPQWPLADG-------VAA
MMAR_1494|M.marinum_M GPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDS-------LAG
MUL_2446|M.ulcerans_Agy99 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDS-------LAG
MAB_4651c|M.abscessus_ATCC_199 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPRMALSIGDT-------LAG
TH_3339|M.thermoresistible__bu GPYASRPGYGAIGEAMGGLRYVVGDPSTPPSRVGISIGDT-------LAA
Mb1897|M.bovis_AF2122/97 GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
Rv1866|M.tuberculosis_H37Rv GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
** : *: .. * * * ..
Mvan_1979|M.vanbaalenii_PYR-1 LTLTIGVMMALFHRDRTG-QGQHVEGALLPTALMLSNAFLIERELLGTDK
Mflv_4365|M.gilvum_PYR-GCK LTLTIGVMMALYHRDRTG-EGQHVEGALLPTAMMLSNAFLIERDLLGTDK
MAV_0341|M.avium_104 LNAAYAVMMALYHRDVHGGPGQLIDVNLIDPLARLLEQTLLGYDQLGLVP
MSMEG_6294|M.smegmatis_MC2_155 LAGAFATMIALRHAEATG-HGQVVDLSIYEPLFWILGAQTSAYDQLGTLP
MMAR_1494|M.marinum_M MFGAQGALAALYRRSVTG-TGQVVDVALTESCLALQESTISDYDVGGVVR
MUL_2446|M.ulcerans_Agy99 MFGPQGALAALYRRSVTG-TGQVVDVALTESCLALQESTISDYDVGGVVR
MAB_4651c|M.abscessus_ATCC_199 MFAAQGALAALYRRTVTG-RGQVVDAALTESCLAVQESTIPDYDVGRVVR
TH_3339|M.thermoresistible__bu LFATIGALAALREREISG-RGQMVDSAIYEAVLGVMESLVPEWTVSGYQR
Mb1897|M.bovis_AF2122/97 RVGALLALAALIHRDRTG-GGAHVHISQAEVVVNQLDTMFVAEAARATDV
Rv1866|M.tuberculosis_H37Rv RVGALLALAALIHRDRTG-GGAHVHISQAEVVVNQLDTMFVAEAARATDV
. .: ** . * * :.
Mvan_1979|M.vanbaalenii_PYR-1 PRMGNRGTSVAPCDLYRTRDDGWVLLQVAGPPMFKRWCRLVGRPELFDDP
Mflv_4365|M.gilvum_PYR-GCK PRMGNQGTSVAPCDLYRTSDDGWVLLQIAGPSMFRRWCRLVGRPELFDDP
MAV_0341|M.avium_104 ERSGNRWDISAPRNTYQTADGRWLAMSGSSPALALRVFRAIGRDDLLGDP
MSMEG_6294|M.smegmatis_MC2_155 TRQGSRTGFNVPRECYRTRDGRWIALSGATTATAQRIMRAVGRPDLADAE
MMAR_1494|M.marinum_M GPSGTRLEGIAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPELATDD
MUL_2446|M.ulcerans_Agy99 GPSGTRLKGIAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPELATDD
MAB_4651c|M.abscessus_ATCC_199 GPSGTRLEGIAPSNIYQSADGSWVVIAANQDTVFRRLCEAMGRPELSSDA
TH_3339|M.thermoresistible__bu ERTGAILPKIAPSNVYPTSDDTWILIAANQDTVFRRLAEAMGRPELAEDE
Mb1897|M.bovis_AF2122/97 AEIHP--DTSVHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPELANDP
Rv1866|M.tuberculosis_H37Rv AEIHP--DTSVHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPELANDP
. : * * : * .* :*
Mvan_1979|M.vanbaalenii_PYR-1 RFANDDLRWQHGDVLNDIMAQWCADKTKAEVLERLEAAKLPAAPMHSTQE
Mflv_4365|M.gilvum_PYR-GCK RFADDDLRWQHGEELNGIMAQWCADKTKAEVLELLEAAKLPAAPMHSTQE
MAV_0341|M.avium_104 DFSDPQRRLARAREVDTLVADWVAGKTLSEAMAVFEAHEVAAAPVYDISD
MSMEG_6294|M.smegmatis_MC2_155 WFSDISGRIEHRETIDEAIASWVGQRDNADVLAMFESVGATAGPVYTAAD
MMAR_1494|M.marinum_M RFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAE
MUL_2446|M.ulcerans_Agy99 RFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAE
MAB_4651c|M.abscessus_ATCC_199 RFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVAD
TH_3339|M.thermoresistible__bu RYATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYRPKE
Mb1897|M.bovis_AF2122/97 RFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMNRPSD
Rv1866|M.tuberculosis_H37Rv RFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMNRPSD
:. * . : :. : : : : .. : :
Mvan_1979|M.vanbaalenii_PYR-1 VLDDPHVQAMGFLQRVPFPGAPRDVPIIETPFRMSATPGQIRRRAPL-LG
Mflv_4365|M.gilvum_PYR-GCK VLEDPHVQAMGYLKRVPFPGTPKDVPLIETPFRLSATPGEIRRRAPL-LG
MAV_0341|M.avium_104 LVADEQLAHRGVFVSVDDQQLG-PMTVQAPVPRFSSASGTVEHLGPR-LG
MSMEG_6294|M.smegmatis_MC2_155 IVADPHFTERGSIVTVDHPTLG-AVRMQGLIAQLSRTPGQIRHPGPA-VG
MMAR_1494|M.marinum_M VVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPG
MUL_2446|M.ulcerans_Agy99 VVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPG
MAB_4651c|M.abscessus_ATCC_199 VVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPG
TH_3339|M.thermoresistible__bu MLADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGPG-LG
Mb1897|M.bovis_AF2122/97 ILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAPL-PG
Rv1866|M.tuberculosis_H37Rv ILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAPL-PG
:: * :. : : : . .* *
Mvan_1979|M.vanbaalenii_PYR-1 EHTDEILG-EIGYTGDQVARLRDRQVI--------------
Mflv_4365|M.gilvum_PYR-GCK EHTDEILE-EIGYSSEAVVGLRDRGVV--------------
MAV_0341|M.avium_104 EHNAEVYGELLGLTPDEIDQLRARGVV--------------
MSMEG_6294|M.smegmatis_MC2_155 EHNDEILRTELAYPDDVVDALAEAGVIGRTLQPTSTKRVSS
MMAR_1494|M.marinum_M QHNDDVYIGLLGKSIEELEQLRAEEVL--------------
MUL_2446|M.ulcerans_Agy99 QHNDDVYIGLLGKSIEELEQLRAVEVL--------------
MAB_4651c|M.abscessus_ATCC_199 QDNDDVYVGLLGKSAQDIERLRAEGVL--------------
TH_3339|M.thermoresistible__bu EHTDEVLR-QLGLSDEELQKLHDAGVV--------------
Mb1897|M.bovis_AF2122/97 QDSVQICRKLLGMTADETERLINERVMFGPAVTA-------
Rv1866|M.tuberculosis_H37Rv QDSVQICRKLLGMTADETERLINERVMFGPAVTA-------
:.. :: :. . : * *: