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VTASQSAGPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGDFARAYDDVVNGPGGLAAHFVWS NRGKESVTLNTKSPAGLEVLHRLLDRADAFVSNLAPGATARLGLSPADLAERHPQVIPVEIDGYGPGGPI SHKRAYDLLVQAESGSCAVTGYPGMPAKPGPAVADFTSGLYAAMSIVSLLYGRATRPEPGPAPHVELSLF DVMTDVMGYALTYTQHSGIDQEPLGVGSPAVAPYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLAD DPRFATNPGRCANRDVLEEAIGAWCARHDLAEIQDKADRAGIGNSRYNLPSEVIAHPHLVARDRWRTVAT PKGDIQALRPPPVISDFEQPMGAIPGLGEHTDAVLTEFGVSAEELAQLRAEGAIGPAYRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2443 | - | - | 100% (410) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_4465 | - | 5e-46 | 30.60% (415) | Formyl-CoA transferase |
| M. gilvum PYR-GCK | Mflv_5186 | - | 5e-43 | 34.68% (395) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 8e-36 | 30.05% (396) | hypothetical protein Mb3300 |
| M. tuberculosis H37Rv | Rv3272 | - | 6e-36 | 30.05% (396) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 5e-42 | 29.48% (407) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 9e-42 | 31.30% (409) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_2651 | - | 3e-92 | 45.48% (387) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_4834 | - | 0.0 | 78.41% (403) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_2496 | - | 1e-179 | 75.43% (403) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_2446 | - | 8e-41 | 30.88% (408) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_4208 | - | 0.0 | 89.05% (411) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2443|M.gilvum_PYR-GCK MTASQ--SAGPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGD
Mvan_4208|M.vanbaalenii_PYR-1 MSSSQP-SAAPLAGVTVVAMEQAVAAPMCTRVLADFGARIIKVENPNGGD
MSMEG_4834|M.smegmatis_MC2_155 MPKDTPEKSGPLAGFTVVALEQAVSAPMCTRVLADFGARVIKVENPKGGD
TH_2496|M.thermoresistible__bu MAESEHADPAPLAGITVVALEQAVSAPMCTRVLADFGARVIKVENPDGGD
MAV_2651|M.avium_104 -----------------MSLEQAVAAPYATRQLADLGARVIKVERPQGGD
Mb3300|M.bovis_AF2122/97 --MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGE
Rv3272|M.tuberculosis_H37Rv --MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGE
MMAR_1494|M.marinum_M -----MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEAP-GAP
MUL_2446|M.ulcerans_Agy99 -----MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEAP-GAP
MAB_4651c|M.abscessus_ATCC_199 -------MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPP-GAP
: : ::.* . : * *:** ::*:* * *.
Mflv_2443|M.gilvum_PYR-GCK FARAYDDVVNGPGGLAAHFVWSNRGKESVTLNTKSPAGLEVLHRLLDRAD
Mvan_4208|M.vanbaalenii_PYR-1 FARDYDDVVNGPGGLAAHFVWSNRGKESVTLNTKTAGGLDLLHRLLDRAD
MSMEG_4834|M.smegmatis_MC2_155 FARDYDDVVLGPGGLAAHFVWANRGKESITLDLKTPGGMDVLHKLLDTAD
TH_2496|M.thermoresistible__bu FARHYDDVVKG---QAAHFVWANRGKESVTLNLKSEAGMAVLHRLLDEAD
MAV_2651|M.avium_104 FARGYDRTVHG---ESSYFVWLNRGKESLTVDLKQPEGRRIVERLLEGAD
Mb3300|M.bovis_AF2122/97 AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
Rv3272|M.tuberculosis_H37Rv AARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
MMAR_1494|M.marinum_M DPLRTWGQAEVDG-HHVFWTVHARNKRAITLDLRRPQGRELFLELVDKSD
MUL_2446|M.ulcerans_Agy99 DPLRTWGQAEVDG-HHVFWTVHARNKRAITLDLRRPQGRELFLELVDKSD
MAB_4651c|M.abscessus_ATCC_199 DPLRTWGQAEVDG-HHVFWTVHARNKKAITLDLRTEAGRALFLDLVDKSD
. .: *.*.::*:: . . * : :*
Mflv_2443|M.gilvum_PYR-GCK AFVSNLAPGATARLGLSPADLAERHPQVIPVEIDGYGPGGPISHKRAYDL
Mvan_4208|M.vanbaalenii_PYR-1 AFVSNLAPGATARLGVAPADLAARHPRVIPVEIDGYGPGGPLSHKRAYDL
MSMEG_4834|M.smegmatis_MC2_155 ALVSNLAPGAMARMGLAPADLAERHPQVIPVEIDGYGSGGPLSHKRAYDL
TH_2496|M.thermoresistible__bu VLVSNLAPGALARMGLAADDLKTSHPRVLPVQIDGYGAGGPISHKRAYDL
MAV_2651|M.avium_104 VLVQNLAPGAAARMGLDTESVARAHPRTITATISGYGQDGPWRDRKAYDL
Mb3300|M.bovis_AF2122/97 VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
Rv3272|M.tuberculosis_H37Rv VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
MMAR_1494|M.marinum_M IVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKAGYAS
MUL_2446|M.ulcerans_Agy99 IVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKAGYAS
MAB_4651c|M.abscessus_ATCC_199 VIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYAS
.:. : **: : .: : : : . : .** ** : .
Mflv_2443|M.gilvum_PYR-GCK LVQAESGSCAVTGYP-GMPAKPGPAVADFTSGLYAAMSIVSLLYGRATR-
Mvan_4208|M.vanbaalenii_PYR-1 LVQAESGSCAVTGYP-GMPAKPGPAVADFSTGLYAAISILALLYGRARH-
MSMEG_4834|M.smegmatis_MC2_155 LVQAESGACAVTGHP-DMPAKPGPPVADISTGLYAALSIMALLIGRLRR-
TH_2496|M.thermoresistible__bu LIQAESGACAVTGYP-GMPAKPGPPVADISTGLYAALSVMALLYGRDRRD
MAV_2651|M.avium_104 LVQAEAGLLSVTGSP-AEVARTGVSIADIAAGMFAFSGILTALYTRATT-
Mb3300|M.bovis_AF2122/97 VVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERN-
Rv3272|M.tuberculosis_H37Rv VVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERN-
MMAR_1494|M.marinum_M VAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGAQGALAALYRRSVT-
MUL_2446|M.ulcerans_Agy99 VAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGPQGALAALYRRSVT-
MAB_4651c|M.abscessus_ATCC_199 VAEAASGLRHLNGFPGGPPPRMALSIGDTLAGMFAAQGALAALYRRTVT-
: * :* * : * :* . :: * *
Mflv_2443|M.gilvum_PYR-GCK -PEPGPAPHVELSLFDVMTDVMGYALTYTQHSGIDQ------EPLGVGSP
Mvan_4208|M.vanbaalenii_PYR-1 -PGSAPAPSVELSLFDVMTDVMGYALTYTQHSGIDQ------EPLGVGSP
MSMEG_4834|M.smegmatis_MC2_155 -PENGAAPAVAVSLFDTMTDIMGYPLTYTQHSGVDQ------QPLGMSSP
TH_2496|M.thermoresistible__bu RATPGPVPAVAVSLFDTMTDIMGYQLTYTQHSGVDQ------QPLGMSSP
MAV_2651|M.avium_104 ----GAVRPVSVSLFDALVEWMSQPLYYGRYGGKAP------PRTGARHP
Mb3300|M.bovis_AF2122/97 ----GVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRK
Rv3272|M.tuberculosis_H37Rv ----GVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRK
MMAR_1494|M.marinum_M ----GTGQVVDVALTESCLALQESTISDYDVGGVVR------GPSGTRLE
MUL_2446|M.ulcerans_Agy99 ----GTGQVVDVALTESCLALQESTISDYDVGGVVR------GPSGTRLK
MAB_4651c|M.abscessus_ATCC_199 ----GRGQVVDAALTESCLAVQESTIPDYDVGRVVR------GPSGTRLE
. * :: : : .
Mflv_2443|M.gilvum_PYR-GCK AV----APYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLADDPRFA
Mvan_4208|M.vanbaalenii_PYR-1 AV----APYGAFPTRDGQTVVLGTTNDREWQRVAREIIDRPDLADDPRFA
MSMEG_4834|M.smegmatis_MC2_155 AV----APYGAFSTRDGQTVVLGTTNDREWQRLAREIIDRPDLADDPRFA
TH_2496|M.thermoresistible__bu AV----APYGAFRTRDGQTVVLGTTNDREWQRLARDIIERPDLADDPAYA
MAV_2651|M.avium_104 TI----APYGPVTAGDGGTVLLGVQNSAEWLRFCEIVLERRDLVDEPRFA
Mb3300|M.bovis_AF2122/97 GVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIG-RPDLVEDQRFA
Rv3272|M.tuberculosis_H37Rv GVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIG-RPDLVEDQRFA
MMAR_1494|M.marinum_M GI----APSNIYRSADESWVVIAANQDTVFTRLCQAMG-CPELATDDRFA
MUL_2446|M.ulcerans_Agy99 GI----APSNIYRSADESWVVIAANQDTVFTRLCQAMG-CPELATDDRFA
MAB_4651c|M.abscessus_ATCC_199 GI----APSNIYQSADGSWVVIAANQDTVFRRLCEAMG-RPELSSDARFA
: * . : * :::.. : :.. : :* : :*
Mflv_2443|M.gilvum_PYR-GCK TNPGRCANRDVLEEAIGAWCARHDLAEIQDKADRAGIGNSRYNLPSEVIA
Mvan_4208|M.vanbaalenii_PYR-1 TNSDRCAHRQILEEAIGSWCAQHDLAEIQKTADAAGIGNSRYNLPSEVVV
MSMEG_4834|M.smegmatis_MC2_155 TNSDRCAHRDVLNEAIGTWCAQHDLAEIQQIADEAGIGNSRFNRPSEVIA
TH_2496|M.thermoresistible__bu TNSDRVRHRDVLNEAIAAWCARHDLAHIQKTADDAGIGNSRYNLPSEVVA
MAV_2651|M.avium_104 TNPDRVAHRDELESIITTVAARLSAEELEARLQSAGVAHARMNGVDHLWL
Mb3300|M.bovis_AF2122/97 EQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVD
Rv3272|M.tuberculosis_H37Rv EQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVD
MMAR_1494|M.marinum_M THRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVK
MUL_2446|M.ulcerans_Agy99 THRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVK
MAB_4651c|M.abscessus_ATCC_199 NHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVVQ
: * : * : * . . *: : .:
Mflv_2443|M.gilvum_PYR-GCK HPHLVARDRWRTVATPKGDIQALRP---PPVISDFEQPMGAIPG-LGEHT
Mvan_4208|M.vanbaalenii_PYR-1 HPHLAARDRWRTVATPKGDIQALRP---PPVISDFEQPMGAIPG-LGEHT
MSMEG_4834|M.smegmatis_MC2_155 HQHLKDRDRWRQVATPKGEIAALLP---PPVIAGYEMPMGAVPG-LGEHT
TH_2496|M.thermoresistible__bu HPHLSARDRWRPVDTPNGQITALRP---PPVIEGFEQPMGPVPG-LGQHT
MAV_2651|M.avium_104 HPVLVGRDRWHEIQTPGGPAAALPP---PAGLAGVDPVIGDVPA-LGEHS
Mb3300|M.bovis_AF2122/97 TPLFAESDLTLEVGRGADTITVIR---TPARYASFRAVVTDPPPTAGEHN
Rv3272|M.tuberculosis_H37Rv TPLFAENDLTLEVGRGADTITVIR---TPARYASFRAVVTDPPPTAGEHN
MMAR_1494|M.marinum_M DRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHN
MUL_2446|M.ulcerans_Agy99 DRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHN
MAB_4651c|M.abscessus_ATCC_199 DPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQDN
: .: * . * *:..
Mflv_2443|M.gilvum_PYR-GCK DAVLTE-FGVSAEELAQLRAEGAIGPAYRG-------
Mvan_4208|M.vanbaalenii_PYR-1 DAVLTE-IGVTPDELRQLRADGAIGPAYRG-------
MSMEG_4834|M.smegmatis_MC2_155 DHILAD-IGLSAEEIASLREQGAVGPAMQTRSEQSHA
TH_2496|M.thermoresistible__bu DAVLSGLLGMTDDEIAALREQGAIGPAYN--------
MAV_2651|M.avium_104 RKILHE-LGYSAQATDELIAAGVTTA-----------
Mb3300|M.bovis_AF2122/97 -AVFLARP-----------------------------
Rv3272|M.tuberculosis_H37Rv -AVFLARP-----------------------------
MMAR_1494|M.marinum_M DDVYIGLLGKSIEELEQLRAEEVL-------------
MUL_2446|M.ulcerans_Agy99 DDVYIGLLGKSIEELEQLRAVEVL-------------
MAB_4651c|M.abscessus_ATCC_199 DDVYVGLLGKSAQDIERLRAEGVL-------------
: