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MRVGFIGLGSQGGPMARRIAEGGFETTLWARRPASLEPYADTPAKTAATPAELGANSDLVCLCVVGDDDV REVLYGESGVLAGLAEGGIIAIHSTVHPDTCREIAEKSAAQGISVIDAPVSGGGPAVEQGTLLVMVGGDE EVAQRCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGAAVSTLELGESLGIPRQKLVEVLNRGSA TSKAVASISMFGGTLEGLAPIAGALLQKDVRHAASLAASAEAAEGAVFTAADAALEAMDHRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4173 | - | - | 100% (272) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_5155 | - | 3e-36 | 37.45% (259) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4174 | - | 3e-36 | 33.20% (256) | 6-phosphogluconate dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 1e-33 | 33.62% (229) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2481 | - | 1e-142 | 92.65% (272) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 2e-34 | 34.06% (229) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02065 | gnd | 6e-05 | 25.32% (237) | 6-phosphogluconate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1220 | - | 3e-30 | 35.93% (231) | dehydrogenase/reductase |
| M. marinum M | MMAR_4926 | - | 9e-36 | 36.33% (245) | dehydrogenase/reductase |
| M. avium 104 | MAV_0917 | - | 6e-96 | 63.60% (272) | 6-phosphogluconate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4816 | - | 1e-116 | 77.70% (269) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 1e-130 | 83.82% (272) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 7e-24 | 29.24% (277) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0793|M.bovis_AF2122/97 ---MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFV
Rv0770|M.tuberculosis_H37Rv ---MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFV
MMAR_4926|M.marinum_M ---MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTPLA
MAB_1220|M.abscessus_ATCC_1997 ---MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAPLV
Mvan_4173|M.vanbaalenii_PYR-1 ----------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRPASLEPYA
Mflv_2481|M.gilvum_PYR-GCK ----------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRQASLEPYS
TH_2512|M.thermoresistible__bu ----------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFA
MSMEG_4816|M.smegmatis_MC2_155 ----------MRVGFIGLGSQGAPMARRIVEGGFETTLWARRPASLEPFA
MAV_0917|M.avium_104 ----------MRVGFIGLGSQGGPMARRIVEGGYPTTLWARRPATLEVFA
MUL_0835|M.ulcerans_Agy99 ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATA
MLBr_02065|M.leprae_Br4923 MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLL
::. **. *. :: .:
Mb0793|M.bovis_AF2122/97 EGGAT-----AAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAK
Rv0770|M.tuberculosis_H37Rv EGGAT-----AAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAK
MMAR_4926|M.marinum_M EAGAS-----AAASVAEVAGA-DIISVTVLNDAQVREVITGANGLAAHAR
MAB_1220|M.abscessus_ATCC_1997 EEGAV-----GASDVADIADA-DLISVTVLDDAQVRQVVG---QVAPKAK
Mvan_4173|M.vanbaalenii_PYR-1 DTPAK-----TAATPAELGANSDLVCLCVVGDDDVREVLYGESGVLAGLA
Mflv_2481|M.gilvum_PYR-GCK DTPAK-----TASTPAELGAASDLVCLCVVGDDDVREVLYGEQGVLAGLA
TH_2512|M.thermoresistible__bu DTPAK-----TAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLA
MSMEG_4816|M.smegmatis_MC2_155 DTAAK-----VAGTPAELAAASDLVCLCVVGDDDVREVLDGETGVLAGLA
MAV_0917|M.avium_104 DTDAK-----VAGSPAELAAASDLVCLCVIGDADIDELTDGEHGLLSAMQ
MUL_0835|M.ulcerans_Agy99 AKGAT-----MFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLPAAR
MLBr_02065|M.leprae_Br4923 KEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVINELADVME
. .: : : :
Mb0793|M.bovis_AF2122/97 PGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVM
Rv0770|M.tuberculosis_H37Rv PGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVM
MMAR_4926|M.marinum_M AGTIIAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATM
MAB_1220|M.abscessus_ATCC_1997 PGTIIAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATM
Mvan_4173|M.vanbaalenii_PYR-1 EGGIIAIHSTVHPDTCREIAEKSAAQGISVIDAPVSGGGPAVEQGTLLVM
Mflv_2481|M.gilvum_PYR-GCK EGGIIAIHSTVHPQTCQEIAEKGAAQGVSVIDAPVSGGGPAVEQGTLLVM
TH_2512|M.thermoresistible__bu PGGVVAIHSTVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVM
MSMEG_4816|M.smegmatis_MC2_155 PGGIIAIHSTVHPDTCTEIAEQVAEKGISLIDAPVSGGEPAAKAGTLLVM
MAV_0917|M.avium_104 PGGVIAVHSTVHPDTCRKLAKRAAALGVSVVDAPVSGGGGAAAEGRLLVM
MUL_0835|M.ulcerans_Agy99 SGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFM
MLBr_02065|M.leprae_Br4923 PSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNG-PSIM
. :. .. : :.* *** .. * *
Mb0793|M.bovis_AF2122/97 VGADDEAFQRIKEPFSRWASLLI------HAGEPGAGTRMKLARNMLTFV
Rv0770|M.tuberculosis_H37Rv VGADDEAFQRIKEPFSRWASLLI------HAGEPGAGTRMKLARNMLTFV
MMAR_4926|M.marinum_M VGAGDDVFARVKEPFSCWASLVV------HAGPPGAGTRMKLARNMLTFT
MAB_1220|M.abscessus_ATCC_1997 VGADGETFARVKEAFSKWASLVI------HAGAPGAGTRMKLARNLLHFV
Mvan_4173|M.vanbaalenii_PYR-1 VGGDEEVAQRCRPVFATYADPIV------HLGPLGSGQNTKILNNLLFSA
Mflv_2481|M.gilvum_PYR-GCK VGGDEEVAERCRPVFATYADPIV------HLGPLGSGQNTKILNNLLFSA
TH_2512|M.thermoresistible__bu VGGDEEVVERCRPVFASYADPIV------HLGPLGSGQVTKILNNLLFTA
MSMEG_4816|M.smegmatis_MC2_155 AGGDEDIVDKVRPVFATYADPVV------RLGGVGSGQVAKILNNLLFSA
MAV_0917|M.avium_104 AGGDADVVERCRPVFETYADPVV------HLGELGSGQTTKLLNNLLFTA
MUL_0835|M.ulcerans_Agy99 VGGDQSALAQARPVLEPMAGKII------HCGAAGAGQAAKVCNNMVLAV
MLBr_02065|M.leprae_Br4923 PGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGIEYS
*. . : : : : * *:* *: .* :
Mb0793|M.bovis_AF2122/97 SYAAAAEAQRLA-EACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPME
Rv0770|M.tuberculosis_H37Rv SYAAAAEAQRLA-EACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPME
MMAR_4926|M.marinum_M IYAAVGEAWKLA-EASGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLE
MAB_1220|M.abscessus_ATCC_1997 AFTAAGEAQRLA-ESCGLDITDLGKVVRHTDAITGGPGAIMLRDTTEPVT
Mvan_4173|M.vanbaalenii_PYR-1 NLGAAVSTLELG-ESLGIPRQKLVEVLNRGSATSKAVASISMFGGTLEGL
Mflv_2481|M.gilvum_PYR-GCK NLGSAVSTLELG-ESLGIPRAKLVEVLSKGSATSKAVSSISMFGGTLDGL
TH_2512|M.thermoresistible__bu NLGSALSTLELG-ESLGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGL
MSMEG_4816|M.smegmatis_MC2_155 NLGAAMSALELG-EALGVPRSALCEVITRGSANSKALGSIAMFGGTLDNL
MAV_0917|M.avium_104 NLATAATALSLA-EQLGVRPERLTEVVSRSSGNSFALNALGGIGG-LDQL
MUL_0835|M.ulcerans_Agy99 QQIAIGEAFVLA-ENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTS
MLBr_02065|M.leprae_Br4923 DMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAEVLRQT
: * : *: : .*.
Mb0793|M.bovis_AF2122/97 PADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGV
Rv0770|M.tuberculosis_H37Rv PADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGV
MMAR_4926|M.marinum_M PGHFLYDGFVHARDLGEKDLGLALALGEALSVDLPLARLALERLAPGLGV
MAB_1220|M.abscessus_ATCC_1997 PDSFWLPIFTHVRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASLGV
Mvan_4173|M.vanbaalenii_PYR-1 AP--------IAGALLQKDVRHAASLAASAEAAEGAVFTAADAALEAMDH
Mflv_2481|M.gilvum_PYR-GCK AP--------IAGGLLQKDVRHAASLAAAAKAPEGAVFTAADAALEAMDH
TH_2512|M.thermoresistible__bu AP--------IAGALLQKDVRHAANIAASASVPEGTVFTVADTALTAMGH
MSMEG_4816|M.smegmatis_MC2_155 AP--------IAGALLQKDCRHAASLADAASASQGAVFGAADEALRLMNV
MAV_0917|M.avium_104 AG--------VAGALLRKDVRLVVDLAEQAGAAGGAVLDAADAALALMGH
MUL_0835|M.ulcerans_Agy99 PANNDFKPG-FATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATD
MLBr_02065|M.leprae_Br4923 DIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARALSG
.:. .
Mb0793|M.bovis_AF2122/97 PHPDTEPAKET---------------------------------------
Rv0770|M.tuberculosis_H37Rv PHPDTEPAKET---------------------------------------
MMAR_4926|M.marinum_M PHTQKDA-------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 PHEEGASNG-----------------------------------------
Mvan_4173|M.vanbaalenii_PYR-1 RR------------------------------------------------
Mflv_2481|M.gilvum_PYR-GCK RR------------------------------------------------
TH_2512|M.thermoresistible__bu ARR-----------------------------------------------
MSMEG_4816|M.smegmatis_MC2_155 PR------------------------------------------------
MAV_0917|M.avium_104 PR------------------------------------------------
MUL_0835|M.ulcerans_Agy99 HADQDFSAVIEMLRGS----------------------------------
MLBr_02065|M.leprae_Br4923 SVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFNHIQ
Mb0793|M.bovis_AF2122/97 --------------------------------------------------
Rv0770|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4926|M.marinum_M --------------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2481|M.gilvum_PYR-GCK --------------------------------------------------
TH_2512|M.thermoresistible__bu --------------------------------------------------
MSMEG_4816|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0917|M.avium_104 --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 TGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLIVAP
Mb0793|M.bovis_AF2122/97 --------------------------------------------------
Rv0770|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4926|M.marinum_M --------------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4173|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2481|M.gilvum_PYR-GCK --------------------------------------------------
TH_2512|M.thermoresistible__bu --------------------------------------------------
MSMEG_4816|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0917|M.avium_104 --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 YFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPAALT
Mb0793|M.bovis_AF2122/97 ----------------------------------
Rv0770|M.tuberculosis_H37Rv ----------------------------------
MMAR_4926|M.marinum_M ----------------------------------
MAB_1220|M.abscessus_ATCC_1997 ----------------------------------
Mvan_4173|M.vanbaalenii_PYR-1 ----------------------------------
Mflv_2481|M.gilvum_PYR-GCK ----------------------------------
TH_2512|M.thermoresistible__bu ----------------------------------
MSMEG_4816|M.smegmatis_MC2_155 ----------------------------------
MAV_0917|M.avium_104 ----------------------------------
MUL_0835|M.ulcerans_Agy99 ----------------------------------
MLBr_02065|M.leprae_Br4923 QAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV