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M. gilvum PYR-GCK Mflv_2481 (-)

annotation: 6-phosphogluconate dehydrogenase, NAD-binding
coordinates: 2581435 - 2582253
length: 272

RVGFIGLGSQGGPMARRIAEGGFETTLWARRQASLEPYSDTPAKTASTPAELGAASDLVCLCVVGDDDVR
EVLYGEQGVLAGLAEGGIIAIHSTVHPQTCQEIAEKGAAQGVSVIDAPVSGGGPAVEQGTLLVMVGGDEE
VAERCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGSAVSTLELGESLGIPRAKLVEVLSKGSAT
SKAVSSISMFGGTLDGLAPIAGGLLQKDVRHAASLAAAAKAPEGAVFTAADAALEAMDHRR*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_2481 - - 100% (272) 6-phosphogluconate dehydrogenase, NAD-binding
M. gilvum PYR-GCK Mflv_2480 - 1e-38 34.87% (238) 6-phosphogluconate dehydrogenase, NAD-binding
M. gilvum PYR-GCK Mflv_1602 - 1e-34 35.55% (256) 6-phosphogluconate dehydrogenase, NAD-binding

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0793 - 4e-32 31.89% (254) dehydrogenase/reductase
M. tuberculosis H37Rv Rv0770 - 7e-33 32.28% (254) dehydrogenase/reductase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_1220 - 2e-29 35.06% (231) dehydrogenase/reductase
M. marinum M MMAR_4926 - 3e-33 34.29% (245) dehydrogenase/reductase
M. avium 104 MAV_0917 - 5e-94 62.87% (272) 6-phosphogluconate dehydrogenase
M. smegmatis MC2 155 MSMEG_4816 - 1e-114 76.21% (269) 6-phosphogluconate dehydrogenase, NAD-binding
M. thermoresistible (build 8) TH_2512 - 1e-129 83.09% (272) PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding
M. ulcerans Agy99 MUL_0835 mmsB 3e-21 28.06% (278) 3-hydroxyisobutyrate dehydrogenase, MmsB
M. vanbaalenii PYR-1 Mvan_4173 - 1e-142 92.65% (272) 6-phosphogluconate dehydrogenase, NAD-binding

CLUSTAL 2.0.9 multiple sequence alignment


Mb0793|M.bovis_AF2122/97            MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
Rv0770|M.tuberculosis_H37Rv         MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGG
MMAR_4926|M.marinum_M               MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTPLAEAG
MAB_1220|M.abscessus_ATCC_1997      MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAPLVEEG
Mflv_2481|M.gilvum_PYR-GCK          -------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRQASLEPYSDTP
Mvan_4173|M.vanbaalenii_PYR-1       -------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRPASLEPYADTP
TH_2512|M.thermoresistible__bu      -------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTP
MSMEG_4816|M.smegmatis_MC2_155      -------MRVGFIGLGSQGAPMARRIVEGGFETTLWARRPASLEPFADTA
MAV_0917|M.avium_104                -------MRVGFIGLGSQGGPMARRIVEGGYPTTLWARRPATLEVFADTD
MUL_0835|M.ulcerans_Agy99           ---MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKG
                                            ::.::***  *.**: .:         :     :        

Mb0793|M.bovis_AF2122/97            ATAAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
Rv0770|M.tuberculosis_H37Rv         ATAAASVSDVAEA-DIISITVFDDAQVSSVITADNGLATHAKPGTIVAIH
MMAR_4926|M.marinum_M               ASAAASVAEVAGA-DIISVTVLNDAQVREVITGANGLAAHARAGTIIAIH
MAB_1220|M.abscessus_ATCC_1997      AVGASDVADIADA-DLISVTVLDDAQVRQVVG---QVAPKAKPGTIIAIH
Mflv_2481|M.gilvum_PYR-GCK          AKTASTPAELGAASDLVCLCVVGDDDVREVLYGEQGVLAGLAEGGIIAIH
Mvan_4173|M.vanbaalenii_PYR-1       AKTAATPAELGANSDLVCLCVVGDDDVREVLYGESGVLAGLAEGGIIAIH
TH_2512|M.thermoresistible__bu      AKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIH
MSMEG_4816|M.smegmatis_MC2_155      AKVAGTPAELAAASDLVCLCVVGDDDVREVLDGETGVLAGLAPGGIIAIH
MAV_0917|M.avium_104                AKVAGSPAELAAASDLVCLCVIGDADIDELTDGEHGLLSAMQPGGVIAVH
MUL_0835|M.ulcerans_Agy99           ATMFDSAAEAVARADVVITMLPNGAVVKRCYA---EVLPAARSGALFIDS
                                    *      ::     *::   : ..  :         : .    * :.   

Mb0793|M.bovis_AF2122/97            STIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGADDEAF
Rv0770|M.tuberculosis_H37Rv         STIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAF
MMAR_4926|M.marinum_M               STISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAGDDVF
MAB_1220|M.abscessus_ATCC_1997      STISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATMVGADGETF
Mflv_2481|M.gilvum_PYR-GCK          STVHPQTCQEIAEKGAAQGVSVIDAPVSGGGPAVEQGTLLVMVGGDEEVA
Mvan_4173|M.vanbaalenii_PYR-1       STVHPDTCREIAEKSAAQGISVIDAPVSGGGPAVEQGTLLVMVGGDEEVA
TH_2512|M.thermoresistible__bu      STVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVV
MSMEG_4816|M.smegmatis_MC2_155      STVHPDTCTEIAEQVAEKGISLIDAPVSGGEPAAKAGTLLVMAGGDEDIV
MAV_0917|M.avium_104                STVHPDTCRKLAKRAAALGVSVVDAPVSGGGGAAAEGRLLVMAGGDADVV
MUL_0835|M.ulcerans_Agy99           STISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSAL
                                    **:    . .:        :  :*** ***  ..  * *  *.*.. .  

Mb0793|M.bovis_AF2122/97            QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
Rv0770|M.tuberculosis_H37Rv         QRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEA
MMAR_4926|M.marinum_M               ARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWKLAEA
MAB_1220|M.abscessus_ATCC_1997      ARVKEAFSKWASLVIHAGAPGAGTRMKLARNLLHFVAFTAAGEAQRLAES
Mflv_2481|M.gilvum_PYR-GCK          ERCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGSAVSTLELGES
Mvan_4173|M.vanbaalenii_PYR-1       QRCRPVFATYADPIVHLGPLGSGQNTKILNNLLFSANLGAAVSTLELGES
TH_2512|M.thermoresistible__bu      ERCRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGES
MSMEG_4816|M.smegmatis_MC2_155      DKVRPVFATYADPVVRLGGVGSGQVAKILNNLLFSANLGAAMSALELGEA
MAV_0917|M.avium_104                ERCRPVFETYADPVVHLGELGSGQTTKLLNNLLFTANLATAATALSLAEQ
MUL_0835|M.ulcerans_Agy99           AQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAEN
                                     : :  :   *. ::: *  *:*   *: .*::  .   :   :  *.* 

Mb0793|M.bovis_AF2122/97            CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
Rv0770|M.tuberculosis_H37Rv         CGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGL
MMAR_4926|M.marinum_M               SGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVHARDL
MAB_1220|M.abscessus_ATCC_1997      CGLDITDLGKVVRHTDAITGGPGAIMLRDTTEPVTPDSFWLPIFTHVRGL
Mflv_2481|M.gilvum_PYR-GCK          LGIPRAKLVEVLSKGSATSKAVSSISMFGGTLDGLAP--------IAGGL
Mvan_4173|M.vanbaalenii_PYR-1       LGIPRQKLVEVLNRGSATSKAVASISMFGGTLEGLAP--------IAGAL
TH_2512|M.thermoresistible__bu      LGIPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAP--------IAGAL
MSMEG_4816|M.smegmatis_MC2_155      LGVPRSALCEVITRGSANSKALGSIAMFGGTLDNLAP--------IAGAL
MAV_0917|M.avium_104                LGVRPERLTEVVSRSSGNSFALNALGGIGG-LDQLAG--------VAGAL
MUL_0835|M.ulcerans_Agy99           LGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATAL
                                     *:    * .*:        .  :           .          .  *

Mb0793|M.bovis_AF2122/97            GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
Rv0770|M.tuberculosis_H37Rv         GEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET----
MMAR_4926|M.marinum_M               GEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA--------
MAB_1220|M.abscessus_ATCC_1997      GEKDLSLALALGEEQSVDLPLATLAREQLAASLGVPHEEGASNG------
Mflv_2481|M.gilvum_PYR-GCK          LQKDVRHAASLAAAAKAPEGAVFTAADAALEAMDHRR-------------
Mvan_4173|M.vanbaalenii_PYR-1       LQKDVRHAASLAASAEAAEGAVFTAADAALEAMDHRR-------------
TH_2512|M.thermoresistible__bu      LQKDVRHAANIAASASVPEGTVFTVADTALTAMGHARR------------
MSMEG_4816|M.smegmatis_MC2_155      LQKDCRHAASLADAASASQGAVFGAADEALRLMNVPR-------------
MAV_0917|M.avium_104                LRKDVRLVVDLAEQAGAAGGAVLDAADAALALMGHPR-------------
MUL_0835|M.ulcerans_Agy99           MNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHADQDFSAVIEMLRG
                                     .**   .                . :                       

Mb0793|M.bovis_AF2122/97            -
Rv0770|M.tuberculosis_H37Rv         -
MMAR_4926|M.marinum_M               -
MAB_1220|M.abscessus_ATCC_1997      -
Mflv_2481|M.gilvum_PYR-GCK          -
Mvan_4173|M.vanbaalenii_PYR-1       -
TH_2512|M.thermoresistible__bu      -
MSMEG_4816|M.smegmatis_MC2_155      -
MAV_0917|M.avium_104                -
MUL_0835|M.ulcerans_Agy99           S

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_2481	-	-	100% (272)	6-phosphogluconate dehydrogenase, NAD-binding
M. gilvum PYR-GCK	Mflv_2480	-	1e-38	34.87% (238)	6-phosphogluconate dehydrogenase, NAD-binding
M. gilvum PYR-GCK	Mflv_1602	-	1e-34	35.55% (256)	6-phosphogluconate dehydrogenase, NAD-binding