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MTQQAMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAPLVEEGAVGASDVADIADADLISVTVLD DAQVRQVVGQVAPKAKPGTIIAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATMVGAD GETFARVKEAFSKWASLVIHAGAPGAGTRMKLARNLLHFVAFTAAGEAQRLAESCGLDITDLGKVVRHTD AITGGPGAIMLRDTTEPVTPDSFWLPIFTHVRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASLGVP HEEGASNG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1220 | - | - | 100% (288) | dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_4486 | - | 3e-26 | 32.36% (275) | 3-hydroxyisobutyrate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1186c | - | 8e-23 | 31.88% (276) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 1e-106 | 67.50% (280) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1602 | - | 1e-102 | 66.67% (276) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 1e-107 | 67.86% (280) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02065 | gnd | 2e-06 | 24.29% (177) | 6-phosphogluconate dehydrogenase |
| M. marinum M | MMAR_4926 | - | 1e-100 | 66.43% (280) | dehydrogenase/reductase |
| M. avium 104 | MAV_0715 | - | 1e-108 | 68.44% (282) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5857 | - | 1e-103 | 65.83% (278) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1259 | - | 9e-99 | 64.49% (276) | putative oxidoreductase |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-26 | 32.25% (276) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5155 | - | 1e-101 | 65.22% (276) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0793|M.bovis_AF2122/97 -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
Rv0770|M.tuberculosis_H37Rv -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
MMAR_4926|M.marinum_M -----MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTP
Mflv_1602|M.gilvum_PYR-GCK -----MST--DDLKLGYIGLGNQGAPMAKRLVDWPGGLVVFDVRTEAMTP
Mvan_5155|M.vanbaalenii_PYR-1 -----MSERADELRVGYIGLGNQGAPMAKRLVDWPGGLIVFDVRTEAMTP
MSMEG_5857|M.smegmatis_MC2_155 -----MSG----VKLGYIGLGNQGAPMAKRLADWPGGLTVFDVRAEAMAP
TH_1259|M.thermoresistible__bu -----MSD----LKLGYIGLGNMGAPMAKRLVDWPGGLIVYDVRTEAMTP
MAV_0715|M.avium_104 -MTTNAAHTTEQLKLGYIGLGNMGAPMATRMTEWPGGVTVYDIRIEAMTP
MAB_1220|M.abscessus_ATCC_1997 -----MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAP
MUL_0835|M.ulcerans_Agy99 MTKS--------CQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASA
MLBr_02065|M.leprae_Br4923 --MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDT
::. **. *: :: .: : .: .
Mb0793|M.bovis_AF2122/97 FVEGG---------ATAAASVSDVAEADIISITVFDDAQVSSVITADNGL
Rv0770|M.tuberculosis_H37Rv FVEGG---------ATAAASVSDVAEADIISITVFDDAQVSSVITADNGL
MMAR_4926|M.marinum_M LAEAG---------ASAAASVAEVAGADIISVTVLNDAQVREVITGANGL
Mflv_1602|M.gilvum_PYR-GCK LVELG---------ATLADSVADVAAADVISVTVLNDAQVRDVVA---EL
Mvan_5155|M.vanbaalenii_PYR-1 LVEMG---------ASAADDVAGVSAADVISVTVLNDAQVRDVVG---EL
MSMEG_5857|M.smegmatis_MC2_155 LVELG---------AEAADSVAAVATADVISVTVLNDAQVRDVVG---QL
TH_1259|M.thermoresistible__bu LAEVG---------ANLADSVADVAKADIISVTVLDDEQVRAVVD---EL
MAV_0715|M.avium_104 LAEAG---------ATLADSVADVAAADLIHITVLDDAQVREVVG---EL
MAB_1220|M.abscessus_ATCC_1997 LVEEG---------AVGASDVADIADADLISVTVLDDAQVRQVVG---QV
MUL_0835|M.ulcerans_Agy99 TAAKG---------ATMFDSAAEAVARADVVITMLPNGAVVKRCY--AEV
MLBr_02065|M.leprae_Br4923 LLKEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVIN---EL
: : : : . . :
Mb0793|M.bovis_AF2122/97 ATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKG
Rv0770|M.tuberculosis_H37Rv ATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKG
MMAR_4926|M.marinum_M AAHARAGTIIAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKG
Mflv_1602|M.gilvum_PYR-GCK AAHAEPGTVIAIHSTIEPATAGELAEQLRPKGIHIVDAPVSGGAGAAEKG
Mvan_5155|M.vanbaalenii_PYR-1 AAHAEPGTVIAIHSTIEPDTAPELAEQLRPKGIHIVDAPVSGGAGAADKG
MSMEG_5857|M.smegmatis_MC2_155 AEHAKPGTVVAIHSTIEPGTAPELAEQLRPKGIHIVDAPVSGGAGAADKG
TH_1259|M.thermoresistible__bu AAGAGPGTVIAIHSTIRPETAVELAEQLRPKDIHLVDAPVSGGGGAAEKG
MAV_0715|M.avium_104 AGHAKPGTVIAIHSTISDTTAVELARDLKARDIHIVDAPVSGGAAAAARG
MAB_1220|M.abscessus_ATCC_1997 APKAKPGTIIAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKG
MUL_0835|M.ulcerans_Agy99 LPAARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAG
MLBr_02065|M.leprae_Br4923 ADVMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNG
.. :. .. : . :.: :.* *** .* *
Mb0793|M.bovis_AF2122/97 ELAVMVGADDEAFQRIKEPFSRWAS------LLIHAGEPGAGTRMKLARN
Rv0770|M.tuberculosis_H37Rv ELAVMVGADDEAFQRIKEPFSRWAS------LLIHAGEPGAGTRMKLARN
MMAR_4926|M.marinum_M QLATMVGAGDDVFARVKEPFSCWAS------LVVHAGPPGAGTRMKLARN
Mflv_1602|M.gilvum_PYR-GCK ELAVMVGADEHAYERVKPVFKKWAS------MVVRAGEPGAGTRMKLARN
Mvan_5155|M.vanbaalenii_PYR-1 ELAVMVGADEHAYDRVKPVFKQWAS------MVVRAGEPGAGTRMKLARN
MSMEG_5857|M.smegmatis_MC2_155 ELAVMVGADDDAYAAVKPVFKKWAS------LVVRAGEPGAGTRMKLARN
TH_1259|M.thermoresistible__bu ELAVMVGADRDVYERIKPAFKRFAS------LVVHAGEPGAGTRMKLARN
MAV_0715|M.avium_104 ELATMVGADREVYERIKPAFKHWAA------VVIHAGEPGAGTRMKLARN
MAB_1220|M.abscessus_ATCC_1997 ELATMVGADGETFARVKEAFSKWAS------LVIHAGAPGAGTRMKLARN
MUL_0835|M.ulcerans_Agy99 TLAFMVGGDQSALAQARPVLEPMAG------KIIHCGAAGAGQAAKVCNN
MLBr_02065|M.leprae_Br4923 -PSIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHN
: * *. :. :. : * *:* *: .*
Mb0793|M.bovis_AF2122/97 MLTFVSYAAAAEAQRLA-EACGLDLVALG--------------------K
Rv0770|M.tuberculosis_H37Rv MLTFVSYAAAAEAQRLA-EACGLDLVALG--------------------K
MMAR_4926|M.marinum_M MLTFTIYAAVGEAWKLA-EASGVNLQDLG--------------------N
Mflv_1602|M.gilvum_PYR-GCK MLTFIGFTAACEAMRLA-EASGIDLQKLG--------------------R
Mvan_5155|M.vanbaalenii_PYR-1 MLTFVGFTAACEAMRLA-EAAGIDLQKLG--------------------R
MSMEG_5857|M.smegmatis_MC2_155 MLTFIGFAASCEAMKLA-EAAGIDLQKLG--------------------R
TH_1259|M.thermoresistible__bu MLTFTSYVAACEAMELA-EAAGLSLQALG--------------------R
MAV_0715|M.avium_104 MLTFTSYAAACEAMKLA-EAAGLDLQALG--------------------R
MAB_1220|M.abscessus_ATCC_1997 LLHFVAFTAAGEAQRLA-ESCGLDITDLG--------------------K
MUL_0835|M.ulcerans_Agy99 MVLAVQQIAIGEAFVLA-ENLGLDAQSLF--------------------D
MLBr_02065|M.leprae_Br4923 GIEYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAE
: ** * : *:. :
Mb0793|M.bovis_AF2122/97 VVRHSDSFTGGAGAIMFRNTTAPMEPADPLRP------------------
Rv0770|M.tuberculosis_H37Rv VVRHSDSFTGGAGAIMFRNTTAPMEPADPLRP------------------
MMAR_4926|M.marinum_M VVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYD------------------
Mflv_1602|M.gilvum_PYR-GCK VVRHSDAQSGGPGAIMVRDDMKALTPDHFLHD------------------
Mvan_5155|M.vanbaalenii_PYR-1 VVRHSDAQSGGPGAIMVRDDMLPLAPEHFLYD------------------
MSMEG_5857|M.smegmatis_MC2_155 VVRHSDAQSGGPGAIIVRDDTKPLTPDHWLYD------------------
TH_1259|M.thermoresistible__bu VVRHSDAQSGGPGAIIVREDMRDLEPDHWLYE------------------
MAV_0715|M.avium_104 VVRHTDALTGGPGAIMVRDNMKDLEPDNFLYQ------------------
MAB_1220|M.abscessus_ATCC_1997 VVRHTDAITGGPGAIMLRDTTEPVTPDSFWLP------------------
MUL_0835|M.ulcerans_Agy99 VITGATGNCWAVHTNCPVPGPVPTSPANNDFK------------------
MLBr_02065|M.leprae_Br4923 VLRQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFA
*: : .
Mb0793|M.bovis_AF2122/97 --------LLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLG
Rv0770|M.tuberculosis_H37Rv --------LLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLG
MMAR_4926|M.marinum_M --------GFVHARDLGEKDLGLALALGEALSVDLPLARLALERLAPGLG
Mflv_1602|M.gilvum_PYR-GCK --------MFVHTRGLAEKDLKLALALGDETGVDLPLARIALQDLAAGLG
Mvan_5155|M.vanbaalenii_PYR-1 --------MFVHTRGLGEKDLRLALGLGESTGVELPLAEIALRDLAAGLG
MSMEG_5857|M.smegmatis_MC2_155 --------MFVHTRGLAEKDLTLALGLGESVGVELPLAHIALERLADGLG
TH_1259|M.thermoresistible__bu --------AFTHTRGLGEKDLSLALDLGRQTGVDLPLARIALQNLAAALG
MAV_0715|M.avium_104 --------PFLHTRGLGEKDLSLALALGEAVSVDLPLARLAYEGLAAGLG
MAB_1220|M.abscessus_ATCC_1997 --------IFTHVRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASLG
MUL_0835|M.ulcerans_Agy99 --------PGFAT-ALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAK-FA
MLBr_02065|M.leprae_Br4923 RALSGSVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQG
. * . .* . * . * .
Mb0793|M.bovis_AF2122/97 VPHPDTEPAKET--------------------------------------
Rv0770|M.tuberculosis_H37Rv VPHPDTEPAKET--------------------------------------
MMAR_4926|M.marinum_M VPHTQKDA------------------------------------------
Mflv_1602|M.gilvum_PYR-GCK VPHTKE--------------------------------------------
Mvan_5155|M.vanbaalenii_PYR-1 VPHTTSTTEE----------------------------------------
MSMEG_5857|M.smegmatis_MC2_155 VPHSKEQE------------------------------------------
TH_1259|M.thermoresistible__bu VPHTKE--------------------------------------------
MAV_0715|M.avium_104 VPHKEKEA------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 VPHEEGASNG----------------------------------------
MUL_0835|M.ulcerans_Agy99 TDHADQDFSAVIEMLRGS--------------------------------
MLBr_02065|M.leprae_Br4923 FNHIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLAS
*
Mb0793|M.bovis_AF2122/97 --------------------------------------------------
Rv0770|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4926|M.marinum_M --------------------------------------------------
Mflv_1602|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5155|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5857|M.smegmatis_MC2_155 --------------------------------------------------
TH_1259|M.thermoresistible__bu --------------------------------------------------
MAV_0715|M.avium_104 --------------------------------------------------
MAB_1220|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0835|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02065|M.leprae_Br4923 LIVAPYFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERL
Mb0793|M.bovis_AF2122/97 ---------------------------------------
Rv0770|M.tuberculosis_H37Rv ---------------------------------------
MMAR_4926|M.marinum_M ---------------------------------------
Mflv_1602|M.gilvum_PYR-GCK ---------------------------------------
Mvan_5155|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_5857|M.smegmatis_MC2_155 ---------------------------------------
TH_1259|M.thermoresistible__bu ---------------------------------------
MAV_0715|M.avium_104 ---------------------------------------
MAB_1220|M.abscessus_ATCC_1997 ---------------------------------------
MUL_0835|M.ulcerans_Agy99 ---------------------------------------
MLBr_02065|M.leprae_Br4923 PAALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV