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SERADELRVGYIGLGNQGAPMAKRLVDWPGGLIVFDVRTEAMTPLVEMGASAADDVAGVSAADVISVTVL NDAQVRDVVGELAAHAEPGTVIAIHSTIEPDTAPELAEQLRPKGIHIVDAPVSGGAGAADKGELAVMVGA DEHAYDRVKPVFKQWASMVVRAGEPGAGTRMKLARNMLTFVGFTAACEAMRLAEAAGIDLQKLGRVVRHS DAQSGGPGAIMVRDDMLPLAPEHFLYDMFVHTRGLGEKDLRLALGLGESTGVELPLAEIALRDLAAGLGV PHTTSTTEE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5155 | - | - | 100% (290) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4173 | - | 3e-36 | 37.45% (259) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_1360 | - | 4e-30 | 34.36% (259) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0793 | - | 1e-102 | 65.03% (286) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1602 | - | 1e-142 | 88.89% (279) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0770 | - | 1e-103 | 65.38% (286) | dehydrogenase/reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1220 | - | 1e-101 | 65.22% (276) | dehydrogenase/reductase |
| M. marinum M | MMAR_4926 | - | 1e-103 | 67.74% (279) | dehydrogenase/reductase |
| M. avium 104 | MAV_0715 | - | 1e-113 | 70.14% (278) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5857 | - | 1e-134 | 84.84% (277) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1259 | - | 1e-121 | 76.98% (278) | putative oxidoreductase |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-24 | 31.44% (264) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5155|M.vanbaalenii_PYR-1 -----MSERADELRVGYIGLGNQGAPMAKRLVDWPGGLIVFDVRTEAMTP
Mflv_1602|M.gilvum_PYR-GCK -----MST--DDLKLGYIGLGNQGAPMAKRLVDWPGGLVVFDVRTEAMTP
MSMEG_5857|M.smegmatis_MC2_155 -----MSG----VKLGYIGLGNQGAPMAKRLADWPGGLTVFDVRAEAMAP
TH_1259|M.thermoresistible__bu -----MSD----LKLGYIGLGNMGAPMAKRLVDWPGGLIVYDVRTEAMTP
MAV_0715|M.avium_104 -MTTNAAHTTEQLKLGYIGLGNMGAPMATRMTEWPGGVTVYDIRIEAMTP
Mb0793|M.bovis_AF2122/97 -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
Rv0770|M.tuberculosis_H37Rv -----MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP
MMAR_4926|M.marinum_M -----MSEH---PKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTP
MAB_1220|M.abscessus_ATCC_1997 -----MTQQ--AMKLGYIGLGNMGAPMARRLVDWPGGLTVFDLRAEAVAP
MUL_0835|M.ulcerans_Agy99 MTKS--------CQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASA
::.::***: ****: .: : :* * :.
Mvan_5155|M.vanbaalenii_PYR-1 LVEMGASAADDVAGVSAADVISVTVLNDAQVRDVVG---ELAAHAEPGTV
Mflv_1602|M.gilvum_PYR-GCK LVELGATLADSVADVAAADVISVTVLNDAQVRDVVA---ELAAHAEPGTV
MSMEG_5857|M.smegmatis_MC2_155 LVELGAEAADSVAAVATADVISVTVLNDAQVRDVVG---QLAEHAKPGTV
TH_1259|M.thermoresistible__bu LAEVGANLADSVADVAKADIISVTVLDDEQVRAVVD---ELAAGAGPGTV
MAV_0715|M.avium_104 LAEAGATLADSVADVAAADLIHITVLDDAQVREVVG---ELAGHAKPGTV
Mb0793|M.bovis_AF2122/97 FVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTI
Rv0770|M.tuberculosis_H37Rv FVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTI
MMAR_4926|M.marinum_M LAEAGASAAASVAEVAGADIISVTVLNDAQVREVITGANGLAAHARAGTI
MAB_1220|M.abscessus_ATCC_1997 LVEEGAVGASDVADIADADLISVTVLDDAQVRQVVG---QVAPKAKPGTI
MUL_0835|M.ulcerans_Agy99 TAAKGATMFDSAAEAVARADVVITMLPNGAVVKRCY--AEVLPAARSGAL
. ** ..: : :*:: : * : * .*::
Mvan_5155|M.vanbaalenii_PYR-1 IAIHSTIEPDTAPELAEQLRPKGIHIVDAPVSGGAGAADKGELAVMVGAD
Mflv_1602|M.gilvum_PYR-GCK IAIHSTIEPATAGELAEQLRPKGIHIVDAPVSGGAGAAEKGELAVMVGAD
MSMEG_5857|M.smegmatis_MC2_155 VAIHSTIEPGTAPELAEQLRPKGIHIVDAPVSGGAGAADKGELAVMVGAD
TH_1259|M.thermoresistible__bu IAIHSTIRPETAVELAEQLRPKDIHLVDAPVSGGGGAAEKGELAVMVGAD
MAV_0715|M.avium_104 IAIHSTISDTTAVELARDLKARDIHIVDAPVSGGAAAAARGELATMVGAD
Mb0793|M.bovis_AF2122/97 VAIHSTIADTTAVDLAEKLKPQGIHIVDAPGSGGAAAAAKGELAVMVGAD
Rv0770|M.tuberculosis_H37Rv VAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGAD
MMAR_4926|M.marinum_M IAIHSTISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAG
MAB_1220|M.abscessus_ATCC_1997 IAIHSTISDTTAVELAQAWRPRDIHVIDAPVSGGAPGAHKGELATMVGAD
MUL_0835|M.ulcerans_Agy99 FIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGD
. *** * :: ..:.: :*** *** .* * ** ***..
Mvan_5155|M.vanbaalenii_PYR-1 EHAYDRVKPVFKQWASMVVRAGEPGAGTRMKLARNMLTFVGFTAACEAMR
Mflv_1602|M.gilvum_PYR-GCK EHAYERVKPVFKKWASMVVRAGEPGAGTRMKLARNMLTFIGFTAACEAMR
MSMEG_5857|M.smegmatis_MC2_155 DDAYAAVKPVFKKWASLVVRAGEPGAGTRMKLARNMLTFIGFAASCEAMK
TH_1259|M.thermoresistible__bu RDVYERIKPAFKRFASLVVHAGEPGAGTRMKLARNMLTFTSYVAACEAME
MAV_0715|M.avium_104 REVYERIKPAFKHWAAVVIHAGEPGAGTRMKLARNMLTFTSYAAACEAMK
Mb0793|M.bovis_AF2122/97 DEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
Rv0770|M.tuberculosis_H37Rv DEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQR
MMAR_4926|M.marinum_M DDVFARVKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWK
MAB_1220|M.abscessus_ATCC_1997 GETFARVKEAFSKWASLVIHAGAPGAGTRMKLARNLLHFVAFTAAGEAQR
MUL_0835|M.ulcerans_Agy99 QSALAQARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFV
. : :. *. :::.* .*** *:..*:: * **
Mvan_5155|M.vanbaalenii_PYR-1 LAEAAGIDLQKLGRVVRHSDAQSGGPGAIMVRDDMLPLAPEHFLYDMFVH
Mflv_1602|M.gilvum_PYR-GCK LAEASGIDLQKLGRVVRHSDAQSGGPGAIMVRDDMKALTPDHFLHDMFVH
MSMEG_5857|M.smegmatis_MC2_155 LAEAAGIDLQKLGRVVRHSDAQSGGPGAIIVRDDTKPLTPDHWLYDMFVH
TH_1259|M.thermoresistible__bu LAEAAGLSLQALGRVVRHSDAQSGGPGAIIVREDMRDLEPDHWLYEAFTH
MAV_0715|M.avium_104 LAEAAGLDLQALGRVVRHTDALTGGPGAIMVRDNMKDLEPDNFLYQPFLH
Mb0793|M.bovis_AF2122/97 LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
Rv0770|M.tuberculosis_H37Rv LAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEH
MMAR_4926|M.marinum_M LAEASGVNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVH
MAB_1220|M.abscessus_ATCC_1997 LAESCGLDITDLGKVVRHTDAITGGPGAIMLRDTTEPVTPDSFWLPIFTH
MUL_0835|M.ulcerans_Agy99 LAENLGLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
*** *:. * *: : . : *
Mvan_5155|M.vanbaalenii_PYR-1 TRGLGEKDLRLALGLGESTGVELPLAEIALRDLAAGLGVPHTTSTTEE--
Mflv_1602|M.gilvum_PYR-GCK TRGLAEKDLKLALALGDETGVDLPLARIALQDLAAGLGVPHTKE------
MSMEG_5857|M.smegmatis_MC2_155 TRGLAEKDLTLALGLGESVGVELPLAHIALERLADGLGVPHSKEQE----
TH_1259|M.thermoresistible__bu TRGLGEKDLSLALDLGRQTGVDLPLARIALQNLAAALGVPHTKE------
MAV_0715|M.avium_104 TRGLGEKDLSLALALGEAVSVDLPLARLAYEGLAAGLGVPHKEKEA----
Mb0793|M.bovis_AF2122/97 TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
Rv0770|M.tuberculosis_H37Rv TRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET
MMAR_4926|M.marinum_M ARDLGEKDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA----
MAB_1220|M.abscessus_ATCC_1997 VRGLGEKDLSLALALGEEQSVDLPLATLAREQLAASLGVPHEEGASNG--
MUL_0835|M.ulcerans_Agy99 T-ALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAK-FATDHADQDFSAVI
. * :*** **: . **. * . * :.. *
Mvan_5155|M.vanbaalenii_PYR-1 ------
Mflv_1602|M.gilvum_PYR-GCK ------
MSMEG_5857|M.smegmatis_MC2_155 ------
TH_1259|M.thermoresistible__bu ------
MAV_0715|M.avium_104 ------
Mb0793|M.bovis_AF2122/97 ------
Rv0770|M.tuberculosis_H37Rv ------
MMAR_4926|M.marinum_M ------
MAB_1220|M.abscessus_ATCC_1997 ------
MUL_0835|M.ulcerans_Agy99 EMLRGS