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SQSYDAGPTDTAILEETIGANFERIAATYPDHEALVDVTGGRRWTYAELDREIDTVAKGLMSLGTESGDR VGIWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGVSTLISATRFKTSDYVAMVDEVRPD VPALQRVLFIGTDDWDRLRSRADVIDDALLRERSASLSHHDPVNIQYTSGTTGFPKGATLSHRNILNNGF FVTEQIRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIPAPGFDPGQTLKTIETERCTAVYGVPTM FIAMQNHADFAERDLSSLRTGIMAGAVCPVEVMKRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLERR TSSIGRVHPHVEIKIVDPDTGHVVERGTPGEFCTRGYSVMLGYWRDEEKTAQAVDADGWMHTGDLAVMRP DGYCNIVGRIKDVVIRGGENIYPREVEEFLYTHPDIEDAQVVGVPDARYGEEICAWIRMRPGRRALDAAA VREFAAGKLAHYKIPRYVHVVDEFPMTVTGKIRKVEMREVSAGLFAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | - | 100% (538) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4008 | - | 0.0 | 75.86% (526) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_5286 | - | 1e-76 | 34.58% (535) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 0.0 | 59.96% (527) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 0.0 | 88.04% (535) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 0.0 | 59.96% (527) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-49 | 28.32% (505) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 0.0 | 72.28% (534) | AMP-binding domain protein |
| M. marinum M | MMAR_3852 | fadD35 | 0.0 | 61.36% (528) | fatty-acid-CoA ligase FadD35 |
| M. avium 104 | MAV_0600 | fadD | 9e-82 | 36.47% (521) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 0.0 | 76.92% (533) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 2e-85 | 38.24% (523) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 3e-80 | 36.15% (520) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ---MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD
Rv2505c|M.tuberculosis_H37Rv ---MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD
MMAR_3852|M.marinum_M ---MATTAAADQNQLSYDRGPIAPALLEMTIGANLAATASQCESRDALVD
Mvan_1563|M.vanbaalenii_PYR-1 ------------MSQSYDAGPTDTAILEETIGANFERIAATYPDHEALVD
Mflv_4867|M.gilvum_PYR-GCK ------------MTGSYDAGPTDVAILEETIGANFARIARTHPGRDALVD
MSMEG_5649|M.smegmatis_MC2_155 -------------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEALVE
MAB_4377c|M.abscessus_ATCC_199 -------------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVD
MAV_0600|M.avium_104 -----------------------MTTDPRTVPAALDRLARRLPDHDALIT
MUL_4126|M.ulcerans_Agy99 -----------------------MTSDPRTVPTALDRLVRRLPNHDALVT
TH_2068|M.thermoresistible__bu ---------------------------MRTIPAVLDRAAERLPDHDALVT
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
. *
Mb2533c|M.bovis_AF2122/97 MV---------------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
Rv2505c|M.tuberculosis_H37Rv MV---------------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
MMAR_3852|M.marinum_M VR---------------SGRRWSYAQLLTDVRQLATGLVRAGIGRGDRVG
Mvan_1563|M.vanbaalenii_PYR-1 VT---------------GGRRWTYAELDREIDTVAKGLMSLGTESGDRVG
Mflv_4867|M.gilvum_PYR-GCK VA---------------GGRRWTYAELDAEIDTVARGLMAIGVERGDRVG
MSMEG_5649|M.smegmatis_MC2_155 VA---------------TGRRWTYAELNDEIDATARGLMALGVDKGDRVG
MAB_4377c|M.abscessus_ATCC_199 VS---------------GDRRWTYRELDAEINRVARGLMSLGVAAGDRVG
MAV_0600|M.avium_104 -----------------EDRSFTAAALRDEVHRAAAALIELGVRAGDRVA
MUL_4126|M.ulcerans_Agy99 -----------------DERSFTVSELNDEVYRAAAALIELGVKPAARVG
TH_2068|M.thermoresistible__bu AATGGA-----------EARRFSYAELRAEVRRAAAAMIAAGIAPGDRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
. * * .:: * . :.
Mb2533c|M.bovis_AF2122/97 IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
Rv2505c|M.tuberculosis_H37Rv IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
MMAR_3852|M.marinum_M IWAPNRWEWVLVQYATAEIGAVLVTINPAYQARELEYALRQSGVAMVIAA
Mvan_1563|M.vanbaalenii_PYR-1 IWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGVSTLISA
Mflv_4867|M.gilvum_PYR-GCK IWAPNCPEWVIVQYATAKIGAILVNINPAYRTHELRYVLEQSGVATLISA
MSMEG_5649|M.smegmatis_MC2_155 IWAPNCAEWIMTQFAAAKVGAILVNINPAYRTHEVAYVLRQSGVRTLVSA
MAB_4377c|M.abscessus_ATCC_199 IWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICA
MAV_0600|M.avium_104 IWSPNTWHWVVACLAIHHAGAAMVPLNTRYTAAEAGDILARVGAPVLFGM
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
TH_2068|M.thermoresistible__bu LWAPNTWHWVVACLATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAA
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: : * : :. . ** :: :*. : : : . :.
Mb2533c|M.bovis_AF2122/97 ASFKDADYAAMLA-EVGPRCPDLADVILLESD----RWDALAG----AEP
Rv2505c|M.tuberculosis_H37Rv ASFKDADYAAMLA-EVGPRCPDLADVILLESD----RWDALAG----AEP
MMAR_3852|M.marinum_M SGFKGSDYAAILA-EVAPGCPELHDVAFLDGD----GWAKLAG----SGA
Mvan_1563|M.vanbaalenii_PYR-1 TRFKTSDYVAMVD-EVRPDVPALQRVLFIGTD----DWDRLRSRA--DVI
Mflv_4867|M.gilvum_PYR-GCK TQFKTSDYVAMVD-EVRPDVPALQRVLFIGTA----DWDTLRAAG--SGV
MSMEG_5649|M.smegmatis_MC2_155 SSFKTSDYASMIA-EVRPECPDLLDVVFLDND----DWDRLR--A--NQV
MAB_4377c|M.abscessus_ATCC_199 KAFKSSDYVAMAS-QVMPDAPGLRDVVFIGTS----DWTELVAGA--ERV
MAV_0600|M.avium_104 GRFLGHDRLADLDRAALPALRHIVRIPIETDDPVPGSWDEFIAHG----T
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIEEPD---GTWDEFIETG----T
TH_2068|M.thermoresistible__bu GEFLGADKTADLDRDALPALRRIVRIPVDKPD---GTWDEFIAGGSMSGA
MLBr_02546|M.leprae_Br4923 DEYT------KVVSKAEPALGKLRALGVNPDE------EEPPGSTDETLA
: . * : : .
Mb2533c|M.bovis_AF2122/97 DLPALQQTA-ARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGE
Rv2505c|M.tuberculosis_H37Rv DLPALQQTA-ARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGE
MMAR_3852|M.marinum_M DLVALQEIA-TTLSADDPINIQYTSGTTGFPKGVTLSHRNILNNGYLVGE
Mvan_1563|M.vanbaalenii_PYR-1 DDALLRERS-ASLSHHDPVNIQYTSGTTGFPKGATLSHRNILNNGFFVTE
Mflv_4867|M.gilvum_PYR-GCK DDADLRRRS-GALSNRDPINIQYTSGTTGFPKGATLSHRNILNNGFFVTE
MSMEG_5649|M.smegmatis_MC2_155 DDAAFHERM-ATLANTDPINIQYTSGTTGFPKGATLSHRNILNNGFFVTE
MAB_4377c|M.abscessus_ATCC_199 TETALRARM-SQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAE
MAV_0600|M.avium_104 DLGAVAERA-AAVTSDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAA
MUL_4126|M.ulcerans_Agy99 DTGAVTARA-AAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAA
TH_2068|M.thermoresistible__bu ALAEVDARA-AAVRPDDVSDILFTSGTTGRSKGALCAHRQSLDASAAWAE
MLBr_02546|M.leprae_Br4923 ELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILS
* *****. .**. *
Mb2533c|M.bovis_AF2122/97 LLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLR
Rv2505c|M.tuberculosis_H37Rv LLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLR
MMAR_3852|M.marinum_M LLEYTAEDRICIPVPFYHCFGMVMGNLAATSHGACMVIPAPGFDPAATLR
Mvan_1563|M.vanbaalenii_PYR-1 QIRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIPAPGFDPGQTLK
Mflv_4867|M.gilvum_PYR-GCK QIRLQPGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVIPAPAFDPGLTLR
MSMEG_5649|M.smegmatis_MC2_155 LIALGPDDRLCIVPPFYHCFGMVMGTLGAVSHGTTIVIPAPGFDPGITLS
MAB_4377c|M.abscessus_ATCC_199 SIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLE
MAV_0600|M.avium_104 NGKITSDDRYLCINPFFHNFGYKAGILACLQTGAT-LIPHLTFDPLRALQ
MUL_4126|M.ulcerans_Agy99 NGKITADDRHLCINPFFHNFGYKAGILACLQTGAT-LFPHLTFDPLRTLQ
TH_2068|M.thermoresistible__bu CGRLSSDDRYLCINPFFHNFGYKAGILACIQTGAT-LYPQLTFDPEQAMR
MLBr_02546|M.leprae_Br4923 KVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR--FKPATVLE
. : *::* :* . *. .: : *.* .:
Mb2533c|M.bovis_AF2122/97 AVQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEV
Rv2505c|M.tuberculosis_H37Rv AVQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEV
MMAR_3852|M.marinum_M AVQAERCTSLYGVPTMFIAELGLAD--FATYDLSSLRTGIMAGSTCPVEV
Mvan_1563|M.vanbaalenii_PYR-1 TIETERCTAVYGVPTMFIAMQNHAD--FAERDLSSLRTGIMAGAVCPVEV
Mflv_4867|M.gilvum_PYR-GCK AIETERCTAVYGVPTMFIAMQNHPD--FAERDLSTLRTGIMAGAVCPVEV
MSMEG_5649|M.smegmatis_MC2_155 AVESEKCTGLYGVPTMFIAMLGHPD--FANFDLSSLRTGIMAGSVCPIEV
MAB_4377c|M.abscessus_ATCC_199 AIERERCVGVYGVPTMFIAMLADPG--FAHRDLSTLRTGIMAGSVCPVEV
MAV_0600|M.avium_104 AIEQHRITVLPGPPTIYQTLLDHPA--RRDYDLSSLRFAVTGAATVPVVL
MUL_4126|M.ulcerans_Agy99 AIERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVL
TH_2068|M.thermoresistible__bu AVAEHRITVLPGPPTIYQTILDHPK--RGEYDLSSLRFAVTGAAVVPVVL
MLBr_02546|M.leprae_Br4923 DIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAEL
: .: . : *.: :*.:** . ..: :
Mb2533c|M.bovis_AF2122/97 MRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLE
Rv2505c|M.tuberculosis_H37Rv MRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLE
MMAR_3852|M.marinum_M MRKVIDQMHMAGISICYGMTETSPVATQTRSNDSLQRRVTTVGRVGPHLE
Mvan_1563|M.vanbaalenii_PYR-1 MKRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLERRTSSIGRVHPHVE
Mflv_4867|M.gilvum_PYR-GCK MKRCVEEMHLTEMSIAYGMTETSPVSCQTLIDDDLERRTSTIGRVHPHVE
MSMEG_5649|M.smegmatis_MC2_155 MKRVVADMHMAEVAICYGMTETSPVSCQTLIDDDLDRRTATIGRAHPHVE
MAB_4377c|M.abscessus_ATCC_199 MKRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIE
MAV_0600|M.avium_104 VERMQSELDIDIVLTAYGLTEANGMGTMCRADDDAVTVATTCGRPFADFE
MUL_4126|M.ulcerans_Agy99 VERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFE
TH_2068|M.thermoresistible__bu IERMQSELDIDIVLTAYGLTEASGFGTMCRPEDDAVTVATTCGRPIAGFE
MLBr_02546|M.leprae_Br4923 ATRALEELG-PVIYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVK
: : : ** ** .. : * .:
Mb2533c|M.bovis_AF2122/97 IKVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHT
Rv2505c|M.tuberculosis_H37Rv IKVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHT
MMAR_3852|M.marinum_M IKVVDPATGRIVPRGTAGEFCTRGYSVMSGYWKAPERTAEVIDPEGWMHT
Mvan_1563|M.vanbaalenii_PYR-1 IKIVDPDTGHVVERGTPGEFCTRGYSVMLGYWRDEEKTAQAVDADGWMHT
Mflv_4867|M.gilvum_PYR-GCK IKIVDPETGEIVERGTPGEFCTRGYSVMLGYWREDEKTAQAIDADGWMHT
MSMEG_5649|M.smegmatis_MC2_155 IKIIDPDTGETVERGQPGEFCTRGYSVMLGYWNDDEKTREAVDADGWMHT
MAB_4377c|M.abscessus_ATCC_199 IKIVDPNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHT
MAV_0600|M.avium_104 LRID-----------DSGEVLLRGPNVMLGYLDDPDATAAAIDADGWLHT
MUL_4126|M.ulcerans_Agy99 LRIGP----------DTGEVLLRGPNVMLGYLDDPRATAAAIDADGWLHT
TH_2068|M.thermoresistible__bu LRIDNPA------EDGTGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHT
MLBr_02546|M.leprae_Br4923 VKILDDS-GKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSS
::: *.. . : ** :* : :
Mb2533c|M.bovis_AF2122/97 GDLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVI
Rv2505c|M.tuberculosis_H37Rv GDLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVI
MMAR_3852|M.marinum_M GDLALMDECGYVQITGRIKDIVVRGGENISPREIEEFLHSHPDIVDAHVV
Mvan_1563|M.vanbaalenii_PYR-1 GDLAVMRPDGYCNIVGRIKDVVIRGGENIYPREVEEFLYTHPDIEDAQVV
Mflv_4867|M.gilvum_PYR-GCK GDLAVMRPDGYCNIVGRIKDVVIRGGENIYPREIEEFLYTHPDVEDAHVI
MSMEG_5649|M.smegmatis_MC2_155 GDLAVMREDGYCTIVGRIKDMVIRGGENIYPREIEEFLYTHPDIDDAQVI
MAB_4377c|M.abscessus_ATCC_199 GDLAVMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVV
MAV_0600|M.avium_104 GDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMEGVADAAVI
MUL_4126|M.ulcerans_Agy99 GDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVI
TH_2068|M.thermoresistible__bu GDVGKVDERGNLTITDRLKDMYICGGFNVYPAEVEQVLARLDGVAEAAVI
MLBr_02546|M.leprae_Br4923 GDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAI
**:. . . * .* .:: : ** *: * *:*:.: : : .:
Mb2533c|M.bovis_AF2122/97 GVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVD
Rv2505c|M.tuberculosis_H37Rv GVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVD
MMAR_3852|M.marinum_M GVPDERMGEELMAVVKLRAGAPELTTGLLREYCAGQIAKFKIPRYLRLVD
Mvan_1563|M.vanbaalenii_PYR-1 GVPDARYGEEICAWIRMRPGRRALDAAAVREFAAGKLAHYKIPRYVHVVD
Mflv_4867|M.gilvum_PYR-GCK GVPDDRYGEEVCAWIRMRPGRTALDAAAVREFATDKLAHYKIPRYVHVVD
MSMEG_5649|M.smegmatis_MC2_155 GVPDERYGEEICAWIRMKPGRPPLDADKVREFASGKLAHYKIPRYVHVVD
MAB_4377c|M.abscessus_ATCC_199 GVPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGRLAHYKIPRYVHVVE
MAV_0600|M.avium_104 GVPDERLGEVGRAFVVPRPG-AQLDEQSVIAYTRDHLANFKAPRSVRFVD
MUL_4126|M.ulcerans_Agy99 GIPDHRLGEVGRAFIVARPG-FNLDEKSVIDYTREHLANFKAPRSVRFVD
TH_2068|M.thermoresistible__bu GVPDQRLGEVGKAFVVRRPG-ATLDEQAVIAYCKQHLANFKVPRSVEFLD
MLBr_02546|M.leprae_Br4923 GVDDKEWGARLRAFVVKKQD-ATIDEDAIKAYVRDHLARYKVPREVIFLE
*: * . * * : : . : : : ::*.:* ** : .::
Mb2533c|M.bovis_AF2122/97 EFPMTVTGKVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv EFPMTVTGKVRKVEMRQQALEYLRGQQ-------
MMAR_3852|M.marinum_M EFPMTVTGKVRKVEMRQQAIEYLRGQH-------
Mvan_1563|M.vanbaalenii_PYR-1 EFPMTVTGKIRKVEMREVSAGLFAD---------
Mflv_4867|M.gilvum_PYR-GCK EFPMTVTGKIRKVEMREVSARLLGL---------
MSMEG_5649|M.smegmatis_MC2_155 EFPMTVTGKIRKVQMREETVALLGLEA-------
MAB_4377c|M.abscessus_ATCC_199 SFPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
MAV_0600|M.avium_104 ALPRNSGGKVVKPQLRELD---------------
MUL_4126|M.ulcerans_Agy99 TLPRNAGGKVVKPQLRELA---------------
TH_2068|M.thermoresistible__bu ALPRNPGGKVVKPLLRERA---------------
MLBr_02546|M.leprae_Br4923 ELPRNPTGKVLKRELRDFEVH-------------
:* . **: * :*: