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MTDITNVRSPVSGSRIVTLTMNPALDIATSTEIVMPTEKMRCSAARYDPGGGGINVARVARTLGASVVAL FPAGGASGDLFADMLEAIGISAHMIPIAGSTRESITVNELRTQRQYRFVLPGPTLTAAEQTECLNQLREV AASADFVVASGSLPPGVSPEFYNRIADVCAQLDAPLVLDASGGGLQHLTGGNVYLLKPSIRELRECVRRE LGSEAEQVAAARELIERGGARNVLVSLGAQGALLVTADGAQRYPAVEVPPGSGVGAGDAMVAGVTCGLGR GWGLPKSVRLGIAAGAAMLMTPGTASCTRADVERLFDRTPDPVDLTVPAADR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4105 | - | - | 100% (332) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | e-100 | 61.79% (301) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0095 | - | 4e-29 | 31.95% (313) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 1e-110 | 63.34% (311) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_4987 | - | 5e-96 | 60.13% (301) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 1e-110 | 63.34% (311) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4197 | - | 5e-05 | 23.67% (245) | phosphomethylpyrimidine kinase |
| M. marinum M | MMAR_3482 | pfkB_1 | 1e-107 | 63.17% (315) | phosphofructokinase, PfkB_1 |
| M. avium 104 | MAV_1743 | - | 2e-08 | 27.61% (297) | kinase, pfkB family protein |
| M. smegmatis MC2 155 | MSMEG_3947 | - | 1e-106 | 63.02% (311) | 6-phosphofructokinase isozyme 2 |
| M. thermoresistible (build 8) | TH_1728 | pfkB | 4e-98 | 59.93% (307) | Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | MUL_3559 | cbhK | 2e-05 | 25.28% (265) | carbohydrate kinase CbhK |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4987|M.gilvum_PYR-GCK -------------MSGTAAIVTLTMNTALDVTADADNVVPTEKIRCRAER
MSMEG_3947|M.smegmatis_MC2_155 MRSAAFAVGKRRMDTGRPNIVTLTMNPALDITTCADQVRHTDKIRCGATR
Mb2054c|M.bovis_AF2122/97 ------MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
Rv2029c|M.tuberculosis_H37Rv ------MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
MMAR_3482|M.marinum_M ------MTSPADPAVRGPQIVTLTMNPALDITTCVGVVRPTEKLRCSETR
TH_1728|M.thermoresistible__bu ------------------------MNPALDISTTTDRVHHTSKVRCHGVR
Mvan_4105|M.vanbaalenii_PYR-1 ----MTDITNVRSPVSGSRIVTLTMNPALDIATSTEIVMPTEKMRCSAAR
MAV_1743|M.avium_104 --------------------MNLDLSLAVDALP-----RPGETVLASSLR
MAB_4197|M.abscessus_ATCC_1997 -----------------------MRSPFLPLPE-----PGTTPVRAMTIA
MUL_3559|M.ulcerans_Agy99 ------MTIAVTGSIATDHLMRFPGHFSEQLLP-EHLHKVSLSFLVDDLV
.
Mflv_4987|M.gilvum_PYR-GCK YDAGGGGVNVARFAHALGAPVSAVFTAGGSTGA-RVIDLVHATGVCEI-P
MSMEG_3947|M.smegmatis_MC2_155 YDPGGGGINVARVAHVLDGPVVAVFTSGGPTGA-MVADLVRREGVAYE-P
Mb2054c|M.bovis_AF2122/97 YDPGGGGINVARIVHVLGGCSTALFPAGGSTGS-LLMALLGDAGVPFR-V
Rv2029c|M.tuberculosis_H37Rv YDPGGGGINVARIVHVLGGCSTALFPAGGSTGS-LLMALLGDAGVPFR-V
MMAR_3482|M.marinum_M YDPGGGGINVARIAHVLGGSVFAVFPVGGSHGA-HVSKLLSEAGVAFG-E
TH_1728|M.thermoresistible__bu HDPGGGGINVARIAHVLGAPVTAVFPIGGHTGE-LLTDMLEHSGVSYH-S
Mvan_4105|M.vanbaalenii_PYR-1 YDPGGGGINVARVARTLGASVVALFPAGGASGD-LFADMLEAIGISAH-M
MAV_1743|M.avium_104 QAPGGKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVGLDGA
MAB_4197|M.abscessus_ATCC_1997 GSDSGGGAG-----IQADMRTMALLGVHGCVAVTAVTVQNSLGVKDFHEI
MUL_3559|M.ulcerans_Agy99 VHRGGVAGNMAFAIGVLGGDVALVGAAGADFAD--YRDWLKAHGVNCDHV
.* . . . : .
Mflv_4987|M.gilvum_PYR-GCK VLIEGGTRESFTVNDRASGRQYRFVLPGPVLSLGEQARCLEALRRAAGTA
MSMEG_3947|M.smegmatis_MC2_155 VEISGVTRESFTVNEGCTGKQYRFVLPGPHLTMTEQAQCVENLRRHAMSA
Mb2054c|M.bovis_AF2122/97 IPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASA
Rv2029c|M.tuberculosis_H37Rv IPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASA
MMAR_3482|M.marinum_M IPIAASTRESFTVNESSTGEQYRFVLPGPVLAPEEQAQCLQELGFAARSA
TH_1728|M.thermoresistible__bu VPIADLTRESLTVNEESTGHQYRFVLPGPFVTHEEQDAVLQRLREVAASA
Mvan_4105|M.vanbaalenii_PYR-1 IPIAGSTRESITVNELRTQRQYRFVLPGPTLTAAEQTECLNQLREVAASA
MAV_1743|M.avium_104 VEIPGPSGTAIVVVDAN-AENTIVVAPGANGRFTLND---ERARAVLAGC
MAB_4197|M.abscessus_ATCC_1997 PPPIVAAQMEVVITDIGIQAAKTGMLASAPIIEAISESWSNLAPSVPLVV
MUL_3559|M.ulcerans_Agy99 LISQTAHTARFTCTTDVDMAQIASFYPG-AMSEARNIKLADVVSAVGTPE
.. . .. . :
Mflv_4987|M.gilvum_PYR-GCK GIVVASGSLPPGVPPDFYQRVADICSDVGAMLVLDTSGGGLRHVTSG-VH
MSMEG_3947|M.smegmatis_MC2_155 EFVVASGSLPPGVDPRFYQQIADMCRESGVPLILDTSGGGLSHIESG-VF
Mb2054c|M.bovis_AF2122/97 AFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSG-VF
Rv2029c|M.tuberculosis_H37Rv AFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSG-VF
MMAR_3482|M.marinum_M QFVVASGSLPPGVPADFYQRVAEACRGLGARLILDTSGGGLSHISAG-VY
TH_1728|M.thermoresistible__bu QFLVASGSLPPGVPADFYQRVADLCRELGVLLILDSSGGGLTQVRYG-AF
Mvan_4105|M.vanbaalenii_PYR-1 DFVVASGSLPPGVSPEFYNRIADVCAQLDAPLVLDASGGGLQHLTGGNVY
MAV_1743|M.avium_104 DVMLTQLEIPVATAVAAAR----HARSGGAVVVVNASPAGRD--------
MAB_4197|M.abscessus_ATCC_1997 DPVCASMHGDPLLHPSALDALRTRLFPLATLVTPN---------------
MUL_3559|M.ulcerans_Agy99 LVIVAAN------DPEAMFLHTEECRQLGLAFAADPSQQLARLSGDEIKR
: : . :
Mflv_4987|M.gilvum_PYR-GCK LLKPSIRELRECLDRPLHTEPEQIAAARELIDRGAAKVVVVS-----LGA
MSMEG_3947|M.smegmatis_MC2_155 VLKPSLRELRECTGKELTTEREQVAAARDLIDRGVTDVVIVS-----LGG
Mb2054c|M.bovis_AF2122/97 LLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVS-----LGS
Rv2029c|M.tuberculosis_H37Rv LLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVS-----LGS
MMAR_3482|M.marinum_M LLKASVRELRECVGRPLVTEAEQLAAASELVETGRAEVVVVS-----LGS
TH_1728|M.thermoresistible__bu LVKPSKRELREYVGRDIPTTADQIAAAHELIDRGVTQAVVVS-----LGA
Mvan_4105|M.vanbaalenii_PYR-1 LLKPSIRELRECVRRELGSEAEQVAAARELIERGGARNVLVS-----LGA
MAV_1743|M.avium_104 --PDSLSELAAAADVVITNEEE----ASEWPWR--PRHLVVT-----LGS
MAB_4197|M.abscessus_ATCC_1997 -----LDEVRLLVDIDVVDEDSQKEAARKLHALGPQWALVKGGHLRSSDT
MUL_3559|M.ulcerans_Agy99 LINGATYLFTNDYEWDLLLSKTGWSEADVMAQIGLRVTTLGP-------K
. : * :
Mflv_4987|M.gilvum_PYR-GCK DGALLVTPDDSERLSAVPMTSV-SCVGAGDALVAGVAVGLARRWPLGR--
MSMEG_3947|M.smegmatis_MC2_155 DGALMVTARQSQRFKAVPVASG-SGVGAGDAMVAAITVGLSRGWPLPK--
Mb2054c|M.bovis_AF2122/97 QGALLATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIK--
Rv2029c|M.tuberculosis_H37Rv QGALLATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIK--
MMAR_3482|M.marinum_M DGALLATRRARHRFRAVEMRGG-SGVGAGDAMVAAITVGLARGWPLVK--
TH_1728|M.thermoresistible__bu DGALLATADVDQKFEAIDVPVVLSGVGAGDAMVAGITVALSRRWSLSD--
Mvan_4105|M.vanbaalenii_PYR-1 QGALLVTADGAQRYPAVEVPPG-SGVGAGDAMVAGVTCGLGRGWGLPK--
MAV_1743|M.avium_104 HGARYVGADGEYSVPSPDVDAV-DTTGAGDVFAGVLAANWPLEPGSPDQR
MAB_4197|M.abscessus_ATCC_1997 STDLLFDGTEFHYFPVERVDTG-HDHGAGDTLAASISCALAHGLPVTE--
MUL_3559|M.ulcerans_Agy99 GVDLVEPDGTSIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLNLER--
*.**.: . .
Mflv_4987|M.gilvum_PYR-GCK --AVRFGIAAASAKLQTPGTAAFHRDDVERYFVTQAAHSEA---------
MSMEG_3947|M.smegmatis_MC2_155 --SVRYGIAAGAAMLLTPGTAVCRRAEVERLFALAAEPEDLTSGW-----
Mb2054c|M.bovis_AF2122/97 --SVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHP
Rv2029c|M.tuberculosis_H37Rv --SVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHP
MMAR_3482|M.marinum_M --SVRLGIAAGAAMLLTPGTQACERADVERLFEHVAEPVEVA--------
TH_1728|M.thermoresistible__bu --AVRYGVATGSAMLLTPGTAPCRPEDVERLFAQAAPPVDVTRSPARN--
Mvan_4105|M.vanbaalenii_PYR-1 --SVRLGIAAGAAMLMTPGTASCTRADVERLFDRTPDPVDLTVPAADR--
MAV_1743|M.avium_104 RLALRRACAAGALATLVPGAGDCAPRAEEIERALRGKS------------
MAB_4197|M.abscessus_ATCC_1997 --AVAFGKQWITECLKAAYPLGHGHGPVSALFRLDA--------------
MUL_3559|M.ulcerans_Agy99 --AAQLGSLVAVLVLESTGTQEWQWDRQVATARLAEAYGDDAANEITAVL
: . . .
Mflv_4987|M.gilvum_PYR-GCK --------
MSMEG_3947|M.smegmatis_MC2_155 --------
Mb2054c|M.bovis_AF2122/97 IVNPEASP
Rv2029c|M.tuberculosis_H37Rv IVNPEASP
MMAR_3482|M.marinum_M --------
TH_1728|M.thermoresistible__bu --------
Mvan_4105|M.vanbaalenii_PYR-1 --------
MAV_1743|M.avium_104 --------
MAB_4197|M.abscessus_ATCC_1997 --------
MUL_3559|M.ulcerans_Agy99 A-------