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VTPLSIVTLTMNTALDVAADADEVVPTEKVRCRAVRYDAGGGGVNVARFARVLGATVSAVFTAGGSTGSR VIDMVEAAGVPGVPVPIEGATRESFTVNERATGKQYRFVLPGPVLSPGEEARCLEALRQAAYSAQFVVAS GSLPPGVPLDFYQRVADMCREAGALLILDTSGGGLSHITSGVYLLKPSVRELRECVGRPLPTEAEQLAAA HELIDRGIARIVVVSLGAQGALLAASSHSERFPALPVAAVSGIGAGDAMVAGITVGLAEGWTLDRAVRYG IAAATAKLQTPATSVFDRADVEHHFAEQLAPSGT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | - | 100% (314) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4105 | - | e-100 | 61.79% (301) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0095 | - | 4e-23 | 28.66% (321) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 1e-104 | 63.52% (307) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_4987 | - | 1e-126 | 73.70% (308) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 1e-104 | 63.52% (307) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3482 | pfkB_1 | 1e-105 | 65.03% (306) | phosphofructokinase, PfkB_1 |
| M. avium 104 | MAV_0347 | - | 7e-06 | 24.51% (253) | kinase, PfkB family protein |
| M. smegmatis MC2 155 | MSMEG_3947 | - | 1e-107 | 63.84% (307) | 6-phosphofructokinase isozyme 2 |
| M. thermoresistible (build 8) | TH_1728 | pfkB | 6e-97 | 60.26% (302) | Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 9e-05 | 35.06% (77) | fructokinase, PfkB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1394|M.vanbaalenii_PYR-1 MT--------------PLSIVTLTMNTALDVAADADEVVPTEKVRCRAVR
Mflv_4987|M.gilvum_PYR-GCK MSG-------------TAAIVTLTMNTALDVTADADNVVPTEKIRCRAER
Mb2054c|M.bovis_AF2122/97 MTEPAAWD------EGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
Rv2029c|M.tuberculosis_H37Rv MTEPAAWD------EGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
MMAR_3482|M.marinum_M MTSPADPA------VRGPQIVTLTMNPALDITTCVGVVRPTEKLRCSETR
MSMEG_3947|M.smegmatis_MC2_155 MRSAAFAVGKRRMDTGRPNIVTLTMNPALDITTCADQVRHTDKIRCGATR
TH_1728|M.thermoresistible__bu ------------------------MNPALDISTTTDRVHHTSKVRCHGVR
MAV_0347|M.avium_104 --------------------MVVIGQIGRDLVLRTDRPPTAGESATVLRR
MUL_4435|M.ulcerans_Agy99 --------------------------MARGLVIGEALIDIVDGP----DP
. .: .
Mvan_1394|M.vanbaalenii_PYR-1 YDAGGG-GVNVARFARVLGATVSAVFTAGG-STGSRVIDMVEAAGVPGVP
Mflv_4987|M.gilvum_PYR-GCK YDAGGG-GVNVARFAHALGAPVSAVFTAGG-STGARVIDLVHATGVCEIP
Mb2054c|M.bovis_AF2122/97 YDPGGG-GINVARIVHVLGGCSTALFPAGG-STGSLLMALLGDAGVPFRV
Rv2029c|M.tuberculosis_H37Rv YDPGGG-GINVARIVHVLGGCSTALFPAGG-STGSLLMALLGDAGVPFRV
MMAR_3482|M.marinum_M YDPGGG-GINVARIAHVLGGSVFAVFPVGG-SHGAHVSKLLSEAGVAFGE
MSMEG_3947|M.smegmatis_MC2_155 YDPGGG-GINVARVAHVLDGPVVAVFTSGG-PTGAMVADLVRREGVAYEP
TH_1728|M.thermoresistible__bu HDPGGG-GINVARIAHVLGAPVTAVFPIGG-HTGELLTDMLEHSGVSYHS
MAV_0347|M.avium_104 EELLGGKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQAQRDGIDVSK
MUL_4435|M.ulcerans_Agy99 AEYVGGSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVS
: ** * * *. : * * : *:
Mvan_1394|M.vanbaalenii_PYR-1 VPIEGATRESFTVNERATGKQYRFVLPGPVLSPGEEARCLEALRQAAYSA
Mflv_4987|M.gilvum_PYR-GCK VLIEGGTRESFTVNDRASGRQYRFVLPGPVLSLGEQARCLEALRRAAGTA
Mb2054c|M.bovis_AF2122/97 IPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASA
Rv2029c|M.tuberculosis_H37Rv IPIAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASA
MMAR_3482|M.marinum_M IPIAASTRESFTVNESSTGEQYRFVLPGPVLAPEEQAQCLQELGFAARSA
MSMEG_3947|M.smegmatis_MC2_155 VEISGVTRESFTVNEGCTGKQYRFVLPGPHLTMTEQAQCVENLRRHAMSA
TH_1728|M.thermoresistible__bu VPIADLTRESLTVNEESTGHQYRFVLPGPFVTHEEQDAVLQRLREVAASA
MAV_0347|M.avium_104 VARRGTTALLVDVVAAPPERMLLEDVPDSSLVRVADLDRSSSLFDTADTV
MUL_4435|M.ulcerans_Agy99 GSQTADRTPTATARIGPDGS--ATYAFDLEWQIPDTPPVAPPLLVHTGSI
. . * : :
Mvan_1394|M.vanbaalenii_PYR-1 QFVVASGSLPPGVPLDFYQRVADMCREAGALLILD--TSGGGLSHITSGV
Mflv_4987|M.gilvum_PYR-GCK GIVVASGSLPPGVPPDFYQRVADICSDVGAMLVLD--TSGGGLRHVTSGV
Mb2054c|M.bovis_AF2122/97 AFVVASGSLPPGVAADYYQRVADICRRSSTPLILD--TSGGGLQHISSGV
Rv2029c|M.tuberculosis_H37Rv AFVVASGSLPPGVAADYYQRVADICRRSSTPLILD--TSGGGLQHISSGV
MMAR_3482|M.marinum_M QFVVASGSLPPGVPADFYQRVAEACRGLGARLILD--TSGGGLSHISAGV
MSMEG_3947|M.smegmatis_MC2_155 EFVVASGSLPPGVDPRFYQQIADMCRESGVPLILD--TSGGGLSHIESGV
TH_1728|M.thermoresistible__bu QFLVASGSLPPGVPADFYQRVADLCRELGVLLILD--SSGGGLTQVRYGA
MAV_0347|M.avium_104 SIQLQQ-------PAATALEAAQRARQRGLRVVADGVPAPQVRADLLATL
MUL_4435|M.ulcerans_Agy99 AAAREPGCLAVAALLDAYRAAATVSFDPNVRPSLR---ADPDLTRERIQR
* . . :
Mvan_1394|M.vanbaalenii_PYR-1 YLLKPSVRELRECVGRPLPTEAEQLAAAHELIDRGIARIVVVSLGAQGAL
Mflv_4987|M.gilvum_PYR-GCK HLLKPSIRELRECLDRPLHTEPEQIAAARELIDRGAAKVVVVSLGADGAL
Mb2054c|M.bovis_AF2122/97 FLLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGAL
Rv2029c|M.tuberculosis_H37Rv FLLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGAL
MMAR_3482|M.marinum_M YLLKASVRELRECVGRPLVTEAEQLAAASELVETGRAEVVVVSLGSDGAL
MSMEG_3947|M.smegmatis_MC2_155 FVLKPSLRELRECTGKELTTEREQVAAARDLIDRGVTDVVIVSLGGDGAL
TH_1728|M.thermoresistible__bu FLVKPSKRELREYVGRDIPTTADQIAAAHELIDRGVTQAVVVSLGADGAL
MAV_0347|M.avium_104 DVLRADATEASIIAGTEITTVEQAFELADHLLSGG-PELVALAVPDVGDL
MUL_4435|M.ulcerans_Agy99 LVERSDIIKASAEDLHWIDPTQPPEQTARAWLACG-PAIVALTFGDQSAV
: :.. : : . * : * . * ::. . :
Mvan_1394|M.vanbaalenii_PYR-1 LAASSHSERFPALPVAAV-SGIGAGDAMVAGITVGLAEGWTLDRAVRYGI
Mflv_4987|M.gilvum_PYR-GCK LVTPDDSERLSAVPMTSV-SCVGAGDALVAGVAVGLARRWPLGRAVRFGI
Mb2054c|M.bovis_AF2122/97 LATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGN
Rv2029c|M.tuberculosis_H37Rv LATRHASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGN
MMAR_3482|M.marinum_M LATRRARHRFRAVEMRGG-SGVGAGDAMVAAITVGLARGWPLVKSVRLGI
MSMEG_3947|M.smegmatis_MC2_155 MVTARQSQRFKAVPVASG-SGVGAGDAMVAAITVGLSRGWPLPKSVRYGI
TH_1728|M.thermoresistible__bu LATADVDQKFEAIDVPVVLSGVGAGDAMVAGITVALSRRWSLSDAVRYGV
MAV_0347|M.avium_104 LTWRGGSELFEFADVEVV-DPTGAGDAFVAGLVAALREGAAPREAGRRAA
MUL_4435|M.ulcerans_Agy99 AFCAAGPASMPAQPVRVV-DTVGAGDAFMAGLLDTLWEQGLLDADRRTEL
: : . *****::*.: * . *
Mvan_1394|M.vanbaalenii_PYR-1 AAATAKLQTPATSVFDRADVEHHFAEQLAPSGT-----------------
Mflv_4987|M.gilvum_PYR-GCK AAASAKLQTPGTAAFHRDDVERYFVTQAAHSEA-----------------
Mb2054c|M.bovis_AF2122/97 AAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
Rv2029c|M.tuberculosis_H37Rv AAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
MMAR_3482|M.marinum_M AAGAAMLLTPGTQACERADVERLFEHVAEPVEVA----------------
MSMEG_3947|M.smegmatis_MC2_155 AAGAAMLLTPGTAVCRRAEVERLFALAAEPEDLTSGW-------------
TH_1728|M.thermoresistible__bu ATGSAMLLTPGTAPCRPEDVERLFAQAAPPVDVTRSPARN----------
MAV_0347|M.avium_104 AAAGATVQRLG----GRPDLTGLRA-------------------------
MUL_4435|M.ulcerans_Agy99 RKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR----------
. . .