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NLDLSLAVDALPRPGETVLASSLRQAPGGKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVG LDGAVEIPGPSGTAIVVVDANAENTIVVAPGANGRFTLNDERARAVLAGCDVMLTQLEIPVATAVAAARH ARSGGAVVVVNASPAGRDPDSLSELAAAADVVITNEEEASEWPWRPRHLVVTLGSHGARYVGADGEYSVP SPDVDAVDTTGAGDVFAGVLAANWPLEPGSPDQRRLALRRACAAGALATLVPGAGDCAPRAEEIERALRG KS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1743 | - | - | 100% (283) | kinase, pfkB family protein |
| M. avium 104 | MAV_0347 | - | 3e-20 | 30.56% (288) | kinase, PfkB family protein |
| M. avium 104 | MAV_2289 | - | 1e-05 | 27.94% (247) | adenosine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 1e-107 | 70.36% (280) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 1e-83 | 61.48% (283) | ribokinase |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 1e-107 | 70.36% (280) | ribokinase RBSK |
| M. leprae Br4923 | MLBr_00873 | - | 4e-07 | 26.62% (278) | putative carbohydrate kinase |
| M. abscessus ATCC 19977 | MAB_1617c | - | 2e-78 | 56.27% (279) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 1e-08 | 29.88% (241) | fructokinase, PfkB |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 3e-85 | 59.86% (279) | ribokinase |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 1e-46 | 61.69% (154) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 5e-08 | 29.84% (258) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | 2e-85 | 60.99% (282) | ribokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
MAV_1743|M.avium_104 ---------------------MNLDLSLAVDALPRPGETVLASSLRQAPG
MSMEG_4585|M.smegmatis_MC2_155 ----------MGAARVCVVGSINADLTFTVANLPRPGQTVLASSLASAPG
TH_1517|M.thermoresistible__bu -----------VAARVCVVGSVNLDLTFNVDALPERGETVLAHSMSSAPG
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPG
Mvan_3935|M.vanbaalenii_PYR-1 -----------MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTPG
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTLRVEELPAPGATVLATSAMPAPG
MMAR_4574|M.marinum_M ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MUL_4435|M.ulcerans_Agy99 ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MLBr_00873|M.leprae_Br4923 ---MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIHRG
. : : *
Mb2462|M.bovis_AF2122/97 GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
Rv2436|M.tuberculosis_H37Rv GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
MAV_1743|M.avium_104 GKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVGLDGAVEIP
MSMEG_4585|M.smegmatis_MC2_155 GKGGNQAVAAARAGAATSLVAAVGDDAAAESLRAHLRANGVDEDAVVSLA
TH_1517|M.thermoresistible__bu GKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNGVGLDGVTTVA
Mflv_2643|M.gilvum_PYR-GCK GKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANSVGLDAVVAVP
Mvan_3935|M.vanbaalenii_PYR-1 GKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANAVGLDGVTAVP
MAB_1617c|M.abscessus_ATCC_199 GKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNNVGLDGLVEVD
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MLBr_00873|M.leprae_Br4923 GVAGNMAYAIGVLGGDVALIGAVGDDFAD--YRDWLQNHGVNCDSVLISK
* * * . . * . : .* * : *
Mb2462|M.bovis_AF2122/97 GPSGTAIIVVDASA--------ENTVLVAPGANAHLTP------------
Rv2436|M.tuberculosis_H37Rv GPSGTAIIVVDASA--------ENTVLVAPGANAHLTP------------
MAV_1743|M.avium_104 GPSGTAIVVVDANA--------ENTIVVAPGANGRFTLNDE--------R
MSMEG_4585|M.smegmatis_MC2_155 GPSGSAAIVVDAAG--------ENHIVVAPGANALLDVDAP--------A
TH_1517|M.thermoresistible__bu GPSGSAVIVVDSDA--------ENTIVVAPGANAALTIDAEGDGADDSAS
Mflv_2643|M.gilvum_PYR-GCK GPSGTAAILVDAGA--------ENCIVVAPGANAHLSLASP--------V
Mvan_3935|M.vanbaalenii_PYR-1 GPSGSAAILVDAAG--------ENCIVVAPGANGHLSLSSP--------A
MAB_1617c|M.abscessus_ATCC_199 GPSGMATITVEDSG--------ENCIVVAPGANTTFTLDEK--------V
MMAR_4574|M.marinum_M DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPG
MUL_4435|M.ulcerans_Agy99 DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPG
MLBr_00873|M.leprae_Br4923 TAHTARFVCTTDLDMAQIGSFYTGAMSEARNIKLVDAIATIGTPELVIIG
: :
Mb2462|M.bovis_AF2122/97 VPSAVANCDVLLTQLEIPVATALAAARAAQ-SADAVVMVNASPAGQDRSS
Rv2436|M.tuberculosis_H37Rv VPSAVANCDVLLTQLEIPVATALAAARAAQ-SADAVVMVNASPAGQDRSS
MAV_1743|M.avium_104 ARAVLAGCDVMLTQLEIPVATAVAAARHAR-SGGAVVVVNASPAGRDPDS
MSMEG_4585|M.smegmatis_MC2_155 ARAAIGSADVVLLQLEISPTTAIAAAQQAR-DAGALVMLNASPVGTAAHH
TH_1517|M.thermoresistible__bu AGAIIAASDVVLMQLEIPAATAVAAAXXXR-XAG---------VG-----
Mflv_2643|M.gilvum_PYR-GCK VRSAIADADVVLLSLEIPIDTAVAAARAGR-YAGATVMLN---ASPTPRE
Mvan_3935|M.vanbaalenii_PYR-1 VREVVADSDVVLLSLEIPIDTAVTAARIGR-SAGATVVLN---ASPASAQ
MAB_1617c|M.abscessus_ATCC_199 HKDIICSHDVLLCQLEIPVRVALTAARWAA-EAGKQFVLNASPVPERSPD
MMAR_4574|M.marinum_M CLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQRLVERSDIIKA
MUL_4435|M.ulcerans_Agy99 CLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQRLVERSDIIKA
MLBr_00873|M.leprae_Br4923 ANDPAAMLGYTQECRKLGLAFAADPSQQLARLSGEEIRNLIDGATYLFTN
. : .:
Mb2462|M.bovis_AF2122/97 LQDLAAIADVVIANEHEANDWPSP----PTHFVITLGVRGARYVGADGVF
Rv2436|M.tuberculosis_H37Rv LQDLAAIADVVIANEHEANDWPSP----PTHFVITLGVRGARYVGADGVF
MAV_1743|M.avium_104 LSELAAAADVVITNEEEASEWPWR----PRHLVVTLGSHGARYVGADGEY
MSMEG_4585|M.smegmatis_MC2_155 LLALSHLTDVVVVNETEAAEWHWP----VRHLVITRGARGASYVSDDERF
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK VGTLAAHVDVVVVNETEADAWRDGDRILVPHLVVTHGARGATCVG-QCHL
Mvan_3935|M.vanbaalenii_PYR-1 ASALADLADVVVVNETESDGWLDGDRPRVPHLVITRGARGATYVG-ETRL
MAB_1617c|M.abscessus_ATCC_199 LAELAFRASVVVVNETEARSWLYP----SRHLVTTLGDEGSRYRSPQGQI
MMAR_4574|M.marinum_M SAEDLHWIDPTQPPEQTARAWLACG---PAIVALTLGDQGAVAFCAAGPA
MUL_4435|M.ulcerans_Agy99 SAEDLHWIDPTQPPEQTARAWLACG---PAIVALTFGDQSAVAFCAAGPA
MLBr_00873|M.leprae_Br4923 DYEWDLLLSKTGWSEADVMAQIQLR-------VTTLGAKGVDLVEPDGTR
Mb2462|M.bovis_AF2122/97 EVP--APTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRRACAA
Rv2436|M.tuberculosis_H37Rv EVP--APTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRRACAA
MAV_1743|M.avium_104 SVP--SPDVDAVDTTGAGDVFAG-VLAANWPLEPGSPDQRRLALRRACAA
MSMEG_4585|M.smegmatis_MC2_155 DVP--ALRVRAVDTTGAGDVFAG-VLAAGWPAG------HEHALQRACAA
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK EVP--APAVEAVDTTGAGDVFAG-VLAANWEQG------VEFAMARACAA
Mvan_3935|M.vanbaalenii_PYR-1 EFP--APAVEAVDTTGAGDVFAG-VLAANWPRG------ADYALARACAA
MAB_1617c|M.abscessus_ATCC_199 TVP--SYPVRPLDTTGAGDVFAG-VLAAWWPQG------AETALRRANVA
MMAR_4574|M.marinum_M SVP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLGADRRTELRKIGVS
MUL_4435|M.ulcerans_Agy99 SMP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLDADRRTELRKIGVS
MLBr_00873|M.leprae_Br4923 VHVSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLSLERSAQLGSLVAVLVL
Mb2462|M.bovis_AF2122/97 GVLATLVSGAGDCAPAAAAIDAALRANRHNGS----
Rv2436|M.tuberculosis_H37Rv GALATLVSGVGDCAPAAAAIDAALRANRHNGS----
MAV_1743|M.avium_104 GALATLVPGAGDCAPRAEEIERALRGKS--------
MSMEG_4585|M.smegmatis_MC2_155 GALATLVRGAGDCAPSAADIDAVLTP----------
TH_1517|M.thermoresistible__bu ------------------------------------
Mflv_2643|M.gilvum_PYR-GCK GALATLVPGAGDCAPSREAVEDVLDAL---------
Mvan_3935|M.vanbaalenii_PYR-1 GALSTLVHGAGDCAPYSEAVEDVLEAS---------
MAB_1617c|M.abscessus_ATCC_199 GALATLRAGAGNCAPTGARIELSLKGS---------
MMAR_4574|M.marinum_M ALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MUL_4435|M.ulcerans_Agy99 ALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MLBr_00873|M.leprae_Br4923 ESTGTQQWGWDRDVAVARLAGAYGEEAAAEITVVLS