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RSAAFAVGKRRMDTGRPNIVTLTMNPALDITTCADQVRHTDKIRCGATRYDPGGGGINVARVAHVLDGPV VAVFTSGGPTGAMVADLVRREGVAYEPVEISGVTRESFTVNEGCTGKQYRFVLPGPHLTMTEQAQCVENL RRHAMSAEFVVASGSLPPGVDPRFYQQIADMCRESGVPLILDTSGGGLSHIESGVFVLKPSLRELRECTG KELTTEREQVAAARDLIDRGVTDVVIVSLGGDGALMVTARQSQRFKAVPVASGSGVGAGDAMVAAITVGL SRGWPLPKSVRYGIAAGAAMLLTPGTAVCRRAEVERLFALAAEPEDLTSGW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3947 | - | - | 100% (332) | 6-phosphofructokinase isozyme 2 |
| M. smegmatis MC2 155 | MSMEG_1378 | - | 1e-28 | 34.28% (283) | 1-phosphofructokinase |
| M. smegmatis MC2 155 | MSMEG_0086 | - | 7e-20 | 28.57% (315) | 1-phosphofructokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 1e-116 | 66.03% (315) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_4987 | - | 1e-104 | 62.78% (309) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 1e-116 | 66.03% (315) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3482 | pfkB_1 | 1e-114 | 66.56% (311) | phosphofructokinase, PfkB_1 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1728 | pfkB | 1e-104 | 61.44% (306) | Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | 1e-107 | 63.84% (307) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2054c|M.bovis_AF2122/97 ------MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
Rv2029c|M.tuberculosis_H37Rv ------MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
MMAR_3482|M.marinum_M ------MTSPADPAVRGPQIVTLTMNPALDITTCVGVVRPTEKLRCSETR
TH_1728|M.thermoresistible__bu ------------------------MNPALDISTTTDRVHHTSKVRCHGVR
Mflv_4987|M.gilvum_PYR-GCK -------------MSGTAAIVTLTMNTALDVTADADNVVPTEKIRCRAER
Mvan_1394|M.vanbaalenii_PYR-1 -------------MT-PLSIVTLTMNTALDVAADADEVVPTEKVRCRAVR
MSMEG_3947|M.smegmatis_MC2_155 MRSAAFAVGKRRMDTGRPNIVTLTMNPALDITTCADQVRHTDKIRCGATR
**.***::: .. * *.*:** *
Mb2054c|M.bovis_AF2122/97 YDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIP
Rv2029c|M.tuberculosis_H37Rv YDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIP
MMAR_3482|M.marinum_M YDPGGGGINVARIAHVLGGSVFAVFPVGGSHGAHVSKLLSEAGVAFGEIP
TH_1728|M.thermoresistible__bu HDPGGGGINVARIAHVLGAPVTAVFPIGGHTGELLTDMLEHSGVSYHSVP
Mflv_4987|M.gilvum_PYR-GCK YDAGGGGVNVARFAHALGAPVSAVFTAGGSTGARVIDLVHATGVCEIPVL
Mvan_1394|M.vanbaalenii_PYR-1 YDAGGGGVNVARFARVLGATVSAVFTAGGSTGSRVIDMVEAAGVPGVPVP
MSMEG_3947|M.smegmatis_MC2_155 YDPGGGGINVARVAHVLDGPVVAVFTSGGPTGAMVADLVRREGVAYEPVE
:*.****:****..:.*.. *:*. ** * : :: ** :
Mb2054c|M.bovis_AF2122/97 IAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAF
Rv2029c|M.tuberculosis_H37Rv IAASTRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAF
MMAR_3482|M.marinum_M IAASTRESFTVNESSTGEQYRFVLPGPVLAPEEQAQCLQELGFAARSAQF
TH_1728|M.thermoresistible__bu IADLTRESLTVNEESTGHQYRFVLPGPFVTHEEQDAVLQRLREVAASAQF
Mflv_4987|M.gilvum_PYR-GCK IEGGTRESFTVNDRASGRQYRFVLPGPVLSLGEQARCLEALRRAAGTAGI
Mvan_1394|M.vanbaalenii_PYR-1 IEGATRESFTVNERATGKQYRFVLPGPVLSPGEEARCLEALRQAAYSAQF
MSMEG_3947|M.smegmatis_MC2_155 ISGVTRESFTVNEGCTGKQYRFVLPGPHLTMTEQAQCVENLRRHAMSAEF
* ****:***: :..********* :: *: :: * * :* :
Mb2054c|M.bovis_AF2122/97 VVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSGVFLLK
Rv2029c|M.tuberculosis_H37Rv VVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISSGVFLLK
MMAR_3482|M.marinum_M VVASGSLPPGVPADFYQRVAEACRGLGARLILDTSGGGLSHISAGVYLLK
TH_1728|M.thermoresistible__bu LVASGSLPPGVPADFYQRVADLCRELGVLLILDSSGGGLTQVRYGAFLVK
Mflv_4987|M.gilvum_PYR-GCK VVASGSLPPGVPPDFYQRVADICSDVGAMLVLDTSGGGLRHVTSGVHLLK
Mvan_1394|M.vanbaalenii_PYR-1 VVASGSLPPGVPLDFYQRVADMCREAGALLILDTSGGGLSHITSGVYLLK
MSMEG_3947|M.smegmatis_MC2_155 VVASGSLPPGVDPRFYQQIADMCRESGVPLILDTSGGGLSHIESGVFVLK
:********** :**::*: * .. *:**:***** :: *..::*
Mb2054c|M.bovis_AF2122/97 ASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATR
Rv2029c|M.tuberculosis_H37Rv ASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATR
MMAR_3482|M.marinum_M ASVRELRECVGRPLVTEAEQLAAASELVETGRAEVVVVSLGSDGALLATR
TH_1728|M.thermoresistible__bu PSKRELREYVGRDIPTTADQIAAAHELIDRGVTQAVVVSLGADGALLATA
Mflv_4987|M.gilvum_PYR-GCK PSIRELRECLDRPLHTEPEQIAAARELIDRGAAKVVVVSLGADGALLVTP
Mvan_1394|M.vanbaalenii_PYR-1 PSVRELRECVGRPLPTEAEQLAAAHELIDRGIARIVVVSLGAQGALLAAS
MSMEG_3947|M.smegmatis_MC2_155 PSLRELRECTGKELTTEREQVAAARDLIDRGVTDVVIVSLGGDGALMVTA
.* ***** . : * :*:*** :*:: * : *:****.:***:.:
Mb2054c|M.bovis_AF2122/97 HASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGA
Rv2029c|M.tuberculosis_H37Rv HASHRFSSIPMTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGA
MMAR_3482|M.marinum_M RARHRFRAVEMRGG-SGVGAGDAMVAAITVGLARGWPLVKSVRLGIAAGA
TH_1728|M.thermoresistible__bu DVDQKFEAIDVPVVLSGVGAGDAMVAGITVALSRRWSLSDAVRYGVATGS
Mflv_4987|M.gilvum_PYR-GCK DDSERLSAVPMTSV-SCVGAGDALVAGVAVGLARRWPLGRAVRFGIAAAS
Mvan_1394|M.vanbaalenii_PYR-1 SHSERFPALPVAAV-SGIGAGDAMVAGITVGLAEGWTLDRAVRYGIAAAT
MSMEG_3947|M.smegmatis_MC2_155 RQSQRFKAVPVASG-SGVGAGDAMVAAITVGLSRGWPLPKSVRYGIAAGA
.:: :: : * :*****:**.::*.*:. *.* :** * *:.:
Mb2054c|M.bovis_AF2122/97 AMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
Rv2029c|M.tuberculosis_H37Rv AMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
MMAR_3482|M.marinum_M AMLLTPGTQACERADVERLFEHVAEPVEVA----------------
TH_1728|M.thermoresistible__bu AMLLTPGTAPCRPEDVERLFAQAAPPVDVTR-----SPARN-----
Mflv_4987|M.gilvum_PYR-GCK AKLQTPGTAAFHRDDVERYFVTQAAHSEA-----------------
Mvan_1394|M.vanbaalenii_PYR-1 AKLQTPATSVFDRADVEHHFAEQLAPSGT-----------------
MSMEG_3947|M.smegmatis_MC2_155 AMLLTPGTAVCRRAEVERLFALAAEPEDLTSGW-------------
* * **.* :**: *