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IVTVTANPSIDRTVSLPSPLTRGAVHRVTSVTNQAGGKGVNVAKVLTMAGVDAVAVLPAAANDPLLHALQ IAAVPYRAVTTTEPARTNLTITEPDGTTTKINEPGAKLDAATLEAFTDAVLDAAGGADWVVMSGSLPPGV PASWYGDVVASLASRDCRVAVDTSDAPLAALIGSLDRGAPDLIKPNAEELAGVLGLSAQSLEDAVLQGDP GPVVAAARQLIDRGIGAVLATLGAAGAVLVDHNGAWMATPPPIVPRSTVGAGDSSLAGYVRAEVGGAVPP QRLQMAVAYGSAAAALPGTTLPSPAEIDLNAVQVSPISPIPATR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0095 | - | - | 100% (325) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4105 | - | 4e-29 | 31.95% (313) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | 4e-23 | 28.66% (321) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 4e-23 | 29.97% (307) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_0751 | - | 1e-152 | 82.46% (325) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 5e-23 | 29.97% (307) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | MLBr_00373 | - | 2e-05 | 27.86% (201) | hypothetical protein MLBr_00373 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3482 | pfkB_1 | 1e-18 | 27.07% (314) | phosphofructokinase, PfkB_1 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0086 | - | 1e-117 | 67.72% (316) | 1-phosphofructokinase |
| M. thermoresistible (build 8) | TH_1728 | pfkB | 2e-25 | 30.25% (324) | Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0095|M.vanbaalenii_PYR-1 ----------------MIVTVTANPSIDRTVS-LPSPLTRGAVHRVTSVT
Mflv_0751|M.gilvum_PYR-GCK ----------------MIVTVTPNPSIDRTVT-LPSALTRGAVHRVTSVT
MSMEG_0086|M.smegmatis_MC2_155 ----------------MIVTVTLNPSLDRTVT-LTAPLTRGAVQRVDSVT
Mb2054c|M.bovis_AF2122/97 ----MTEPAAWDEGKPRIITLTMNPALDITTS-VDVVRPT-EKMRCGAPR
Rv2029c|M.tuberculosis_H37Rv ----MTEPAAWDEGKPRIITLTMNPALDITTS-VDVVRPT-EKMRCGAPR
MMAR_3482|M.marinum_M ----MTSPADPAVRGPQIVTLTMNPALDITTC-VGVVRPT-EKLRCSETR
TH_1728|M.thermoresistible__bu ----------------------MNPALDISTT-TDRVHHT-SKVRCHGVR
MLBr_00373|M.leprae_Br4923 MRHYYSVAAIRDAEASLLASLPDGVLMKRAAYGLASVIIRELAVRTGGVT
. :. :. *
Mvan_0095|M.vanbaalenii_PYR-1 ----------NQAGGKGVNVAKVLTMAGVDAVAVLPAAAND--PLLHALQ
Mflv_0751|M.gilvum_PYR-GCK ----------SQAGGKGVNVAKVLTMAGVDTVAVLPAAAND--PLITALQ
MSMEG_0086|M.smegmatis_MC2_155 ----------VEAGGKGINVAKALTSAGVDALALLPAATDD--PLLTALR
Mb2054c|M.bovis_AF2122/97 ----------YDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLG
Rv2029c|M.tuberculosis_H37Rv ----------YDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLG
MMAR_3482|M.marinum_M ----------YDPGGGGINVARIAHVLGGSVFAVFPVGGSHGAHVSKLLS
TH_1728|M.thermoresistible__bu ----------HDPGGGGINVARIAHVLGAPVTAVFPIGGHTGELLTDMLE
MLBr_00373|M.leprae_Br4923 GRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRVHRKALVAFR
: ** .: .* * *:: :
Mvan_0095|M.vanbaalenii_PYR-1 IAA---------VPYRAVTTTEPARTNLTITEP-DGTTTKINEPGAKLDA
Mflv_0751|M.gilvum_PYR-GCK AAA---------VPHRIVTTAEPARTNLTITEP-DGTTTKINEPGATLDD
MSMEG_0086|M.smegmatis_MC2_155 CAD---------VPFAAVPIAEPVRTNIAITEN-DGTTTKLNERGATLDA
Mb2054c|M.bovis_AF2122/97 DAG---------VPFRVIPIAASTRESFTVNESRTAKQYRFVLPGPSLTV
Rv2029c|M.tuberculosis_H37Rv DAG---------VPFRVIPIAASTRESFTVNESRTAKQYRFVLPGPSLTV
MMAR_3482|M.marinum_M EAG---------VAFGEIPIAASTRESFTVNESSTGEQYRFVLPGPVLAP
TH_1728|M.thermoresistible__bu HSG---------VSYHSVPIADLTRESLTVNEESTGHQYRFVLPGPFVTH
MLBr_00373|M.leprae_Br4923 KAGGRIVENVSAATDLVIDGVVGISGSGPLRPAAAAVFATVSASGVPVVA
: .. : . . .: . . * :
Mvan_0095|M.vanbaalenii_PYR-1 ATL----EAFTDAVLDAAGGADWVVMSGSLP-------------------
Mflv_0751|M.gilvum_PYR-GCK AAL----QAFSAAVLDASGNADWVVMSGSLP-------------------
MSMEG_0086|M.smegmatis_MC2_155 AAL----DAITRCVVDEAQHAAWVVLSGSLP-------------------
Mb2054c|M.bovis_AF2122/97 AEQ----EQCLDELRGAAASAAFVVASGSLP-------------------
Rv2029c|M.tuberculosis_H37Rv AEQ----EQCLDELRGAAASAAFVVASGSLP-------------------
MMAR_3482|M.marinum_M EEQ----AQCLQELGFAARSAQFVVASGSLP-------------------
TH_1728|M.thermoresistible__bu EEQ----DAVLQRLREVAASAQFLVASGSLP-------------------
MLBr_00373|M.leprae_Br4923 VDLPSGIDVVTGVINGPAVHAALTVTFGGLKPVHALADCGDVTLVDIGLD
: : * * *.*
Mvan_0095|M.vanbaalenii_PYR-1 --------------------PGVPASWYGD-VVASLASR-----DCRVAV
Mflv_0751|M.gilvum_PYR-GCK --------------------PGIPASWYAD-ITARLSGQ-----GCRIAV
MSMEG_0086|M.smegmatis_MC2_155 --------------------PGVPPQWYAD-LVAKLAPL-----PCRVAV
Mb2054c|M.bovis_AF2122/97 --------------------PGVAADYYQR-VADICRRS-----STPLIL
Rv2029c|M.tuberculosis_H37Rv --------------------PGVAADYYQR-VADICRRS-----STPLIL
MMAR_3482|M.marinum_M --------------------PGVPADFYQR-VAEACRGL-----GARLIL
TH_1728|M.thermoresistible__bu --------------------PGVPADFYQR-VADLCREL-----GVLLIL
MLBr_00373|M.leprae_Br4923 LPDSDILGLQAADVAAYWPVPGVHDDKYTQGVTGVLAGSSTYPGAAVLCT
**: . * :. :
Mvan_0095|M.vanbaalenii_PYR-1 DTSDAPLAALIGSLDRGAPDLIKPNAEELAGVLGLSAQSLEDAVL-----
Mflv_0751|M.gilvum_PYR-GCK DTSDAPLTALVDNLDRGAPDLIKPNAEELAGVLGLDADVLENAVA-----
MSMEG_0086|M.smegmatis_MC2_155 DTSDAPLAALASKLSTASPELMKPNVEELASISGVAEADLETTVA-----
Mb2054c|M.bovis_AF2122/97 DTSGGGLQHIS-----SGVFLLKASVRELRECVGSELLTEP---------
Rv2029c|M.tuberculosis_H37Rv DTSGGGLQHIS-----SGVFLLKASVRELRECVGSELLTEP---------
MMAR_3482|M.marinum_M DTSGGGLSHIS-----AGVYLLKASVRELRECVGRPLVTEA---------
TH_1728|M.thermoresistible__bu DSSGGGLTQVR-----YGAFLVKPSKRELREYVGRDIPTTA---------
MLBr_00373|M.leprae_Br4923 GAAVAATSGMVRYAGSAYTQVLAHWPEVIASATPTAAGRVQSWVVGPGLG
.:: . : :: . :
Mvan_0095|M.vanbaalenii_PYR-1 ---------------------QGDPGPVVAAARQLIDRG-IGAVLATLGA
Mflv_0751|M.gilvum_PYR-GCK ---------------------QGDPAPVVAAGRQMIDRG-IGAVLATLGA
MSMEG_0086|M.smegmatis_MC2_155 ---------------------EGDLSLVVAAAVKLVERG-VGAVLATLGA
Mb2054c|M.bovis_AF2122/97 --------------------------EQLAAAHELIDRGRAEVVVVSLGS
Rv2029c|M.tuberculosis_H37Rv --------------------------EQLAAAHELIDRGRAEVVVVSLGS
MMAR_3482|M.marinum_M --------------------------EQLAAASELVETGRAEVVVVSLGS
TH_1728|M.thermoresistible__bu --------------------------DQIAAAHELIDRGVTQAVVVSLGA
MLBr_00373|M.leprae_Br4923 IDATATAALWFALETDLPVLVDADGLTMLAAHPDLVINRNAPTVLTPHAS
:** .:: .*:.. .:
Mvan_0095|M.vanbaalenii_PYR-1 AGAVLVDHN--------------------------------GAWMATPPP
Mflv_0751|M.gilvum_PYR-GCK AGAVLVDKD--------------------------------GAWLAAPPP
MSMEG_0086|M.smegmatis_MC2_155 AGAVLVDGT--------------------------------GAWFAAPPP
Mb2054c|M.bovis_AF2122/97 QGALLATRH--------------------------------ASHRFSSIP
Rv2029c|M.tuberculosis_H37Rv QGALLATRH--------------------------------ASHRFSSIP
MMAR_3482|M.marinum_M DGALLATRR--------------------------------ARHRFRAVE
TH_1728|M.thermoresistible__bu DGALLATAD--------------------------------VDQKFEAID
MLBr_00373|M.leprae_Br4923 EFARLAGTPPGDDRVGACRKLADSFGATVLLKGNVTVIADPGGPVYLNPA
* *.
Mvan_0095|M.vanbaalenii_PYR-1 IVPR-STVGAGDSSLAGYVRAEVGGAVPPQRLQMAVAYGSAAAALPGTTL
Mflv_0751|M.gilvum_PYR-GCK IVPR-STVGAGDSSLAGYLRAEVSGAAPPERLQMAVAYGSAAAALPGTTL
MSMEG_0086|M.smegmatis_MC2_155 ITAR-STVGAGDASLAGYLRAEVGGAEPSQRLRMAVAYGSAAAALPGSAL
Mb2054c|M.bovis_AF2122/97 MTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGAAMLLTPGTAA
Rv2029c|M.tuberculosis_H37Rv MTAV-SGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGAAMLLTPGTAA
MMAR_3482|M.marinum_M MRGG-SGVGAGDAMVAAITVGLARGWPLVKSVRLGIAAGAAMLLTPGTQA
TH_1728|M.thermoresistible__bu VPVVLSGVGAGDAMVAGITVALSRRWSLSDAVRYGVATGSAMLLTPGTAP
MLBr_00373|M.leprae_Br4923 GQSWAATAGSGD-VLSGMIGALLAAGLPAAEAAAAAAFVHARAAALSAAD
: .*:** ::. . . * * .:
Mvan_0095|M.vanbaalenii_PYR-1 PSPAEIDLNAVQVSPISPIPATR-------------
Mflv_0751|M.gilvum_PYR-GCK PSPAEIDVDGVRVTPISPVPVTQQQL----------
MSMEG_0086|M.smegmatis_MC2_155 PVPAQLDVDAVRVTGLITTNREVLQ-----------
Mb2054c|M.bovis_AF2122/97 CNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
Rv2029c|M.tuberculosis_H37Rv CNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP
MMAR_3482|M.marinum_M CERADVERLFEHVAEPVEVA----------------
TH_1728|M.thermoresistible__bu CRPEDVERLFAQAAPPVDVTR-----SPARN-----
MLBr_00373|M.leprae_Br4923 PGPGDVPTSASRMVSHIRTALAAL------------
::