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AVLDAFMAIWSKARGTFGDGVPQDGSVYDASPALTRLQDEVRGAAPRETWTGSASDGYASANERHASVLG ETALLDRRLRAEIDRSAEVVRAGRRELDAVRRRVSEAAAGVPPTPEGESMLYPAISRGSGEIVDIVQRSH TDLNMIAGRIEAIASEYQALGEGTELGVGDGAEPAGGAEPGDEPRLAVSNENEPWTYPFDPPAPPDSAPG GGRWELGQAYPPGPGGGPPMGPIPAPKPWHRSIDPPVKGGGSGLEDVVTPPPNGVGVRPPLVLQESYEFR VTGEGFRDGDGHLRWIQRDGSWYQAQWIDYELEANHLQQLTGNVSVPLGDHTWEPIDIKDIYQLQVDNPR LTLYIPDPSGSVLELDPDRPAASGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4060 | - | - | 100% (376) | hypothetical protein Mvan_4060 |
| M. vanbaalenii PYR-1 | Mvan_1151 | - | 2e-41 | 44.74% (190) | hypothetical protein Mvan_1151 |
| M. vanbaalenii PYR-1 | Mvan_0656 | - | 1e-06 | 32.91% (79) | hypothetical protein Mvan_0656 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3646c | - | 2e-07 | 32.56% (86) | hypothetical protein Mb3646c |
| M. gilvum PYR-GCK | Mflv_1605 | - | 1e-38 | 49.10% (167) | hypothetical protein Mflv_1605 |
| M. tuberculosis H37Rv | Rv3616c | - | 2e-07 | 32.56% (86) | hypothetical protein Rv3616c |
| M. leprae Br4923 | MLBr_00405 | - | 1e-07 | 33.72% (86) | hypothetical protein MLBr_00405 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4166 | espA | 2e-08 | 28.43% (102) | ESX-1 secretion-associated protein A, EspA |
| M. avium 104 | MAV_1372 | - | 5e-05 | 34.65% (101) | hypothetical protein MAV_1372 |
| M. smegmatis MC2 155 | MSMEG_5089 | - | 7e-30 | 33.19% (229) | hypothetical protein MSMEG_5089 |
| M. thermoresistible (build 8) | TH_3234 | - | 3e-41 | 47.03% (185) | PUTATIVE putative hypothetical protein Mvan_4060 |
| M. ulcerans Agy99 | MUL_0202 | pra | 2e-06 | 36.36% (99) | proline-rich antigen Pra-like protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3646c|M.bovis_AF2122/97 MSRAFIIDPTISAIDGLYDLLGIGIPNQ--GGILYSSLEYFEKALEELAA
Rv3616c|M.tuberculosis_H37Rv MSRAFIIDPTISAIDGLYDLLGIGIPNQ--GGILYSSLEYFEKALEELAA
MMAR_4166|M.marinum_M MSRAFIIDPTISAINGLHALLGIGLPED--GGIIDSALSFFGKALDDLGS
MLBr_00405|M.leprae_Br4923 MSGAFIIDPTLKAIEAWHALLGIGVPND--GGVLYSSLSFFEKALEHLAA
Mvan_4060|M.vanbaalenii_PYR-1 ---MAVLDAFMAIWSKARGTFGDGVPQD--GSVYDASPA-LTRLQDEVRG
Mflv_1605|M.gilvum_PYR-GCK ---MSVLGSFLTTWSQARATFGDGVPLP--GSTFDGSST-LRRLEAETRR
TH_3234|M.thermoresistible__bu ---VSALAAFLTTWSAARATFGEGTPRT--GERFDHSAL-FHRLQAEAQT
MSMEG_5089|M.smegmatis_MC2_155 ---MGALDGFYSTWNKARETFGQGAPTD--GSQFDQSRS-LTQMKASVEA
MAV_1372|M.avium_104 ----------MNTMTAPGAGFGESAQHDHHGDQAHGDKPNDDATSAPHAQ
MUL_0202|M.ulcerans_Agy99 ----------MTDQPPPGGSYPPPPPPP---GSSGGSEPPAGGYQAPPPP
Mb3646c|M.bovis_AF2122/97 AFPGDGWLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTT
Rv3616c|M.tuberculosis_H37Rv AFPGDGWLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTT
MMAR_4166|M.marinum_M AFPGDGWLGSAADHYSGKNRKHVNFFKELAELDRELQKLIADQASAVKTT
MLBr_00405|M.leprae_Br4923 AFPGDGWLGSAADKYAGQNRKRVDIFQELAELDKELIELIHNQANSVQTT
Mvan_4060|M.vanbaalenii_PYR-1 AAPRETWTGSASDGYASANERHASVLGETALLDRRLRAEIDRSAEVVRAG
Mflv_1605|M.gilvum_PYR-GCK AAPRSDWTGGAADTYAAGNAEHARALARMAELDERMGREVDRSAVVVRDG
TH_3234|M.thermoresistible__bu AAPGDVWTGTAADAYGAVNSEMIGVLGGLAALDVRLRAQVDSAAEVVSAG
MSMEG_5089|M.smegmatis_MC2_155 AAPDDRWQGSGANAYAAANKEHAQVYQKLADLDQKMAAEVKNAANVVSAG
MAV_1372|M.avium_104 PAPWEPPAGSVPPPYPPPGYPADYPPGYPPPYPPPAPSPVPPPPPGYGPP
MUL_0202|M.ulcerans_Agy99 SAPSG--GGYPPPPPPPPPSTSGYPPPPPPPPLEGGYPPPPPPSAGGYAP
. * * . . .
Mb3646c|M.bovis_AF2122/97 RDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGA
Rv3616c|M.tuberculosis_H37Rv RDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGA
MMAR_4166|M.marinum_M REILEDAKKGLEFVRPVAVDLTYIPIVGWAMSAAFQAPVCAAAMAVVGGA
MLBr_00405|M.leprae_Br4923 RGILDGAKKALLFVRPVAIDLNYIPLVGSVMSASIQAQACAAAMAAVSGG
Mvan_4060|M.vanbaalenii_PYR-1 RRELDAVRRRVSEAAAGVPPTPEG--ESMLYPAISRGSGEIVDIVQRSHT
Mflv_1605|M.gilvum_PYR-GCK RVHLDSVKDWVLSAAASVPDNAAG--ERMLLPIVGKGCTDIADIVTSSNG
TH_3234|M.thermoresistible__bu RRDLESIRQAVTTAAAALPTGTVG--ERMLWPIVAQGLGEITGIVRRSSG
MSMEG_5089|M.smegmatis_MC2_155 RTNLDNAKSWVEGMANSLPATSQQDRERKLIPIAREGINRVDNIVKSATA
MAV_1372|M.avium_104 PPPGYGPPGYPGGYYPGPDYGGYPPQPPLLGGQPGTNGLAIASLIASFTG
MUL_0202|M.ulcerans_Agy99 PPPGPAIRALPAESYTPWITRVLAALIDFAPYVVVTGIGWLIMMVTTTPS
:
Mb3646c|M.bovis_AF2122/97 LAYLAVKTLINATQLLKLLAKLAELVA-----------------------
Rv3616c|M.tuberculosis_H37Rv LAYLVVKTLINATQLLKLLAKLAELVA-----------------------
MMAR_4166|M.marinum_M LAYLVVKTLINSMKLVSLLAQLAKLLA-----------------------
MLBr_00405|M.leprae_Br4923 LAYLLVQTAIHTAKFVALLARLAHLLA-----------------------
Mvan_4060|M.vanbaalenii_PYR-1 DLNMIAGRIEAIASEYQALGEGTELG------------------------
Mflv_1605|M.gilvum_PYR-GCK QLATIAERIRSLGVEYAALDD-----------------------------
TH_3234|M.thermoresistible__bu DLSQIGAELTRIGEEYRQLSEQKFGGG-----------------------
MSMEG_5089|M.smegmatis_MC2_155 DMMGIKGNVEKLRGEYDTIKTTMRFGPESEKKPGDKKDDAQMLGNEEKDD
MAV_1372|M.avium_104 LLCGIGSVVAIVLGAIALDQIKRTRQD-----------------------
MUL_0202|M.ulcerans_Agy99 CVTDISQYDIGQYCVSQPSMIGQLAQWLLSLVG-----------------
Mb3646c|M.bovis_AF2122/97 ----------------AAIADIISDVADIIKGILGEVWEFITNALNGLKE
Rv3616c|M.tuberculosis_H37Rv ----------------AAIADIISDVADIIKGTLGEVWEFITNALNGLKE
MMAR_4166|M.marinum_M ----------------EAVADVVSDVVDIIKGILEEVWEFLTHPFEFLKD
MLBr_00405|M.leprae_Br4923 ----------------SAVADVVSDGVAIIKGIVDHLWHFIAGALTGLKD
Mvan_4060|M.vanbaalenii_PYR-1 ---------VGDGAEPAGGAEPGDEPRLAVSNENEPWTYPFDPPAPPDSA
Mflv_1605|M.gilvum_PYR-GCK ----------------AASVTPRSE---ATTSD-----------------
TH_3234|M.thermoresistible__bu --------LPEQPAGEAPGEEPEHEDEDPAEAERDRRLEEIMRDYQVGED
MSMEG_5089|M.smegmatis_MC2_155 DGIPEMHAPSTEDQARMDVEQVLSEGDGGAAERVDEVLSSIKPGDELTPQ
MAV_1372|M.avium_104 -------------GFGLAVAGIVIGIATLVVTLVVVLFALHTH-------
MUL_0202|M.ulcerans_Agy99 ------------LAYLVWDYGYRQGTTGSSIGKSIMKFKVVSETTGEPLG
Mb3646c|M.bovis_AF2122/97 LWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFGAAGLS
Rv3616c|M.tuberculosis_H37Rv LWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFGAAGLS
MMAR_4166|M.marinum_M LLNKLVSWASSLLSQWGSKLQSFFGGIPGLSGMGGGLSQLTSFFSSAGAA
MLBr_00405|M.leprae_Br4923 IVEKIIHWFFGLFSHWWSRLHSFFGGIPGLSGATSGLSQVTGLFGVPGLA
Mvan_4060|M.vanbaalenii_PYR-1 PGGGRWELGQAYPPGPGGGPPMGPIPAPKPWHRSIDPPVKGGGSGLEDVV
Mflv_1605|M.gilvum_PYR-GCK ------------------------LRRPTPRHR-----------------
TH_3234|M.thermoresistible__bu PDG-----VIEWKSGGLVGMLTGSKEMTATEGRMMDELGLFGQRDMQQIV
MSMEG_5089|M.smegmatis_MC2_155 QDAYLSEMQRQQKGMSVEDLRAAEQRLGDHKNVIADSWQLMSNDDVEYSA
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 FGMSVVRQLAHIVDAVICYIGFLFPLWDAKRQTLADKIMTTVCLPL----
Mb3646c|M.bovis_AF2122/97 ASSG---LAHADSLASSASLPALAGIGGGSGFGG----------------
Rv3616c|M.tuberculosis_H37Rv ASSG---LAHADSLASSASLPALAGIGGGSGFGG----------------
MMAR_4166|M.marinum_M GSAGSVGAADSASLVSSAGLPGGLGLGGGSGFGS----------------
MLBr_00405|M.leprae_Br4923 GSSG---LLSGESLLSTENLPSLAGVGAGLGLGS----------------
Mvan_4060|M.vanbaalenii_PYR-1 TPPPNGVGVRPPLVLQESYEFRVTGEGFRDGDGH----------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu EQAREEANKR--FPPPEGREIDNHNDAFRHAYWN----------------
MSMEG_5089|M.smegmatis_MC2_155 GAGDDKKGAASQLPDSVQKALTNAGDTWPIGDGIGQLRYEGDLKAISEIV
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mvan_4060|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu --------------------------------------------------
MSMEG_5089|M.smegmatis_MC2_155 KDGNPGFQTGTELDRQLIVAADKAMDARDIPGGQILGRESTVQSLFEAVD
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 ----------------------------------------LPSLAQVHAA
Rv3616c|M.tuberculosis_H37Rv ----------------------------------------LPSLAQVHAA
MMAR_4166|M.marinum_M ----------------------------------------MPNVAQLRSA
MLBr_00405|M.leprae_Br4923 ----------------------------------------LPQLAQLHAA
Mvan_4060|M.vanbaalenii_PYR-1 ----------------------------------------LRWIQRDGSW
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu ----------------------------------------ALMTQRFGDE
MSMEG_5089|M.smegmatis_MC2_155 DDHQIINDHLMGRNGVDVDDFLRDVNTTDWPDNGKAAGYLFSWTNEASSG
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 STRQALRPRADGPVGAAAEQVGGQSQLVSAQG------------------
Rv3616c|M.tuberculosis_H37Rv STRQALRPRADGPVGAAAEQVGGQSQLVSAQG------------------
MMAR_4166|M.marinum_M ATRQDPRLTSEGPTRVSSEPVGEHAQAASAQG------------------
MLBr_00405|M.leprae_Br4923 STRQGTRSQAGVSAELSTEQFGGQQEPVSAQG------------------
Mvan_4060|M.vanbaalenii_PYR-1 YQAQWIDYEL---------EANHLQQLTGNVS---------------VPL
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu WAEKFATAHEGIPRNYAASEAMDLFNNEVGRN---------------LAV
MSMEG_5089|M.smegmatis_MC2_155 PEAHIAAEVADKYAGYIGEHRTDLMNFDGQTLGQRNPELVQQYAHGLVPF
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 SQGMGGPVGMGGMHPSSGASK--GTTTKKYSEGAAAGTEDAERAPVEADA
Rv3616c|M.tuberculosis_H37Rv SQGMGGPVGMGGMHPSSGASK--GTTTKKYSEGAAAGTEDAERAPVEADA
MMAR_4166|M.marinum_M GQGMG------GMHPASAGSK--GATSKKYSEGAAAGTEDAERAPVEVGV
MLBr_00405|M.leprae_Br4923 SQGMGGSQGMGGMTPASTKSKKDERKKKKYSEGAAAGTDDAERAPIEVQS
Mvan_4060|M.vanbaalenii_PYR-1 GDHTWEPIDIKDIYQLQVDNPRLTLYIPDPSGSVLELDPDRPAASGP---
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu ANPDASKDELADLVEQAVRNGDTVVVRPDGQGLEWSDRITPESTGDSSRS
MSMEG_5089|M.smegmatis_MC2_155 VDDMAGNNGSGGEFEIDTEKDRRAGLMPNAKGVFSVLNTDPTAATTINSA
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 GGGQKVLVRNVV--------------------------------------
Rv3616c|M.tuberculosis_H37Rv GGGQKVLVRNVV--------------------------------------
MMAR_4166|M.marinum_M GAAARIAERRAG--------------------------------------
MLBr_00405|M.leprae_Br4923 GGGKRALAQHVV--------------------------------------
Mvan_4060|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu APVDGQIPTPAGQPNPHGGYEIG---------------------------
MSMEG_5089|M.smegmatis_MC2_155 AISQAMIAETAFAENPNDPLAHSYLSSAATLRGLVDVGAHEAFQAFNENG
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mvan_4060|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu --------------------------------------------------
MSMEG_5089|M.smegmatis_MC2_155 YNAGVDETTWKKAGFDAAVTAFSTGSTFVPGVGVVASPVISQVGSIFSNE
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mvan_4060|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu --------------------------------------------------
MSMEG_5089|M.smegmatis_MC2_155 FFENPPGPVERPLPQLSEPVATTTLLNAMLAANQPLDLPPGYVVGNEVVQ
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mvan_4060|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1605|M.gilvum_PYR-GCK --------------------------------------------------
TH_3234|M.thermoresistible__bu --------------------------------------------------
MSMEG_5089|M.smegmatis_MC2_155 PPGVSDHEFAATLNAEIGRQTVTVDGDGPDEIYADQYNLIIQDPDIQAPP
MAV_1372|M.avium_104 --------------------------------------------------
MUL_0202|M.ulcerans_Agy99 --------------------------------------------------
Mb3646c|M.bovis_AF2122/97 --------
Rv3616c|M.tuberculosis_H37Rv --------
MMAR_4166|M.marinum_M --------
MLBr_00405|M.leprae_Br4923 --------
Mvan_4060|M.vanbaalenii_PYR-1 --------
Mflv_1605|M.gilvum_PYR-GCK --------
TH_3234|M.thermoresistible__bu --------
MSMEG_5089|M.smegmatis_MC2_155 TATRSENK
MAV_1372|M.avium_104 --------
MUL_0202|M.ulcerans_Agy99 --------