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MSRAFIIDPTISAINGLHALLGIGLPEDGGIIDSALSFFGKALDDLGSAFPGDGWLGSAADHYSGKNRKH VNFFKELAELDRELQKLIADQASAVKTTREILEDAKKGLEFVRPVAVDLTYIPIVGWAMSAAFQAPVCAA AMAVVGGALAYLVVKTLINSMKLVSLLAQLAKLLAEAVADVVSDVVDIIKGILEEVWEFLTHPFEFLKDL LNKLVSWASSLLSQWGSKLQSFFGGIPGLSGMGGGLSQLTSFFSSAGAAGSAGSVGAADSASLVSSAGLP GGLGLGGGSGFGSMPNVAQLRSAATRQDPRLTSEGPTRVSSEPVGEHAQAASAQGGQGMGGMHPASAGSK GATSKKYSEGAAAGTEDAERAPVEVGVGAAARIAERRAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4166 | espA | - | 100% (389) | ESX-1 secretion-associated protein A, EspA |
| M. marinum M | MMAR_5439 | - | 2e-34 | 28.86% (402) | hypothetical protein MMAR_5439 |
| M. marinum M | MMAR_1325 | - | 4e-15 | 24.93% (373) | hypothetical protein MMAR_1325 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3646c | - | 1e-138 | 63.78% (392) | hypothetical protein Mb3646c |
| M. gilvum PYR-GCK | Mflv_0157 | - | 1e-11 | 28.47% (137) | hypothetical protein Mflv_0157 |
| M. tuberculosis H37Rv | Rv3616c | - | 1e-138 | 63.78% (392) | hypothetical protein Rv3616c |
| M. leprae Br4923 | MLBr_00405 | - | 1e-116 | 57.44% (390) | hypothetical protein MLBr_00405 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-06 | 29.66% (145) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_5287 | - | 6e-05 | 29.61% (179) | hypothetical protein MAV_5287 |
| M. smegmatis MC2 155 | MSMEG_0723 | - | 2e-11 | 26.74% (172) | hypothetical protein MSMEG_0723 |
| M. thermoresistible (build 8) | TH_2666 | - | 3e-09 | 21.51% (172) | PUTATIVE putative hypothetical protein MSMEG_0078 |
| M. ulcerans Agy99 | MUL_2554 | - | 1e-14 | 24.66% (373) | hypothetical protein MUL_2554 |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 5e-09 | 31.13% (151) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------MALGKLWVDANYFYGVADHANMMSSDPALG
TH_2666|M.thermoresistible__bu ----------------------MLDAYSTLNWGKSVVEHPMSAKDHTGWG
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 ----------MPAGLIAAAVRTIVNLGSFGQQFVGVNDPKFTNPEYLAAS
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTPNNLAASL
MAB_4284c|M.abscessus_ATCC_199 -------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGA
Mb3646c|M.bovis_AF2122/97 ---------------------------------------MSRAFIIDPTI
Rv3616c|M.tuberculosis_H37Rv ---------------------------------------MSRAFIIDPTI
MMAR_4166|M.marinum_M ---------------------------------------MSRAFIIDPTI
MLBr_00405|M.leprae_Br4923 ---------------------------------------MSGAFIIDPTL
Mflv_0157|M.gilvum_PYR-GCK SAAIATD---------AAILMQSLAAVGGSTMGATGLATSVATPIINAGL
TH_2666|M.thermoresistible__bu IAGTGAD---------FVTLMQGMTEAG-SGLDQGRLAKAAATPIIRAAL
MSMEG_0723|M.smegmatis_MC2_155 -----------------------------------MFPKCPQTPIIQAGL
MUL_2554|M.ulcerans_Agy99 ATGMASDGLTAVFGQTWVPQALAKRVGHSQLTSLASSKAAQGASAILWTI
MAV_5287|M.avium_104 -------------------------MGGPGGIIKNDLPTTTAIVGGPPAS
Mvan_1264|M.vanbaalenii_PYR-1 VDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGL
MAB_4284c|M.abscessus_ATCC_199 VMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPS
Mb3646c|M.bovis_AF2122/97 SAIDGLYDLLGIGIPNQGGI-------LYSSLEYFEKALEELAAAFPGDG
Rv3616c|M.tuberculosis_H37Rv SAIDGLYDLLGIGIPNQGGI-------LYSSLEYFEKALEELAAAFPGDG
MMAR_4166|M.marinum_M SAINGLHALLGIGLPEDGGI-------IDSALSFFGKALDDLGSAFPGDG
MLBr_00405|M.leprae_Br4923 KAIEAWHALLGIGVPNDGGV-------LYSSLSFFEKALEHLAAAFPGDG
Mflv_0157|M.gilvum_PYR-GCK MTLTAASNTLGFGRPEDGER-------FTDGARQFSEANDELQQAVPPPD
TH_2666|M.thermoresistible__bu LAMMVMSNTCGVGTPEKGDR-------FEEGAQAFEAAGEALGATKSPES
MSMEG_0723|M.smegmatis_MC2_155 LAISAMSLQCGLGTPDDGSR-------FGDGCGEFRKTDELQESAAPNEQ
MUL_2554|M.ulcerans_Agy99 NIVEVLETLMGFGPPAEGDE-------LLVGSTQFAKAQAQLGSALPDNS
MAV_5287|M.avium_104 IPRPFPVPPGGTSPADAGQG-------MVGGAGNANVPKDAADAAAADAD
Mvan_1264|M.vanbaalenii_PYR-1 FGGNGGNGGNGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG
MAB_4284c|M.abscessus_ATCC_199 LLSPRDNDFLSHNDTDFASHN------PIASGNQVMSPSGNVDSFNRGPL
. . .
Mb3646c|M.bovis_AF2122/97 WLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTTRDILEG
Rv3616c|M.tuberculosis_H37Rv WLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTTRDILEG
MMAR_4166|M.marinum_M WLGSAADHYSGKNRKHVNFFKELAELDRELQKLIADQASAVKTTREILED
MLBr_00405|M.leprae_Br4923 WLGSAADKYAGQNRKRVDIFQELAELDKELIELIHNQANSVQTTRGILDG
Mflv_0157|M.gilvum_PYR-GCK WQGDASDAYGLRNTEQQQRAGSMATFDGQIQEVLAEEAGQVQDTRDFVST
TH_2666|M.thermoresistible__bu WQGKASNTYTDRNDEQRARAERMAAIDRTVKEILDAEAHQVDVARKMLDR
MSMEG_0723|M.smegmatis_MC2_155 WQGSASKAYDAQVVRQRERAQKLAQADEMMQEVIRSQAEQVSQTRQLLDI
MUL_2554|M.ulcerans_Agy99 WQGSASYAYASQNTALQNRGQALAELDVKFAALVKDQAEWATHGRLGIAI
MAV_5287|M.avium_104 RKARAADAAAKFPANEANGSQEMQMLQQMLSSVTGALGGAMGGVMGPLTQ
Mvan_1264|M.vanbaalenii_PYR-1 APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAGAVG
MAB_4284c|M.abscessus_ATCC_199 LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSN
. .
Mb3646c|M.bovis_AF2122/97 AKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLAV
Rv3616c|M.tuberculosis_H37Rv AKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVV
MMAR_4166|M.marinum_M AKKGLEFVRPVAVDLTYIPIVGWAMSAAFQAPVCAAAMAVVGGALAYLVV
MLBr_00405|M.leprae_Br4923 AKKALLFVRPVAIDLNYIPLVGSVMSASIQAQACAAAMAAVSGGLAYLLV
Mflv_0157|M.gilvum_PYR-GCK RQVMLAAAIPAAITAKLIPPGGAAAAMAIELAAVAATVPFAMQRVTEMVS
TH_2666|M.thermoresistible__bu CQTVLSLSIPAAIAAKAIPFKGPAISTAIEVAAVAGTAPLASLRYNELTR
MSMEG_0723|M.smegmatis_MC2_155 YSIALAAMIVPATIAMYTPY-GQPASVAIQAGAVAGTVPLATGSMLAMAA
MUL_2554|M.ulcerans_Agy99 LKNLLLATFAVEMALMFAVPAGPAMARSFGFTVSGLGIAIAMGLLSTVLT
MAV_5287|M.avium_104 LPQQAMQAGQSALQPLMSAVQGAHGAASLADNAHLVDSVGGAGSGLGGGA
Mvan_1264|M.vanbaalenii_PYR-1 SAGTAGSAGAPGVWGNAGLPGAAGAAGGAGAIGTAGVAGAAGTAGATGGT
MAB_4284c|M.abscessus_ATCC_199 IINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTT
.
Mb3646c|M.bovis_AF2122/97 KTLINATQLLKLLAKLAELVAAAIADIISDVADIIKGILGEVWEFITNAL
Rv3616c|M.tuberculosis_H37Rv KTLINATQLLKLLAKLAELVAAAIADIISDVADIIKGTLGEVWEFITNAL
MMAR_4166|M.marinum_M KTLINSMKLVSLLAQLAKLLAEAVADVVSDVVDIIKGILEEVWEFLTHPF
MLBr_00405|M.leprae_Br4923 QTAIHTAKFVALLARLAHLLASAVADVVSDGVAIIKGIVDHLWHFIAGAL
Mflv_0157|M.gilvum_PYR-GCK HSADNADRIRQIGSHYGVVDESAQMPGGLSGAQSGTPAPLRVSESIRGTA
TH_2666|M.thermoresistible__bu AVIRNAARMTQAAGEYSSVASAANPS------------------------
MSMEG_0723|M.smegmatis_MC2_155 LANANAAKVLQATAHYTEVAGEA---------------------------
MUL_2554|M.ulcerans_Agy99 YSVENSKKADVLTANYQDLTPDPYQGADPSMPMAAN-MPASAESTISSFA
MAV_5287|M.avium_104 GAGGGGAGLGGGGTVPTSSLGPPPVPTSS-----PPTTPAGAKAAMMPPT
Mvan_1264|M.vanbaalenii_PYR-1 GVGGNGGAGQAGGIGGTGAAGAAGQAGTAGETGVTGGVGGIGGQGTEGGT
MAB_4284c|M.abscessus_ATCC_199 NINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVGGNAGL
Mb3646c|M.bovis_AF2122/97 NGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFG
Rv3616c|M.tuberculosis_H37Rv NGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFG
MMAR_4166|M.marinum_M EFLKDLLNKLVSWASSLLSQWGSKLQSFFGGIPGLSGMGGGLSQLTSFFS
MLBr_00405|M.leprae_Br4923 TGLKDIVEKIIHWFFGLFSHWWSRLHSFFGGIPGLSGATSGLSQVTGLFG
Mflv_0157|M.gilvum_PYR-GCK GIQQNVAATIDSARS------------------APDGSAGDVFKTHGVVC
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 ASGTAFTAEAAG----------------------SLGRASGAADESAFYS
MAV_5287|M.avium_104 GGMPAMPG--------------------------QTGMTGMPMMPPGAMG
Mvan_1264|M.vanbaalenii_PYR-1 GGVGGVGGVGATGGAGGVGGKGIQGGQGLQGGQGGDGGTGGTGGDATSMG
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG
Mb3646c|M.bovis_AF2122/97 AAGLSASSG---LAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAAS
Rv3616c|M.tuberculosis_H37Rv AAGLSASSG---LAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAAS
MMAR_4166|M.marinum_M SAGAAGSAGSVGAADSASLVSSAGLPGGLGLGGGSGFGSMPNVAQLRSAA
MLBr_00405|M.leprae_Br4923 VPGLAGSSG---LLSGESLLSTENLPSLAGVGAGLGLGSLPQLAQLHAAS
Mflv_0157|M.gilvum_PYR-GCK TSTAAALKS-------------------------AELARRSAAEKMHLIS
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 AAADEAVPL-------------------EDAPSATSAFTMPTLAQLMAIS
MAV_5287|M.avium_104 AGGEGGNKD---------------KPVEKRVTAPGVPNGQPVKGRLTIPP
Mvan_1264|M.vanbaalenii_PYR-1 EAGATGGKGGNGGNGGRGSLFGRGGNAGNGGNGGTGGNGGNGGTGGTGGN
MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAG----LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGL
Mb3646c|M.bovis_AF2122/97 TRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSSGA
Rv3616c|M.tuberculosis_H37Rv TRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSSGA
MMAR_4166|M.marinum_M TRQDPRLTSEGPTRVSSEPVGEHAQAASAQGGQGMG------GMHPASAG
MLBr_00405|M.leprae_Br4923 TRQGTRSQAGVSAELSTEQFGGQQEPVSAQGSQGMGGSQGMGGMTPASTK
Mflv_0157|M.gilvum_PYR-GCK TDLSAKLGSSATEYSHTEQQNADAVDRQMPPR------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 GQGAKFSGHVSQHANLANQAMGQVQQVASMAQQGKGTAPAEDTAQTEATT
MAV_5287|M.avium_104 SAPGSKPGEAKPTVVTNRPNRRIVIMPSDDEPKE----------------
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGG
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAGNAAVGG
Mb3646c|M.bovis_AF2122/97 SK--GTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV-------
Rv3616c|M.tuberculosis_H37Rv SK--GTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV-------
MMAR_4166|M.marinum_M SK--GATSKKYSEGAAAGTEDAERAPVEVGVGAAARIAERRAG-------
MLBr_00405|M.leprae_Br4923 SKKDERKKKKYSEGAAAGTDDAERAPIEVQSGGGKRALAQHVV-------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 VEDVEGAG-ADSAGAAAGRAPIEAAAADTPPAQQPIFAQQVV--------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 KGGTGGTGGDGGTGGTGGTGGTGGTGGTGGTGGTGGTGGAGDGLGGTGGT
MAB_4284c|M.abscessus_ATCC_199 VLNTGVSGAIGGSSHVGGAINESLGGSGSVGGSTAVGGGAHTGVGGGVST
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGFGGQGGQGGTGGTGGQGGLGGVGGTGGTGGTGGTGGQGGTGGTGG
MAB_4284c|M.abscessus_ATCC_199 G--VGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGS
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGGQ
MAB_4284c|M.abscessus_ATCC_199 HVGGGISESLGGSGSVGGSTAVGG-GAHTGVGGGVNTGVGVGSHVGGGIS
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 AGVAGKGGLFGGSGSAGTAGVTGASGASGGKGAQGATGAQGATGAQGATG
MAB_4284c|M.abscessus_ATCC_199 ESLGGSGSVGGSTAVGGGAHTSAINDALGGSGSVGGSTAVGGGAHTSAIN
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ATGASGAQGSAGSAGSAGVAGSAGTTGAQGSAGTNGANGANGSQGAAGKA
MAB_4284c|M.abscessus_ATCC_199 ESMNSSINASHSSSMNESFGSSMGSHGAAG-------TGFEAQGHAQGHA
Mb3646c|M.bovis_AF2122/97 --------------------------------------------------
Rv3616c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4166|M.marinum_M --------------------------------------------------
MLBr_00405|M.leprae_Br4923 --------------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK --------------------------------------------------
TH_2666|M.thermoresistible__bu --------------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2554|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GATGTTGATGAAGDAGDPGSEAVDINGGAGGAGGAGGEGGEGGAGGAGGD
MAB_4284c|M.abscessus_ATCC_199 SETAHTTLPGAEHH------------------------------------
Mb3646c|M.bovis_AF2122/97 ----------------------------------------------
Rv3616c|M.tuberculosis_H37Rv ----------------------------------------------
MMAR_4166|M.marinum_M ----------------------------------------------
MLBr_00405|M.leprae_Br4923 ----------------------------------------------
Mflv_0157|M.gilvum_PYR-GCK ----------------------------------------------
TH_2666|M.thermoresistible__bu ----------------------------------------------
MSMEG_0723|M.smegmatis_MC2_155 ----------------------------------------------
MUL_2554|M.ulcerans_Agy99 ----------------------------------------------
MAV_5287|M.avium_104 ----------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GSEGGAGGSGGAGGSGTGGAGGAGGSGGSGGSGGAGGSGGAAGDSD
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------