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SRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAADKYAGKNRNHV NFFQELADLDRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGA MAVVGGALAYLVVKTLINATQLLKLLAKLAELVAAAIADIISDVADIIKGTLGEVWEFITNALNGLKELW DKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFGAAGLSASSGLAHADSLASSASLPALAG IGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSSGA SKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3616c | - | - | 100% (392) | CONSERVED HYPOTHETICAL ALANINE AND GLYCINE RICH PROTEIN |
M. tuberculosis H37Rv | Rv3864 | - | 1e-32 | 31.20% (407) | hypothetical protein Rv3864 |
M. tuberculosis H37Rv | Rv0833 | PE_PGRS13 | 7e-10 | 31.29% (163) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3646c | - | 0.0 | 99.49% (392) | hypothetical protein Mb3646c |
M. gilvum PYR-GCK | Mflv_0157 | - | 7e-10 | 24.84% (161) | hypothetical protein Mflv_0157 |
M. leprae Br4923 | MLBr_00405 | - | 1e-139 | 62.69% (394) | hypothetical protein MLBr_00405 |
M. abscessus ATCC 19977 | MAB_4284c | - | 8e-08 | 31.16% (138) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4166 | espA | 1e-137 | 63.78% (392) | ESX-1 secretion-associated protein A, EspA |
M. avium 104 | MAV_2926 | - | 2e-06 | 29.76% (168) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0055 | - | 2e-11 | 23.86% (373) | hypothetical protein MSMEG_0055 |
M. thermoresistible (build 8) | TH_2666 | - | 8e-11 | 23.84% (172) | PUTATIVE putative hypothetical protein MSMEG_0078 |
M. ulcerans Agy99 | MUL_2554 | - | 8e-15 | 25.73% (377) | hypothetical protein MUL_2554 |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 2e-07 | 29.87% (154) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0157|M.gilvum_PYR-GCK -------------------------------------------------- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv -------------------------------------------------- Mb3646c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00405|M.leprae_Br4923 -------------------------------------------------- MMAR_4166|M.marinum_M -------------------------------------------------- MSMEG_0055|M.smegmatis_MC2_155 -------------------------------------------------- MUL_2554|M.ulcerans_Agy99 -------------------------------------------------- MAV_2926|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTPNNLAASL Mflv_0157|M.gilvum_PYR-GCK ------------------------------------------MALGKLWV TH_2666|M.thermoresistible__bu --------------------------------------------MLDAYS Rv3616c|M.tuberculosis_H37Rv --------------------------------------------MSRAFI Mb3646c|M.bovis_AF2122/97 --------------------------------------------MSRAFI MLBr_00405|M.leprae_Br4923 --------------------------------------------MSGAFI MMAR_4166|M.marinum_M --------------------------------------------MSRAFI MSMEG_0055|M.smegmatis_MC2_155 --------------------------------------------MGVLSD MUL_2554|M.ulcerans_Agy99 --------------------------------MPAGLIAAAVRTIVNLGS MAV_2926|M.avium_104 -------------------------------------------MMLDYGT MAB_4284c|M.abscessus_ATCC_199 MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAE Mvan_1264|M.vanbaalenii_PYR-1 VDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGL Mflv_0157|M.gilvum_PYR-GCK DAN-----------------------YFYGVADHANMMSSDPALGSAAIA TH_2666|M.thermoresistible__bu TLN-----------------------WGKSVVEHPMSAKDHTGWGIAGTG Rv3616c|M.tuberculosis_H37Rv IDP-----------------------TISAIDGLYDLLGIGIPNQGGILY Mb3646c|M.bovis_AF2122/97 IDP-----------------------TISAIDGLYDLLGIGIPNQGGILY MLBr_00405|M.leprae_Br4923 IDP-----------------------TLKAIEAWHALLGIGVPNDGGVLY MMAR_4166|M.marinum_M IDP-----------------------TISAINGLHALLGIGLPEDGGIID MSMEG_0055|M.smegmatis_MC2_155 VAD-----------------------FGKDVIDDRDKWADRFKKVGHFIE MUL_2554|M.ulcerans_Agy99 FGQ-----------------------QFVGVNDPKFTNPEYLAASATGMA MAV_2926|M.avium_104 FPP-----------------------EFNSARIYSGPGSGSLVAAASAWS MAB_4284c|M.abscessus_ATCC_199 SVA-----------------------SNYGYQSQWVNTGNPIHDLSGNLQ Mvan_1264|M.vanbaalenii_PYR-1 FGGNGGNGGNGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG Mflv_0157|M.gilvum_PYR-GCK T--------DAAILMQSLAAVGGSTMGA-----TGLAT-SVATPIIN--- TH_2666|M.thermoresistible__bu A--------DFVTLMQGMTEAG-SGLDQ-----GRLAK-AAATPIIR--- Rv3616c|M.tuberculosis_H37Rv S--------SLEYFEKALEELAAAFPGD-----GWLGS-AADKYAGKNRN Mb3646c|M.bovis_AF2122/97 S--------SLEYFEKALEELAAAFPGD-----GWLGS-AADKYAGKNRN MLBr_00405|M.leprae_Br4923 S--------SLSFFEKALEHLAAAFPGD-----GWLGS-AADKYAGQNRK MMAR_4166|M.marinum_M S--------ALSFFGKALDDLGSAFPGD-----GWLGS-AADHYSGKNRK MSMEG_0055|M.smegmatis_MC2_155 RNAKGDRLERVAKFGRALGDFSGKFTDF-----FESNLGKRMVKAARSPI MUL_2554|M.ulcerans_Agy99 SDG-----LTAVFGQTWVPQALAKRVGH-----SQLTSLASSKAAQGASA MAV_2926|M.avium_104 SLAAELNAAALSYDKVVTALASEEWLGS-----ASASMASAVAPYVGWMS MAB_4284c|M.abscessus_ATCC_199 NYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSG Mvan_1264|M.vanbaalenii_PYR-1 APGVAGATGATGVTSNVTGGNGADAVGYGATG-AAGAAGAAGAAGKAGAV . Mflv_0157|M.gilvum_PYR-GCK --AGLMTLTAASNTLGFGRPEDGERFTDGARQFSEANDELQQAVPPPDW- TH_2666|M.thermoresistible__bu --AALLAMMVMSNTCGVGTPEKGDRFEEGAQAFEAAGEALGATKSPESW- Rv3616c|M.tuberculosis_H37Rv HVNFFQELADLDRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVD- Mb3646c|M.bovis_AF2122/97 HVNFFQELADLDRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVD- MLBr_00405|M.leprae_Br4923 RVDIFQELAELDKELIELIHNQANSVQTTRGILDGAKKALLFVRPVAID- MMAR_4166|M.marinum_M HVNFFKELAELDRELQKLIADQASAVKTTREILEDAKKGLEFVRPVAVD- MSMEG_0055|M.smegmatis_MC2_155 LAAGQHVITGMKLTTGVGDPENGRRFGEGADHMSAAGRTLDSAYPTSDW- MUL_2554|M.ulcerans_Agy99 ILWTINIVEVLETLMGFGPPAEGDELLVGSTQFAKAQAQLGSALPDNSW- MAV_2926|M.avium_104 TTAAQAEEAASQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVL- MAB_4284c|M.abscessus_ATCC_199 NVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGS- Mvan_1264|M.vanbaalenii_PYR-1 GSAGTAGSAGAPGVWGNAGLPGAAGAAGGAGAIGTAGVAGAAGTAGATGG . . Mflv_0157|M.gilvum_PYR-GCK -----QGDASDAYGL--RNTE-QQQ--RAGSMATFDGQIQEVLAEEAGQV TH_2666|M.thermoresistible__bu -----QGKASNTYTD--RNDE-QRA--RAERMAAIDRTVKEILDAEAHQV Rv3616c|M.tuberculosis_H37Rv -----LTYIPVVGHA--LSAA-FQAPFCAGAMAVVGGALAYLVVKTLINA Mb3646c|M.bovis_AF2122/97 -----LTYIPVVGHA--LSAA-FQAPFCAGAMAVVGGALAYLAVKTLINA MLBr_00405|M.leprae_Br4923 -----LNYIPLVGSV--MSAS-IQAQACAAAMAAVSGGLAYLLVQTAIHT MMAR_4166|M.marinum_M -----LTYIPIVGWA--MSAA-FQAPVCAAAMAVVGGALAYLVVKTLINS MSMEG_0055|M.smegmatis_MC2_155 -----DSAASDAYLS--QNNG-QVT--RAEALVHADQVVAAVLSREAEQI MUL_2554|M.ulcerans_Agy99 -----QGSASYAYAS--QNTA-LQN--RGQALAELDVKFAALVKDQAEWA MAV_2926|M.avium_104 -----GQNTPLIAQL--EAQYGEYWAQDAAAMYSYAGQSASASKVTPFQK MAB_4284c|M.abscessus_ATCC_199 -----TAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADI Mvan_1264|M.vanbaalenii_PYR-1 TGVGGNGGAGQAGGIGGTGAAGAAGQAGTAGETGVTGGVGGIGGQGTEGG Mflv_0157|M.gilvum_PYR-GCK QDTRDFVSTRQVM--LAAAIPAAITAKLIPPGGAAAAMAIELAAVAAT-V TH_2666|M.thermoresistible__bu DVARKMLDRCQTV--LSLSIPAAIAAKAIPFKGPAISTAIEVAAVAGT-A Rv3616c|M.tuberculosis_H37Rv TQLLKLLAKLAEL--VAAAIADIISDVADIIKGTLGEVWEFITNALNG-L Mb3646c|M.bovis_AF2122/97 TQLLKLLAKLAEL--VAAAIADIISDVADIIKGILGEVWEFITNALNG-L MLBr_00405|M.leprae_Br4923 AKFVALLARLAHL--LASAVADVVSDGVAIIKGIVDHLWHFIAGALTG-L MMAR_4166|M.marinum_M MKLVSLLAQLAKL--LAEAVADVVSDVVDIIKGILEEVWEFLTHPFEF-L MSMEG_0055|M.smegmatis_MC2_155 ATTREVLDSEADW--LGDMSLVTMATGLIPYVGRAAQTAAEIAMVTKA-V MUL_2554|M.ulcerans_Agy99 THGRLGIAILKNL--LLATFAVEMALMFAVPAGPAMARSFGFTVSGLG-I MAV_2926|M.avium_104 APQVTNPSGQAAQ--SAAVSTATANSTSTNTTKALQSLAQPASSSTTA-T MAB_4284c|M.abscessus_ATCC_199 DKSVTVVDDHSQR--NTTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANI Mvan_1264|M.vanbaalenii_PYR-1 TGGVGGVGGVGATGGAGGVGGKGIQGGQGLQGGQGGDGGTGGTGGDATSM Mflv_0157|M.gilvum_PYR-GCK PFAMQRVTEMVSHSADN------------------ADRIRQIGS---HYG TH_2666|M.thermoresistible__bu PLASLRYNELTRAVIRN------------------AARMTQAAG---EYS Rv3616c|M.tuberculosis_H37Rv KELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTG---LFG Mb3646c|M.bovis_AF2122/97 KELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTGATSGLSQVTG---LFG MLBr_00405|M.leprae_Br4923 KDIVEKIIHWFFGLFSHWWSRLHSFFGGIPGLSGATSGLSQVTG---LFG MMAR_4166|M.marinum_M KDLLNKLVSWASSLLSQWGSKLQSFFGGIPGLSGMGGGLSQLTS---FFS MSMEG_0055|M.smegmatis_MC2_155 GASTDQFMMMRDKADENAAEVRDAIGKYEAVAGDADDTTADDTAGDAPES MUL_2554|M.ulcerans_Agy99 AIAMGLLSTVLTYSVENSKKADVLTANYQDLTPDPYQGADPSMP---MAA MAV_2926|M.avium_104 KAATTAASTTSTDPLSEIWFLLTGQTTLPTSLGSAVNGYSPFAS--LFYN MAB_4284c|M.abscessus_ATCC_199 GTSTSAGGSAAVGGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG Mvan_1264|M.vanbaalenii_PYR-1 GEAGATGGKGGNGGNGGRGSLFGRGGNAGNGGNGGTGGNGGNGGTGGTGG Mflv_0157|M.gilvum_PYR-GCK VVDESAQMPG-----GLSGAQSGTPAPLRVSESIRGTAGIQQNVAATIDS TH_2666|M.thermoresistible__bu SVASAANPS----------------------------------------- Rv3616c|M.tuberculosis_H37Rv AAGLSASS---GLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAAS Mb3646c|M.bovis_AF2122/97 AAGLSASS---GLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAAS MLBr_00405|M.leprae_Br4923 VPGLAGSS---GLLSGESLLSTENLPSLAGVGAGLGLGSLPQLAQLHAAS MMAR_4166|M.marinum_M SAGAAGSAGSVGAADSASLVSSAGLPGGLGLGGGSGFGSMPNVAQLRSAA MSMEG_0055|M.smegmatis_MC2_155 EPTAAEDSSETSKEDGQSRHENPVAAPSGGGGGATSGGGGGAPSSASSAG MUL_2554|M.ulcerans_Agy99 NMPASAESTISSFAASGTAFTAEAAGSLGRASGAADESAFYSAAADEAVP MAV_2926|M.avium_104 TEGLPYFSTG----MANTFTQIAKSVGAIGGAAPAAAKALPGLGGLGGML MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNA Mvan_1264|M.vanbaalenii_PYR-1 NGGTGGTGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTG Mflv_0157|M.gilvum_PYR-GCK ARSAPDGSAGDVFKTHGVVCTSTAAALKSAELARRSAAEKMHLISTDL-- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv TRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSS-- Mb3646c|M.bovis_AF2122/97 TRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQGMGGPVGMGGMHPSS-- MLBr_00405|M.leprae_Br4923 TRQGTRSQAGVSAELSTEQFGGQQEPVSAQGSQGMGGSQGMGGMTPAS-- MMAR_4166|M.marinum_M TRQDPRLTSEGPTRVSSEPVGEHAQAASAQGGQGMGG------MHPAS-- MSMEG_0055|M.smegmatis_MC2_155 PAGTPQVPSPPGFGAANTPTDAQPGAAAASDAAGMLGSVMGAMLGPLGGI MUL_2554|M.ulcerans_Agy99 LEDAPSATSAFTMPTLAQLMAISGQGAKFSGHVSQHANLANQAMGQVQQV MAV_2926|M.avium_104 GGGAAAAHPVAALGGAGSIGGKLSVPVAWSGAPATPALGHAIPVSSIS-- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAV Mvan_1264|M.vanbaalenii_PYR-1 GKGGTGGTGGDGGTGGTGGTGGTGGTGGTGGTGGTGGTGGAGDGLGGTGG Mflv_0157|M.gilvum_PYR-GCK -------------------------------------------------S TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv -------------------------------------------------G Mb3646c|M.bovis_AF2122/97 -------------------------------------------------G MLBr_00405|M.leprae_Br4923 -------------------------------------------------T MMAR_4166|M.marinum_M -------------------------------------------------A MSMEG_0055|M.smegmatis_MC2_155 VGGVVQAAGQALQAAT--QAGAQAAQLAGQAAAAPDVDRADTDEDTDKDP MUL_2554|M.ulcerans_Agy99 ASMAQQGKG----------------------------------TAPAEDT MAV_2926|M.avium_104 -------------------------------------------------A MAB_4284c|M.abscessus_ATCC_199 AGNAAVAGNAAVGGVL--NTGVSGAIGGSSHVGGAINESLGGSGSVGGST Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGFGGQGGQGGTGGTGGQGGLGGVGGTGGTGGTGGTGGQGGTGGTG Mflv_0157|M.gilvum_PYR-GCK AKLGSSATEYSHTEQQNADAVDRQMPPR---------------------- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv ASKG--TTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV------ Mb3646c|M.bovis_AF2122/97 ASKG--TTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV------ MLBr_00405|M.leprae_Br4923 KSKKDERKKKKYSEGAAAGTDDAERAPIEVQSGGGKRALAQHVV------ MMAR_4166|M.marinum_M GSKG--ATSKKYSEGAAAGTEDAERAPVEVGVGAAARIAERRAG------ MSMEG_0055|M.smegmatis_MC2_155 DAEGDKDSDKRDGEGKEDGTAPRDRESTDAMGADDDDRNAHPQAGSGTD- MUL_2554|M.ulcerans_Agy99 AQTEATTVEDVEGAGADSAGAAAGRAPIEAAAADTPPAQQPIFAQQVV-- MAV_2926|M.avium_104 APEAAGGPGNLLGGMPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG---- MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAH- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG Mflv_0157|M.gilvum_PYR-GCK -------------------------------------------------- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv -------------------------------------------------- Mb3646c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00405|M.leprae_Br4923 -------------------------------------------------- MMAR_4166|M.marinum_M -------------------------------------------------- MSMEG_0055|M.smegmatis_MC2_155 -SAGEDDKKPAMTLPPDLQAASALDTGAGSAPVHVGADFEHSQLRTVAAA MUL_2554|M.ulcerans_Agy99 -------------------------------------------------- MAV_2926|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -TGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGV Mvan_1264|M.vanbaalenii_PYR-1 QAGVAGKGGLFGGSGSAGTAGVTGASGASGGKGAQGATGAQGATGAQGAT Mflv_0157|M.gilvum_PYR-GCK -------------------------------------------------- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv -------------------------------------------------- Mb3646c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00405|M.leprae_Br4923 -------------------------------------------------- MMAR_4166|M.marinum_M -------------------------------------------------- MSMEG_0055|M.smegmatis_MC2_155 TLDHGIPGSAAARGA----------------------------------- MUL_2554|M.ulcerans_Agy99 -------------------------------------------------- MAV_2926|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTSAINDALGGSGSVG Mvan_1264|M.vanbaalenii_PYR-1 GATGASGAQGSAGSAGSAGVAGSAG-TTGAQGSAGTNGANGANGSQGAAG Mflv_0157|M.gilvum_PYR-GCK -------------------------------------------------- TH_2666|M.thermoresistible__bu -------------------------------------------------- Rv3616c|M.tuberculosis_H37Rv -------------------------------------------------- Mb3646c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00405|M.leprae_Br4923 -------------------------------------------------- MMAR_4166|M.marinum_M -------------------------------------------------- MSMEG_0055|M.smegmatis_MC2_155 -------------------------------------------------- MUL_2554|M.ulcerans_Agy99 -------------------------------------------------- MAV_2926|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEA Mvan_1264|M.vanbaalenii_PYR-1 KAGATGTTGATGAAGDAGDPGSEAVDINGGAGGAGGAGGEGGEGGAGGAG Mflv_0157|M.gilvum_PYR-GCK ------------------------------------------------ TH_2666|M.thermoresistible__bu ------------------------------------------------ Rv3616c|M.tuberculosis_H37Rv ------------------------------------------------ Mb3646c|M.bovis_AF2122/97 ------------------------------------------------ MLBr_00405|M.leprae_Br4923 ------------------------------------------------ MMAR_4166|M.marinum_M ------------------------------------------------ MSMEG_0055|M.smegmatis_MC2_155 ------------------------------------------------ MUL_2554|M.ulcerans_Agy99 ------------------------------------------------ MAV_2926|M.avium_104 ------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 QGHAQGHASETAHTTLPGAEHH-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GDGSEGGAGGSGGAGGSGTGGAGGAGGSGGSGGSGGAGGSGGAAGDSD