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VGGSHATAQPPPTQAALADLTRTLRGSVIGPDGGRFTELATPRNLRFAATMPRAVVLCADADDVAKTVLW ARNTGTSFAIRGGGHNYAEASSSRGVIISTRQMTAATIDGATLRAHAGVRNADLAALLPQGGGGRLLLPG GNCPGVGVVGLTLGGGIGPNAPWAGLTADRLRKVTMVTAHGDVVTASPTENPDLFWGLRGGAGGNFGVVT DLEYELVEVPVRRATTAELSVTGADAATRVALAFQQLRADAERIVTGNLYLGHAAGDVEAALTTQLLVDE ADARDLLAPLTAIPGLTAEITEQPWWGAYAWYVTPPSPAYPFWDRSLYADQFLSGDALAAALEVVRRFPA GNDPERYGALGLYGWVGGAVNDVAPDATAYVHRTARILVEMSSGWSPAPSGAPVAPIPPDIRDWEDELWE TVLPHTTGRSYQNFPDPELADWPRAYYGANLDRLTRVKATWDPEDVFRYPQGIPPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | - | 100% (476) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 2e-31 | 29.66% (472) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0156 | - | 7e-17 | 26.01% (419) | FAD linked oxidase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 1e-31 | 28.09% (477) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 9e-29 | 28.36% (469) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1726 | - | 1e-31 | 28.01% (482) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 5e-05 | 24.76% (206) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 2e-45 | 28.89% (495) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 9e-41 | 31.34% (469) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 4e-29 | 36.70% (218) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1964 | - | 2e-33 | 29.38% (480) | mitomycin radical oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 1e-14 | 31.95% (169) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 9e-40 | 30.92% (469) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4651|M.gilvum_PYR-GCK ----------------------------MTVPTDLRR-----DEALRSLR
MSMEG_1964|M.smegmatis_MC2_155 ----------------------------MTL-TDLPNGTEGLADALDGLR
MMAR_1179|M.marinum_M --------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
Mb1755|M.bovis_AF2122/97 --------------------------------------MTATLTKTLGSL
Rv1726|M.tuberculosis_H37Rv --------------------------------------MTATLTKTLGSL
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mvan_4048|M.vanbaalenii_PYR-1 -----------------------------MGGSHATAQPPPTQAALADLT
TH_1540|M.thermoresistible__bu ------------------------------------------------MA
MLBr_01103|M.leprae_Br4923 ------------------------------------------MGVLTSLI
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALP-GEPGYERCR-PWN-VVAPVEPAAVVLATSPEDVAGTVRF
MSMEG_1964|M.smegmatis_MC2_155 AHVVAPVALP-GEAGYERAT-PWN-VAAEVKPAAVVLATSAYDVANTVRY
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
Mb1755|M.bovis_AF2122/97 DDFRGTLCVP-GDPDYPRVRAIWNGQVAR-EPALIATCHDACDVRTVLRR
Rv1726|M.tuberculosis_H37Rv DDFRGTLCVP-GDPDYPRVRAIWNGQVAR-EPALIATCHDACDVRTVLRR
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
Mvan_4048|M.vanbaalenii_PYR-1 RTLRGSVIGP-DGGRFTELATPRNLRFAATMPRAVVLCADADDVAKTVLW
TH_1540|M.thermoresistible__bu ALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MLBr_01103|M.leprae_Br4923 AGLPDGMVVT-DSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRW
. * :. :* :
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAV-GVG--PDTILIQTSAMR-HVSVDVVNGTARV
MSMEG_1964|M.smegmatis_MC2_155 AASRGLRVTVQATGHGAL-KVT--DDTILIVTSGMT-GCTVDPSTRTARV
MMAR_1179|M.marinum_M AAANKLKIAPRGGGHSYI-GASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYI-GASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYT-GASTANGTMVLDLRQLPGDANYDAATGQVTV
Mb1755|M.bovis_AF2122/97 PVDAGMVTAVRGGGHNVA-GTALCDGGVVIDLSAMR-AVSLDPATGRVRV
Rv1726|M.tuberculosis_H37Rv AVDAGMVTAVRGGGHNVA-GTALCDGGVVIDLSAMR-AVSLDPATGRVRV
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYA-AYCIPNDGLVVDLARMA---AVSVTGTRAVV
Mvan_4048|M.vanbaalenii_PYR-1 ARNTGTSFAIRGGGHNYA-EAS-SSRGVIISTRQMT-AATIDGATLRAHA
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWA-ASHLRDGGMLLDVSRLD-HCGIDADRMVAVA
MLBr_01103|M.leprae_Br4923 ASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITVDPVTRTAVC
. . * . ::: : . .
Mflv_4651|M.gilvum_PYR-GCK GAG-ARWQDVLDVATPHGLAPLC--GSAPGVGVIGYLTGGGIGPLVRTYG
MSMEG_1964|M.smegmatis_MC2_155 QAG-ARWQHVIDAAAPHGLAPLC--GSSPNVGVVGYLTGGGVGPLVRTVG
MMAR_1179|M.marinum_M PAG-VSLTDVHQVLAGAGRAIPT--GSCPTVGVGGLALGGGMGADSRHAG
MUL_1431|M.ulcerans_Agy99 PAG-VSLTDVHQVLAGAGRAIPT--GSCPTVGVGGLALGGGMGADSRHAG
MAV_0089|M.avium_104 TPA-TSLYTMHRTLAAVGRGVPT--GTCPSVGAAGHALGGGMGAQSRHAG
Mb1755|M.bovis_AF2122/97 QGG-ATLADLDHATVPFARVAPA--GIVTTTGVGGLTLGGGVGWTTRRFG
Rv1726|M.tuberculosis_H37Rv QGG-ATLADLDHATVPFARVAPA--GIVTTTGVGGLTLGGGVGWTTRRFG
MAB_2456|M.abscessus_ATCC_1997 GAG-ARLIDVYAGIAGAGRMLAG--GSCPTVGIAGLTLGGGVGVLTRRFG
Mvan_4048|M.vanbaalenii_PYR-1 GVRNADLAALLPQGGGGRLLLPG--GNCPGVGVVGLTLGGGIGPNAPWAG
TH_1540|M.thermoresistible__bu GPG-KIGSELAGELDKLDLFFPA--GHCEGICLGGYLLQGGYGWNSRVLG
MLBr_01103|M.leprae_Br4923 QPG-LFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYG
: . * .. * *
Mflv_4651|M.gilvum_PYR-GCK LSSDHVRSFDVVTGGGRLLRAA----PDENADLFWGLR-GGKATLGIVTS
MSMEG_1964|M.smegmatis_MC2_155 LSSDHVRSFELVTGKGELLRAT----PEENAELFWGLR-GGKATLGIVTS
MMAR_1179|M.marinum_M LTCDALRSATVVLPSGETVTAS----AEDHPDLFWALRGGGGGNFGVTTA
MUL_1431|M.ulcerans_Agy99 LTCNALRSATVVLPSGETVTAS----AEDHPDLFWALRGGGGGNFGVTTA
MAV_0089|M.avium_104 LLCDQLTSASVVLPSGQAVTAS----TASNPDLFWALRGGGGGNFGVTTS
Mb1755|M.bovis_AF2122/97 LSCDNLVAVRLVTAAGDYLSVD----DERDPELMWGLRGGGG-NFGIVTE
Rv1726|M.tuberculosis_H37Rv LSCDNLVAVRLVTAAGDYLSVD----DERDPELMWGLRGGGG-NFGIVTE
MAB_2456|M.abscessus_ATCC_1997 LTCDQLISARVVTADGKIRVVS----ADTESDLFWAIRGVGGGNFCIATE
Mvan_4048|M.vanbaalenii_PYR-1 LTADRLRKVTMVTAHGDVVTAS----PTENPDLFWGLRGGAGGNFGVVTD
TH_1540|M.thermoresistible__bu PACESIVGVDVVTADGEVLYCD----DETNADLFWAARGSGPGFFAVVTS
MLBr_01103|M.leprae_Br4923 VTGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITE
: : :* * : . : : *
Mflv_4651|M.gilvum_PYR-GCK AEIDL--LPVPEFYGGA-VYFAADDVADVLRAWAAWCVDLPETINTSIAI
MSMEG_1964|M.smegmatis_MC2_155 VEIDL--PPIPEFYGGA-VIFDGADAASVLHAWRTWCVTLPESVNTSISL
MMAR_1179|M.marinum_M MTFET--FPVADSDVVR-VDFTPSSAAQVLAGWQTWLAAADRDTWGLVDM
MUL_1431|M.ulcerans_Agy99 MTFET--FPVADSDVVR-VDFTPSSAAQVLAGWQTWLAAADRDTWGLVDM
MAV_0089|M.avium_104 LTFAT--FPTKDVDAVN-LNFPPQSFAQVLVGWQNWLRTADPNSWALADA
Mb1755|M.bovis_AF2122/97 FEFAT--HPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVL
Rv1726|M.tuberculosis_H37Rv FEFAT--HPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVL
MAB_2456|M.abscessus_ATCC_1997 LAFET--AASTDLTVFT-LDYAAGEMAPIVHRWLTFMAGAPDELWTTLHA
Mvan_4048|M.vanbaalenii_PYR-1 LEYELVEVPVRRATTAELSVTGADAATRVALAFQQLRADAERIVTGNLYL
TH_1540|M.thermoresistible__bu FHLRL--HPRPPVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIA
MLBr_01103|M.leprae_Br4923 VTLRL----LPTQNTSSIVVATFASVQAAVDAVLGVAARLRPAMLEFMDS
Mflv_4651|M.gilvum_PYR-GCK QQ--LPPLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLD
MSMEG_1964|M.smegmatis_MC2_155 QN--LPPLPGVPEPLAGKLTVAVRYTAIGDFARAERLLAPMRAVATPVLD
MMAR_1179|M.marinum_M S-----------VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIE
MUL_1431|M.ulcerans_Agy99 S-----------VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIE
MAV_0089|M.avium_104 T-----------VDAMGVHCRILATCPAGSGNSAAAAITQAVGIQPSGVE
Mb1755|M.bovis_AF2122/97 RH--APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VA
Rv1726|M.tuberculosis_H37Rv RH--APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VA
MAB_2456|M.abscessus_ATCC_1997 IGGAIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLDAMK
Mvan_4048|M.vanbaalenii_PYR-1 GH---------AAGDVEAALTTQLLVDEADARDLLAPLTAIPGLTAEITE
TH_1540|M.thermoresistible__bu SR---DLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIK
MLBr_01103|M.leprae_Br4923 VA----------INAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLI
.
Mflv_4651|M.gilvum_PYR-GCK TVGVLPYAAIGAVHADPVDPMP--INEDQALLRELPPEAVEALLAAAGPE
MSMEG_1964|M.smegmatis_MC2_155 TVAVHPYAAIGGVHMDPVDPMP--CNETHTLLRELPSEAVDVLLAAAGPD
MMAR_1179|M.marinum_M TKTFNHMELVKYLAGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAVGKW
MUL_1431|M.ulcerans_Agy99 TKTFNHMELVKYLAGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAVGKS
MAV_0089|M.avium_104 THTFNYMDLVNYLAVGNLNPQPLGYVGGSDVFPTVNAAVAQGIAAAVNAF
Mb1755|M.bovis_AF2122/97 DTVWPTPFLAHQAVLDASNPAGHRYYWKSDYLAELNDEAIDLLVEQTAQL
Rv1726|M.tuberculosis_H37Rv DTVWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEAIDLLVEQTAQL
MAB_2456|M.abscessus_ATCC_1997 FMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARIETL
Mvan_4048|M.vanbaalenii_PYR-1 QPWWGAYAWYVTPPSPAYPFWDRSLYADQFLSGDALAAALEVVRRFPAGN
TH_1540|M.thermoresistible__bu IPYATTDLAGWYGAIMTNYPTGHRYATDNMWTSASPEALLPGIHRIIETL
MLBr_01103|M.leprae_Br4923 GAVFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPL
Mflv_4651|M.gilvum_PYR-GCK SGSP--QAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAPEIAD
MSMEG_1964|M.smegmatis_MC2_155 TPPV--QTIVEIRLFGGALAREPRHRSAFCHRDAAFGVTAIGVPVPPVAD
MMAR_1179|M.marinum_M PPASGRASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA
MUL_1431|M.ulcerans_Agy99 PPASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA
MAV_0089|M.avium_104 PRNAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVET--SGDPA
Mb1755|M.bovis_AF2122/97 SSPD---SLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDD
Rv1726|M.tuberculosis_H37Rv SSPD---SLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDD
MAB_2456|M.abscessus_ATCC_1997 LAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG--ADPA
Mvan_4048|M.vanbaalenii_PYR-1 DPERYGALGLYGWVGGAVNDVAPDATAYVHRTARILVEMSSGWSPAPSGA
TH_1540|M.thermoresistible__bu PPAP------SHFLMFNWSPTSTRDNLFYGLEADFNLALYAVWNDPEDDE
MLBr_01103|M.leprae_Br4923 PALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAH
Mflv_4651|M.gilvum_PYR-GCK MVI-------AHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTL
MSMEG_1964|M.smegmatis_MC2_155 TVR-------AHGAALVDAMAPWSTGGQLPNFAPSDDAGRASRVYDEDTL
MMAR_1179|M.marinum_M AAT-------KWINSAHQAVQQFSVG-GYVNYLEANT---APSRYFGSNL
MUL_1431|M.ulcerans_Agy99 AAT-------KWINSAHQAVQQFSVG-GYVNYLEANT---ALSRYFGSNL
MAV_0089|M.avium_104 AAT-------NWLASAHQAVQQYSVG-GYVNYLEANQ---SPARYFGPNL
Mb1755|M.bovis_AF2122/97 LHR-------QWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEF
Rv1726|M.tuberculosis_H37Rv LHR-------QWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEF
MAB_2456|M.abscessus_ATCC_1997 VAH-------ERVSQARDGLGDICGPAAYVNYIDPGMP-DWATAYYGDNL
Mvan_4048|M.vanbaalenii_PYR-1 PVAPIPPDIRDWEDELWETVLPHTTGRSYQNFPDPELA-DWPRAYYGANL
TH_1540|M.thermoresistible__bu RFS-------AWPGTNMAALAHLAMG---VGLADENLGRRPARFATDANM
MLBr_01103|M.leprae_Br4923 RAFG-------EIMDMAVGLGGTITG----EHGVGRLKRPWLDDYLGPDV
: .
Mflv_4651|M.gilvum_PYR-GCK HWLAG-LADRYDPARTLATGQVIRTVV
MSMEG_1964|M.smegmatis_MC2_155 HWLAA-LAERHDPAGVYRCGQVVRFVS
MMAR_1179|M.marinum_M SRLTQ-IRQRYDPSRLMYSGLNF----
MUL_1431|M.ulcerans_Agy99 SRLTQ-IRQRYDPSRLMYSGLNF----
MAV_0089|M.avium_104 SRLSA-VRQKYDPGRVMFSGLNY----
Mb1755|M.bovis_AF2122/97 SRLVT-LKNRLDPDNVFRNNHNIRPSA
Rv1726|M.tuberculosis_H37Rv SRLVT-LKNRLDPDNVFRNNHNIRPSA
MAB_2456|M.abscessus_ATCC_1997 PRLRG-IAAAYDPKGIFRFAQAVRP--
Mvan_4048|M.vanbaalenii_PYR-1 DRLTR-VKATWDPEDVFRYPQGIPPR-
TH_1540|M.thermoresistible__bu ARLDG-IRARRDPAGRFHGWMGRV---
MLBr_01103|M.leprae_Br4923 MELNQRIKHALDPYGILNPGAAI----
* : **