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MELPTRHFFRGDDGYEQARARTVWNARTPERYPDLVAQAADVDDVVAAVRYAAAHDLQIGIRSGGHSWAG NHIRDGGVLLDVHGLDRCEVDAEAGTAVVGPGVGGSVLAGRLWEQDLFFPAGHCKGVCIGGYLLQGGYGW NSRVLGPACESVLGLDVVTADGEQIYIDGENHADLYWAARGSGPGFFAVVTAFHLKLHRRPRVCGSSLYV YPIELAEQIYPWARSISAEVDRRVEFQMVASRAVPGAGLDSPGIVMASPVFADTEQEAIDALALLETCPV RDRALVAVPYAPTDLETWYAGVMSNYPDGYRYATDNIWTSASADELMPGITRILETMPPHPAHFLWLNWG PSPQRQDMAYSMEDEVYLALYGVWRDAADDEKYGDWARSNMAAMEPLQTGIQLADENLGRRPAPFATPEA MARLDRVRAEYDPQGRFHSWMGRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0156 | - | - | 100% (444) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 4e-22 | 29.48% (251) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | 6e-17 | 26.01% (419) | FAD linked oxidase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1803 | - | 1e-179 | 64.84% (438) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 2e-20 | 27.87% (287) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1774 | - | 1e-179 | 64.84% (438) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 2e-07 | 27.11% (166) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 3e-18 | 30.13% (229) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 1e-22 | 35.36% (181) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 7e-22 | 24.07% (428) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 7e-24 | 26.11% (406) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 1e-170 | 62.13% (441) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 1e-22 | 35.36% (181) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1803|M.bovis_AF2122/97 -----MRALPAGRHFFRGSDGYEAAR------------------------
Rv1774|M.tuberculosis_H37Rv -----MRALPAGRHFFRGSDGYEAAR------------------------
Mvan_0156|M.vanbaalenii_PYR-1 ------MELPT-RHFFRGDDGYEQAR------------------------
TH_1540|M.thermoresistible__bu -----MAALPA-LSFRRGAQGYEQAR------------------------
MMAR_1179|M.marinum_M --------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mflv_4651|M.gilvum_PYR-GCK ---MTVPTDLRRDEALRSLRDQVATP------------------------
MSMEG_1746|M.smegmatis_MC2_155 -MLQVHPTMVDELAMSMPERVHLPGS------------------------
MLBr_01103|M.leprae_Br4923 --MGVLTSLIAGLPDGMVVTDSAVTDG-----------------------
Mb1803|M.bovis_AF2122/97 ------------------RGTVWHRRVPDRYPEVIVQAVSADDIVSAIRY
Rv1774|M.tuberculosis_H37Rv ------------------RGTVWHRRVPDRYPEVIVQAVSADDIVSAIRY
Mvan_0156|M.vanbaalenii_PYR-1 ------------------ARTVWNARTPERYPDLVAQAADVDDVVAAVRY
TH_1540|M.thermoresistible__bu ------------------RTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
Mflv_4651|M.gilvum_PYR-GCK --------VALPGEPGYERCRPWNVVAP-VEPAAVVLATSPEDVAGTVRF
MSMEG_1746|M.smegmatis_MC2_155 -------------PEYGDAVAIWNGAVT-ERPAAVVRPTSSGDVRNVVRF
MLBr_01103|M.leprae_Br4923 ------------------YRHDRALDPSAGKPLAVVQPRRTDEVQTVLRW
* :. :: : :
Mb1803|M.bovis_AF2122/97 ATVNGHKVSVVSGGHSFAASHLRDGA-VLLDVSRID-HASIDADKGRAVV
Rv1774|M.tuberculosis_H37Rv ATVNGHKVSVVSGGHSFAASHLRDGA-VLLDVSRID-HASIDADKGRAVV
Mvan_0156|M.vanbaalenii_PYR-1 AAAHDLQIGIRSGGHSWAGNHIRDGG-VLLDVHGLD-RCEVDAEAGTAVV
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWAASHLRDGG-MLLDVSRLD-HCGIDADRMVAVA
MMAR_1179|M.marinum_M AAANKLKIAPRGGGHSYIGASTAVGA-MVIDLRGLPGGVNFDAGSGTVTV
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYIGASTAVGA-MVIDLRGLPGGVNFDAGSGTVTV
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYTGASTANGT-MVLDLRQLPGDANYDAATGQVTV
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYAAYCIPNDG-LVVDLARMA---AVSVTGTRAVV
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAVG--VGPDT-ILIQTSAMR-HVSVDVVNGTARV
MSMEG_1746|M.smegmatis_MC2_155 AHEQRIPITVRAGGHDWGGRALNEGG-LVIDLSSMR-KVYIDPAAREALV
MLBr_01103|M.leprae_Br4923 ASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITVDPVTRTAVC
* : . * . . . :::. : . .
Mb1803|M.bovis_AF2122/97 GPGKGGSVLMAELEAQGLFFPGG--HCRGVCLGGYLLQGGYGWNSRIYGP
Rv1774|M.tuberculosis_H37Rv GPGKGGSVLMAELEAQGLFFPGG--HCRGVCLGGYLLQGGYGWNSRIYGP
Mvan_0156|M.vanbaalenii_PYR-1 GPGVGGSVLAGRLWEQDLFFPAG--HCKGVCIGGYLLQGGYGWNSRVLGP
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPAG--HCEGICLGGYLLQGGYGWNSRVLGP
MMAR_1179|M.marinum_M PAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAGL
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAGL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPTG--TCPSVGAAGHALGGGMGAQSRHAGL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAGG--SCPTVGIAGLTLGGGVGVLTRRFGL
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLCG--SAPGVGVIGYLTGGGIGPLVRTYGL
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAAP--NLADVGFTGFTLGGGYGPLNGIAGL
MLBr_01103|M.leprae_Br4923 QPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGV
. : . * .. * *
Mb1803|M.bovis_AF2122/97 ACESVIGLDVITADGAQIHCDADNHADLY----WAARGAGPGFFGVVTSF
Rv1774|M.tuberculosis_H37Rv ACESVIGLDVITADGAQIHCDADNHADLY----WAARGAGPGFFGVVTSF
Mvan_0156|M.vanbaalenii_PYR-1 ACESVLGLDVVTADGEQIYIDGENHADLY----WAARGSGPGFFAVVTAF
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDDETNADLF----WAARGSGPGFFAVVTSF
MMAR_1179|M.marinum_M TCDALRSATVVLPSGETVTASAEDHPDLF----WALRGGGGGNFGVTTAM
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASAEDHPDLF----WALRGGGGGNFGVTTAM
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTASTASNPDLF----WALRGGGGGNFGVTTSL
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSADTESDLF----WAIRGVGGGNFCIATEL
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAPDENADLF----WGLRG-GKATLGIVTSA
MSMEG_1746|M.smegmatis_MC2_155 GVDNLLEAHVVLADGRSVTANAADEADLL----WALRG-GGANFGVVTHL
MLBr_01103|M.leprae_Br4923 TGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEV
: : *: .* *: . . : : *
Mb1803|M.bovis_AF2122/97 YLKLYPRPATCGTSVYVYPFDLADEVFTWARAVSAEVDPRVELQALASRG
Rv1774|M.tuberculosis_H37Rv YLKLYPRPATCGTSVYVYPFDLADEVFTWARAVSAEVDPRVELQALASRG
Mvan_0156|M.vanbaalenii_PYR-1 HLKLHRRPRVCGSSLYVYPIELAEQIYPWARSISAEVDRRVEFQMVASRA
TH_1540|M.thermoresistible__bu HLRLHPRPPVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIASRD
MMAR_1179|M.marinum_M TFETFPVADSDVVRVDFTPSSAAQVLAGWQTWLAAADR---DTWGLVDMS
MUL_1431|M.ulcerans_Agy99 TFETFPVADSDVVRVDFTPSSAAQVLAGWQTWLAAADR---DTWGLVDMS
MAV_0089|M.avium_104 TFATFPTKDVDAVNLNFPPQSFAQVLVGWQNWLRTADP---NSWALADAT
MAB_2456|M.abscessus_ATCC_1997 AFETAASTDLTVFTLDYAAGEMAPIVHRWLTFMAGAPD---ELWTTLHAI
Mflv_4651|M.gilvum_PYR-GCK EIDLLPVPEFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQLP
MSMEG_1746|M.smegmatis_MC2_155 RVRLHPVPHLATGVLMFPWEQAADVMRRYDALAPSLPDG-----LTAQIG
MLBr_01103|M.leprae_Br4923 TLRLLPTQNTSSIVVAT----FASVQAAVDAVLGVAARLRPAMLEFMDSV
. :
Mb1803|M.bovis_AF2122/97 EPSMGIDVPVISLASPAFADSPEEAEQALALFGTC-PVVEQALVKVPYMP
Rv1774|M.tuberculosis_H37Rv EPSMGIDVPVISLASPAFADSPEEAEQALALFGTC-PVVEQALVKVPYMP
Mvan_0156|M.vanbaalenii_PYR-1 VPGAGLDSPGIVMASPVFADTEQEAIDALALLETC-PVRDRALVAVPYAP
TH_1540|M.thermoresistible__bu LPALGLNQPSIVVASPVFAESESAAAQALAVLGDC-PAVDRAIIKIPYAT
MMAR_1179|M.marinum_M VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPT-GIETKTFNHMELVK
MUL_1431|M.ulcerans_Agy99 VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPT-GIETKTFNHMELVK
MAV_0089|M.avium_104 VDAMGVHCRILATCPAGSGNSAAAAITQAVGIQPS-GVETHTFNYMDLVN
MAB_2456|M.abscessus_ATCC_1997 GGAIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAA-DSFIAEMTFLDAMK
Mflv_4651|M.gilvum_PYR-GCK PLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTVGVLP
MSMEG_1746|M.smegmatis_MC2_155 VIPAPDGGPVVFVAPYWVGDPDEGDRWVAELRRLGTPVVDQVAPMSPSAQ
MLBr_01103|M.leprae_Br4923 AINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQ
Mb1803|M.bovis_AF2122/97 TDLPAWYDVAMTHYLSDH---------HYAVDNMWTSASAEDLLPGIRSI
Rv1774|M.tuberculosis_H37Rv TDLPAWYDVAMTHYLSDH---------HYAVDNMWTSASAEDLLPGIRSI
Mvan_0156|M.vanbaalenii_PYR-1 TDLETWYAGVMSNYPDGY---------RYATDNIWTSASADELMPGITRI
TH_1540|M.thermoresistible__bu TDLAGWYGAIMTNYPTGH---------RYATDNMWTSASPEALLPGIHRI
MMAR_1179|M.marinum_M YLAGGSSASSPRGFVAGS---------DVIGTVNSAAAQAIVAAVGKWPP
MUL_1431|M.ulcerans_Agy99 YLAGGSSASSPRGFVAGS---------DVIGTVNSAAAQAIVAAVGKSPP
MAV_0089|M.avium_104 YLAVGNLNPQPLGYVGGS---------DVFPTVNAAVAQGIAAAVNAFPR
MAB_2456|M.abscessus_ATCC_1997 FMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARIETL
Mflv_4651|M.gilvum_PYR-GCK YAAIGAVHADPVDPMPIN---------EDQALLRELPPEAVEALLAAAGP
MSMEG_1746|M.smegmatis_MC2_155 LRLLDPLVPRGRHYEMRT------------VNVDTLSPGVIDALVAAGSS
MLBr_01103|M.leprae_Br4923 VSSTNDPDEGEAFVAARR------------FCIPAVESKGSLLLEDVGVP
.
Mb1803|M.bovis_AF2122/97 LDTLP--PHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPADEA
Rv1774|M.tuberculosis_H37Rv LDTLP--PHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPADEA
Mvan_0156|M.vanbaalenii_PYR-1 LETMP--PHPAHFLWLNWGPSPQRQDMAYSMEDEVYLALYGVWRDAADDE
TH_1540|M.thermoresistible__bu IETLP--PAPSHFLMFNWSPTSTRDNLFYGLEADFNLALYAVWNDPEDDE
MMAR_1179|M.marinum_M ASGRA--SALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA
MUL_1431|M.ulcerans_Agy99 ASGWA--SALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA
MAV_0089|M.avium_104 NAGRM--LAIMHALDGALATVAPAATAFPWRRQSALVQWYVET--SGDPA
MAB_2456|M.abscessus_ATCC_1997 LAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG--ADPA
Mflv_4651|M.gilvum_PYR-GCK ESGSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVP-APEIAD
MSMEG_1746|M.smegmatis_MC2_155 RTSPAS-VLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDADSDDD
MLBr_01103|M.leprae_Br4923 LPALG---KLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMT
:
Mb1803|M.bovis_AF2122/97 K--YADWARSHMAAMSHLA-VGIQLADENLGA--RPARFASDAAMAKLDR
Rv1774|M.tuberculosis_H37Rv K--YADWARSHMAAMSHLA-VGIQLADENLGA--RPARFASDAAMAKLDR
Mvan_0156|M.vanbaalenii_PYR-1 K--YGDWARSNMAAMEPLQ-TGIQLADENLGR--RPAPFATPEAMARLDR
TH_1540|M.thermoresistible__bu R--FSAWPGTNMAALAHLA-MGVGLADENLGR--RPARFATDANMARLDG
MMAR_1179|M.marinum_M A--ATKWINSAHQAVQQFS-VGGYVNYLEANT--APSRYFG-SNLSRLTQ
MUL_1431|M.ulcerans_Agy99 A--ATKWINSAHQAVQQFS-VGGYVNYLEANT--ALSRYFG-SNLSRLTQ
MAV_0089|M.avium_104 A--ATNWLASAHQAVQQYS-VGGYVNYLEANQ--SPARYFG-PNLSRLSA
MAB_2456|M.abscessus_ATCC_1997 V--AHERVSQARDGLGDICGPAAYVNYIDPGMPDWATAYYG-DNLPRLRG
Mflv_4651|M.gilvum_PYR-GCK M--VIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTLHWLAG
MSMEG_1746|M.smegmatis_MC2_155 GERHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAYG-PNAERLLA
MLBr_01103|M.leprae_Br4923 ERAHRAFGEIMDMAVGLGGTITGEHGVGRLKRP-WLDDYLGPDVMELNQR
.:
Mb1803|M.bovis_AF2122/97 VRAEYDPDGLFNSWMGRI-----
Rv1774|M.tuberculosis_H37Rv VRAEYDPDGLFNSWMGRI-----
Mvan_0156|M.vanbaalenii_PYR-1 VRAEYDPQGRFHSWMGRA-----
TH_1540|M.thermoresistible__bu IRARRDPAGRFHGWMGRV-----
MMAR_1179|M.marinum_M IRQRYDPSRLMYSGLNF------
MUL_1431|M.ulcerans_Agy99 IRQRYDPSRLMYSGLNF------
MAV_0089|M.avium_104 VRQKYDPGRVMFSGLNY------
MAB_2456|M.abscessus_ATCC_1997 IAAAYDPKGIFRFAQAVRP----
Mflv_4651|M.gilvum_PYR-GCK LADRYDPARTLATGQVIRTVV--
MSMEG_1746|M.smegmatis_MC2_155 AKDRWDAGNVFTAIPLPSRSSTS
MLBr_01103|M.leprae_Br4923 IKHALDPYGILNPGAAI------
*. :