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VQDFDTLFTYLRYELVEQGRVAVITLDRPKQRNAQNRGILVELGSAFELAEADDTVRVVILRGAGPSFSA GHDLGSSDDVRERAPGPGQHPTYQCNGGTLGGVESRHRQEWHYFFENTRRWRNLRKITIAEVHGMVLSAG LMLAWCCDLIVAAEDTVFADVVGTRLGMCGVEFFGHPWEFGPRKAKELLLTGDALGADDAHAIGMVSKVF GNDELSDRAVEFAGRIAKLPTATALFIKESVNQSVDAMGFSSALDACFSIHQLNHAYWAEITGNPLGIGT VEDGLEDWQIAPEILPATKNRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4005 | - | - | 100% (302) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_5190 | - | 4e-92 | 58.63% (278) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4219 | - | 1e-48 | 40.37% (270) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1970c | echA13 | 1e-142 | 78.64% (295) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_1568 | - | 7e-92 | 58.99% (278) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1935c | echA13 | 1e-142 | 78.64% (295) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 8e-16 | 28.57% (231) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2058 | - | 6e-20 | 31.47% (232) | enoyl-CoA dehydratase/isomerase |
| M. marinum M | MMAR_2863 | echA13 | 1e-147 | 81.36% (295) | enoyl-CoA hydratase EchA13 |
| M. avium 104 | MAV_0670 | - | 2e-95 | 59.45% (291) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5886 | - | 2e-95 | 58.93% (280) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_2027 | echA13 | 1e-112 | 66.09% (289) | POSSIBLE ENOYL-CoA HYDRATASE ECHA13 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_1114 | echA1 | 2e-18 | 33.72% (258) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1568|M.gilvum_PYR-GCK -----MQRVADQD------------QVTYETLDEGRIARIWLNRPDAQNA
MSMEG_5886|M.smegmatis_MC2_155 -MPYLLMRWFDMTGSDGDGG--QARQIEYETLDEGRIARIWLNRPQAQNA
MAV_0670|M.avium_104 -----MTLSEQAGAQPGARP--AEELVTYETLDEGRIARIWLNRPDAHNA
Mb1970c|M.bovis_AF2122/97 MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQRNA
Rv1935c|M.tuberculosis_H37Rv MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRPKQRNA
MMAR_2863|M.marinum_M MNVAGVSPVDRRSNGERAAP--DFTYVRYETIDDGRIATITLNRPKQRNA
Mvan_4005|M.vanbaalenii_PYR-1 -----MQDFDT-----------LFTYLRYELVEQGRVAVITLDRPKQRNA
TH_2027|M.thermoresistible__bu -----MQMTERTG--------AEYSYVTYEVLDEGRIARIMMNRPRQRNA
MAB_2058|M.abscessus_ATCC_1997 --------MAEQP-------------IRYEVVD--SVAWLTINRPEARNA
MUL_1114|M.ulcerans_Agy99 --------MSELNGD-------TEPEVLVEQRD--RILIITINRPKAKNS
MLBr_02402|M.leprae_Br4923 -----MKYDT----------------ILVDGYQ--RVGIITLNRPQALNA
: : : : : ::** *:
Mflv_1568|M.gilvum_PYR-GCK QSRTLLVQLDEAFGRAEADDVVRVVILAARGK-NFSAGHDLGSEAALAER
MSMEG_5886|M.smegmatis_MC2_155 QSRTLLVQLDEAFARAEADDTVRVVILAARGK-NFSAGHDLGSEEALAER
MAV_0670|M.avium_104 QSRGLLVQLDEAFVRAEADDAVRVVILAARGK-NFSAGHDLGSELALAER
Mb1970c|M.bovis_AF2122/97 QTRGMLVELGAAFELAEADDTVRVVILRAAGP-AFSAGHDLGSADDIRER
Rv1935c|M.tuberculosis_H37Rv QTRGMLVELGAAFELAEADDTVRVVILRAAGP-AFSAGHDLGSADDIRER
MMAR_2863|M.marinum_M QTRGMLVELGAAFELAEADDTVRVVILRGEGP-AFSAGHDLGSADDVRER
Mvan_4005|M.vanbaalenii_PYR-1 QNRGILVELGSAFELAEADDTVRVVILRGAGP-SFSAGHDLGSSDDVRER
TH_2027|M.thermoresistible__bu QNRGLLVELDDAFMRAERDDDVRVVILGGIGP-MFSSGHDLGSSDDRAER
MAB_2058|M.abscessus_ATCC_1997 LNNAVRTGLIDAVLRFNDDDAAKVLVLTGVGDKAFCAGGDLKEMAQN-AL
MUL_1114|M.ulcerans_Agy99 VNAAVSRALADAMDRLDADAGLSVGILTGAGG-SFCAGMDLKAFAR--GE
MLBr_02402|M.leprae_Br4923 LNSQMMNEITNAAKELDIDPDVGAILITGSPK-VFAAGADIKEMASLTFT
. : : * : * . :: . *.:* *:
Mflv_1568|M.gilvum_PYR-GCK APGPDQHPTFTCNGATREAVIERTYLQEWHYFFNNTSRWRDLRKITIAQV
MSMEG_5886|M.smegmatis_MC2_155 EPGPGQHPTFAGYGATVAGVAERTYRQEWHFYFENTKRWRDLRKITIAQV
MAV_0670|M.avium_104 QPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIAQV
Mb1970c|M.bovis_AF2122/97 SPGPDQHPSYRCNGATFGGVESR-NRQEWHYYFENTKRWRNLRKITIAQV
Rv1935c|M.tuberculosis_H37Rv SPGPDQHPSYRCNGATFGGVESR-NRQEWHYYFENTKRWRNLRKITIAQV
MMAR_2863|M.marinum_M APGPDQHPTYQCNGGTYGGVESR-NRQEWHYYFENTKRWRNLRKITVAQV
Mvan_4005|M.vanbaalenii_PYR-1 APGPGQHPTYQCNGGTLGGVESR-HRQEWHYFFENTRRWRNLRKITIAEV
TH_2027|M.thermoresistible__bu SGGPAGHPTYLFNGGSRQGTEQR-MLQEWHYYFENARRWRNLKKITIAET
MAB_2058|M.abscessus_ATCC_1997 KVPPKDF-------------------------APQFGRNIDVAKPTIAAV
MUL_1114|M.ulcerans_Agy99 NVVVEGR-------------------------GLGFTE-RPPAKPLIAAV
MLBr_02402|M.leprae_Br4923 DAFDADF-------------------------FSAWGKLAAVRTPMIAAV
. . :* .
Mflv_1568|M.gilvum_PYR-GCK QGNAISAALMLIWACDLIVASDDAKFS-DVVAVRMGMPGVEYYAHPWEFG
MSMEG_5886|M.smegmatis_MC2_155 QGNAISAALMLIWACDLIVAADDARFS-DVVAVRMGMPGVEYYAHPWEFG
MAV_0670|M.avium_104 QGNAISAGLMLIWACDLIVAADNAKFS-DVVGVRMGMPGVEYYAHPWEFG
Mb1970c|M.bovis_AF2122/97 HGAVLSAGLMLAWCCDLIVASEDTVFA-DVVGTRLGMCGVEYFGHPWEFG
Rv1935c|M.tuberculosis_H37Rv HGAVLSAGLMLAWCCDLIVASEDTVFA-DVVGTRLGMCGVEYFGHPWEFG
MMAR_2863|M.marinum_M HGTVLSAGLMLAWCCDLIVAADDTVFA-DVVGTRLGMCGVEYFGHPWEFG
Mvan_4005|M.vanbaalenii_PYR-1 HGMVLSAGLMLAWCCDLIVAAEDTVFA-DVVGTRLGMCGVEFFGHPWEFG
TH_2027|M.thermoresistible__bu HGPVLAAGLMIAWTCDLIVATPTTTFA-DVVGTRIGMCGVEYFAHPWELG
MAB_2058|M.abscessus_ATCC_1997 NGVAFAGGFLLAQQCDLVVAAEHATFAVSEVKVG--RGSPWATPLSWLVP
MUL_1114|M.ulcerans_Agy99 EGYALAGGTELALATDLIVAARDSAFGIPEVKRGLAAGGGGLLRLPERIP
MLBr_02402|M.leprae_Br4923 AGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIG
* .:... : **::*: : *. : . .
Mflv_1568|M.gilvum_PYR-GCK ARKAKELLLTGDAIDADEAHRLGMVSKVFPRAELEDKTLEFARRIAERPT
MSMEG_5886|M.smegmatis_MC2_155 PRKAKELLLTGDSIDADEAYRLGMVSKVFGREELEDKTLEFARRIAERPT
MAV_0670|M.avium_104 PRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIAERPT
Mb1970c|M.bovis_AF2122/97 PRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAKVPT
Rv1935c|M.tuberculosis_H37Rv PRKTKELLLTGDCIGADEAHALGMVSKVFPADELATSTIEFARRIAKVPT
MMAR_2863|M.marinum_M PRKAKELLLTGDSIGADEAHALGMVSKVFPGEDLADSAIEFARRIAKLPT
Mvan_4005|M.vanbaalenii_PYR-1 PRKAKELLLTGDALGADDAHAIGMVSKVFGNDELSDRAVEFAGRIAKLPT
TH_2027|M.thermoresistible__bu PRRAKELLLTGDSLDAHTAHQWGMVSRIFPDDELQKRTMELAQRIAGLPT
MAB_2058|M.abscessus_ATCC_1997 PRVAMQILLTGDPITAARAHQVGLVNEVVPADQLRERTQQLALSIAANAP
MUL_1114|M.ulcerans_Agy99 YAIAMELALTGDNLSAERAHALGMVNVLAEPGAALDAAIALAEKITANGP
MLBr_02402|M.leprae_Br4923 KAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSR
: :: *** : * * *:*. : : .* *:
Mflv_1568|M.gilvum_PYR-GCK MAALLVKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAYNENRYPVGLP
MSMEG_5886|M.smegmatis_MC2_155 MAALLVKDSVNAAADSMGFAEALHHAFHIHELGHAHWAAANENRWPVGMP
MAV_0670|M.avium_104 MAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLP
Mb1970c|M.bovis_AF2122/97 MAALLIKESVNQTVDAMGFSAALDGCFKIHQLNHAHWGEVTGGKLSYGTV
Rv1935c|M.tuberculosis_H37Rv MAALLIKESVNQTVDAMGFSAALDGCFKIHQLNHAHWGEVTGGKLSYGTV
MMAR_2863|M.marinum_M MAALLIKESVNQTVDAMGFTTALDGCFKIHQLNHAHWAEVTGGKLCYGTV
Mvan_4005|M.vanbaalenii_PYR-1 ATALFIKESVNQSVDAMGFSSALDACFSIHQLNHAYWAEITGNPLGIGTV
TH_2027|M.thermoresistible__bu VTALLIKEAVNQSVDNMGFYNALNACFSLHQINHAHWAEVTGGESHLGTP
MAB_2058|M.abscessus_ATCC_1997 LSVLASKRTVYLSAQHH----LAAAYDLADEIWEPVYLSDDAQEGPAAFR
MUL_1114|M.ulcerans_Agy99 LAVAATKRIITESRGWS----LDTRFAQQMKILFPIFTSNDAKEGAIAFA
MLBr_02402|M.leprae_Br4923 SATRMAKEAVNRSFEST----LAEGLLHERRLFHSTFVTDDQSEGMAAFI
:. * : : .: . : .
Mflv_1568|M.gilvum_PYR-GCK PN-VPDWRTLGAPKLSRRDEP
MSMEG_5886|M.smegmatis_MC2_155 PD-VPDWRTLGAPKLARRDTP
MAV_0670|M.avium_104 PD-VEDWRNAKPTRLARRDTP
Mb1970c|M.bovis_AF2122/97 EYGLEDWRAAPQIRPAIKQRP
Rv1935c|M.tuberculosis_H37Rv EYGLEDWRAAPQIRPAIKQRP
MMAR_2863|M.marinum_M EYGLDDWRAAPEILPATKRRP
Mvan_4005|M.vanbaalenii_PYR-1 EDGLEDWQIAPEILPATKNRP
TH_2027|M.thermoresistible__bu EFGVPRWQDAGPILPRPMSEA
MAB_2058|M.abscessus_ATCC_1997 EKRAPQWKGH-----------
MUL_1114|M.ulcerans_Agy99 EKRPPRWTGT-----------
MLBr_02402|M.leprae_Br4923 EKRAPQFTHR-----------
: