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VGRLSGKVAVITGAARGIGRAQAVRFAQEGAGVIGIDLCGGVDTVVIPPSTPDDLAETARRVRAVGADVV TAIADVRDVDALGAAVDDGVRALGGLDIVCATAGITSRGMAVEMSEQTWQTMLDVNLTGVFHTCQVTAPH LITRGGGSIVLVSSIAGLRGLVGVAHYTAAKHGVVGLMRSLANELARHRIRVNTVHPTNVDTPLIQNDAV RSAFRPDLDRPPTREEFAAAARPMNMLETAWVDPFDVANASLFLASDEARYITAAALPVDAGSTQRQPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2896 | - | - | 100% (279) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5168 | - | 8e-77 | 54.55% (275) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4222 | - | 1e-76 | 54.01% (274) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 2e-61 | 48.57% (280) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2430 | - | 1e-76 | 54.01% (274) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2750 | - | 2e-61 | 48.57% (280) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-29 | 32.32% (263) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0072c | - | 1e-105 | 68.00% (275) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 3e-74 | 54.38% (274) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3017 | - | 1e-114 | 74.53% (267) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6031 | - | 4e-76 | 53.82% (275) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_3237 | - | 7e-80 | 56.20% (274) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 7e-59 | 46.26% (281) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIAS-
Rv2750|M.tuberculosis_H37Rv ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIAS-
MUL_3392|M.ulcerans_Agy99 MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIAS-
Mvan_2896|M.vanbaalenii_PYR-1 -----MGRLSGKVAVITGAARGIGRAQAVRFAQEGAGVIGIDLCGGVDT-
MAV_3017|M.avium_104 --------------MITGAARGIGRAQAVRFAQEGADIVALDLCGPVDT-
MAB_0072c|M.abscessus_ATCC_199 ----MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHT-
Mflv_2430|M.gilvum_PYR-GCK ----MAGRVEGKVAFITGAARGQGRAHAVRLAEEGADIIAVDICKQIDS-
TH_3237|M.thermoresistible__bu ----MAGRLEGKVAFITGAARGQGRAHAVRMAQEGADIIAVDICRQIDS-
MSMEG_6031|M.smegmatis_MC2_155 ----MAGRVEGKVAFITGAARGQGRSHAVRLAEEGADIIAVDVCRRISSN
MMAR_4754|M.marinum_M MTEQLGGRVAGKVAFITGAARGQGRSHAVRLAQEGADIIAVDVCKPIVEN
MLBr_01807|M.leprae_Br4923 --------------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLA
. .**: . . : * . .:: . :
Mb2771|M.bovis_AF2122/97 VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFG
Rv2750|M.tuberculosis_H37Rv VPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFG
MUL_3392|M.ulcerans_Agy99 VPYPLGTAEELATTVKLVEDTGARIVASQADVRDREALAAALQAGIDELG
Mvan_2896|M.vanbaalenii_PYR-1 VVIPPSTPDDLAETARRVRAVGADVVTAIADVRDVDALGAAVDDGVRALG
MAV_3017|M.avium_104 VMVPPSTPDDLDHTASLVGEVGGRMHAELVDVRDLDGVQAATERGARRFG
MAB_0072c|M.abscessus_ATCC_199 TITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEFG
Mflv_2430|M.gilvum_PYR-GCK VLIPLSTPEDLAETADLVKNAGGRIHTAEVDVRDYDALKAAVDAGVEEFG
TH_3237|M.thermoresistible__bu VQIPLASPEDLAETADLVKGLNRRIYTAEVDVRDFDALKAAVDTGVEQLG
MSMEG_6031|M.smegmatis_MC2_155 EDIPASTPEDLAETVELVKGLNRRIVAEEVDVRDYDALKAVVDSGVEQLG
MMAR_4754|M.marinum_M TTIPASTPEDLAETADLVKGHNRRIFTAEADVRDYDALKAAVDAGVDELG
MLBr_01807|M.leprae_Br4923 VARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQG
: . . . . ** : : . . *
Mb2771|M.bovis_AF2122/97 RLDIVVANAGIAMMQ-----AGDDGWRDVIDVNLTGVFHTVQVAIPTLIE
Rv2750|M.tuberculosis_H37Rv RLDIVVANAGIAMMQ-----AGDDGWRDVIDVNLTGVFHTVQVAIPTLIE
MUL_3392|M.ulcerans_Agy99 QVDIVVANAGIAPMQ-----SGDDGWRDVIDVNLSGAYYTVEVAIPTMIE
Mvan_2896|M.vanbaalenii_PYR-1 GLDIVCATAGITSRGMAVEMS-EQTWQTMLDVNLTGVFHTCQVTAPHLIT
MAV_3017|M.avium_104 GLDVVCATAGITSRAMTVEMN-ESVWRTMLDVNLTGVWHTCRAAAPHLIA
MAB_0072c|M.abscessus_ATCC_199 GLDIVCATAGITSRRMLLDMP-ESDWQTMLDVNLTGVWHTTRAATPHLIA
Mflv_2430|M.gilvum_PYR-GCK RLDIIVANAGIGNGGQTLDKTDEPDWDDMIGVNLSGVWKTVKAGVPHILA
TH_3237|M.thermoresistible__bu RLDIIVANAGIGNGGETLDKTSEGDWTDMIDVNLAGVWKTVKAGVPHILA
MSMEG_6031|M.smegmatis_MC2_155 GLDIVVANAGIGNGGATLDKTSEADWDDMIGVNLSGVWKTVKAAVPHLIS
MMAR_4754|M.marinum_M RLDIIVANAGIGNGGATLDKTSEHDWQEMIDVNLSGVWKSVKAAVPHLIA
MLBr_01807|M.leprae_Br4923 PVEVLVANAGITSDMLIMRMS-EEQFQKVIDVNLTGVFRVAKLASRNMIK
:::: *.*** : : ::.***:*.: . ::
Mb2771|M.bovis_AF2122/97 QGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLAPQ
Rv2750|M.tuberculosis_H37Rv QGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLAPQ
MUL_3392|M.ulcerans_Agy99 QGRGGSIVLISSAAGLVGISSADAGAIGYVASKHALVGLMRVYANLLAPH
Mvan_2896|M.vanbaalenii_PYR-1 RG-GGSIVLVSSIAGLRGLVGVA----HYTAAKHGVVGLMRSLANELARH
MAV_3017|M.avium_104 RG-AGSMILTNSIAGLRGLVGVA----HYTAAKHGVVGLMQSLAHELAPH
MAB_0072c|M.abscessus_ATCC_199 RG-GGAMVLVSSIAGLRGLVGVS----HYVAAKHGVVGLMRSLAIELAPH
Mflv_2430|M.gilvum_PYR-GCK GGNGGSIILTSSVGGLKAYPHTG----HYVAAKHGVVGLMRTFAVELGAQ
TH_3237|M.thermoresistible__bu GGRGGSIILTSSVGGLKAYPHTG----HYVAAKHGVVGLMRTFAVELGQH
MSMEG_6031|M.smegmatis_MC2_155 GGNGGSIILTSSVGGLKAYPHTG----HYIAAKHGVVGLMRTFAVELGQH
MMAR_4754|M.marinum_M GGNGGSIVLTSSVGGMKAYPHCG----NYVAAKHGVVGLMRSFAVELGQH
MLBr_01807|M.leprae_Br4923 QR-FGRYIFMGSVVGLSGVPGQAN----YAASKSGLIGMARSLARELGSR
* :: .* *: . * *:* .::*: : * *. :
Mb2771|M.bovis_AF2122/97 NIRVNSVHPCGVDTPMINNEFFQQWLT--------TADMDAPHNLGNALP
Rv2750|M.tuberculosis_H37Rv NIRVNSVHPCGVDTPMINNEFFQQWLT--------TADMDAPHNLGNALP
MUL_3392|M.ulcerans_Agy99 SIRVNSLHPSGVDPPMINNEFIRHWLAD------LVAETGSGPGAGNALP
Mvan_2896|M.vanbaalenii_PYR-1 RIRVNTVHPTNVDTPLIQNDAVRSAFRPDLDRPPTREEFAAAARPMNMLE
MAV_3017|M.avium_104 RVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAMNLLQ
MAB_0072c|M.abscessus_ATCC_199 KIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQP-TREDFAAAAKTMNLLD
Mflv_2430|M.gilvum_PYR-GCK NIRVNSVHPTNVNTPLFMNEPTMKLFRPDLENP-GPDDMKVVGQLMHTLP
TH_3237|M.thermoresistible__bu NIRVNSVHPTNVNTPLFMNEPTMKLFRPDLENP-GPEDLKVVAQMMHTLP
MSMEG_6031|M.smegmatis_MC2_155 SIRVNSVHPTNVNTPLFMNEGTMKLFRPDLENP-GPDDMAVVAQMMHVLP
MMAR_4754|M.marinum_M MIRVNSVHPTHVRTPMLHNEGTFKMFRPDLENP-GPDDMAPICQLFHTLP
MLBr_01807|M.leprae_Br4923 SITANVVAPGFIDTEMTR-----------------AMDSKYQEAALQAIP
: .* : * : . : : : :
Mb2771|M.bovis_AF2122/97 VELVQP-TDIANAVAWLASEEARYVTGVTLPVDAGFVNKR--
Rv2750|M.tuberculosis_H37Rv VELVQP-TDIANAVAWLASEEARYVTGVTLPVDAGFVNKR--
MUL_3392|M.ulcerans_Agy99 VQILQA-DDIAGALAWLVSDEARYITGVALPVDAGCVNKR--
Mvan_2896|M.vanbaalenii_PYR-1 TAWVDP-FDVANASLFLASDEARYITAAALPVDAGSTQRQPL
MAV_3017|M.avium_104 VPWVDP-VDVANAALFLASDEARYITAVTLPVDAGATQR---
MAB_0072c|M.abscessus_ATCC_199 LPWVEP-LDIANASLFLASDEARYITSVSLPVDAGSTQR---
Mflv_2430|M.gilvum_PYR-GCK IGWVEP-EDIANAVLFLASDEARFITGVTLPVDGGSCLK---
TH_3237|M.thermoresistible__bu IGWVEP-EDIANAVLFLASDEARYITGVTLPVDGGSCLK---
MSMEG_6031|M.smegmatis_MC2_155 VGWVEP-RDISNAVLFLASDEARYVTGLPMTVDAGSMLK---
MMAR_4754|M.marinum_M IPWVEA-EDISNAVLFLASDESRYITGVTLPVDAGGCLK---
MLBr_01807|M.leprae_Br4923 LGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH--
: . :::.* :*.*::: :::. :.**.*