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LTDTQIDLLSAARTAHQRRDWAASYEAFELASRYAPLRTDDLEAFAFASWRLGHIKESSRAAERVFAELT RTDPNAAAMKANELALAWLVRGDINIGQGWMSRARRLLAAAEESQAHGYLIYLDAVVAAISQDLDALAGH VRSLRETSERLDVPAVTALGLIAAGIEAILHARTAEGYALIDEAILPLMADQVPIEWAGDIYCMVLHHCH KLADLPRMRSWTQSMEQWCGLSGSVPYGGVCDVHRLQVQVASTDLRGLEDRLGTASRALVEVNAWAAAEG YYQLGEVRRLKGDLDGAATAFEQARALGLDPQPGEALLACRRGDNAAAWTSIRLALAGGDRLARVRLLRA AVEIALGRDALSEAENYCRELEADAKAFGTPGFRAWAAHARGAVAVRRGDFGVALESLQSALREYRVQQS RYETAEVYEWMALAKRGLGDREGAVADAATADAIYVQLGVEPAGICGAPTPGGLTRRELDVLTRIARGAT NRQVAEQLHLSDKTVSRHLANIYAKLGVSTRTAAANWAFQQGVLTDER*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_3766 | - | - | 100% (539) | response regulator receiver protein |
M. vanbaalenii PYR-1 | Mvan_5928 | - | 7e-13 | 26.73% (333) | regulatory protein, LuxR |
M. vanbaalenii PYR-1 | Mvan_2058 | - | 3e-12 | 38.30% (94) | metal dependent phosphohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0393 | - | 6e-11 | 24.72% (538) | LuxR/UHPA family transcriptional regulator |
M. gilvum PYR-GCK | Mflv_1351 | - | 8e-15 | 32.96% (179) | response regulator receiver protein |
M. tuberculosis H37Rv | Rv2488c | - | 1e-10 | 24.91% (546) | LuxR family transcriptional regulator |
M. leprae Br4923 | MLBr_01753 | - | 8e-09 | 22.50% (551) | putative transcriptional regulator |
M. abscessus ATCC 19977 | MAB_1522 | - | 2e-11 | 40.00% (95) | putative two-component system response regulator LuxR |
M. marinum M | MMAR_2962 | - | 5e-16 | 25.36% (560) | transcriptional regulatory protein |
M. avium 104 | MAV_4201 | - | 1e-14 | 29.90% (291) | transcriptional regulator, LuxR family protein |
M. smegmatis MC2 155 | MSMEG_4339 | - | 0.0 | 59.13% (526) | TPR repeat-containing protein |
M. thermoresistible (build 8) | TH_3184 | - | 4e-10 | 45.90% (61) | PUTATIVE two component transcriptional regulator, LuxR family |
M. ulcerans Agy99 | MUL_0351 | narL | 3e-08 | 43.28% (67) | nitrate/nitrite response regulator protein NarL |
CLUSTAL 2.0.9 multiple sequence alignment Mb0393|M.bovis_AF2122/97 -----------------------------------------------MSK Rv2488c|M.tuberculosis_H37Rv MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE MMAR_2962|M.marinum_M -----------------------------------------------MDE MLBr_01753|M.leprae_Br4923 ----------------MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTD Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 LLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGVIAAHDGVR Rv2488c|M.tuberculosis_H37Rv LVPTGTVTLLLADIEGATHLPGSQLDTT--AIAKLDRTLTELVREHRGVC MMAR_2962|M.marinum_M LLLTDTVTLLSADIEDSARLRQTQPTELSAALERLDQILTDAVSAYGGVR MLBr_01753|M.leprae_Br4923 LHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDCVVSEAVAAHGGVQ Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 PVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALR- Rv2488c|M.tuberculosis_H37Rv PVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSP- MMAR_2962|M.marinum_M AVEQSPGESLVVAFGRAQDAVECALQLQQAPLAPIRLCIGIHTGEVAQPR MLBr_01753|M.leprae_Br4923 QVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIALHTGEVQISN Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 DEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGT Rv2488c|M.tuberculosis_H37Rv DEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGT MMAR_2962|M.marinum_M DDGTYVGPTIDRTARLRDLARGGQTLLSAATKDIVINQLPEQAWLTDRGL MLBr_01753|M.leprae_Br4923 DDVNNVVFMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPADTWLVDLGS Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 HALRDLSRPERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGA Rv2488c|M.tuberculosis_H37Rv YRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVD MMAR_2962|M.marinum_M APLRDLIHFERVAQLCHPNLRNEFPPLCVTKSPAASGLPVHLTSFVGRGR MLBr_01753|M.leprae_Br4923 HLLRDLARPVRVMQLCHRNLRRNLHELGIRTVPGGPSLPVPLTTFVGRAA Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 QITEVHRLVTDNRLVTLTGAGGVGKTRLAAQLAAQIAGEFGR-AWFVDLA Rv2488c|M.tuberculosis_H37Rv EVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWYVNLA MMAR_2962|M.marinum_M ELAEVHGLVVENRLVTLIGSGGVGKSRLAEQVVAQLAAQFVDGVRYVDLG MLBr_01753|M.leprae_Br4923 QIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFSGELSYFDLA Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 PITDPDLVPVTVAGALGLHDQPGRSTTDTVLRFLGGRPALVVLDNCEHLL Rv2488c|M.tuberculosis_H37Rv PITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEHLL MMAR_2962|M.marinum_M SITDPAVAPITMARALGLPNQPGRSAMDTLLHHLGDRQMLLLVDNCEHLL MLBr_01753|M.leprae_Br4923 PDTDHDIFPITVL--------------DNLRRCIGDRRMLMVLDNCEYLL Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 DATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPSLSLSDEAVEMF Rv2488c|M.tuberculosis_H37Rv DGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHG-EAIELF MMAR_2962|M.marinum_M DASAPRLGAMLRDCPGLRLLVTSREPIKVAGEVTWRVPPLAVG-DAIALF MLBr_01753|M.leprae_Br4923 DVCANVMTTLLGACPSLTILATSREPIGVAGEVIWRVSMLSPADEAVELF Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 CYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLDEI Rv2488c|M.tuberculosis_H37Rv TDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALTEI MMAR_2962|M.marinum_M TDRARLAQPDFALTDDNAGTVSQICRRLDTQPLGIELAAARVRTLSLAEI MLBr_01753|M.leprae_Br4923 TERAALVQPGFSVTDGNRQIVTEICQRLDGMPLAIELAAARIRTLSLTEI Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 IDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVF Rv2488c|M.tuberculosis_H37Rv VDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRRLAVF MMAR_2962|M.marinum_M SAGLDDKIRLLTGGARTAVPRQQTLRASLEWSHGLLTDTERVLFRRLGVF MLBr_01753|M.leprae_Br4923 ADGLDDRFRLLTGGARTAVRRQQTLRASMDWSYALLTESERALFRRLSAI Mvan_3766|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4339|M.smegmatis_MC2_155 -------------------------------------------------- MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 -------------------------------------------------- Mb0393|M.bovis_AF2122/97 VGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLC Rv2488c|M.tuberculosis_H37Rv PSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLL MMAR_2962|M.marinum_M VGGFDLQAAQAVAAFGDVHPRDVLGDLSQLVDKSLVVADSSNGRTRYRRF MLBr_01753|M.leprae_Br4923 SGTFDLKVAYAVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLL Mvan_3766|M.vanbaalenii_PYR-1 --------------------------------------MLTDT------- MSMEG_4339|M.smegmatis_MC2_155 --------------------------------------MTTATGSVGRAS MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 ----------------------------------MMLMAQAVLPTRAELL Mb0393|M.bovis_AF2122/97 ETMRHYALEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQA Rv2488c|M.tuberculosis_H37Rv ETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERRLNQA MMAR_2962|M.marinum_M EGVGQLALEKLREAGEADIARARHCDHYTAVVAPLDLPARADYDFLLARV MLBr_01753|M.leprae_Br4923 ETVRQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPGDIDHEQLVEQV Mvan_3766|M.vanbaalenii_PYR-1 QIDLLSAARTAHQRRDWAASYEAFELASRYAPLRTDDLEAFAFASWRLGH MSMEG_4339|M.smegmatis_MC2_155 DHPALLEARAAHSRAEWAAAYQAYLRAEAIGPMTLDDLDAYATTAWRLGH MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 AALSVAIDLGLGQPAEHMLRAALIATRLCDRLGLSRQQRDCVYYTTLVMW Mb0393|M.bovis_AF2122/97 ETEIDNLRAAFVWNRENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSI Rv2488c|M.tuberculosis_H37Rv ELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAWFAAA MMAR_2962|M.marinum_M EGELENLRAASAWLLESSDGESALMLASRLQPLWLVRGRISEGRSWFDAA MLBr_01753|M.leprae_Br4923 ETELDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRGHMYEGLAWFDSI Mvan_3766|M.vanbaalenii_PYR-1 IKESSRAAERVFAELTRTDPNAAAMKANELALAWLVRGDINIGQGWMSRA MSMEG_4339|M.smegmatis_MC2_155 SREAVRLAERVYGQLVRRDPATAATKAVDIALEWLTRGDLNIAQGWMNRA MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 VGCHADSHEYARWFGDDIAVRHDSYLVDWSGIPYLRFLASNVGRGQPLAH Mb0393|M.bovis_AF2122/97 LADENARHLEVAAAVRARALADKALLDIFVDAAAG-----MEQAQQALVI Rv2488c|M.tuberculosis_H37Rv LADHDAHPAGADPGLYARALADRALIDAVAGITDR-----LDDAQKALAI MMAR_2962|M.marinum_M LAG--ASVLEVSPTVRARALADAAVLTMFVDVATS-----LESAAAALAI MLBr_01753|M.leprae_Br4923 FEHKNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALTM Mvan_3766|M.vanbaalenii_PYR-1 RRLLAAAEESQAHGYLIYLDAVVAAISQDLDALAG-------HVRSLRET MSMEG_4339|M.smegmatis_MC2_155 RRLLTGAPTGPTHCYLAYLDVVLAVAEQDPEELAR-------RAEAVRHL MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 RLSVMATLFANARGHISRLIHSHCASAALLADRIG----LGPNVQAALAY Mb0393|M.bovis_AF2122/97 AREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRWRL Rv2488c|M.tuberculosis_H37Rv ARDIEDPALLARALTACG--GVAAYNADLARPWLAEAVGLARAVGDKWRL MMAR_2962|M.marinum_M ARELDDPASLVRALTACGLTASFSHHTEAVGQYFAEAASLAEELDDQWGL MLBr_01753|M.leprae_Br4923 AREIGDSAVLARALTACG--FSSGYDTEVARPYFAEAVELARTQGDKWTL Mvan_3766|M.vanbaalenii_PYR-1 SERLDVPAVTALGLIAAGIEAILHARTAEGYALIDEAILPLMADQVPIEW MSMEG_4339|M.smegmatis_MC2_155 CDSVEDPALESLSLVSQAIAALHQGRVADGYALVDEALLPLLAGHVRVEW MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 TFERYDGGGLPTGARGEDIPIQMRIAQLADMVEVHHRSYGVAGAVAMVGA Mb0393|M.bovis_AF2122/97 AQILTFQA-VDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGY Rv2488c|M.tuberculosis_H37Rv AEVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAA MMAR_2962|M.marinum_M SQILSWQS-NAAVVAGDAIAARRIGTEGRDLADAIGDRFNSWLCRLSLGY MLBr_01753|M.leprae_Br4923 SQIRLWGV-VGFCVSGDPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSI Mvan_3766|M.vanbaalenii_PYR-1 AGDIYCMVLHHCHKLADLPRMRSWTQSMEQWCGLSGSVPYGGVCDVHRLQ MSMEG_4339|M.smegmatis_MC2_155 AGDIYCVVLNLCHKLADHPRMRAWTQSMERWCDVHSASPFYRVCDVHRLQ MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3184|M.thermoresistible__bu -------------------------------------------------- MUL_0351|M.ulcerans_Agy99 -------------------------------------------------- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 RRGGQFDPGIADVFLRDADAILAGPQTGDAWAAALREAPDRHRVDEQSLD Mb0393|M.bovis_AF2122/97 AQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSA Rv2488c|M.tuberculosis_H37Rv ANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEA MMAR_2962|M.marinum_M AQLWQGDLTGATTQFGALS-EAENLASLSS-----KGLGDALAYRGDVDA MLBr_01753|M.leprae_Br4923 AQLWQGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHR-DVSA Mvan_3766|M.vanbaalenii_PYR-1 VQVASTDLRGLEDR-----------------------LGTASRALVEVNA MSMEG_4339|M.smegmatis_MC2_155 LAAADDDYRRLEDQ-----------------------LFSASTALEDVNS MAB_1522|M.abscessus_ATCC_1997 ------------------------------------------MTDTEVGV TH_3184|M.thermoresistible__bu --------------------------------------MEPVAAPSPVRI MUL_0351|M.ulcerans_Agy99 ---------------------------------------MDVTKTEKVRV Mflv_1351|M.gilvum_PYR-GCK ---------------------------------------------MVLTG MAV_4201|M.avium_104 AALVA--------------------------------LGDFVDLKCPFTL Mb0393|M.bovis_AF2122/97 ARAAADAALE-AAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRN Rv2488c|M.tuberculosis_H37Rv AAAAQASIDT-AVGLSPVLSGSACSALVFATLAAGDVAAAEHARESATR- MMAR_2962|M.marinum_M ARTAAEAALERAAESSEYTLGLGYSTVALAALAGGDVETARNASDLAWH- MLBr_01753|M.leprae_Br4923 ALVTAGLVVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRP- Mvan_3766|M.vanbaalenii_PYR-1 WAAAEGYYQLGEVRR-------------LKGDLDGAATAFEQARALGLD- MSMEG_4339|M.smegmatis_MC2_155 WVGAEGFYQLGEVRR-------------LRGDTEGALAAFAKARSLGKD- MAB_1522|M.abscessus_ATCC_1997 LLVDDQELVRTGLRR-------------ILRR-KDGFAIVGECADGS--- TH_3184|M.thermoresistible__bu VLVDDHEMVIEGLKA-------------MLAAFEDRVCVVGHAVGAE--- MUL_0351|M.ulcerans_Agy99 VVGDDHPLFREGVVR-------------ALSL-SGSVNVVGEADDGA--- Mflv_1351|M.gilvum_PYR-GCK DLAAAEDFLRPHAQR---------------AKSRGHRSAQARLGWVRGR- MAV_4201|M.avium_104 GHSRAVARLAGQAAR-------------AAGLDADAVALTRRAGHVHDLG . . Mb0393|M.bovis_AF2122/97 LSLALPLSAAVQRAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALA Rv2488c|M.tuberculosis_H37Rv FFGASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRARALT MMAR_2962|M.marinum_M KLSVQPYAAMFWHSFRAEIALACGNVAGAKRCADEAVSVTTGWHRALALT MLBr_01753|M.leprae_Br4923 HLGADHGLVAIHLELMAAVALARGDVIVARRLADNSVSATTGWHQMAALT Mvan_3766|M.vanbaalenii_PYR-1 -------------PQPGEALLACRRGDNAAAWTSIRLALAGGDRLARVRL MSMEG_4339|M.smegmatis_MC2_155 -------------PQPGEALLHCSVGQSRKAWTDLRVALAGAGPLDRMRL MAB_1522|M.abscessus_ATCC_1997 -----------------EVAAAVSRARPDVVIMDLRMKQMSGIEA-IRLL TH_3184|M.thermoresistible__bu -----------------RAVEVVAELDPDIVLCDVRMQNTSGLDLCLTLR MUL_0351|M.ulcerans_Agy99 -----------------AALELIETHLPDVALLDYRMPRMDGAQVAAAVR Mflv_1351|M.gilvum_PYR-GCK ------------------LLGARGDIASAREAFEQSLALLDGLPLRYETA MAV_4201|M.avium_104 -----------RIGVSNQIWSRPGPLSGSQFERVRLHPYLTVRILDQVPG Mb0393|M.bovis_AF2122/97 TRARIAVAEGKREEAERDAHKALACAAESGAHLDLPDVLECLAGLASDAG Rv2488c|M.tuberculosis_H37Rv TRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLASVMADAG MMAR_2962|M.marinum_M TRARVAMAEGEPEQAERAAYEALTCAADVGARTCLPDILECLGALAADQG MLBr_01753|M.leprae_Br4923 TRARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELISQGD Mvan_3766|M.vanbaalenii_PYR-1 LRAAVEIALGRDALSEAENYCRELEADAKAFGTPGFRAWAAHARGAVAVR MSMEG_4339|M.smegmatis_MC2_155 LRAAVVVALARDDIGEAQRYCDQLAAGAEAFATPGYRGWAAHARGAVLVR MAB_1522|M.abscessus_ATCC_1997 HAAQGPPALALTTFDDDELLSGALRAGAAGFILK---------------- TH_3184|M.thermoresistible__bu EQAPHRKVVMLSVYDDEQYLYQALRVGASGYLLK---------------- MUL_0351|M.ulcerans_Agy99 SNGLPTRVLLISAHDESAIVYQALQQGAAGFLLK---------------- Mflv_1351|M.gilvum_PYR-GCK RVNFAYGQTLRRAGKRREADTVISAARELYVALG---------------- MAV_4201|M.avium_104 LRRLAEVAGNHHECLDGSGYPRGLAGSALGMPDRILAAAVCYQS------ Mb0393|M.bovis_AF2122/97 THHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEKDFAAA Rv2488c|M.tuberculosis_H37Rv SNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDA MMAR_2962|M.marinum_M RDREAARVYGAAEGIRQRIGAMRFKIYDAGYQKSVAALHATMSTDEFDTA MLBr_01753|M.leprae_Br4923 NHRQAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDFDSA Mvan_3766|M.vanbaalenii_PYR-1 RGDFGVALESLQSALRE------YRVQQSRYETAEVYEWMALAKRGLGDR MSMEG_4339|M.smegmatis_MC2_155 RGEFEAALDNLGAALRE------YRLQQERYDIAEVYEWMALAHRGLGDD MAB_1522|M.abscessus_ATCC_1997 -----------------------------DSPAEELVRAVHAVARGE--- TH_3184|M.thermoresistible__bu -----------------------------SISSDELVRQLEMVHRGQ--- MUL_0351|M.ulcerans_Agy99 -----------------------------DSTRTEIVKAVLDCAKGR--- Mflv_1351|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4201|M.avium_104 ---------------------------GREPRPYREQLSEAEAARRLRGR Mb0393|M.bovis_AF2122/97 WAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLAN Rv2488c|M.tuberculosis_H37Rv WAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSN MMAR_2962|M.marinum_M WAHGAAFSAEEAIDYLQHRRGERKRATSGWAALTRAELNVVRLVGQGLSN MLBr_01753|M.leprae_Br4923 WAEGAAMPIDDAITYAQRGRGNRKRPTTGWESLTPAEHNVIRLVSEGLDT Mvan_3766|M.vanbaalenii_PYR-1 EGAVADAATADAIYVQLGVEPAGICGAPTPGGLTRRELDVLTRIARGATN MSMEG_4339|M.smegmatis_MC2_155 TAADTDIATAENIYEQLAVQPSGVCGRASPGGLTRREIEVLRAIAGGATN MAB_1522|M.abscessus_ATCC_1997 --AYLDPAVTSRVLN-AYRRAPAAVSGDAQDKLTARELDVLALIASGATN TH_3184|M.thermoresistible__bu --TALDPGMAARAVDTAARLQRDEFWPGARHGLTQRESEILSYVVNGLSN MUL_0351|M.ulcerans_Agy99 --DVVAPSLVGGLAG-EIRQRAAPMAP----VLSAREREVLHRIAKGQSI Mflv_1351|M.gilvum_PYR-GCK ----ADTYVARCDRELKAGGLHQSRESRHTVELTPQEEAVSTLVSRGLSN MAV_4201|M.avium_104 VRCGELDPVAAEAVLHAAGQPVGPRPNPRPDGLTPREIEVLGHVARGASN *: * : : * Mb0393|M.bovis_AF2122/97 KDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT--------- Rv2488c|M.tuberculosis_H37Rv KEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESERGPSRP MMAR_2962|M.marinum_M KDIAQRLFLSPRTVQTHLTHVYTKLGFNSRVQLAQQAAQHS--------- MLBr_01753|M.leprae_Br4923 KDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN--------- Mvan_3766|M.vanbaalenii_PYR-1 RQVAEQLHLSDKTVSRHLANIYAKLGVSTRTAAANWAFQQGVLTDER--- MSMEG_4339|M.smegmatis_MC2_155 RQVAHQFVISDKTVGRHLANIYTKLGVSSRTAAVTWAYQNGVVRKDN--- MAB_1522|M.abscessus_ATCC_1997 SEIAEQLVISEVTVKSHIGRIFVKLDLRDRAAAIVYAYDHGIVTPK---- TH_3184|M.thermoresistible__bu RGIAAKLVIGDETVKSHLRSIYRKLGVSDRAAAVATALREGIYQ------ MUL_0351|M.ulcerans_Agy99 PAIAGELYVAPSTVKTHVQRLYEKLGVSDRAAAVAEAMRQGLLD------ Mflv_1351|M.gilvum_PYR-GCK REVAAELYVSPKTVQYHLTRIYAKLGIRSRSELAALRR------------ MAV_4201|M.avium_104 KEIAAALVISEKTARNHVERTYAKIGVSNRIGASMYALQHGLVPAAPPHS :. : :. *. *: : *:.. *