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HRTSVRCMDVVSGAVAAIAEQVAVLSKAAEGASHRELIGLLAQLTQVLRSVPTLEHQILARLTAETEPHR LGEGSWKKVLTTSLRVSGAEAGRRLSRAKTLGPRCAMTGELLAPLWEATAAAQAQGLLSEEHVAVIAKFH KDLPAWVDVDTRAHADRQLARKGVGVGPEELDEAAGRLLMMIDQDGPEPCDKDLARKRSFRVGKQQPDGF RKVSGYVDAELGAYLDATLAKEAAPGANMPTDQPGSDEPAGDEEPGSDEPDSDESDSGDEVSGGGEAAEQ TGDRSARTSARAGRDTRTQDQRNHDGLKALLRRLLGSGRLGSHNGLPVTVVVSTTLQELEKGAGVAVTGG GSLLPMPDLIRLAARAHHYLYVYDQHSGQSLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAH HASADFVDGGLTNIDDLTLACPCDHRMLDNTGWRTRKNGKNQTEWLPPPDLDTGQHRTNDYHHPERHLLP EDDQGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3379 | - | - | 100% (497) | hypothetical protein Mvan_3379 |
| M. vanbaalenii PYR-1 | Mvan_4451 | - | 0.0 | 71.11% (488) | hypothetical protein Mvan_4451 |
| M. vanbaalenii PYR-1 | Mvan_3851 | - | 0.0 | 70.44% (504) | hypothetical protein Mvan_3851 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-94 | 40.45% (487) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_4014 | - | 0.0 | 68.83% (494) | hypothetical protein Mflv_4014 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-94 | 40.45% (487) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-105 | 46.25% (467) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-102 | 44.70% (481) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_1426 | - | 1e-101 | 43.39% (484) | hypothetical protein MAV_1426 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-104 | 43.96% (480) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 4e-65 | 37.53% (437) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-99 | 43.70% (476) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3379|M.vanbaalenii_PYR-1 -----MHRTSVRCMDVVSGAVAAIAEQV-AVLSKAAEGASHRELIGLLAQ
Mflv_4014|M.gilvum_PYR-GCK MAGLSVGRTSVRCMDGVAEAVGVIGEQL-AVLAKAAEDLSHRELIGLLSE
MSMEG_6573|M.smegmatis_MC2_155 ------------MDDGVQDAVAALDAALNTLLTLPHSALTDAELLTICAG
Mb1159c|M.bovis_AF2122/97 -----MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEH
Rv1128c|M.tuberculosis_H37Rv -----MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEH
MAV_1426|M.avium_104 -----MSSGGIIDRDAISAAFDALDAALDGVAALGFDGLTPRECLALLGR
MMAR_1523|M.marinum_M -----MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQR
MUL_2371|M.ulcerans_Agy99 -----MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLER
MAB_0394c|M.abscessus_ATCC_199 -----------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQ
TH_3287|M.thermoresistible__bu --MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAER
. : : . :
Mvan_3379|M.vanbaalenii_PYR-1 LTQVLRSVPTLEHQILARLTAETEPHRLGEGSWKKVLTTSLRVSGAEAGR
Mflv_4014|M.gilvum_PYR-GCK LTTVLRSAPAVEHAVLARLLDETEPHHLGEASWKKVLTTSLRMSSAEAGR
MSMEG_6573|M.smegmatis_MC2_155 LQDARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARR
Mb1159c|M.bovis_AF2122/97 CETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKR
Rv1128c|M.tuberculosis_H37Rv CETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKR
MAV_1426|M.avium_104 CEKARRRLPVAEHQLINLVARQASPAELGG-RLSHAIAEATLISRAEAAR
MMAR_1523|M.marinum_M CEVARRRLPSIEHPLINQLVEQAGEQELGG-KLAAVLAGRLRVSRGEASR
MUL_2371|M.ulcerans_Agy99 LEVVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSEAGR
MAB_0394c|M.abscessus_ATCC_199 LEIAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARR
TH_3287|M.thermoresistible__bu LETQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGEVKR
. : : : : :: . *
Mvan_3379|M.vanbaalenii_PYR-1 RLSRAKTLGPRCAMTGELLAPLWEATAAAQAQGLLSEEHVAVIAKFHKDL
Mflv_4014|M.gilvum_PYR-GCK RLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVEIIAKFHKKL
MSMEG_6573|M.smegmatis_MC2_155 RCTDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKC
Mb1159c|M.bovis_AF2122/97 RVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRL
Rv1128c|M.tuberculosis_H37Rv RVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRL
MAV_1426|M.avium_104 RVHTAADLGPRVGLTGEPLPPVLAATAAAQRAGSLGPEQVAVIRKFCHQL
MMAR_1523|M.marinum_M RLREAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQV
MUL_2371|M.ulcerans_Agy99 RVAEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQL
MAB_0394c|M.abscessus_ATCC_199 RLADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVL
TH_3287|M.thermoresistible__bu RLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAAL
* * : * ::* : * * * * : :: : .
Mvan_3379|M.vanbaalenii_PYR-1 PAWVDVDTRAHADRQLARKGVGVGPEELDEAAGRLLMMIDQDGPEPCDKD
Mflv_4014|M.gilvum_PYR-GCK PSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPSEKE
MSMEG_6573|M.smegmatis_MC2_155 PDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNP
Mb1159c|M.bovis_AF2122/97 PSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDED
Rv1128c|M.tuberculosis_H37Rv PSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDED
MAV_1426|M.avium_104 PGWIDQATRERAETDLAREGTRYRPEQLAALAGTLADCLNPDG-LYRDED
MMAR_1523|M.marinum_M PAEVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDED
MUL_2371|M.ulcerans_Agy99 PAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDED
MAB_0394c|M.abscessus_ATCC_199 PDAVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDID
TH_3287|M.thermoresistible__bu PSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQD
* : : * . . : .: ** :
Mvan_3379|M.vanbaalenii_PYR-1 LARKRSFRVGKQQPDGFRKVSGYVDAELGAYLDATLAKEAAPGANMPTDQ
Mflv_4014|M.gilvum_PYR-GCK KATRFWVKLGTQQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMAEQE
MSMEG_6573|M.smegmatis_MC2_155 PTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTDQ
Mb1159c|M.bovis_AF2122/97 RARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQK
Rv1128c|M.tuberculosis_H37Rv RARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQK
MAV_1426|M.avium_104 RARRRSLTLGNQHADGMSELRGWLSPELRATLEAVLAKLAAPGMCNPLDE
MMAR_1523|M.marinum_M RARRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDDE
MUL_2371|M.ulcerans_Agy99 RARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPEDE
MAB_0394c|M.abscessus_ATCC_199 RARRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRDE
TH_3287|M.thermoresistible__bu RARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTT
: . .* * ** : * : .: * :. ** .
Mvan_3379|M.vanbaalenii_PYR-1 PGSDEPAGDEEPGSDEPDSDESDSGDEVSGGGEAAEQTGDRSARTSARAG
Mflv_4014|M.gilvum_PYR-GCK -----------------------------------------------KAG
MSMEG_6573|M.smegmatis_MC2_155 TPCISG------------------------------------TPSQQQID
Mb1159c|M.bovis_AF2122/97 APCVNG------------------------------------APSKEQAR
Rv1128c|M.tuberculosis_H37Rv APCVNG------------------------------------APSKEQAR
MAV_1426|M.avium_104 SPCVDG------------------------------------TPTEQAIE
MMAR_1523|M.marinum_M SPVVQA------------------------------------PAGADAVS
MUL_2371|M.ulcerans_Agy99 AAVVDG------------------------------------PVSRDAAD
MAB_0394c|M.abscessus_ATCC_199 SPMTEG------------------------------------EPDSAAAE
TH_3287|M.thermoresistible__bu TDTTGTTG----------TTETTGTAGTAGTAATAADTAADGVGDIDTGG
Mvan_3379|M.vanbaalenii_PYR-1 RDTRTQDQRNHDGLKALLRRLLGSGRLGSHNGLPVTVVVSTTLQELEKGA
Mflv_4014|M.gilvum_PYR-GCK -DTRTQGQRNHDGLKAVLRRTLESGQLGSHNGLPVTVIVSTTLQELEKGA
MSMEG_6573|M.smegmatis_MC2_155 SDQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA
Mb1159c|M.bovis_AF2122/97 RDTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA
Rv1128c|M.tuberculosis_H37Rv RDTRSCPQRNHDALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA
MAV_1426|M.avium_104 GDTRSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLETAA
MMAR_1523|M.marinum_M RDRRSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC
MUL_2371|M.ulcerans_Agy99 RDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA
MAB_0394c|M.abscessus_ATCC_199 RDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA
TH_3287|M.thermoresistible__bu VDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAA
* * :*.**.: :: : ** .* *.:::* *** :*: ..
Mvan_3379|M.vanbaalenii_PYR-1 -----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGQSLY
Mflv_4014|M.gilvum_PYR-GCK -----------GVAVTGGGSLLPIPELIRLAADAHHYLYVYDGHTGQSLY
MSMEG_6573|M.smegmatis_MC2_155 -----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLY
Mb1159c|M.bovis_AF2122/97 -----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGKALA
Rv1128c|M.tuberculosis_H37Rv -----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGKALA
MAV_1426|M.avium_104 -----------GKGLTGGGTLLPISDVIRLSRHAHHYLAIF--DHGKALA
MMAR_1523|M.marinum_M -----------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGKAVG
MUL_2371|M.ulcerans_Agy99 -----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIG
MAB_0394c|M.abscessus_ATCC_199 -----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGRPLH
TH_3287|M.thermoresistible__bu HAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLY
* . :.. :.: ::**:: * *** :: . .:
Mvan_3379|M.vanbaalenii_PYR-1 LGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGLT
Mflv_4014|M.gilvum_PYR-GCK LGRAKRLANAAQRIVMHARDRGCTRPGCTVPGYWCQAHHASADWKDDGHT
MSMEG_6573|M.smegmatis_MC2_155 LGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLT
Mb1159c|M.bovis_AF2122/97 LYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHV-TPYAQCRNT
Rv1128c|M.tuberculosis_H37Rv LYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHV-TPYAQCRNT
MAV_1426|M.avium_104 LYHTKRLASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHC-TDYATCHTT
MMAR_1523|M.marinum_M LYHAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHV-AAWATSGRT
MUL_2371|M.ulcerans_Agy99 LYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHV-AAWAISGRT
MAB_0394c|M.abscessus_ATCC_199 LGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHV-DDWRDDGPT
TH_3287|M.thermoresistible__bu LGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQ-PAWEDGGLT
* : :* *.. **: *:* **: *** ** .:.** : *
Mvan_3379|M.vanbaalenii_PYR-1 NIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQHRTN
Mflv_4014|M.gilvum_PYR-GCK DIDDLTFACGPENRMIENTG--WTTAKN-SRNQTEWIPPPDLETGQHRVN
MSMEG_6573|M.smegmatis_MC2_155 DADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQHRTN
Mb1159c|M.bovis_AF2122/97 DVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVN
Rv1128c|M.tuberculosis_H37Rv DVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVN
MAV_1426|M.avium_104 DINDLTFACGPHHRLLQPGA--WTTHKN-AKGETQWLPPPHLDRNQPRTN
MMAR_1523|M.marinum_M DIDQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTN
MUL_2371|M.ulcerans_Agy99 DINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTN
MAB_0394c|M.abscessus_ATCC_199 DIDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTN
TH_3287|M.thermoresistible__bu DADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVN
: : * :.* .: * : . * : .*
Mvan_3379|M.vanbaalenii_PYR-1 DYHHPERHLLPEDD----------QGP-----------------------
Mflv_4014|M.gilvum_PYR-GCK GYHHPERHLLPHEEGEDSSTSRDCDDP-----------------------
MSMEG_6573|M.smegmatis_MC2_155 TYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPP
Mb1159c|M.bovis_AF2122/97 TFHHPEKLLADDEGDP----------------------------------
Rv1128c|M.tuberculosis_H37Rv TFHHPEKLLADDEGDP----------------------------------
MAV_1426|M.avium_104 TFHHPEKLLRGEYGEDEVDGEQEADQGDDHAA------------------
MMAR_1523|M.marinum_M TYHHPEKLLRDSAADEGEEGG-----------------------------
MUL_2371|M.ulcerans_Agy99 SYHHPEKLLRDSADDDDEGHGAA---------------------------
MAB_0394c|M.abscessus_ATCC_199 DHHHPERFIRRF--------------------------------------
TH_3287|M.thermoresistible__bu HAHHPEELLRAHTDPPEDPG------------------------------
**** :
Mvan_3379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4014|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 ELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENR
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1426|M.avium_104 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_3379|M.vanbaalenii_PYR-1 ---------------
Mflv_4014|M.gilvum_PYR-GCK ---------------
MSMEG_6573|M.smegmatis_MC2_155 NGPSKNAAGDDDEPR
Mb1159c|M.bovis_AF2122/97 ---------------
Rv1128c|M.tuberculosis_H37Rv ---------------
MAV_1426|M.avium_104 ---------------
MMAR_1523|M.marinum_M ---------------
MUL_2371|M.ulcerans_Agy99 ---------------
MAB_0394c|M.abscessus_ATCC_199 ---------------
TH_3287|M.thermoresistible__bu ---------------