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DDGVQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQDARNRIPAVEHRAIAALSQQTTPAAIGAKSW PLVLATRLGISSKEARRRCTDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPDW VTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPTKPFGITFGPQQPDGSYHLRGK VSAEFKATFDPIDEKLAAPGMCNPTDQTPCISGTPSQQQIDSDQRGAPERRHDAMLTAMRLLLAHKDLGQ INGLPATLLVTTTLQELEKAAGVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYLGRARRTASA GQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALALACGCDNRLVGEAPNKWTTRINNH GQCEWIPPDLLDRGQHRTNTYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPE LLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRNGPSKNAAGDDDEPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6573 | - | - | 100% (555) | hypothetical protein MSMEG_6573 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 0.0 | 81.17% (563) | hypothetical protein MSMEG_2663 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 3e-95 | 42.57% (451) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_3477 | - | 1e-115 | 48.65% (446) | hypothetical protein Mflv_3477 |
| M. tuberculosis H37Rv | Rv1128c | - | 4e-95 | 42.57% (451) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-86 | 40.90% (445) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 9e-93 | 42.60% (453) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2999 | - | 1e-101 | 43.51% (462) | hypothetical protein MAV_2999 |
| M. thermoresistible (build 8) | TH_3287 | - | 1e-48 | 31.48% (486) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 3e-88 | 40.68% (440) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3231 | - | 1e-113 | 44.76% (496) | hypothetical protein Mvan_3231 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3477|M.gilvum_PYR-GCK ---MYVR-IMSGGDLQARIAALRAAFDDVAAAEIDLLTRAELVAALDDLE
Mvan_3231|M.vanbaalenii_PYR-1 ---MYVR-AMSGSDVQATVTALRTAFDDMAACDVDLLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mb1159c|M.bovis_AF2122/97 ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MAV_2999|M.avium_104 MRGMSS----DREAVSAAFDAIDAALDDLLDCDYAALATREKLALLNRCE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
. : . : : : :
Mflv_3477|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQVEATPQQLGAKSWSEVLRVRWRISTTEANRRL
Mvan_3231|M.vanbaalenii_PYR-1 TLGCRLPSVSHRLLARLQAEATPPQMGAKSWKEVLAVRWRISTSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mb1159c|M.bovis_AF2122/97 TARRQLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKRRV
Rv1128c|M.tuberculosis_H37Rv TARRQLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKRRV
MAV_2999|M.avium_104 RLRRRLPAIEHPLINALARDATPAELGGR-LSHAIAEATLISRAEAARRV
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGEVKRRL
. : : : : :: . **
Mflv_3477|M.gilvum_PYR-GCK TEAGLLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
Mvan_3231|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGEALAPVLPATAAAQAHGLINAEHVEVIRKTMAKVPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mb1159c|M.bovis_AF2122/97 AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
Rv1128c|M.tuberculosis_H37Rv AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
MAV_2999|M.avium_104 HTAADLGPRVGLTGEPLPPLLAATAAAQREGSLGLEQVAVIRKFCHQLPG
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
*. : * ::* : * * * * : :: : *
Mflv_3477|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGNGPKELRDAAELTLFLLDQDGPEPDDTERA
Mvan_3231|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mb1159c|M.bovis_AF2122/97 WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDE-DRA
Rv1128c|M.tuberculosis_H37Rv WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDE-DRA
MAV_2999|M.avium_104 WIDQATRERAEADLANQGTRYRPEQLAALAGTLADCLNPDGLYRDE-DRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDGRYSDE-DRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-DRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDGRFSDI-DRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDGHYDDQ-DRA
: * * . . : .: ** :
Mflv_3477|M.gilvum_PYR-GCK RKRGLTKGKQRPDGMIDLAGTLTPEAWAVLEVIFAKYAAP----------
Mvan_3231|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAP----------
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP----------
Mb1159c|M.bovis_AF2122/97 RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP----------
Rv1128c|M.tuberculosis_H37Rv RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP----------
MAV_2999|M.avium_104 RRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAP----------
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP----------
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAP----------
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAP----------
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTTDT
: .: * ** : . : .: * : : .
Mflv_3477|M.gilvum_PYR-GCK ----------GMCNPADPEPCTAGTPTQAQIDNDQ-----RSLAQRQHDA
Mvan_3231|M.vanbaalenii_PYR-1 ----------GMCNPDDPEPCTSGTPSQAQIDHDQ-----RSLAQRQHDA
MSMEG_6573|M.smegmatis_MC2_155 ----------GMCNPTDQTPCISGTPSQQQIDSDQ-----RGAPERRHDA
Mb1159c|M.bovis_AF2122/97 ----------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNHDA
Rv1128c|M.tuberculosis_H37Rv ----------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNHDA
MAV_2999|M.avium_104 ----------GMCNPLDESPCVDGTPTEQAIEGDT-----RSAAQRNHDG
MMAR_1523|M.marinum_M ----------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHHDG
MUL_2371|M.ulcerans_Agy99 ----------GMCNPEDEAAVVDGPVSRDAADRDS-----RSVSQRQHDG
MAB_0394c|M.abscessus_ATCC_199 ----------GMCDPRDESPMTEGEPDSAAAERDT-----RTSAQRNHDG
TH_3287|M.thermoresistible__bu TGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHDG
* ... . * * :*.**.
Mflv_3477|M.gilvum_PYR-GCK LVAVGRIALMSGELGQLNGLPVSIIIRTTLQDLESRA-----------GV
Mvan_3231|M.vanbaalenii_PYR-1 LLAAGRIALMSGELGKLNGLPVSVIIRTTLQDLESRA-----------GV
MSMEG_6573|M.smegmatis_MC2_155 MLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-----------GV
Mb1159c|M.bovis_AF2122/97 LNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------GA
Rv1128c|M.tuberculosis_H37Rv LNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------GA
MAV_2999|M.avium_104 LLAGLRALLASGNLGQHNGLPASIIVTTTLADLETAA-----------GK
MMAR_1523|M.marinum_M LNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------GR
MUL_2371|M.ulcerans_Agy99 FNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------GR
MAB_0394c|M.abscessus_ATCC_199 LRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------GR
TH_3287|M.thermoresistible__bu LTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPGP
: : : ** .* *.:::: *** :*: . *
Mflv_3477|M.gilvum_PYR-GCK GTTGGGTVVPIKDVIRMGGHANHYLAVFDRATGSALDLFRTRRVASPAQR
Mvan_3231|M.vanbaalenii_PYR-1 GVTGGGTVMPIAEVIRMAGHANHYLAVFDRATGSALDLFRTRRIASPAQR
MSMEG_6573|M.smegmatis_MC2_155 AITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYLGRARRTASAGQR
Mb1159c|M.bovis_AF2122/97 GLTGGGTILPISDVIRLARHANHYLAIFDR--GKALALYHTKRLASPAQR
Rv1128c|M.tuberculosis_H37Rv GLTGGGTILPISDVIRLARHANHYLAIFDR--GKALALYHTKRLASPAQR
MAV_2999|M.avium_104 GLTGGGTLLPMSDVIRLSRHAHHYLAIFDK--GKALALYHTKRLASPGQR
MMAR_1523|M.marinum_M GLTGGGTVLPISDVIRLARHAHHYLAVFDR--GKAVGLYHAKRLATAGQR
MUL_2371|M.ulcerans_Agy99 GLTGGGTLLPMSDVIRLARHAHHYLAVFDR--GEAIGLYHAKRLATPGQR
MAB_0394c|M.abscessus_ATCC_199 AISGSGNLVPIPDLIRMATHAFHYLTIFGD-DGRPLHLGRSKRIATPDQR
TH_3287|M.thermoresistible__bu ARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYLGRQKRIATADQR
. :.. :.: ::**:. .* ***:::. .: * : :* *:. **
Mflv_3477|M.gilvum_PYR-GCK VMLIARDGGCTKPCCTVGAYGCQVHHAETDYAHGGNTNIDELGLACGPDN
Mvan_3231|M.vanbaalenii_PYR-1 IMLIARDGGCTKPGCTVGAYGCQGHHVEADFAKGGNTNVDELGLACGPDN
MSMEG_6573|M.smegmatis_MC2_155 LAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALALACGCDN
Mb1159c|M.bovis_AF2122/97 IMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGHH
Rv1128c|M.tuberculosis_H37Rv IMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGHH
MAV_2999|M.avium_104 IVLYAKDRGCTAPGCTVPGYYAEVHHCT-DYATCHTTDINDLTFACGPHH
MMAR_1523|M.marinum_M LVLYAKDRGCTRPGCDVPGYQCEVHHVA-AWATSGRTDIDQLTLACGPDH
MUL_2371|M.ulcerans_Agy99 IVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTDINQLTLACGPDH
MAB_0394c|M.abscessus_ATCC_199 IVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPTDIDNLTFACGPHH
TH_3287|M.thermoresistible__bu LICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLTDADHLFFACGPHH
: *:* **: * * .* .: ** : *: : * :.** .:
Mflv_3477|M.gilvum_PYR-GCK RSVT--EGGWTTRMN-DRCEVEWIPPPGLDTGQARVNTYHRPERLLAP--
Mvan_3231|M.vanbaalenii_PYR-1 RSVDN-NGGWTTRMN-ERCEVEWIPPPSLDTGQARINNYHRPERLLHP--
MSMEG_6573|M.smegmatis_MC2_155 RLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQHRTNTYHHPETLLADIN
Mb1159c|M.bovis_AF2122/97 PLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNTFHHPEKLL----
Rv1128c|M.tuberculosis_H37Rv PLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNTFHHPEKLL----
MAV_2999|M.avium_104 RLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRTNTFHHPEKLLRGE-
MMAR_1523|M.marinum_M KLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNTYHHPEKLLR---
MUL_2371|M.ulcerans_Agy99 KLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNSYHHPEKLLR---
MAB_0394c|M.abscessus_ATCC_199 RLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTNDHHHPERFIRRF-
TH_3287|M.thermoresistible__bu SGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVNHAHHPEELLR---
* : * * * *:** ::
Mflv_3477|M.gilvum_PYR-GCK -----------------------------------PEDPEPPDQTRSTAT
Mvan_3231|M.vanbaalenii_PYR-1 -----------------------------------PDEPEPQGHNDTEAE
MSMEG_6573|M.smegmatis_MC2_155 RDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPELLDQGQQRTAPY
Mb1159c|M.bovis_AF2122/97 --------------------------------------ADDEGDP-----
Rv1128c|M.tuberculosis_H37Rv --------------------------------------ADDEGDP-----
MAV_2999|M.avium_104 -----------------------------------DGGEDDDGDDDEAA-
MMAR_1523|M.marinum_M ------------------------------------DSAADEGEEGG---
MUL_2371|M.ulcerans_Agy99 ------------------------------------DSADDDDEGHGAA-
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu -------------------------------------AHTDPPEDPG---
Mflv_3477|M.gilvum_PYR-GCK EPAAVQAIDDP---EAQAPRPAD------DPGEPGGPAPPEGEAA-----
Mvan_3231|M.vanbaalenii_PYR-1 IESAGSAQGNPRGDETNGPRPTD------DAGKPGGPAPPGDQAA-----
MSMEG_6573|M.smegmatis_MC2_155 HQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRNGPSKNAAGDDDE
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2999|M.avium_104 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mflv_3477|M.gilvum_PYR-GCK --
Mvan_3231|M.vanbaalenii_PYR-1 --
MSMEG_6573|M.smegmatis_MC2_155 PR
Mb1159c|M.bovis_AF2122/97 --
Rv1128c|M.tuberculosis_H37Rv --
MAV_2999|M.avium_104 --
MMAR_1523|M.marinum_M --
MUL_2371|M.ulcerans_Agy99 --
MAB_0394c|M.abscessus_ATCC_199 --
TH_3287|M.thermoresistible__bu --