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SSGGIIDRDAISAAFDALDAALDGVAALGFDGLTPRECLALLGRCEKARRRLPVAEHQLINLVARQASPA ELGGRLSHAIAEATLISRAEAARRVHTAADLGPRVGLTGEPLPPVLAATAAAQRAGSLGPEQVAVIRKFC HQLPGWIDQATRERAETDLAREGTRYRPEQLAALAGTLADCLNPDGLYRDEDRARRRSLTLGNQHADGMS ELRGWLSPELRATLEAVLAKLAAPGMCNPLDESPCVDGTPTEQAIEGDTRSAAQRNHDGLLAGLRALLAS GNLGQHNGLPASIIVTTTLADLETAAGKGLTGGGTLLPISDVIRLSRHAHHYLAIFDHGKALALYHTKRL ASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHCTDYATCHTTDINDLTFACGPHHRLLQPGAWTTHKNAK GETQWLPPPHLDRNQPRTNTFHHPEKLLRGEYGEDEVDGEQEADQGDDHAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1426 | - | - | 100% (472) | hypothetical protein MAV_1426 |
| M. avium 104 | MAV_4180 | - | 0.0 | 90.75% (465) | hypothetical protein MAV_4180 |
| M. avium 104 | MAV_2999 | - | 0.0 | 89.25% (465) | hypothetical protein MAV_2999 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-173 | 66.67% (447) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_1835 | - | 1e-114 | 47.89% (474) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-172 | 66.44% (447) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-125 | 53.32% (437) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-164 | 63.44% (454) | hypothetical protein MMAR_1523 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-100 | 42.77% (470) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 7e-73 | 40.44% (413) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-160 | 60.83% (457) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-111 | 45.16% (496) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1159c|M.bovis_AF2122/97 ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MAV_1426|M.avium_104 ---MSSGGIIDRDAISAAFDALDAALDGVAALGFDGLTPRECLALLGRCE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
. : . : . : : :
Mb1159c|M.bovis_AF2122/97 TARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKRRV
Rv1128c|M.tuberculosis_H37Rv TARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKRRV
MAV_1426|M.avium_104 KARRRLPVAEHQLINLVARQASPAELGG-RLSHAIAEATLISRAEAARRV
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGG-KLAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSEAGRRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mvan_3050|M.vanbaalenii_PYR-1 RNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAEAGRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGEVKRRL
: : : : :: . **
Mb1159c|M.bovis_AF2122/97 AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
Rv1128c|M.tuberculosis_H37Rv AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
MAV_1426|M.avium_104 HTAADLGPRVGLTGEPLPPVLAATAAAQRAGSLGPEQVAVIRKFCHQLPG
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mvan_3050|M.vanbaalenii_PYR-1 KRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKRLPA
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
* : * ::* : * * * * : :: : *
Mb1159c|M.bovis_AF2122/97 WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
Rv1128c|M.tuberculosis_H37Rv WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
MAV_1426|M.avium_104 WIDQATRERAETDLAREGTRYRPEQLAALAGTLADCLNPDG-LYRDEDRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mvan_3050|M.vanbaalenii_PYR-1 WVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
: : * . . : .: ** *
Mb1159c|M.bovis_AF2122/97 RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQKA-
Rv1128c|M.tuberculosis_H37Rv RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQKA-
MAV_1426|M.avium_104 RRRSLTLGNQHADGMSELRGWLSPELRATLEAVLAKLAAPGMCNPLDES-
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDDES-
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPEDEA-
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRDES-
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAPGMCNPDDEQ-
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTDQT-
Mvan_3050|M.vanbaalenii_PYR-1 RKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNPESEHT
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
: .: :. * :. : * : .: * :.: ** *
Mb1159c|M.bovis_AF2122/97 -PCVNG------------------------------APSKEQAR------
Rv1128c|M.tuberculosis_H37Rv -PCVNG------------------------------APSKEQAR------
MAV_1426|M.avium_104 -PCVDG------------------------------TPTEQAIE------
MMAR_1523|M.marinum_M -PVVQA------------------------------PAGADAVS------
MUL_2371|M.ulcerans_Agy99 -AVVDG------------------------------PVSRDAAD------
MAB_0394c|M.abscessus_ATCC_199 -PMTEG------------------------------EPDSAAAE------
Mflv_1835|M.gilvum_PYR-GCK -PCTSG------------------------------TPSQAQID------
MSMEG_6573|M.smegmatis_MC2_155 -PCISG------------------------------TPSQQQID------
Mvan_3050|M.vanbaalenii_PYR-1 EDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCG------
TH_3287|M.thermoresistible__bu TTGTTG---------------TTETTGTAGTAGTAATAADTAADGVGDID
.
Mb1159c|M.bovis_AF2122/97 ---RDTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLE
Rv1128c|M.tuberculosis_H37Rv ---RDTRSCPQRNHDALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLE
MAV_1426|M.avium_104 ---GDTRSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLE
MMAR_1523|M.marinum_M ---RDRRSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQ
MUL_2371|M.ulcerans_Agy99 ---RDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELE
MAB_0394c|M.abscessus_ATCC_199 ---RDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQ
Mflv_1835|M.gilvum_PYR-GCK ---GDHRSLAQRQHDALLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLE
MSMEG_6573|M.smegmatis_MC2_155 ---SDQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELE
Mvan_3050|M.vanbaalenii_PYR-1 ---SDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELE
TH_3287|M.thermoresistible__bu TGGVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELN
* * :*.**.: : : ** .* *.:::: *** :*:
Mb1159c|M.bovis_AF2122/97 AAA-----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGK
Rv1128c|M.tuberculosis_H37Rv AAA-----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGK
MAV_1426|M.avium_104 TAA-----------GKGLTGGGTLLPISDVIRLSRHAHHYLAIF--DHGK
MMAR_1523|M.marinum_M RAC-----------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGK
MUL_2371|M.ulcerans_Agy99 AAA-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGE
MAB_0394c|M.abscessus_ATCC_199 SAA-----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGR
Mflv_1835|M.gilvum_PYR-GCK SRA-----------GIGVSGGGTKLPIRDVIRMAGHANHYLAVFDRATGS
MSMEG_6573|M.smegmatis_MC2_155 KAA-----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGI
Mvan_3050|M.vanbaalenii_PYR-1 KGA-----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGK
TH_3287|M.thermoresistible__bu QAAHAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTER
. * . :.. :.: ::**:: * *** ::
Mb1159c|M.bovis_AF2122/97 ALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQC
Rv1128c|M.tuberculosis_H37Rv ALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQC
MAV_1426|M.avium_104 ALALYHTKRLASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHCT-DYATC
MMAR_1523|M.marinum_M AVGLYHAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVA-AWATS
MUL_2371|M.ulcerans_Agy99 AIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAIS
MAB_0394c|M.abscessus_ATCC_199 PLHLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDD
Mflv_1835|M.gilvum_PYR-GCK ALDLFRTRRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHG
MSMEG_6573|M.smegmatis_MC2_155 PLYLGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKG
Mvan_3050|M.vanbaalenii_PYR-1 SLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDG
TH_3287|M.thermoresistible__bu PLYLGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDG
.: * : :* *.. **: *:* **: * * .* .:.** :
Mb1159c|M.bovis_AF2122/97 RNTDVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQP
Rv1128c|M.tuberculosis_H37Rv RNTDVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQP
MAV_1426|M.avium_104 HTTDINDLTFACGPHHRLLQPGA--WTTHKN-AKGETQWLPPPHLDRNQP
MMAR_1523|M.marinum_M GRTDIDQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQP
MUL_2371|M.ulcerans_Agy99 GRTDINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQP
MAB_0394c|M.abscessus_ATCC_199 GPTDIDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQS
Mflv_1835|M.gilvum_PYR-GCK GNTNIDELGLACGPDNRSVTDGG--WTTRMN-DRCEVEWIPPPGLDTGQA
MSMEG_6573|M.smegmatis_MC2_155 GLTDADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQH
Mvan_3050|M.vanbaalenii_PYR-1 GLTNIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQH
TH_3287|M.thermoresistible__bu GLTDADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPP
*: : * :.* .: * : * *
Mb1159c|M.bovis_AF2122/97 RVNTFHHPEKLLADDEGDP-------------------------------
Rv1128c|M.tuberculosis_H37Rv RVNTFHHPEKLLADDEGDP-------------------------------
MAV_1426|M.avium_104 RTNTFHHPEKLLRGEYGEDEVDGEQEADQGDDHAA---------------
MMAR_1523|M.marinum_M RTNTYHHPEKLLRDSAADEGEEGG--------------------------
MUL_2371|M.ulcerans_Agy99 RTNSYHHPEKLLRDSADDDDEGHGAA------------------------
MAB_0394c|M.abscessus_ATCC_199 RTNDHHHPERFIRRF-----------------------------------
Mflv_1835|M.gilvum_PYR-GCK RVNTYHRPERLLRPEDPEPLGDNDSQASRPADDPGEPG---------GPA
MSMEG_6573|M.smegmatis_MC2_155 RTNTYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPA
Mvan_3050|M.vanbaalenii_PYR-1 RVNGHHHPERYLLPEDDLPEDDQGP-------------------------
TH_3287|M.thermoresistible__bu TVNHAHHPEELLRAHTDPPEDPG---------------------------
.* *:** :
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1426|M.avium_104 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK PP-----EGEAA--------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 IPPELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSA
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mb1159c|M.bovis_AF2122/97 ------------------
Rv1128c|M.tuberculosis_H37Rv ------------------
MAV_1426|M.avium_104 ------------------
MMAR_1523|M.marinum_M ------------------
MUL_2371|M.ulcerans_Agy99 ------------------
MAB_0394c|M.abscessus_ATCC_199 ------------------
Mflv_1835|M.gilvum_PYR-GCK ------------------
MSMEG_6573|M.smegmatis_MC2_155 ENRNGPSKNAAGDDDEPR
Mvan_3050|M.vanbaalenii_PYR-1 ------------------
TH_3287|M.thermoresistible__bu ------------------