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MCSTREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCETARRQLPSVEHTLINQIGEQSTEEELG GKLGLTLADRLRITRSEAKRRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRL PSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDEDRARRRGLTLGKQDVDGMSRLS GYVTPELRATIEAVWAKLAAPGMCNPEQKAPCVNGAPSKEQARRDTRSCPQRNHDALNAGLRSLLTSGNL GQHNGLPASIIVTTTLKDLEAAAGAGLTGGGTILPISDVIRLARHANHYLAIFDRGKALALYHTKRLASP AQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTPYAQCRNTDVNDLTLGCGGHHPLAERGWTTRKNAHGDTE WLPPPHLDHGQPRVNTFHHPEKLLADDEGDP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | - | 100% (451) | hypothetical protein Mb1159c |
| M. bovis AF2122 / 97 | Mb1728c | - | e-168 | 64.30% (451) | hypothetical protein Mb1728c |
| M. bovis AF2122 / 97 | Mb1179c | - | e-165 | 63.31% (447) | hypothetical protein Mb1179c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4397 | - | 1e-116 | 50.22% (452) | hypothetical protein Mflv_4397 |
| M. tuberculosis H37Rv | Rv1128c | - | 0.0 | 99.78% (451) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-123 | 51.04% (433) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-178 | 66.89% (447) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2352 | - | 0.0 | 69.96% (446) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 3e-95 | 42.57% (451) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 4e-74 | 36.38% (492) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-177 | 65.26% (449) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_4912 | - | 1e-114 | 49.45% (453) | hypothetical protein Mvan_4912 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1159c|M.bovis_AF2122/97 ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MAV_2352|M.avium_104 --MHSS----TREEIRADVDALRAAVSRVLGHSYDALTTPERLRLLEIFD
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAB_0394c|M.abscessus_ATCC_199 -----------MSPIDDLLTTATAVVESS----FDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mflv_4397|M.gilvum_PYR-GCK ---------MSGGDLQTSIAALRAAFEEVAAADVDLLTRPDLVAALDELE
Mvan_4912|M.vanbaalenii_PYR-1 ----MYVRAMSGSDVQAAVTALRTAFDDMAACDVDLLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
: . . . : : :
Mb1159c|M.bovis_AF2122/97 TARRQLPSVEHTLINQIGEQSTEEELGGKLGLTLADR-LRITRSEAKRRV
Rv1128c|M.tuberculosis_H37Rv TARRQLPSVEHTLINQIGEQSTEEELGGKLGLTLADR-LRITRSEAKRRV
MAV_2352|M.avium_104 RETRRLRVPGHQLINQLAEQSDPTELGGRLSFALAER-LHITRSDASRRI
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGKLAAVLAGR-LRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGRLAAVVASR-LRITRSEAGRRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPAVRDRLWAR-LRITPGEVKRRL
Mflv_4397|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQVETSAREMGAKSWNQVLAVRWRISTGEAHRRL
Mvan_4912|M.vanbaalenii_PYR-1 TLGCRLPSVSHRLLARLQAEATPPQMGAKSWKEVLAVRWRISTSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
: : : : :: . **
Mb1159c|M.bovis_AF2122/97 AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
Rv1128c|M.tuberculosis_H37Rv AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
MAV_2352|M.avium_104 AEAADLGPRRALTGEPLPPLLPATAAAQRDGAIGTDHVAVIRQFFDQLPE
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Mflv_4397|M.gilvum_PYR-GCK TEAALLAPRQSLTGTPLPPALPATAVAQSRGLINAEHVEVIRKAVKKLPG
Mvan_4912|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGESLPPALPATATAQAHGLINAEHVEVIRKAMAKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
** : * ::* : * * * * : *: : *
Mb1159c|M.bovis_AF2122/97 WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
Rv1128c|M.tuberculosis_H37Rv WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
MAV_2352|M.avium_104 AVDVETCEHAERQLAAQATQFRPDQLSKLARRLMDCLNPDG-RYSDEDRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
Mflv_4397|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGNGPKELRDAAELTLFLLDQDGPEPDDTERA
Mvan_4912|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
* * * . . : .: ** : :
Mb1159c|M.bovis_AF2122/97 RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQ---
Rv1128c|M.tuberculosis_H37Rv RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQ---
MAV_2352|M.avium_104 RARGLVLGNQQADGMSRLSGWLTPEARAGWEAVLAKLAAPGMCNPDD---
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDD---
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED---
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRD---
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
Mflv_4397|M.gilvum_PYR-GCK RKRGLTKGKQRPDGMIDLAGTLTPEAWAVLEVIFAKYAAPGMCNPAD---
Mvan_4912|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAPGMCNPDD---
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTD---
: .: * ** : . : .: * : : ** *
Mb1159c|M.bovis_AF2122/97 --------KAPCVNGAPSKEQARRDT---------------RSCPQRNHD
Rv1128c|M.tuberculosis_H37Rv --------KAPCVNGAPSKEQARRDT---------------RSCPQRNHD
MAV_2352|M.avium_104 --------DAPVVDGPPPEAASQRDS---------------RSAAQRNHD
MMAR_1523|M.marinum_M --------ESPVVQAPAGADAVSRDR---------------RSVGQRHHD
MUL_2371|M.ulcerans_Agy99 --------EAAVVDGPVSRDAADRDS---------------RSVSQRQHD
MAB_0394c|M.abscessus_ATCC_199 --------ESPMTEGEPDSAAAERDT---------------RTSAQRNHD
TH_3287|M.thermoresistible__bu TTGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHD
Mflv_4397|M.gilvum_PYR-GCK --------PEPCTYGTPTQAQIDNDQ---------------RSLAQRQHD
Mvan_4912|M.vanbaalenii_PYR-1 --------PEPCTSGTPSQAQIDHDQ---------------RSLAQRQHD
MSMEG_6573|M.smegmatis_MC2_155 --------QTPCISGTPSQQQIDSDQ---------------RGAPERRHD
. . * * :*.**
Mb1159c|M.bovis_AF2122/97 ALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------G
Rv1128c|M.tuberculosis_H37Rv ALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------G
MAV_2352|M.avium_104 GLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLESAA-----------G
MMAR_1523|M.marinum_M GLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------G
MUL_2371|M.ulcerans_Agy99 GFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------G
MAB_0394c|M.abscessus_ATCC_199 GLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------G
TH_3287|M.thermoresistible__bu GLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPG
Mflv_4397|M.gilvum_PYR-GCK ALVAVGRIALMSGELGQLNGLPVSIIIRTTLQDLESRA-----------G
Mvan_4912|M.vanbaalenii_PYR-1 ALLAGGRIALMSGELGKLNGLPVSVIIRTTLQDLESRA-----------G
MSMEG_6573|M.smegmatis_MC2_155 AMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-----------G
.: : : ** .* *.:::: *** :*: . *
Mb1159c|M.bovis_AF2122/97 AGLTGGGTILPISDVIRLARHANHYLAIFDRG--KALALYHTKRLASPAQ
Rv1128c|M.tuberculosis_H37Rv AGLTGGGTILPISDVIRLARHANHYLAIFDRG--KALALYHTKRLASPAQ
MAV_2352|M.avium_104 KGLTGGGTLLPMSEVIRLARHAHHYLAVFDNG--KPLALYHTKRLASPGQ
MMAR_1523|M.marinum_M RGLTGGGTVLPISDVIRLARHAHHYLAVFDRG--KAVGLYHAKRLATAGQ
MUL_2371|M.ulcerans_Agy99 RGLTGGGTLLPMSDVIRLARHAHHYLAVFDRG--EAIGLYHAKRLATPGQ
MAB_0394c|M.abscessus_ATCC_199 RAISGSGNLVPIPDLIRMATHAFHYLTIFGDD-GRPLHLGRSKRIATPDQ
TH_3287|M.thermoresistible__bu PARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYLGRQKRIATADQ
Mflv_4397|M.gilvum_PYR-GCK VGTTGGGTVVPIKDVIRMAGHANHYLAVFDRATGSALDLFRTRRVASPAQ
Mvan_4912|M.vanbaalenii_PYR-1 VGVTGGGTVMPIAEVIRMAGHANHYLAVFDRATGSALDLFRTKRVASAAQ
MSMEG_6573|M.smegmatis_MC2_155 VAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYLGRARRTASAGQ
. :.. :.: ::**:* .* ***:::. .: * : :* *:. *
Mb1159c|M.bovis_AF2122/97 RIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGH
Rv1128c|M.tuberculosis_H37Rv RIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGH
MAV_2352|M.avium_104 RIVLYAKDRGCSHPGCDVSGYYCEVHHVT-GYAKCGRTDIDQLTFACGGH
MMAR_1523|M.marinum_M RLVLYAKDRGCTRPGCDVPGYQCEVHHVA-AWATSGRTDIDQLTLACGPD
MUL_2371|M.ulcerans_Agy99 RIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTDINQLTLACGPD
MAB_0394c|M.abscessus_ATCC_199 RIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPTDIDNLTFACGPH
TH_3287|M.thermoresistible__bu RLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLTDADHLFFACGPH
Mflv_4397|M.gilvum_PYR-GCK RVMLIARDGGCTKPCCTVGAYGCQVHHAETDYAHGGNTNIDELGLACGPD
Mvan_4912|M.vanbaalenii_PYR-1 RIMLIARDGGCTKPGCTVGAYGCQGHHVEADFAKGGNTNVDELGLACGPD
MSMEG_6573|M.smegmatis_MC2_155 RLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALALACGCD
*: *:* **: * * .* .: ** : *: : * :.** .
Mb1159c|M.bovis_AF2122/97 HPLAER--GWTTRK-NAHGDTEWLPPPHLDHGQPRVNTFHHPEKLLADDE
Rv1128c|M.tuberculosis_H37Rv HPLAER--GWTTRK-NAHGDTEWLPPPHLDHGQPRVNTFHHPEKLLADDE
MAV_2352|M.avium_104 HPLAEQ--GWITRK-NGRGETEWIPPPHLERGQPRVNSFHHPEDMLCDTE
MMAR_1523|M.marinum_M HKLLEQ--GWRTRK-NAHGDTEWLPPPHLDHGQPRTNTYHHPEKLLRDSA
MUL_2371|M.ulcerans_Agy99 HKLLEQ--GWRTRK-NAHGDTEWLPPPHLDHGQPRTNSYHHPEKLLRDSA
MAB_0394c|M.abscessus_ATCC_199 HRLLQQ--GWTTRKRRSDGITEWIPPPHLDTGQSRTNDHHHPERFIRRF-
TH_3287|M.thermoresistible__bu HSGLTE--GRWQATITPTGRLAWTNDHHPPT----VNHAHHPEELLRAHT
Mflv_4397|M.gilvum_PYR-GCK NRSVT--EGGWTTRINDRCEVEWIPPPGLDTGQARVNTYHRPERLLAPPD
Mvan_4912|M.vanbaalenii_PYR-1 NRSVDN-NGGWTTQMNERCEVEWIPPPPLDTGQARINNYHRPERLLRPPE
MSMEG_6573|M.smegmatis_MC2_155 NRLVGEAPNKWTTRINNHGQCEWIPPDLLDRGQHRTNTYHHPETLLADIN
: . * * *:** ::
Mb1159c|M.bovis_AF2122/97 ----------------------------------------GDP-------
Rv1128c|M.tuberculosis_H37Rv ----------------------------------------GDP-------
MAV_2352|M.avium_104 ----------------------------------------DQQDQQDQQD
MMAR_1523|M.marinum_M ----------------------------------------ADEGEEGG--
MUL_2371|M.ulcerans_Agy99 ----------------------------------------DDDDEGHGAA
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu ----------------------------------------DPPEDPG---
Mflv_4397|M.gilvum_PYR-GCK -------DPEPPNQTRTTAT-EPVEDQAIDDPETDAPPPLDDPGEPGGP-
Mvan_4912|M.vanbaalenii_PYR-1 -------EPDPHSDNDTAASAKPAEGNEIGDAQPGAPQPADNPSEPGGP-
MSMEG_6573|M.smegmatis_MC2_155 RDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPELLDQGQQRTAPY
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2352|M.avium_104 QADEEDGAA-----------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mflv_4397|M.gilvum_PYR-GCK ----APPDNRAA--------------------------------------
Mvan_4912|M.vanbaalenii_PYR-1 ----APPDNQAA--------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 HQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRNGPSKNAAGDDDE
Mb1159c|M.bovis_AF2122/97 --
Rv1128c|M.tuberculosis_H37Rv --
MAV_2352|M.avium_104 --
MMAR_1523|M.marinum_M --
MUL_2371|M.ulcerans_Agy99 --
MAB_0394c|M.abscessus_ATCC_199 --
TH_3287|M.thermoresistible__bu --
Mflv_4397|M.gilvum_PYR-GCK --
Mvan_4912|M.vanbaalenii_PYR-1 --
MSMEG_6573|M.smegmatis_MC2_155 PR