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VAGLSVGRTSVRCMDGVAEAVGVIGEQLAVLAKAAEDLSHRELIGLLSELTTVLRSAPAVEHAVLARLLD ETEPHHLGEASWKKVLTTSLRMSSAEAGRRLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVE IIAKFHKKLPSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPSEKEKATRFWVKLGT QQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMAEQEKAGDTRTQGQRNHDGLKAVLRRTLESGQLGS HNGLPVTVIVSTTLQELEKGAGVAVTGGGSLLPIPELIRLAADAHHYLYVYDGHTGQSLYLGRAKRLANA AQRIVMHARDRGCTRPGCTVPGYWCQAHHASADWKDDGHTDIDDLTFACGPENRMIENTGWTTAKNSRNQ TEWIPPPDLETGQHRVNGYHHPERHLLPHEEGEDSSTSRDCDDP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4014 | - | - | 100% (464) | hypothetical protein Mflv_4014 |
| M. gilvum PYR-GCK | Mflv_1835 | - | e-111 | 45.61% (478) | hypothetical protein Mflv_1835 |
| M. gilvum PYR-GCK | Mflv_4397 | - | e-108 | 46.38% (442) | hypothetical protein Mflv_4397 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1980 | - | 1e-96 | 44.50% (436) | hypothetical protein Mb1980 |
| M. tuberculosis H37Rv | Rv1945 | - | 1e-96 | 44.50% (436) | hypothetical protein Rv1945 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-115 | 50.81% (431) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-103 | 45.96% (433) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2999 | - | 1e-102 | 45.98% (435) | hypothetical protein MAV_2999 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 1e-102 | 44.12% (476) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-67 | 37.64% (457) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-102 | 45.66% (438) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3379 | - | 0.0 | 68.83% (494) | hypothetical protein Mvan_3379 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4014|M.gilvum_PYR-GCK MAGLSVGRTSVRCMDGVA--EAVGVIGEQLAVLAKAAEDLSHRELIGLLS
Mvan_3379|M.vanbaalenii_PYR-1 -----MHRTSVRCMDVVS--GAVAAIAEQVAVLSKAAEGASHRELIGLLA
MSMEG_2663|M.smegmatis_MC2_155 -----MIRTSVRYMAAEVGTALAALHAAMRDVLALPYTALSDADLLDVCA
Mb1980|M.bovis_AF2122/97 ------MRS---DTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQ
Rv1945|M.tuberculosis_H37Rv ------MRS---DTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQ
MMAR_1523|M.marinum_M ------MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQ
MUL_2371|M.ulcerans_Agy99 ------MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLE
MAV_2999|M.avium_104 ------MRG-MSSDREAVSAAFDAIDAALDDLLDCDYAALATREKLALLN
MAB_0394c|M.abscessus_ATCC_199 ------------------MSPIDDLLTTATAVVESSFDELNNPELLSALR
TH_3287|M.thermoresistible__bu ---MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAE
: :
Mflv_4014|M.gilvum_PYR-GCK ELTTVLRSAPAVEHAVLARLLDETEPHHLGEASWKKVLTTSLRMSSAEAG
Mvan_3379|M.vanbaalenii_PYR-1 QLTQVLRSVPTLEHQILARLTAETEPHRLGEGSWKKVLTTSLRVSGAEAG
MSMEG_2663|M.smegmatis_MC2_155 GIQDVRNLAPAVEHRAIAALSEQTTPAAIGAKSWPLVLATRLGISSKEAR
Mb1980|M.bovis_AF2122/97 RLEVERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGEAS
Rv1945|M.tuberculosis_H37Rv RLEVERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGEAS
MMAR_1523|M.marinum_M RCEVARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEAS
MUL_2371|M.ulcerans_Agy99 RLEVVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAG
MAV_2999|M.avium_104 RCERLRRRLPAIEHPLINALARDATPAELGGR-LSHAIAEATLISRAEAA
MAB_0394c|M.abscessus_ATCC_199 QLEIAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATAR
TH_3287|M.thermoresistible__bu RLETQCRINRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGEVK
. : * : : :: .
Mflv_4014|M.gilvum_PYR-GCK RRLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVEIIAKFHKK
Mvan_3379|M.vanbaalenii_PYR-1 RRLSRAKTLGPRCAMTGELLAPLWEATAAAQAQGLLSEEHVAVIAKFHKD
MSMEG_2663|M.smegmatis_MC2_155 RRCADAAELGPRVSLTGEALAPKREHIAAAQADGALTPDHVTELFKFFTK
Mb1980|M.bovis_AF2122/97 RRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKE
Rv1945|M.tuberculosis_H37Rv RRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKE
MMAR_1523|M.marinum_M RRLREAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQ
MUL_2371|M.ulcerans_Agy99 RRVAEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQ
MAV_2999|M.avium_104 RRVHTAADLGPRVGLTGEPLPPLLAATAAAQREGSLGLEQVAVIRKFCHQ
MAB_0394c|M.abscessus_ATCC_199 RRLADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDV
TH_3287|M.thermoresistible__bu RRLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAA
** * : * ::* : . * * .* : :: : .
Mflv_4014|M.gilvum_PYR-GCK LPSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPSEK
Mvan_3379|M.vanbaalenii_PYR-1 LPAWVDVDTRAHADRQLARKGVGVGPEELDEAAGRLLMMIDQDGPEPCDK
MSMEG_2663|M.smegmatis_MC2_155 CPDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDN
Mb1980|M.bovis_AF2122/97 LSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFSDQ
Rv1945|M.tuberculosis_H37Rv LSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFSDQ
MMAR_1523|M.marinum_M VPAEVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDE
MUL_2371|M.ulcerans_Agy99 LPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDE
MAV_2999|M.avium_104 LPGWIDQATRERAEADLANQGTRYRPEQLAALAGTLADCLNPDG-LYRDE
MAB_0394c|M.abscessus_ATCC_199 LPDAVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDI
TH_3287|M.thermoresistible__bu LPSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQ
. : : : * . . : .. ** :
Mflv_4014|M.gilvum_PYR-GCK EKATRFWVKLGTQQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMAEQ
Mvan_3379|M.vanbaalenii_PYR-1 DLARKRSFRVGKQQPDGFRKVSGYVDAELGAYLDATLAKEAAPGANMPTD
MSMEG_2663|M.smegmatis_MC2_155 PPTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTD
Mb1980|M.bovis_AF2122/97 ERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDD
Rv1945|M.tuberculosis_H37Rv ERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDD
MMAR_1523|M.marinum_M DRARRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDD
MUL_2371|M.ulcerans_Agy99 DRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED
MAV_2999|M.avium_104 DRARRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAPGMCNPLD
MAB_0394c|M.abscessus_ATCC_199 DRARRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRD
TH_3287|M.thermoresistible__bu DRARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHT
: . .* * ** : * : .: * :. ** .
Mflv_4014|M.gilvum_PYR-GCK E-----------------------------------------------KA
Mvan_3379|M.vanbaalenii_PYR-1 QPGSDEPAGDEEPGSDEPDSDESDSGDEVSGGGEAAEQTGDRSARTSARA
MSMEG_2663|M.smegmatis_MC2_155 QTPCISG------------------------------------TPSQQQI
Mb1980|M.bovis_AF2122/97 QTPLVDD------------------------------------TPDADAV
Rv1945|M.tuberculosis_H37Rv QTPVVDD------------------------------------TPDADAV
MMAR_1523|M.marinum_M ESPVVQA------------------------------------PAGADAV
MUL_2371|M.ulcerans_Agy99 EAAVVDG------------------------------------PVSRDAA
MAV_2999|M.avium_104 ESPCVDG------------------------------------TPTEQAI
MAB_0394c|M.abscessus_ATCC_199 ESPMTEG------------------------------------EPDSAAA
TH_3287|M.thermoresistible__bu TTDTTGTTG----------TTETTGTAGTAGTAATAADTAADGVGDIDTG
Mflv_4014|M.gilvum_PYR-GCK G-DTRTQGQRNHDGLKAVLRRTLESGQLGSHNGLPVTVIVSTTLQELEKG
Mvan_3379|M.vanbaalenii_PYR-1 GRDTRTQDQRNHDGLKALLRRLLGSGRLGSHNGLPVTVVVSTTLQELEKG
MSMEG_2663|M.smegmatis_MC2_155 DHDERGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLITTTLQELEKA
Mb1980|M.bovis_AF2122/97 RRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAA
Rv1945|M.tuberculosis_H37Rv RRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAA
MMAR_1523|M.marinum_M SRDRRSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRA
MUL_2371|M.ulcerans_Agy99 DRDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAA
MAV_2999|M.avium_104 EGDTRSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLETA
MAB_0394c|M.abscessus_ATCC_199 ERDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSA
TH_3287|M.thermoresistible__bu GVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQA
* * :*.**.: :: : ** .* *.:::: *** :*: .
Mflv_4014|M.gilvum_PYR-GCK A-----------GVAVTGGGSLLPIPELIRLAADAHHYLYVYDGHTGQSL
Mvan_3379|M.vanbaalenii_PYR-1 A-----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGQSL
MSMEG_2663|M.smegmatis_MC2_155 A-----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGVPL
Mb1980|M.bovis_AF2122/97 T-----------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPL
Rv1945|M.tuberculosis_H37Rv T-----------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPL
MMAR_1523|M.marinum_M C-----------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGKAV
MUL_2371|M.ulcerans_Agy99 A-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAI
MAV_2999|M.avium_104 A-----------GKGLTGGGTLLPMSDVIRLSRHAHHYLAIF--DKGKAL
MAB_0394c|M.abscessus_ATCC_199 A-----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGRPL
TH_3287|M.thermoresistible__bu AHAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPL
* . :.. :.: ::**:: * *** :: . .:
Mflv_4014|M.gilvum_PYR-GCK YLGRAKRLANAAQRIVMHARDRGCTRPGCTVPGYWCQAHHASADWKDDGH
Mvan_3379|M.vanbaalenii_PYR-1 YLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGL
MSMEG_2663|M.smegmatis_MC2_155 YLGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGL
Mb1980|M.bovis_AF2122/97 ALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHV-TPWTTTHR
Rv1945|M.tuberculosis_H37Rv ALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHV-TPWTTTHR
MMAR_1523|M.marinum_M GLYHAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHV-AAWATSGR
MUL_2371|M.ulcerans_Agy99 GLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHV-AAWAISGR
MAV_2999|M.avium_104 ALYHTKRLASPGQRIVLYAKDRGCTAPGCTVPGYYAEVHHC-TDYATCHT
MAB_0394c|M.abscessus_ATCC_199 HLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHV-DDWRDDGP
TH_3287|M.thermoresistible__bu YLGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQ-PAWEDGGL
* : :* *.. **: *:* **: *** .* .:.** :
Mflv_4014|M.gilvum_PYR-GCK TDIDDLTFACGPENRMIENTG--WTTAKN-SRNQTEWIPPPDLETGQHRV
Mvan_3379|M.vanbaalenii_PYR-1 TNIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQHRT
MSMEG_2663|M.smegmatis_MC2_155 TDADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPQLLDRGQHRT
Mb1980|M.bovis_AF2122/97 TDINDLTLACGPDNRLVEKG---WKTRKN-AKGDTEWLPPAHLDHGQPRI
Rv1945|M.tuberculosis_H37Rv TDINDLTLACGPDNRLVEKG---WKTRKN-AKGDTEWLPPAHLDHGQPRI
MMAR_1523|M.marinum_M TDIDQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRT
MUL_2371|M.ulcerans_Agy99 TDINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRT
MAV_2999|M.avium_104 TDINDLTFACGPHHRLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRT
MAB_0394c|M.abscessus_ATCC_199 TDIDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRT
TH_3287|M.thermoresistible__bu TDADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPPTV
*: : * :** .: : * : . * :
Mflv_4014|M.gilvum_PYR-GCK NGYHHPERHLLPHEEGEDSSTSRDCDDP----------------------
Mvan_3379|M.vanbaalenii_PYR-1 NDYHHPERHLLPEDD----------QGP----------------------
MSMEG_2663|M.smegmatis_MC2_155 NTYHHPETLLADIKSGFTDDTADSRSQTSKTTGSETHAKQAADTEPDTAI
Mb1980|M.bovis_AF2122/97 NRYHHPEKILC----EPDDDEPH---------------------------
Rv1945|M.tuberculosis_H37Rv NRYHHPEKILC----EPDDDEPH---------------------------
MMAR_1523|M.marinum_M NTYHHPEKLLR--DSAADEGEEGG--------------------------
MUL_2371|M.ulcerans_Agy99 NSYHHPEKLLR--DSADDDDEGHGAA------------------------
MAV_2999|M.avium_104 NTFHHPEKLLRGEDGGEDDDGDDDEAA-----------------------
MAB_0394c|M.abscessus_ATCC_199 NDHHHPERFIRRF-------------------------------------
TH_3287|M.thermoresistible__bu NHAHHPEELLRAHTDPPEDPG-----------------------------
* **** :
Mflv_4014|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3379|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2663|M.smegmatis_MC2_155 ARGNDLSDRPAIPPELLGQNHQQPNTNHHPDTERGDARNSGATGHNQDHS
Mb1980|M.bovis_AF2122/97 --------------------------------------------------
Rv1945|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAV_2999|M.avium_104 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mflv_4014|M.gilvum_PYR-GCK -------------------------------
Mvan_3379|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_2663|M.smegmatis_MC2_155 RKNGDRNSGDASKGNNGNADGDDGESDCHPA
Mb1980|M.bovis_AF2122/97 -------------------------------
Rv1945|M.tuberculosis_H37Rv -------------------------------
MMAR_1523|M.marinum_M -------------------------------
MUL_2371|M.ulcerans_Agy99 -------------------------------
MAV_2999|M.avium_104 -------------------------------
MAB_0394c|M.abscessus_ATCC_199 -------------------------------
TH_3287|M.thermoresistible__bu -------------------------------