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GCSREDVLGAFDALDTVVESILALDYDALSAAERVGLDARLERNLRRLPVAEQALIASVIAETEPARLGE GSWKKVLITALRVSGAEAGRRLRRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLGEEHVAIIAKFHKDL PAWVDVDTRAEADRQLARKGAGLGPEELDEAAGRLMMMIDQDGPEPCDKERARKRGVRISKQHSDGTATI SGTLTPEALAVWQAIFAKEAAPGANKPESEHTEDSTSGGTPRDTETSDHADASGDGVAPSSTAGDGNTSG DDGGDAPAEDHDPQPERRGSDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGAG VAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGQSLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPG YWCQAHHASADFVDGGLTNIDDLTLACPCDHRMLDNTGWRTRKNGKNQTEWLPPPDLDTGQHRVNGYHHP ERHLLPEDGLPEDDLPEDDLPEDGQGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4451 | - | - | 100% (518) | hypothetical protein Mvan_4451 |
| M. vanbaalenii PYR-1 | Mvan_3851 | - | 0.0 | 97.49% (518) | hypothetical protein Mvan_3851 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 0.0 | 85.94% (505) | hypothetical protein Mvan_3050 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-103 | 41.63% (502) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_4014 | - | 1e-166 | 61.18% (492) | hypothetical protein Mflv_4014 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-103 | 41.63% (502) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-100 | 42.77% (484) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 1e-111 | 45.15% (505) | hypothetical protein MMAR_3121 |
| M. avium 104 | MAV_2999 | - | 1e-112 | 44.12% (510) | hypothetical protein MAV_2999 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-100 | 41.51% (489) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-71 | 36.59% (522) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-110 | 45.54% (505) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4451|M.vanbaalenii_PYR-1 ---MGCSREDV---LGAFDALDTVVES----ILALDYDALSAAERVGLDA
Mflv_4014|M.gilvum_PYR-GCK MAGLSVGRTSVRCMDGVAEAVGVIGEQL--AVLAKAAEDLSHRELIGLLS
MSMEG_6573|M.smegmatis_MC2_155 ---MDDG------VQDAVAALDAALNT----LLTLPHSALTDAELLTICA
Mb1159c|M.bovis_AF2122/97 ------MCSTREEITEAFASLATALSR----VLGLTFDALTTPERLALLE
Rv1128c|M.tuberculosis_H37Rv ------MCSTREEITEAFASLATALSR----VLGLTFDALTTPERLALLE
MAV_2999|M.avium_104 ---MRGMSSDREAVSAAFDAIDAALDD----LLDCDYAALATREKLALLN
MMAR_3121|M.marinum_M --MHSNGCSDRESVVATLDRLDRAVDA----LVEVSFEALTTPERLRVLE
MUL_2371|M.ulcerans_Agy99 --MHSNGCSDRESVVATLDRLDRAVDA----LVEVSFEALTTPERLRVLE
MAB_0394c|M.abscessus_ATCC_199 --------------MSPIDDLLTTATA----VVESSFDELNNPELLSALR
TH_3287|M.thermoresistible__bu ---MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAE
: : : :
Mvan_4451|M.vanbaalenii_PYR-1 RLERNLRRLPVAEQALIASVIAETEPARLGEGSWKKVLITALRVSGAEAG
Mflv_4014|M.gilvum_PYR-GCK ELTTVLRSAPAVEHAVLARLLDETEPHHLGEASWKKVLTTSLRMSSAEAG
MSMEG_6573|M.smegmatis_MC2_155 GLQDARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEAR
Mb1159c|M.bovis_AF2122/97 HCETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAK
Rv1128c|M.tuberculosis_H37Rv HCETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAK
MAV_2999|M.avium_104 RCERLRRRLPAIEHPLINALARDATPAELGG-RLSHAIAEATLISRAEAA
MMAR_3121|M.marinum_M RLEVVARRLPVAQYALLNQLDEQAGEAELGG-RLAAVVASRLRITRSEAG
MUL_2371|M.ulcerans_Agy99 RLEVVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSEAG
MAB_0394c|M.abscessus_ATCC_199 QLEIAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATAR
TH_3287|M.thermoresistible__bu RLETQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGEVK
. : : : :: .
Mvan_4451|M.vanbaalenii_PYR-1 RRLRRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLGEEHVAIIAKFHKD
Mflv_4014|M.gilvum_PYR-GCK RRLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVEIIAKFHKK
MSMEG_6573|M.smegmatis_MC2_155 RRCTDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTK
Mb1159c|M.bovis_AF2122/97 RRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHR
Rv1128c|M.tuberculosis_H37Rv RRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHR
MAV_2999|M.avium_104 RRVHTAADLGPRVGLTGEPLPPLLAATAAAQREGSLGLEQVAVIRKFCHQ
MMAR_3121|M.marinum_M RRVAEAADVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRR
MUL_2371|M.ulcerans_Agy99 RRVAEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQ
MAB_0394c|M.abscessus_ATCC_199 RRLADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDV
TH_3287|M.thermoresistible__bu RRLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAA
** * : * ::* .: * * * * : :: : .
Mvan_4451|M.vanbaalenii_PYR-1 LPAWVDVDTRAEADRQLARKGAGLGPEELDEAAGRLMMMIDQDGPEPCDK
Mflv_4014|M.gilvum_PYR-GCK LPSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPSEK
MSMEG_6573|M.smegmatis_MC2_155 CPDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDN
Mb1159c|M.bovis_AF2122/97 LPSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDE
Rv1128c|M.tuberculosis_H37Rv LPSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDE
MAV_2999|M.avium_104 LPGWIDQATRERAEADLANQGTRYRPEQLAALAGTLADCLNPDG-LYRDE
MMAR_3121|M.marinum_M LPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDE
MUL_2371|M.ulcerans_Agy99 LPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDE
MAB_0394c|M.abscessus_ATCC_199 LPDAVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDI
TH_3287|M.thermoresistible__bu LPSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQ
* : : * . . : .: ** :
Mvan_4451|M.vanbaalenii_PYR-1 ERARKRGVRISKQHSDGTATISGTLTPEALAVWQAIFAKEAAPGANKPES
Mflv_4014|M.gilvum_PYR-GCK EKATRFWVKLGTQQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMAEQ
MSMEG_6573|M.smegmatis_MC2_155 PPTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTD
Mb1159c|M.bovis_AF2122/97 DRARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQ
Rv1128c|M.tuberculosis_H37Rv DRARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQ
MAV_2999|M.avium_104 DRARRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAPGMCNPLD
MMAR_3121|M.marinum_M DRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED
MUL_2371|M.ulcerans_Agy99 DRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED
MAB_0394c|M.abscessus_ATCC_199 DRARRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRD
TH_3287|M.thermoresistible__bu DRARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHT
: : :. * ** : * : .: * :.: ** .
Mvan_4451|M.vanbaalenii_PYR-1 EHTEDSTSGGTPRDTETSDHADASGDGVAPSSTAGDGNTSGDDGGDAPAE
Mflv_4014|M.gilvum_PYR-GCK EK-------------------------------AG---------------
MSMEG_6573|M.smegmatis_MC2_155 QTP----------------------------CISG---------------
Mb1159c|M.bovis_AF2122/97 KAP----------------------------CVNG---------------
Rv1128c|M.tuberculosis_H37Rv KAP----------------------------CVNG---------------
MAV_2999|M.avium_104 ESP----------------------------CVDG---------------
MMAR_3121|M.marinum_M EAA----------------------------VVDG---------------
MUL_2371|M.ulcerans_Agy99 EAA----------------------------VVDG---------------
MAB_0394c|M.abscessus_ATCC_199 ESP----------------------------MTEG---------------
TH_3287|M.thermoresistible__bu TTDTTGTTG--TTETTGTAGTAGTAATAADTAADG---------------
*
Mvan_4451|M.vanbaalenii_PYR-1 DHDPQPERRGSDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVS
Mflv_4014|M.gilvum_PYR-GCK -----------DTRTQGQRNHDGLKAVLRRTLESGQLGSHNGLPVTVIVS
MSMEG_6573|M.smegmatis_MC2_155 --TPSQQQIDSDQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVT
Mb1159c|M.bovis_AF2122/97 --APSKEQARRDTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVT
Rv1128c|M.tuberculosis_H37Rv --APSKEQARRDTRSCPQRNHDALNAELRSLLTSGNLGQHNGLPASIIVT
MAV_2999|M.avium_104 --TPTEQAIEGDTRSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVT
MMAR_3121|M.marinum_M --PVSPDAADRDSRSVGQRQHDGFNAALRAVLASGELGQHNGLPASIIVS
MUL_2371|M.ulcerans_Agy99 --PVSRDAADRDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVS
MAB_0394c|M.abscessus_ATCC_199 --EPDSAAAERDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVS
TH_3287|M.thermoresistible__bu --VGDIDTGGVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVR
* * :*.**.: : : ** .* *.:::*
Mvan_4451|M.vanbaalenii_PYR-1 TTLQELEKGA-----------GVAVTGGGSLLPMPDLIRLAARAHHYLYV
Mflv_4014|M.gilvum_PYR-GCK TTLQELEKGA-----------GVAVTGGGSLLPIPELIRLAADAHHYLYV
MSMEG_6573|M.smegmatis_MC2_155 TTLQELEKAA-----------GVAITAGGTKLSIPDLIRLASQALHYLAV
Mb1159c|M.bovis_AF2122/97 TTLKDLEAAA-----------GAGLTGGGTILPISDVIRLARHANHYLAI
Rv1128c|M.tuberculosis_H37Rv TTLKDLEAAA-----------GAGLTGGGTILPISDVIRLARHANHYLAI
MAV_2999|M.avium_104 TTLADLETAA-----------GKGLTGGGTLLPMSDVIRLSRHAHHYLAI
MMAR_3121|M.marinum_M TTLKELEAAA-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAV
MUL_2371|M.ulcerans_Agy99 TTLKELEAAA-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAV
MAB_0394c|M.abscessus_ATCC_199 TTLRELQSAA-----------GRAISGSGNLVPIPDLIRMATHAFHYLTI
TH_3287|M.thermoresistible__bu TTLGELNQAAHAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAV
*** :*: .* * . :.. :.: ::**:: * *** :
Mvan_4451|M.vanbaalenii_PYR-1 YDQHSGQSLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHA
Mflv_4014|M.gilvum_PYR-GCK YDGHTGQSLYLGRAKRLANAAQRIVMHARDRGCTRPGCTVPGYWCQAHHA
MSMEG_6573|M.smegmatis_MC2_155 YDEHTGIPLYLGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHA
Mb1159c|M.bovis_AF2122/97 F--DRGKALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHV
Rv1128c|M.tuberculosis_H37Rv F--DRGKALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHV
MAV_2999|M.avium_104 F--DKGKALALYHTKRLASPGQRIVLYAKDRGCTAPGCTVPGYYAEVHHC
MMAR_3121|M.marinum_M F--DRGEAIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHV
MUL_2371|M.ulcerans_Agy99 F--DRGEAIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHV
MAB_0394c|M.abscessus_ATCC_199 FG-DDGRPLHLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHV
TH_3287|M.thermoresistible__bu FDDHTERPLYLGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQ
: . .: * : :* *.. **: *:* **: *** ** .:.**
Mvan_4451|M.vanbaalenii_PYR-1 SADFVDGGLTNIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPP
Mflv_4014|M.gilvum_PYR-GCK SADWKDDGHTDIDDLTFACGPENRMIENTG--WTTAKN-SRNQTEWIPPP
MSMEG_6573|M.smegmatis_MC2_155 TTDYAKGGLTDADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPD
Mb1159c|M.bovis_AF2122/97 T-PYAQCRNTDVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPP
Rv1128c|M.tuberculosis_H37Rv T-PYAQCRNTDVNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPP
MAV_2999|M.avium_104 T-DYATCHTTDINDLTFACGPHHRLLQPGA--WTTHKN-ARGETQWLPPP
MMAR_3121|M.marinum_M A-AWAISGRTDINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPP
MUL_2371|M.ulcerans_Agy99 A-AWAISGRTDINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPP
MAB_0394c|M.abscessus_ATCC_199 D-DWRDDGPTDIDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPP
TH_3287|M.thermoresistible__bu P-AWEDGGLTDADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN--
: *: : * :.* .: * : . *
Mvan_4451|M.vanbaalenii_PYR-1 DLDTGQHRVNGYHHPERHLLPEDGLPEDDLPEDDLPEDGQGP--------
Mflv_4014|M.gilvum_PYR-GCK DLETGQHRVNGYHHPERHLLPHE-----EGEDSSTSRDCDDP--------
MSMEG_6573|M.smegmatis_MC2_155 LLDRGQHRTNTYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVN
Mb1159c|M.bovis_AF2122/97 HLDHGQPRVNTFHHPEKLL------ADDEGDP------------------
Rv1128c|M.tuberculosis_H37Rv HLDHGQPRVNTFHHPEKLL------ADDEGDP------------------
MAV_2999|M.avium_104 HLDRNQPRTNTFHHPEKLLRGEDGGEDDDGDDDEAA--------------
MMAR_3121|M.marinum_M HLDHGQPRTNTYHHPEKLLR---DSADDDDEGHGAA--------------
MUL_2371|M.ulcerans_Agy99 HLDHGQPRTNSYHHPEKLLR---DSADDDDEGHGAA--------------
MAB_0394c|M.abscessus_ATCC_199 HLDTGQSRTNDHHHPERFIRRF----------------------------
TH_3287|M.thermoresistible__bu --DHHPPTVNHAHHPEELLRAHTDPPEDPG--------------------
: .* **** :
Mvan_4451|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4014|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 GHGEKPAIPPELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNG
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2999|M.avium_104 --------------------------------------------------
MMAR_3121|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_4451|M.vanbaalenii_PYR-1 -------------------------
Mflv_4014|M.gilvum_PYR-GCK -------------------------
MSMEG_6573|M.smegmatis_MC2_155 NGDRNSAENRNGPSKNAAGDDDEPR
Mb1159c|M.bovis_AF2122/97 -------------------------
Rv1128c|M.tuberculosis_H37Rv -------------------------
MAV_2999|M.avium_104 -------------------------
MMAR_3121|M.marinum_M -------------------------
MUL_2371|M.ulcerans_Agy99 -------------------------
MAB_0394c|M.abscessus_ATCC_199 -------------------------
TH_3287|M.thermoresistible__bu -------------------------