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VAESDRADRRSVLLTLCLTEITSWGVLYYAFSVLSPAICADTGWSAPAVTAAFSAGLVISALLGIPVGRW LDRHGPRWIMTGGSVLGSIALAGVAAAPDVVSFTAAWVVAGVAMSAVFYAPAFAALTRYFRPDAVRALTA LTLAAGLASTVFAPLTAAISAHMDWRETYLVLAAAMAVITVPAHFFGLRRPWPHIEHHHLVEPPTRIARS RQFVALTVAFAMAGLASYAVIVNLVPLMTAHGISTQAAALALGLGGAGQVLGRLGYQRMVRHLSVVPRTA LIMAGVAVTTALLGLLTSVATLITVAVVAGVVRGVMTLLQATAVTERWGITHYGQLSGILSAPVMLSTAL GPFVGAGLATLLGGYGAMFVVLGAVALAAALLATATRVRPVDADG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | - | 100% (395) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 4e-15 | 24.73% (376) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 2e-12 | 27.42% (361) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2483c | - | 1e-11 | 23.86% (373) | putative integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1096 | - | 9e-21 | 25.76% (396) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2456c | - | 1e-11 | 23.86% (373) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4839c | - | 1e-145 | 67.37% (377) | MFS family transporter |
| M. marinum M | MMAR_0434 | - | 2e-11 | 23.81% (378) | integral membrane protein |
| M. avium 104 | MAV_4987 | - | 1e-13 | 25.27% (376) | sugar transporter family protein |
| M. smegmatis MC2 155 | MSMEG_1169 | - | 1e-161 | 73.23% (381) | integral membrane transport protein |
| M. thermoresistible (build 8) | TH_1008 | - | 5e-08 | 25.98% (204) | AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1084 | - | 1e-11 | 23.81% (378) | integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3219|M.vanbaalenii_PYR-1 -MAE---SDRAD----RRSVLLTLCLTEITSWGVLYYAFSVLSP----AI
MSMEG_1169|M.smegmatis_MC2_155 -MTPPSLSAGPG----LRWVLITLCVTEITSWGVLYYAFTVLSA----SI
MAB_4839c|M.abscessus_ATCC_199 -MSTAAVHAQPHSITGLRGVLITLCLTEITSWGVLYYAFPVLAP----RI
MMAR_0434|M.marinum_M -MTSEARTATTAAR--PWTPRVAAQLSVLAAAAFIYVTAEILPVGALSAI
MUL_1084|M.ulcerans_Agy99 -MTSEARTATTAAR--PWTPRVAAQLSVLAAAAFIYVTAEILPVGALSAI
MAV_4987|M.avium_104 -MT--AETANAAAR--TWTPRIAAQLAILAAAAFTYVTAEILPVGALPAI
Mb2483c|M.bovis_AF2122/97 -MSGTVVAVPPRVA--RALDLLNFSLADVRDGLGPYLSIYLLLIH-----
Rv2456c|M.tuberculosis_H37Rv -MSGTVVAVPPRVA--RALDLLNFSLADVRDGLGPYLSIYLLLIH-----
Mflv_1096|M.gilvum_PYR-GCK -MGGPVTRFDSAAIAEWRRYGTVPLAAGLGYSMGVIHVYSLGAFMG--PL
TH_1008|M.thermoresistible__bu MRRATAAAIRPPRGHNRTIAISAGSLAVLLGALDTYVVITIMVDIMR--D
. : : :
Mvan_3219|M.vanbaalenii_PYR-1 CADTGWSAPAVTAAFSAGLVISALLGIPVGRWLDRHGPRWIMTGG-SVLG
MSMEG_1169|M.smegmatis_MC2_155 SSDTGWSAPAVTGAFSAGLVTSALMGIVVGRWLDRYGPRWIMTIG-SVLG
MAB_4839c|M.abscessus_ATCC_199 TADTGWSAPAVTAAFSAALVVAAAAGIGVGRWLDRHGPRWLMTAG-SLWG
MMAR_0434|M.marinum_M ARNLHISVVLVGTLLSWYALVAALTTVPLVRWTAHWPRRHALMVS-LVCL
MUL_1084|M.ulcerans_Agy99 ARNLHISVVLVGTLLSWYALVAALTTVPLVRWTAHWPRRHALMVS-LVCL
MAV_4987|M.avium_104 ARNLQVSLVLVGTLLSWYALVAALTTIPLVRWTAHLPRRRVLVAS-LTCL
Mb2483c|M.bovis_AF2122/97 ----DWDQASIGFVMAVGGIAAIVAQTPIGALVDRTTAKRALVVAGAVLV
Rv2456c|M.tuberculosis_H37Rv ----DWDQASIGFVMAVGGIAAIVAQTPIGALVDRTTAKRALVVAGAVLV
Mflv_1096|M.gilvum_PYR-GCK QDEFGWSRAQASVGLTIVGMAAAVAALPIGLMVDRLGPRRVGIIGAGLMA
TH_1008|M.thermoresistible__bu VGIALNKIHQVTPIITGYLLGYIAAMPLLGRASDRFGRKMLIQVGLAGFA
. :: : : : : .
Mvan_3219|M.vanbaalenii_PYR-1 SIALAGVAA--APDVVSFTAAWVVAGVAMSAVFYAPAFAALTRYFRPDAV
MSMEG_1169|M.smegmatis_MC2_155 VVAVLAVVV--APNYACFVAAWILAGVAMSGVFYAPAFAALTRYFAPNAV
MAB_4839c|M.abscessus_ATCC_199 PAALIGVAM--APNYGWFLAAWLMAGIAMAAVFYPPAFAALTRWYGPGAV
MMAR_0434|M.marinum_M TISQLISAL--APNFAVLAAGRALCAITHGLLWSVIAPIATRLVPPSHAG
MUL_1084|M.ulcerans_Agy99 TISQLISAL--APNFAVLAAGRALCAITHGLLWSVIAPIATRLVPPSHAG
MAV_4987|M.avium_104 TASQLISAL--APNFAVLAAGRVLCAITHGLLWSVIAPIATRLVPPSHAG
Mb2483c|M.bovis_AF2122/97 TAAAVAMPL--FAGLYSISVLQAVTGIASSVFAPALAAITLGAVGPQFFA
Rv2456c|M.tuberculosis_H37Rv TAAAVAMPL--FAGLYSISVLQAVTGIASSVFAPALAAITLGAVGPQFFA
Mflv_1096|M.gilvum_PYR-GCK GAFALLGTA--TGTMGNWILLWSVLAFACFWVQTTVWTSAVASRFETSRG
TH_1008|M.thermoresistible__bu IGSVVTALAGDLQSLHMLVTGRIIQGAASGALLPVTLALAADLWAERNRA
: . : . :
Mvan_3219|M.vanbaalenii_PYR-1 RALTALTLAAGLASTVFAPLTAAISAHMD-----WRETYLVLAAAMAVIT
MSMEG_1169|M.smegmatis_MC2_155 RALTVLTLVAGLSSTVFAPLTAALGSHLS-----WRQTYLVLAALLAVIT
MAB_4839c|M.abscessus_ATCC_199 RALMVLTLVAGLASTVFVPLTAVLASHMD-----WRTTYLALAVLLTIIT
MMAR_0434|M.marinum_M RATTSIYIGTSLALVIGSPLTAALSLMWG-----WRLAAVCVTVAAAVVT
MUL_1084|M.ulcerans_Agy99 RATTSIYIGTSLALVIGSPLTAALSLMWG-----WRLAAVCVTVAAAVVT
MAV_4987|M.avium_104 RATMSIYVGTSLALVVGSPLTAALSLMWG-----WRLAVVCVTVAAAVVT
Mb2483c|M.bovis_AF2122/97 RRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVLAGMALISVLATLR
Rv2456c|M.tuberculosis_H37Rv RRIGRNEAFNHAGNASAAGATGALAYFFGPVVVFWVLAGMALISVLATLR
Mflv_1096|M.gilvum_PYR-GCK LAFAVTLSGGSLAAAVFPPLATLLIGEWG-----WRGALFGLGGLWGGLV
TH_1008|M.thermoresistible__bu GVLGGIGAAQELGAVLGPLYGIAMVWLFG----AWESVFWVNVPLAALAM
. . : . * .
Mvan_3219|M.vanbaalenii_PYR-1 VPAHFFG---------------------------LRRPWPHIEHHHLVEP
MSMEG_1169|M.smegmatis_MC2_155 IPAHLFG---------------------------LRRPWPPVQHHHNVEA
MAB_4839c|M.abscessus_ATCC_199 VPAHIIG---------------------------LRRPWPSLPATHLAES
MMAR_0434|M.marinum_M VAARLL----------------------------LPEMVLSADQLQYVGP
MUL_1084|M.ulcerans_Agy99 VAARLL----------------------------LPEMVLSADQLQHVGP
MAV_4987|M.avium_104 VAARLM----------------------------LPEMVLTEHQLAHVGP
Mb2483c|M.bovis_AF2122/97 IPPDAVDHD-------------------------LARGMDHAPGEPHPQP
Rv2456c|M.tuberculosis_H37Rv IPPDAVDHD-------------------------LARGMDHAPGEPHPQP
Mflv_1096|M.gilvum_PYR-GCK LIVVLLFFRGAQDDKKP---------------APARTVIAPTAAAADLPG
TH_1008|M.thermoresistible__bu VMIHFSLPARDPDGPRERIDVVGGVLLGITLFLIVVGLYNPQPSAREVVP
:
Mvan_3219|M.vanbaalenii_PYR-1 P--------------------------TRIARSRQFVALTVAFAMAGLAS
MSMEG_1169|M.smegmatis_MC2_155 P--------------------------TRTARSAPFLALMVSFALAALAS
MAB_4839c|M.abscessus_ATCC_199 P--------------------------TRIARSRPFISLIIAFALASCAS
MMAR_0434|M.marinum_M R--------------------------SRHHRNR-ALIIVSLITMVGVTG
MUL_1084|M.ulcerans_Agy99 R--------------------------SRHHRNR-ALIIVSLITMVGVTG
MAV_4987|M.avium_104 R--------------------------SRHHRNG-RLITVSLLAMVAVTG
Mb2483c|M.bovis_AF2122/97 SR------------------------FTVLAHNRELVIFGAAVVAFHFAN
Rv2456c|M.tuberculosis_H37Rv SR------------------------FTVLAHNRELVIFGAAVVAFHFAN
Mflv_1096|M.gilvum_PYR-GCK VT------------------------LAEGLRSATFYKLLVAAGLFAFTT
TH_1008|M.thermoresistible__bu TWRLWLLAAAAVTLIGFFVWERRARTKLIDPAGVRFRPFLAALGASFVAG
. :
Mvan_3219|M.vanbaalenii_PYR-1 YAVIVNLVPLMTAHGISTQAAALALGLGGAGQVLGRLGYQRMVRHLSVVP
MSMEG_1169|M.smegmatis_MC2_155 YAVIVNLVPLMVQRGFSTSAAAVALGLGGAGQVLGRLGYQTMARRIGVVP
MAB_4839c|M.abscessus_ATCC_199 YAVIVNLVPLMNQRGLDGTVAATALALGGVGQVIGRFGYPALAQCISVVP
MMAR_0434|M.marinum_M HFVSYTYIVVIIRQVVGVRGPSLAWLLAAYG-VAGVVAVALVARPLDRRP
MUL_1084|M.ulcerans_Agy99 HFVSYTYIVVIIRQVVGVRGPSLAWLLAAYG-VAGVVAVALVARPLDRRP
MAV_4987|M.avium_104 HFVSYTFIVEIIRNVVGVRGPTLAWVLAAYG-LAGLLSVPLVARPLDHRP
Mb2483c|M.bovis_AF2122/97 AAMLPLVGELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTRADAWGR
Rv2456c|M.tuberculosis_H37Rv AAMLPLVGELLALHNRDEGTALMSSCIVAAQVVMVPVAYVVGTRADAWGR
Mflv_1096|M.gilvum_PYR-GCK LGIVVHLVPILRDAGAEPLAAAGTAALVGIFSIVGRLGVGLLLDRFPGRV
TH_1008|M.thermoresistible__bu AALMVTLVNVELFGQGVLGKDQFEAAMLLLRFLIALPIGALIGGWLATRV
: : :
Mvan_3219|M.vanbaalenii_PYR-1 RTALIMAGVAVTTA--LLGLLTSVATLITV---------------AVVAG
MSMEG_1169|M.smegmatis_MC2_155 RTVLIMAAVAVTTA--LLGVFTTLAALVAA---------------SIVAG
MAB_4839c|M.abscessus_ATCC_199 RTLLIMGVVAATTA--LLGVFASAVSLIAV---------------AVAAG
MMAR_0434|M.marinum_M KGTIIFCVAGLTFA--FVLLTALAFGGHLA---------------PMTAL
MUL_1084|M.ulcerans_Agy99 KGTIIFCVAGLTFA--FVLLTALAFGGHLA---------------PMTAL
MAV_4987|M.avium_104 KSAVILCMTGLTAA--FAVLTALAFGGPTG---------------ATTAL
Mb2483c|M.bovis_AF2122/97 KPIFLVGFAVLTARGFLYTLSDNSYWLVGV---------------QLLDG
Rv2456c|M.tuberculosis_H37Rv KPIFLVGFAVLTARGFLYTLSDNSYWLVGV---------------QLLDG
Mflv_1096|M.gilvum_PYR-GCK VGACAYLVPILGCAALLIDG-SSPLSQTVA---------------AALFG
TH_1008|M.thermoresistible__bu GDRIVTFVGLLIAAGGFWLISHWPVDLLAARHDLGVVTLPVLDTDLAIVG
:
Mvan_3219|M.vanbaalenii_PYR-1 VVRGVMTLLQATAVTERWGITHYGQLSGILSAP-----------------
MSMEG_1169|M.smegmatis_MC2_155 MARGIMTLLQATAVTDRWGTTHYGHLSGMLMAP-----------------
MAB_4839c|M.abscessus_ATCC_199 MARGIMTLLQATAITERWGSTHYGHLSGLLTAP-----------------
MMAR_0434|M.marinum_M VVGTGAIVLWGAAATAVSPMLQSAAMRSGADDPDGA--------------
MUL_1084|M.ulcerans_Agy99 VVGTGAIVLWGAAVTAVSPMLQSAAMRSGADDPDGA--------------
MAV_4987|M.avium_104 IG-TAAIVLWGAMATAVSPMMQSAAMRNGADDPDGA--------------
Mb2483c|M.bovis_AF2122/97 IGAGIFGALFPLVVQDVTHGTGHFNISLGAVTT-----------------
Rv2456c|M.tuberculosis_H37Rv IGAGIFGALFPLVVQDVTHGTGHFNISLGAVTT-----------------
Mflv_1096|M.gilvum_PYR-GCK LTLGAEVDVIAYLASRYFGLRNFGGLFGGLVAA-----------------
TH_1008|M.thermoresistible__bu IGLGLVIGPLTSAALRVVPAAEHGIASAAVVVARMIGMVIGLAALSAWGL
: .
Mvan_3219|M.vanbaalenii_PYR-1 --------------VMLSTALGPFVGAGLA---TLLGGYGAMFVVLGAVA
MSMEG_1169|M.smegmatis_MC2_155 --------------IMITTALGPFVGAALA---SLLDGYDAMFLVLGVVA
MAB_4839c|M.abscessus_ATCC_199 --------------IMLTTALAPFTGAALA---QLLHGYPAMFVALGVAG
MMAR_0434|M.marinum_M -----------SGLYVTAFQVGIMAGSLIG---GLLYERSVAMMLTASAG
MUL_1084|M.ulcerans_Agy99 -----------SGLYVTAFQVGIMAGSLIG---GLLYERSVAMMLTASAG
MAV_4987|M.avium_104 -----------SGLYVTAFQVGIMAGSLLG---GLLYERSVILMLSASGV
Mb2483c|M.bovis_AF2122/97 -----------------ATGIGAALSNLVAGWIVVVAGYDAAFMSLGALA
Rv2456c|M.tuberculosis_H37Rv -----------------ATGIGAALSNLVAGWIVVVAGYDAAFMSLGALA
Mflv_1096|M.gilvum_PYR-GCK --------------LSLGTAFGPLAAGATS---DHFGGYTNFLILTMVLM
TH_1008|M.thermoresistible__bu YRFNQHLQSLAAREPGGDSLAARLAAEAARYREAYAMQYGEIFAITALLC
. . :
Mvan_3219|M.vanbaalenii_PYR-1 LAAALLATATRVRPVDADG-------------------------------
MSMEG_1169|M.smegmatis_MC2_155 AVAAALAAATGVRPTSGSADPSAAGDRRPPCSAEH---------------
MAB_4839c|M.abscessus_ATCC_199 IIGAAAATAT--NPSQ----------------------------------
MMAR_0434|M.marinum_M LMGVALVGMTSARRVFEAPVAVAGATSHNQ--------------------
MUL_1084|M.ulcerans_Agy99 LMGVALVGMTSARRVFEAPVAVAGATSHNQ--------------------
MAV_4987|M.avium_104 LMAVALVGIAANRRMLD----VAPTSSRDS--------------------
Mb2483c|M.bovis_AF2122/97 GAGFLLYLVAMPETVDSDVRVRSRPTLGGK--------------------
Rv2456c|M.tuberculosis_H37Rv GAGFLLYLVAMPETVDSDVRVRSRPTLGGK--------------------
Mflv_1096|M.gilvum_PYR-GCK GLSSMALASLKPPPVWTVTSPGEDARADRFPQP-----------------
TH_1008|M.thermoresistible__bu VAGALLGLLIAGHGDRADDTGTPDGSVWDLHGSGDDDTPTRVIGRQVPLP
.
Mvan_3219|M.vanbaalenii_PYR-1 --------------
MSMEG_1169|M.smegmatis_MC2_155 --------------
MAB_4839c|M.abscessus_ATCC_199 --------------
MMAR_0434|M.marinum_M --------------
MUL_1084|M.ulcerans_Agy99 --------------
MAV_4987|M.avium_104 --------------
Mb2483c|M.bovis_AF2122/97 --------------
Rv2456c|M.tuberculosis_H37Rv --------------
Mflv_1096|M.gilvum_PYR-GCK --------------
TH_1008|M.thermoresistible__bu SMEQTVRMPRPPGD