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RGLLAAAGAASVAALGVTCPSPYTLAANVLTVTGYTAGGALEWDMSEVFQGSYCDADSGNTCTPVKYLSG VPLVGEYDGLRALRSAITSSTGETVVLAYSQGALIAADWIEQNAGTSGSPSPENLSFVFLGNSLRKYGGV RPAYEIDPPTPESDYHVTDIAIEYDGAADFPDNPFNLLALANAFAGFQYVHIYGYDDVDLENDEKLVWND GNTTYVLIRRENIPLLEPLRLMGLHELADQLNGPLKEIIDSAYNRDYPGLVDSTPQRAATQDLSALQVDE DDEVEEVGEVTDAAADDIDAAADKASDDISDIDDESASSAVDSEEDAGDGADTESGDTDGGDLLDDSSEE DSADDSTGGSAPDSDDSASEPTSGAGDDSSAPSASEADSDSGSDAEGSAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2967 | - | - | 100% (401) | hypothetical protein Mvan_2967 |
| M. vanbaalenii PYR-1 | Mvan_3106 | - | 9e-60 | 36.45% (417) | hypothetical protein Mvan_3106 |
| M. vanbaalenii PYR-1 | Mvan_2068 | - | 2e-58 | 36.32% (413) | hypothetical protein Mvan_2068 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 3e-22 | 32.00% (250) | PE family protein |
| M. gilvum PYR-GCK | Mflv_3250 | - | 1e-106 | 51.00% (402) | hypothetical protein Mflv_3250 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 3e-22 | 32.00% (250) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 2e-15 | 27.57% (301) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 8e-16 | 32.49% (197) | PE/PPE family protein |
| M. marinum M | MMAR_2235 | - | 4e-21 | 30.04% (283) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 8e-13 | 27.05% (207) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-25 | 30.67% (326) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-19 | 30.72% (306) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-14 | 29.83% (295) | PPE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2967|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3250|M.gilvum_PYR-GCK --------------------------------------------------
Mb1465|M.bovis_AF2122/97 ----MSFVFAVPEMVAATASDLASLG------------------------
Rv1430|M.tuberculosis_H37Rv ----MSFVFAVPEMVAATASDLASLG------------------------
MMAR_2235|M.marinum_M ----MSFVVTAPETVVAAASQLTGIG------------------------
MUL_2440|M.ulcerans_Agy99 MLAAAAAWDGTGQELAAAASAFSSLTSDLAGAAWQGPSAAAMASVATSYV
MLBr_01232|M.leprae_Br4923 -----------MKRLLATTLAALTVG------------------------
MAV_1760|M.avium_104 -----------MKQLLAGVTALLSVS------------------------
TH_3724|M.thermoresistible__bu ---------------------VVAVG------------------------
MAB_4141|M.abscessus_ATCC_1997 ---------------MAGQYSVPGKR------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2967|M.vanbaalenii_PYR-1 -----------MRGLLAAAGAASVAALGVTCPSPYTLAANVLTVTGYTAG
Mflv_3250|M.gilvum_PYR-GCK -----------MRGILAAAGIAAVAASSVAPTPSVALAANVLTVTGYTFG
Mb1465|M.bovis_AF2122/97 ------------AALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
Rv1430|M.tuberculosis_H37Rv ------------AALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
MMAR_2235|M.marinum_M ------------SAIEAANAAAAALTTRLLPAAADEVSAGIAALMSTHAQ
MUL_2440|M.ulcerans_Agy99 RWLGSAASGAVQTARQVATSAAVFEAARTATVPLELVAANRSALMSMVAA
MLBr_01232|M.leprae_Br4923 -----------TVSGFGSTVASSEPGEPWLPPSPVPVRENSPAKIVYALG
MAV_1760|M.avium_104 -----------TAGYFGIGTAAADGGPIGGPPTPGAPGD----QTAYALG
TH_3724|M.thermoresistible__bu -----------ALTWGGXGVASPAGQPERAAALRLTATADAIIMPGTKIG
MAB_4141|M.abscessus_ATCC_1997 ----------HSLRRYVATITAVAATCTVLAPLAMESRTIASTLASYVIG
MSMEG_6144|M.smegmatis_MC2_155 ---------------MIAAVAAVVTAALVTTVPALGATAFTISGTRILHD
:
Mvan_2967|M.vanbaalenii_PYR-1 ----------GALEWDMSEVFQGSYCDAD---------------------
Mflv_3250|M.gilvum_PYR-GCK ----------GTIKWDMDEMFGGRFCSHN---------------------
Mb1465|M.bovis_AF2122/97 -----EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD------
Rv1430|M.tuberculosis_H37Rv -----EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD------
MMAR_2235|M.marinum_M -----EYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALLRNVQQEL
MUL_2440|M.ulcerans_Agy99 NVFGLNAPAIAAIEAQYEQMWAQNVGAMFGYHVGVSEALSGLAPWQEVLS
MLBr_01232|M.leprae_Br4923 ----------GARPPTFDWDYYTIRAGDEFFP------------------
MAV_1760|M.avium_104 ----------GAHVLGIPYDQYIRMEGADWFP------------------
TH_3724|M.thermoresistible__bu ---------YIPSQDEFTAYATAVIGATAG--------------------
MAB_4141|M.abscessus_ATCC_1997 ---------IGGNNDGASANIPRKLGGAYS--------------------
MSMEG_6144|M.smegmatis_MC2_155 -------------PPYPEQLVPGEFAGYD---------------------
Mvan_2967|M.vanbaalenii_PYR-1 ----------------------------------------------SGNT
Mflv_3250|M.gilvum_PYR-GCK ----------------------------------------------SGNS
Mb1465|M.bovis_AF2122/97 -----------------TAATGAS--------ELGSGGRTALILGSTGTP
Rv1430|M.tuberculosis_H37Rv -----------------TAATGAS--------ELGSGGRTALILGSTGTP
MMAR_2235|M.marinum_M LTG--LTAPGRAWSGAGAASAGASGVDALMSSALLSGGRSVLVVGSTGTP
MUL_2440|M.ulcerans_Agy99 GVSGRVASALEGTSAAAAAALGPTALTAAGSALPAAATDVTLVIGGSGFP
MLBr_01232|M.leprae_Br4923 -----------------------------------------------DVN
MAV_1760|M.avium_104 -----------------------------------------------GQQ
TH_3724|M.thermoresistible__bu -------------------------------------------------A
MAB_4141|M.abscessus_ATCC_1997 ------------------------------------------------VD
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2967|M.vanbaalenii_PYR-1 CTPVKYLSGVPL------------------------------------VG
Mflv_3250|M.gilvum_PYR-GCK CTPVRYNSDQSE------------------------------------GG
Mb1465|M.bovis_AF2122/97 RPPFDYMQQVYDRYIAPHYLGYAFS---GLYTPAQFQPWTGIPSLTYDQS
Rv1430|M.tuberculosis_H37Rv RPPFDYMQQVYDRYIAPHYLGYAFS---GLYTPAQFQPWTGIPSLTYDQS
MMAR_2235|M.marinum_M RPSYRFMREVYDLFVAPHYFGDSLF---GVQTPAQFQPFTGIPNLTFDES
MUL_2440|M.ulcerans_Agy99 IPSQSYVDNVVNNFVTPNFPSFTVSNAISLFTPAESYWITGIKTMTEDAS
MLBr_01232|M.leprae_Br4923 RKLIDYPARAPFRYVPTFLVPGP------------------RDEVTIGEA
MAV_1760|M.avium_104 RQIVRYPAGQVQGHVLERLFPGIGK-------LDESFPGLGMDGPSVGES
TH_3724|M.thermoresistible__bu PGAVDYLGVPGEFWPATG-----------------------LDSLTFDAS
MAB_4141|M.abscessus_ATCC_1997 YHPVSYPGAIWPVSG--------------------------LTAPTFKTS
MSMEG_6144|M.smegmatis_MC2_155 VEHIKYPASVFGMDRG---------------------------IWEAAGA
: .
Mvan_2967|M.vanbaalenii_PYR-1 EYDGLRALRSAITSSTG---ETVVLAYSQGALIAADWIE--QNAGTSGSP
Mflv_3250|M.gilvum_PYR-GCK EQDGLRALTAAVTAASG---PTTVLGFSQGATISGLWIR--ENAGEADAP
Mb1465|M.bovis_AF2122/97 VAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAP
Rv1430|M.tuberculosis_H37Rv VAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAP
MMAR_2235|M.marinum_M AATGASYLHAAITQQLADGNRVVVAGFSQGASVATLEMRHLQSLPIDSRP
MUL_2440|M.ulcerans_Agy99 WAEGLTILDTAIKAQLAAGNNVVVQGYSQGAGIASLEMSNLKAAGVPTG-
MLBr_01232|M.leprae_Br4923 IAVATKNLNQAIHRGTE---PAAVVGLSQGSLALDTEQE--QLATDPTAP
MAV_1760|M.avium_104 VAEGIDNLDAAIRTTGR---PGTAIGLSEGAFVVDGEQA--RLANDPTAP
TH_3724|M.thermoresistible__bu VAXGQAMLTPMVDGAIESDTPIVVFGHSQSAVIATKEKQR-LLAEYPDPD
MAB_4141|M.abscessus_ATCC_1997 VAQGRTNLNDEIVTAGN--QPITIVGYSLGAVVVSKSHS---DLLQRYPG
MSMEG_6144|M.smegmatis_MC2_155 VAAGVDRFVGVDDEGNPITEKIIVAGFSQGAIVIAYEKKRLMKLDEDERP
. : . * .:
Mvan_2967|M.vanbaalenii_PYR-1 SPENLSFVFLGNSLRKYGG----VRPAYE----------IDPPTPE---S
Mflv_3250|M.gilvum_PYR-GCK SPRQLSFVMVANPHRQYGG----IRPHYD----------IGDSTPT---S
Mb1465|M.bovis_AF2122/97 SPDQLSFVLLGNPNNPNGG----ILARFPGLYLQSLGLTFNGATPD---T
Rv1430|M.tuberculosis_H37Rv SPDQLSFVLLGNPNNPNGG----ILARFPGLYLQSLGLTFNGATPD---T
MMAR_2235|M.marinum_M SPEDLSFVLLGNPNNPNGG----ILARFPGLYIQSVGLTFNGATPV---T
MUL_2440|M.ulcerans_Agy99 ---SVSFSLIGNAMNPNGG----LYERFAGLVSPSLGKTFWGATPD---N
MLBr_01232|M.leprae_Br4923 PPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMD---S
MAV_1760|M.avium_104 PPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMPPPYE---S
TH_3724|M.thermoresistible__bu TAPDVTFVMVANPNRPNGG----LLARFPGLYIPILGVTFNGATPAPADG
MAB_4141|M.abscessus_ATCC_1997 GNPNIQFVLMGSANTPNGG----IFARFPWLKIPLADIESNGAWEP---D
MSMEG_6144|M.smegmatis_MC2_155 TVDQLKFVTIGDPTGPNGI------LRWIPFRIPIIGLTPVRPPDT----
: * .... . :
Mvan_2967|M.vanbaalenii_PYR-1 DYHVTDIAIEYDGAADFPDNPFNLLALANAFAGFQYVHIYGYDDVD--LE
Mflv_3250|M.gilvum_PYR-GCK DYKVLDIAVEYDGAADFPANPLNLLAFANALAGFQYVHVPGYNEID--LD
Mb1465|M.bovis_AF2122/97 DYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTP--EQ
Rv1430|M.tuberculosis_H37Rv DYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTP--EQ
MMAR_2235|M.marinum_M EYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHSLYYGLTP--DQ
MUL_2440|M.ulcerans_Agy99 YYTTDVYTLEYDGFADFPRYPPNFVSDLNAIMGIYYVHTQYPTLTA--AQ
MLBr_01232|M.leprae_Br4923 QYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHTPSGFFNP--ED
MAV_1760|M.avium_104 QYDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHTAVAFTNP--SM
TH_3724|M.thermoresistible__bu PFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYELLT--EN
MAB_4141|M.abscessus_ATCC_1997 QFKTKVINTEYDTYGDFPAY-FNPLALANSIAAIQYAHPDAYYDRI--DP
MSMEG_6144|M.smegmatis_MC2_155 PYETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYEDKVDGWDL
: :* .:** * .: * : . *
Mvan_2967|M.vanbaalenii_PYR-1 ND---EKLVWNDGN----TTYVLIRRENIPLLEPLRL----MGLHELADQ
Mflv_3250|M.gilvum_PYR-GCK TA---EKLVWVEGN----TTYVLIRRENLPLLEPLRN----LGLGALADQ
Mb1465|M.bovis_AF2122/97 VA---SGIVLPVSSPDTNTTYILLPNEDLPLLQPLRG----IVPEPLLDL
Rv1430|M.tuberculosis_H37Rv VA---SGIVLPVSSPDTNTTYILLPNEDLPLLQPLRG----IVPEPLLDL
MMAR_2235|M.marinum_M VA---AGVVLPVSSPDVNTTYILIPNEHLPLLQPLRG----IVPDSVLDG
MUL_2440|M.ulcerans_Agy99 VA---TAFTLPTEG-ATMTTYHMIPTENLPLLEPLRGV--PFIGNTLADL
MLBr_01232|M.leprae_Br4923 VPP--QNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRY---LGWSDALVDQ
MAV_1760|M.avium_104 VPP--QNIRTTINSRGAKDTTIMIPEKHLPLVMPLKY---IGIDENTLNK
TH_3724|M.thermoresistible__bu PDIL-DDPERTIVQQYGDTTYYLIRTEQLPLLRPLRD---LGVPEEFVDA
MAB_4141|M.abscessus_ATCC_1997 AALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDA
MSMEG_6144|M.smegmatis_MC2_155 STVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRD---LGFPESFVAA
* :: :.:** **:
Mvan_2967|M.vanbaalenii_PYR-1 LNGPLKEIIDSAYNR-----------------DYPGLVDST---------
Mflv_3250|M.gilvum_PYR-GCK LNAPLKEIIDSAYDR-----------------DYPDLVDEE---------
Mb1465|M.bovis_AF2122/97 IEPDLRAIIELGYDR------TGYADVPTPAALFPVHIDP----------
Rv1430|M.tuberculosis_H37Rv IEPDLRAIIELGYDR------TGYADVPTPAALFPVHIDP----------
MMAR_2235|M.marinum_M IEPGLRDVVELGYDR------TGYADVPTPASLFPANVNPNVVAGAFVEG
MUL_2440|M.ulcerans_Agy99 VQPDLKVLVNLGYGDPNYGYSTGPANVPTPFGLFPDVAPATVFDALVAGT
MLBr_01232|M.leprae_Br4923 IDAVLQPKIDAAYAY-----------------------------------
MAV_1760|M.avium_104 LDAILTPRVNAGYSR-----------------------------------
TH_3724|M.thermoresistible__bu LEPYVRRIVDLGYDR-----------------------------------
MAB_4141|M.abscessus_ATCC_1997 IEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAH
MSMEG_6144|M.smegmatis_MC2_155 LEAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQTAVTEIDETPS
:: : :: .*
Mvan_2967|M.vanbaalenii_PYR-1 ----------------------------------------------PQRA
Mflv_3250|M.gilvum_PYR-GCK ----------------------------------------------DHAE
Mb1465|M.bovis_AF2122/97 ----------------------------------------------IAVP
Rv1430|M.tuberculosis_H37Rv ----------------------------------------------IAVP
MMAR_2235|M.marinum_M AVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSAIAVP
MUL_2440|M.ulcerans_Agy99 QQG---------------------------------ISDAAADIGAWQLP
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 NVENG--------------------------------LAGATPKQSASPE
MSMEG_6144|M.smegmatis_MC2_155 TDG--------------------------------------DIDETAVQS
Mvan_2967|M.vanbaalenii_PYR-1 ATQDLSALQVDEDDEVEEVGEVTDAAADDIDAAADKASDDISDIDDESAS
Mflv_3250|M.gilvum_PYR-GCK VLQ--QALATRGRSTATLSTRISTAVENDIDPEIDN-TAEVETQTEVEIQ
Mb1465|M.bovis_AF2122/97 PQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGA
Rv1430|M.tuberculosis_H37Rv PQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGA
MMAR_2235|M.marinum_M PQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQYGADLSAEAARHGA
MUL_2440|M.ulcerans_Agy99 SLPDISLSGISNALGSDPWSALSNATLPTLSVSTIENAIKGVQTATTDIA
MLBr_01232|M.leprae_Br4923 -----------------NDNPLNKPISVDPVNGMDP----IAGIDAELR-
MAV_1760|M.avium_104 -----------------NDDPATAPVQVDPVHGFDPAEVTAPANQATFGG
TH_3724|M.thermoresistible__bu -NTPYGEPAPVRVLPPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVE
MAB_4141|M.abscessus_ATCC_1997 KPASPPVPQPGPTNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAA
MSMEG_6144|M.smegmatis_MC2_155 TTQRRTVANTAADRTAETAEVAEVTEDVDELAEQEEPVKEEATKDDEVTK
Mvan_2967|M.vanbaalenii_PYR-1 SAVDSEEDAGDGADTESGDTDGGDLLDDSSE------EDSADDSTGGSAP
Mflv_3250|M.gilvum_PYR-GCK ADIEADIEAGDDSAAIELDDDAS---ADSDP------TGTGDAPTG-TAD
Mb1465|M.bovis_AF2122/97 PAGVTNAIFIGQQVLPILVEGPGALVTADTH---YLVDAIQDLAAGDLSG
Rv1430|M.tuberculosis_H37Rv PAGVTNAIFIGQQVLPILVEGPGALVTADTH---YLVDAIQDLAAGDLSG
MMAR_2235|M.marinum_M SSELLNAIYVGRQVLPILIEGPGVILTADTY---YSINAIKDLAAGNLSG
MUL_2440|M.ulcerans_Agy99 NTISFDATTAYATLLPTADVVNAMVTTLPAYNLKLFLDGILQVLDGDPAG
MLBr_01232|M.leprae_Br4923 --DSILNVFAQLRSILPPPPG-----------------------------
MAV_1760|M.avium_104 GADPLSQIMAGAMSVLSHGAGEADH-------------------------
TH_3724|M.thermoresistible__bu APVEEPPVQTGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDV
MAB_4141|M.abscessus_ATCC_1997 DPTAISVSTAGASTARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLK
MSMEG_6144|M.smegmatis_MC2_155 VADEADKATPVKESTSVEKTDQAVKPDDTDKTVTTAEKVEKADEAEKVEK
Mvan_2967|M.vanbaalenii_PYR-1 DSDDSASEPTSGAGDDSSAPSAS-EADSDSGSDAEGSAE-----------
Mflv_3250|M.gilvum_PYR-GCK SSEDAGESSTDAADSDASSDSAKPDASEDRGDPGE---------------
Mb1465|M.bovis_AF2122/97 FNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV------------
Rv1430|M.tuberculosis_H37Rv FNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV------------
MMAR_2235|M.marinum_M FNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP-------------
MUL_2440|M.ulcerans_Agy99 LIYALGAPIAADTALVTLLAGFNLYAYLYAFNKILPGVL-----------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu TPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE---------------
MAB_4141|M.abscessus_ATCC_1997 PTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHS
MSMEG_6144|M.smegmatis_MC2_155 TKPNVRKVKRPQFNVFKPKKTRVTVPKAEPSTKAKPATKPDNDNDDTSDT
Mvan_2967|M.vanbaalenii_PYR-1 -------------------------
Mflv_3250|M.gilvum_PYR-GCK -------------------------
Mb1465|M.bovis_AF2122/97 -------------------------
Rv1430|M.tuberculosis_H37Rv -------------------------
MMAR_2235|M.marinum_M -------------------------
MUL_2440|M.ulcerans_Agy99 -------------------------
MLBr_01232|M.leprae_Br4923 -------------------------
MAV_1760|M.avium_104 -------------------------
TH_3724|M.thermoresistible__bu -------------------------
MAB_4141|M.abscessus_ATCC_1997 QPANAPAHTSDKTSDHASETGRGAA
MSMEG_6144|M.smegmatis_MC2_155 TDKTAEKDAA---------------