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RGILAAAGIAAVAASSVAPTPSVALAANVLTVTGYTFGGTIKWDMDEMFGGRFCSHNSGNSCTPVRYNSD QSEGGEQDGLRALTAAVTAASGPTTVLGFSQGATISGLWIRENAGEADAPSPRQLSFVMVANPHRQYGGI RPHYDIGDSTPTSDYKVLDIAVEYDGAADFPANPLNLLAFANALAGFQYVHVPGYNEIDLDTAEKLVWVE GNTTYVLIRRENLPLLEPLRNLGLGALADQLNAPLKEIIDSAYDRDYPDLVDEEDHAEVLQQALATRGRS TATLSTRISTAVENDIDPEIDNTAEVETQTEVEIQADIEADIEAGDDSAAIELDDDASADSDPTGTGDAP TGTADSSEDAGESSTDAADSDASSDSAKPDASEDRGDPGE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3250 | - | - | 100% (391) | hypothetical protein Mflv_3250 |
| M. gilvum PYR-GCK | Mflv_3374 | - | 6e-47 | 32.53% (415) | hypothetical protein Mflv_3374 |
| M. gilvum PYR-GCK | Mflv_3378 | - | 1e-36 | 35.42% (271) | hypothetical protein Mflv_3378 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 1e-27 | 34.12% (255) | PE family protein |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 1e-27 | 34.12% (255) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 8e-14 | 31.94% (191) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 6e-19 | 26.15% (325) | PE/PPE family protein |
| M. marinum M | MMAR_2235 | - | 7e-25 | 30.74% (283) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 4e-10 | 25.63% (199) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5759 | - | 5e-26 | 28.71% (411) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 7e-24 | 30.23% (344) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 6e-17 | 33.85% (192) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_2967 | - | 1e-106 | 51.24% (402) | hypothetical protein Mvan_2967 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3250|M.gilvum_PYR-GCK ----------------------------MRGILAAAGIAAVAASSVAPTP
Mvan_2967|M.vanbaalenii_PYR-1 ----------------------------MRGLLAAAGAASVAALGVTCPS
MLBr_01232|M.leprae_Br4923 ----------------------------MKRLLATTLAALTVGTVSGFGS
MAV_1760|M.avium_104 ----------------------------MKQLLAGVTALLSVSTAGYFGI
Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
Rv1430|M.tuberculosis_H37Rv --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu -------------------VVAVGALTWGGXGVASPAGQPERAAALRLTA
MSMEG_5759|M.smegmatis_MC2_155 ------------------------------MTVGSAVRQLIAVGSVIAAG
MAB_4141|M.abscessus_ATCC_1997 -------------------MAGQYSVPGKRHSLRRYVATITAVAATCTVL
Mflv_3250|M.gilvum_PYR-GCK SVALAANVLTVTGYTFGGTIKWDMDEMFGGRFCSHN--------------
Mvan_2967|M.vanbaalenii_PYR-1 PYTLAANVLTVTGYTAGGALEWDMSEVFQGSYCDAD--------------
MLBr_01232|M.leprae_Br4923 TVASSE-----PGEPWLPPSPVPVRENSPAKIVYAL--------------
MAV_1760|M.avium_104 GTAAAD-----GGPIGGPPTPGAPGD----QTAYAL--------------
Mb1465|M.bovis_AF2122/97 AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
Rv1430|M.tuberculosis_H37Rv AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu TADAIIMPGTKIGYIPSQDEFTAYATAVIGATAGAPG-------------
MSMEG_5759|M.smegmatis_MC2_155 AIAVAPAVVADTVLTVGGTGSALVGDQGPWRLPYTHG-------------
MAB_4141|M.abscessus_ATCC_1997 APLAMESRTIASTLASYVIGIGGNNDGASANIPRKLG-------------
Mflv_3250|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2967|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 D---------------------TAATGAS--------ELGSGG-----RT
Rv1430|M.tuberculosis_H37Rv D---------------------TAATGAS--------ELGSGG-----RT
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGG-----RS
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN---LFAPVLSGPESVAASAT--------ALLSGAPLKPVEA
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_5759|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3250|M.gilvum_PYR-GCK ------SGNSCTPVRYNSDQ-------------------SEGGE--QDGL
Mvan_2967|M.vanbaalenii_PYR-1 ------SGNTCTPVKYLSGV-------------------PLVGE--YDGL
MLBr_01232|M.leprae_Br4923 ------GGARPPTFDWDYYT-------------------IRAGDEFFPDV
MAV_1760|M.avium_104 ------GGAHVLGIPYDQYI-------------------RMEGADWFPGQ
Mb1465|M.bovis_AF2122/97 ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
Rv1430|M.tuberculosis_H37Rv ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
MMAR_2235|M.marinum_M VLVVGSTGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTPAQFQPFTGI
MUL_0967|M.ulcerans_Agy99 ALILSESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGI
TH_3724|M.thermoresistible__bu ------------AVDYLGVP---------------------GEFWPATGL
MSMEG_5759|M.smegmatis_MC2_155 --------APEVNIVYPSSP-------------------VFMDWSVAHGA
MAB_4141|M.abscessus_ATCC_1997 ---------GAYSVDYHPVS-------------------YPGAIWPVSGL
: .
Mflv_3250|M.gilvum_PYR-GCK RALTAAVTAASGPTTVLGFSQGATIS---------------------GLW
Mvan_2967|M.vanbaalenii_PYR-1 RALRSAITSSTGETVVLAYSQGALIA---------------------ADW
MLBr_01232|M.leprae_Br4923 NRKLIDYPARAPFRYVPTFLVPGP--------------------------
MAV_1760|M.avium_104 QRQIVRYPAGQVQGHVLERLFPGIGK---------------------LDE
Mb1465|M.bovis_AF2122/97 PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
Rv1430|M.tuberculosis_H37Rv PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
MMAR_2235|M.marinum_M PNLTFDESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMR
MUL_0967|M.ulcerans_Agy99 KDLSLDISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMP
TH_3724|M.thermoresistible__bu DSLTFDASVAXGQAMLTPMVDGAIES----DTPIVVFGHSQSAVIATKEK
MSMEG_5759|M.smegmatis_MC2_155 GSLHAAIVSTPEGKTAVGISQGGLVL-------------------AEVKR
MAB_4141|M.abscessus_ATCC_1997 TAPTFKTSVAQGRTNLNDEIVTAGNQ--------PITIVGYSLGAVVVSK
Mflv_3250|M.gilvum_PYR-GCK IRENAGEADAPSPRQLSFVMVANPHRQYGGIRP----------HYDIGDS
Mvan_2967|M.vanbaalenii_PYR-1 IEQNAGTSGSPSPENLSFVFLGNSLRKYGGVRP----------AYEIDPP
MLBr_01232|M.leprae_Br4923 ------RDEVTIGEAIAVATKNLNQAIHRGTEP----------AAVVGLS
MAV_1760|M.avium_104 SFPGLGMDGPSVGESVAEGIDNLDAAIRTTGRP----------GTAIGLS
Mb1465|M.bovis_AF2122/97 HLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGA
Rv1430|M.tuberculosis_H37Rv HLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGA
MMAR_2235|M.marinum_M HLQSLPIDSRPSPEDLSFVLLGNPNNPNGGILARFPGLYIQSVGLTFNGA
MUL_0967|M.ulcerans_Agy99 KLLAEGVTSS----QVNFVLLGNPMNPNGGVLARFPDLTLPSLGFTFYGA
TH_3724|M.thermoresistible__bu QRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVTFNGA
MSMEG_5759|M.smegmatis_MC2_155 RLMALPESDRPASGELVFIGVGDPSNPQGGLLRHFPEG---FRLPGFGVT
MAB_4141|M.abscessus_ATCC_1997 SHSDLLQRYPGGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIESNGA
: .
Mflv_3250|M.gilvum_PYR-GCK TPT---SDYKVLDIAVEYDGAADFPANPLNLLAFANALAGFQYVHVPGY-
Mvan_2967|M.vanbaalenii_PYR-1 TPE---SDYHVTDIAIEYDGAADFPDNPFNLLALANAFAGFQYVHIYGY-
MLBr_01232|M.leprae_Br4923 QGS---LALDTEQEQLATDPTAPPP-DQLTFNTFGDPSGYHGFGKSVLA-
MAV_1760|M.avium_104 EGA---FVVDGEQARLANDPTAPPP-NTLNFATFGDPIGRHAFGQSFLT-
Mb1465|M.bovis_AF2122/97 TPD---TDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYG
Rv1430|M.tuberculosis_H37Rv TPD---TDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYG
MMAR_2235|M.marinum_M TPV---TEYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHSLYYG
MUL_0967|M.ulcerans_Agy99 TPD---NAFPTVSYTLEYDGFADFPRYPINLLADINAVMGIPFVHADYQD
TH_3724|M.thermoresistible__bu TPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYE
MSMEG_5759|M.smegmatis_MC2_155 VVETPETPWNTIYVTREYDGFADFPDRVHNLVAVANALVGIVYVHAQPGY
MAB_4141|M.abscessus_ATCC_1997 WEP---DQFKTKVINTEYDTYGDFP-AYFNPLALANSIAAIQYAHPDAYY
* . * . : :. : :
Mflv_3250|M.gilvum_PYR-GCK -----NEIDL-DTAEKLVWVEGNTTYVLIRRENLPLLEPLRNLG----LG
Mvan_2967|M.vanbaalenii_PYR-1 -----DDVDL-ENDEKLVWNDGNTTYVLIRRENIPLLEPLRLMG----LH
MLBr_01232|M.leprae_Br4923 -----SIFRP-GDYIPLIDYTMPQRMDSQYDSNRVVAAYDGLSE----FP
MAV_1760|M.avium_104 -----AMFGV-GSVVPALDYTMPPPYESQYDTNRFVAAYDSIAD----FP
Mb1465|M.bovis_AF2122/97 LTP--EQVAS-GIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI----VPE
Rv1430|M.tuberculosis_H37Rv LTP--EQVAS-GIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI----VPE
MMAR_2235|M.marinum_M LTP--DQVAA-GVVLPVSSPDVNTTYILIPNEHLPLLQPLRGI----VPD
MUL_0967|M.ulcerans_Agy99 LTQ--AQLDS-AVQLPTEGP-TQSTYYMIPTEHLPLLAPLRFIPY--VGD
TH_3724|M.thermoresistible__bu LLTENPDILD-DPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG---VPE
MSMEG_5759|M.smegmatis_MC2_155 ASVDLEAVPDRDVTVTTNTLGGVTTSYLVRTERLPLLQPARDLG---VPE
MAB_4141|M.abscessus_ATCC_1997 DRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGAS
. :
Mflv_3250|M.gilvum_PYR-GCK ALADQLNAPLKEIIDSAYDR-----------------DYPDLVDEEDHAE
Mvan_2967|M.vanbaalenii_PYR-1 ELADQLNGPLKEIIDSAYNR-----------------DYPGLVDSTPQRA
MLBr_01232|M.leprae_Br4923 DRADNLLAQLNCFAGGAISH-----------------TPSGFFN--PEDV
MAV_1760|M.avium_104 DRPDNMFALANTLMGLATGH-----------------TAVAFTN--PSMV
Mb1465|M.bovis_AF2122/97 PLLDLIEPDLRAIIELGYDR-------------TGYADVPTPAALFPVHI
Rv1430|M.tuberculosis_H37Rv PLLDLIEPDLRAIIELGYDR-------------TGYADVPTPAALFPVHI
MMAR_2235|M.marinum_M SVLDGIEPGLRDVVELGYDR-------------TGYADVPTPASLFPANV
MUL_0967|M.ulcerans_Agy99 PLAELLEPNLRVLVNFGYGDPA-------YGYDTGPANVPTPFGLFPP-V
TH_3724|M.thermoresistible__bu EFVDALEPYVRRIVDLGYDRN-------------TPYGEPAPVRVLPPLT
MSMEG_5759|M.smegmatis_MC2_155 KIVKHLEAALKPVVDAGYVRN----------------DPPRTPALTAASA
MAB_4141|M.abscessus_ATCC_1997 FVLDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAI
. : . . .
Mflv_3250|M.gilvum_PYR-GCK VLQ-----------------------------------------------
Mvan_2967|M.vanbaalenii_PYR-1 ATQD----------------------------------------------
MLBr_01232|M.leprae_Br4923 PPQN----------------------------------------------
MAV_1760|M.avium_104 PPQN----------------------------------------------
Mb1465|M.bovis_AF2122/97 DP------------------------------------------------
Rv1430|M.tuberculosis_H37Rv DP------------------------------------------------
MMAR_2235|M.marinum_M NPNVVAGAF--VEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPI
MUL_0967|M.ulcerans_Agy99 SP------------------------------------------------
TH_3724|M.thermoresistible__bu PAPG----------------------------------------------
MSMEG_5759|M.smegmatis_MC2_155 PEP-----------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 AEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEA
Mflv_3250|M.gilvum_PYR-GCK -----------QALATRGRSTATLSTRISTAVENDIDPEIDN-TAEVETQ
Mvan_2967|M.vanbaalenii_PYR-1 ----------LSALQVDEDDEVEEVGEVTDAAADDIDAAADKASDDISDI
MLBr_01232|M.leprae_Br4923 ----------IRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLGWSDALVDQ
MAV_1760|M.avium_104 ----------IRTTINSRGAKDTTIMIPEKHLPLVMPLKYIGIDENTLNK
Mb1465|M.bovis_AF2122/97 ----------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQ
Rv1430|M.tuberculosis_H37Rv ----------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQ
MMAR_2235|M.marinum_M PGWPASVPSAIAVPPQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQ
MUL_0967|M.ulcerans_Agy99 ----------LTVAEHLAAGTQQGIVNSG----AALQAQGPPSIP--LSD
TH_3724|M.thermoresistible__bu ------------PATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQT
MSMEG_5759|M.smegmatis_MC2_155 ------------VAASVEPEPEPERKRHLRVASPGRIAVGGPAKGRHARV
MAB_4141|M.abscessus_ATCC_1997 PTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPD
Mflv_3250|M.gilvum_PYR-GCK TEVEIQADIE-ADIEAGDDSAAIELDDDAS---ADSDPTGTGDAPTG-TA
Mvan_2967|M.vanbaalenii_PYR-1 DDESASSAVD-SEEDAGDGADTESGDTDGGDLLDDSSEEDSADDSTGGSA
MLBr_01232|M.leprae_Br4923 IDAVLQPKID-AAYAYNDNPLN---------------KPISVDPVNGMDP
MAV_1760|M.avium_104 LDAILTPRVN-AGYSRNDDPAT---------------APVQVDPVHGFDP
Mb1465|M.bovis_AF2122/97 AGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDA
Rv1430|M.tuberculosis_H37Rv AGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDA
MMAR_2235|M.marinum_M YGADLSAEAARHGASSELLNAIYVGRQVLPILIEGPGVILTADTYYSINA
MUL_0967|M.ulcerans_Agy99 IAHTLTANPPWAGTPA-LPPSTSPASSIEDFIL----AVQAANSSISRGF
TH_3724|M.thermoresistible__bu GRSTLKREKPVSARHLVRNSLRAVP------------GLRRGEPAATPTP
MSMEG_5759|M.smegmatis_MC2_155 VEAELR-------------------------------DPRDDERPDVRTQ
MAB_4141|M.abscessus_ATCC_1997 PKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKN
Mflv_3250|M.gilvum_PYR-GCK DSSEDAGESSTDAADSDASSDSAKPDASEDRGDPGE-------------
Mvan_2967|M.vanbaalenii_PYR-1 PDSDDSASEPTSGAGDDSSAPSAS-EADSDSGSDAEGSAE---------
MLBr_01232|M.leprae_Br4923 ----IAGIDAELR---DSILNVFAQLRSILPPPPG--------------
MAV_1760|M.avium_104 AEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH----------
Mb1465|M.bovis_AF2122/97 IQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
Rv1430|M.tuberculosis_H37Rv IQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
MMAR_2235|M.marinum_M IKDLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP-
MUL_0967|M.ulcerans_Agy99 VKTLSTAYAT-LLPTTDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD
TH_3724|M.thermoresistible__bu DVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE------------
MSMEG_5759|M.smegmatis_MC2_155 ASTPESAAHAGAKSDPPGDSPSDNSGADAERGDE---------------
MAB_4141|M.abscessus_ATCC_1997 HLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA-