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MTKSVPGRHRKAGTRNRWTRAALVAAAFPLAGVPALGAAPTVAGAAELLGDDAATVLHHGPTPWDMTNNL SGEPCEEPRVCREVYYQWILPLGTVEIGVDSNVETLDYAIKNITADGAGDKKIVYAFSGGARVASVWLDE HADDVDAPDAEDLTFVLIGNGGRKYGGINGWWYGDALLTPTDTQYSVIDVAREYDPIADFPDNPFNLLAL ANALAAFYYVHLDYSDVDLDDDANYVWTEGNTTYVFVPTEDLPLLQGLRDLGLDWLADEWEEPLREIIDE AYDRDYLEGVEPQGEQSPVEESADLVEIKSLSAVQDSTSEEATSDDVAGRDSSAEAESEAAADGGNSLDV LGDIDSSGTTAGDGPQLTPADVEDPDVDVDSAGEDEADHTDVDSAAESIDDAGAESADDANDDDSTVNSA DQSTDSTSTDDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2068 | - | - | 100% (432) | hypothetical protein Mvan_2068 |
| M. vanbaalenii PYR-1 | Mvan_3102 | - | e-117 | 52.58% (426) | hypothetical protein Mvan_3102 |
| M. vanbaalenii PYR-1 | Mvan_3110 | - | 2e-96 | 56.48% (324) | hypothetical protein Mvan_3110 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 2e-21 | 31.82% (308) | PE family protein |
| M. gilvum PYR-GCK | Mflv_3374 | - | 5e-66 | 38.66% (432) | hypothetical protein Mflv_3374 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 2e-21 | 31.82% (308) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 2e-07 | 28.77% (219) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-17 | 29.80% (349) | PE/PPE family protein |
| M. marinum M | MMAR_2235 | - | 2e-20 | 30.31% (320) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 2e-07 | 25.79% (190) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 2e-26 | 30.43% (437) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 6e-24 | 31.50% (327) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-15 | 28.57% (329) | PPE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1465|M.bovis_AF2122/97 ----MSFVFAVPEMVAATASDLASLG------------------------
Rv1430|M.tuberculosis_H37Rv ----MSFVFAVPEMVAATASDLASLG------------------------
MMAR_2235|M.marinum_M ----MSFVVTAPETVVAAASQLTGIG------------------------
MUL_2440|M.ulcerans_Agy99 MLAAAAAWDGTGQELAAAASAFSSLTSDLAGAAWQGPSAAAMASVATSYV
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mvan_2068|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3374|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 ------------AALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
Rv1430|M.tuberculosis_H37Rv ------------AALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
MMAR_2235|M.marinum_M ------------SAIEAANAAAAALTTRLLPAAADEVSAGIAALMSTHAQ
MUL_2440|M.ulcerans_Agy99 RWLGSAASGAVQTARQVATSAAVFEAARTATVPLELVAANRSALMSMVAA
MLBr_01232|M.leprae_Br4923 ------------MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSP
MAV_1760|M.avium_104 ------------MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTP
Mvan_2068|M.vanbaalenii_PYR-1 -------------MTKSVPGRHRKAGTRNRWTRAALVAAAFPLAGVPALG
Mflv_3374|M.gilvum_PYR-GCK ----------------MAKGHNAGKRTRRRRATGIAAAVAIPLLALPVGG
TH_3724|M.thermoresistible__bu ----------------VVAVGALTWGGXGVASPAGQPERAAALRLTATAD
MSMEG_6144|M.smegmatis_MC2_155 ----------------MIAAVAAVVTAALVTTVPALGATAFTISGTRILH
MAB_4141|M.abscessus_ATCC_1997 -----------------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAP
Mb1465|M.bovis_AF2122/97 -----EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD------
Rv1430|M.tuberculosis_H37Rv -----EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD------
MMAR_2235|M.marinum_M -----EYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALLRNVQQEL
MUL_2440|M.ulcerans_Agy99 NVFGLNAPAIAAIEAQYEQMWAQNVGAMFGYHVGVSEALSGLAPWQEVLS
MLBr_01232|M.leprae_Br4923 ------VPVRENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFP------
MAV_1760|M.avium_104 ------GAPGD----QTAYALGGAHVLGIPYDQYIRMEGADWFP------
Mvan_2068|M.vanbaalenii_PYR-1 ---------AAPTVAGAAELLGDDAATVLHHGPTPWDMTNNLS-------
Mflv_3374|M.gilvum_PYR-GCK ---------ASASAATTYEYFPTEPTRVLTLSLLPGGNNDDLN-------
TH_3724|M.thermoresistible__bu ----------AIIMPGTKIGYIPSQDEFTAYATAVIGATAGAPG------
MSMEG_6144|M.smegmatis_MC2_155 -------------DPPYPEQLVPG--EFAGYDVEHIKYPASVFG------
MAB_4141|M.abscessus_ATCC_1997 ---------LAMESRTIASTLASYVIGIGGNNDGASANIPRKLG------
Mb1465|M.bovis_AF2122/97 -----------------TAATGAS--------ELGSGGRTALILGSTGTP
Rv1430|M.tuberculosis_H37Rv -----------------TAATGAS--------ELGSGGRTALILGSTGTP
MMAR_2235|M.marinum_M LTG--LTAPGRAWSGAGAASAGASGVDALMSSALLSGGRSVLVVGSTGTP
MUL_2440|M.ulcerans_Agy99 GVSGRVASALEGTSAAAAAALGPTALTAAGSALPAAATDVTLVIGGSGFP
MLBr_01232|M.leprae_Br4923 -----------------------------------------------DVN
MAV_1760|M.avium_104 -----------------------------------------------GQQ
Mvan_2068|M.vanbaalenii_PYR-1 -----------------------------------------------GEP
Mflv_3374|M.gilvum_PYR-GCK -----------------------------------------------GVM
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 -----------------------------------------------GAY
Mb1465|M.bovis_AF2122/97 RPPFDYMQQVYDRYIAPHYLGYAFS---GLYTPAQFQPWTGIPSLTYDQS
Rv1430|M.tuberculosis_H37Rv RPPFDYMQQVYDRYIAPHYLGYAFS---GLYTPAQFQPWTGIPSLTYDQS
MMAR_2235|M.marinum_M RPSYRFMREVYDLFVAPHYFGDSLF---GVQTPAQFQPFTGIPNLTFDES
MUL_2440|M.ulcerans_Agy99 IPSQSYVDNVVNNFVTPNFPSFTVSNAISLFTPAESYWITGIKTMTEDAS
MLBr_01232|M.leprae_Br4923 RKLIDYPARAPFRYVPTFLVPGP------------------RDEVTIGEA
MAV_1760|M.avium_104 RQIVRYPAGQVQGHVLERLFPGIGK-------LDESFPGLGMDGPSVGES
Mvan_2068|M.vanbaalenii_PYR-1 CEEPRVCREVYYQWILPLGTVEIGV-------------------------
Mflv_3374|M.gilvum_PYR-GCK CESPRTCRNVVYSRASTP--------------------------------
TH_3724|M.thermoresistible__bu --AVDYLGVPGEFWPATG-----------------------LDSLTFDAS
MSMEG_6144|M.smegmatis_MC2_155 --------MDRGIWEAAG-------------------------------A
MAB_4141|M.abscessus_ATCC_1997 SVDYHPVSYPGAIWPVSG-----------------------LTAPTFKTS
Mb1465|M.bovis_AF2122/97 VAEGAGYLHTAIMQQV--AAGNDVVVLGFSQGASVATLEMRHLASLPAGV
Rv1430|M.tuberculosis_H37Rv VAEGAGYLHTAIMQQV--AAGNDVVVLGFSQGASVATLEMRHLASLPAGV
MMAR_2235|M.marinum_M AATGASYLHAAITQQL--ADGNRVVVAGFSQGASVATLEMRHLQSLPIDS
MUL_2440|M.ulcerans_Agy99 WAEGLTILDTAIKAQL--AAGNNVVVQGYSQGAGIASLEMSNLKAAGVPT
MLBr_01232|M.leprae_Br4923 IAVATKNLNQAIHRGT--EPA---AVVGLSQGSLALDTEQEQLATD--PT
MAV_1760|M.avium_104 VAEGIDNLDAAIRTTG--RPG---TAIGLSEGAFVVDGEQARLAND--PT
Mvan_2068|M.vanbaalenii_PYR-1 -DSNVETLDYAIKNITADGAGDKKIVYAFSGGARVASVWLDEHADD--VD
Mflv_3374|M.gilvum_PYR-GCK --EAVGTLDAVLR----DGTDGKQIVFAYSQGARVSAAWIREHGGT--EG
TH_3724|M.thermoresistible__bu VAXGQAMLTPMVDGAI--ESDTPIVVFGHSQSAVIATKEKQRLLAEY-PD
MSMEG_6144|M.smegmatis_MC2_155 VAAGVDRFVGVDDEGN--PITEKIIVAGFSQGAIVIAYEKKRLMKLDEDE
MAB_4141|M.abscessus_ATCC_1997 VAQGRTNLNDEIVTAG----NQPITIVGYSLGAVVVSKSHSDLLQR---Y
: . * .:
Mb1465|M.bovis_AF2122/97 APSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATP----DTD
Rv1430|M.tuberculosis_H37Rv APSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATP----DTD
MMAR_2235|M.marinum_M RPSPEDLSFVLLGNPNNPNGGILARFPGLYIQSVGLTFNGATP----VTE
MUL_2440|M.ulcerans_Agy99 G----SVSFSLIGNAMNPNGGLYERFAGLVSPSLGKTFWGATP----DNY
MLBr_01232|M.leprae_Br4923 APPPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMDSQ
MAV_1760|M.avium_104 APPPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMPPPYESQ
Mvan_2068|M.vanbaalenii_PYR-1 APDAEDLTFVLIGNGGRKYGGINGWWYGDALLTP------------TDTQ
Mflv_3374|M.gilvum_PYR-GCK VPTAENLTFVLMGNPARKYSGSDKVRGPDVFP---------------DLG
TH_3724|M.thermoresistible__bu PDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVTFNGATPAP-ADGP
MSMEG_6144|M.smegmatis_MC2_155 RPTVDQLKFVTIGDPTGPNG--ILRWIPFRIPIIGLTPVRPP-----DTP
MAB_4141|M.abscessus_ATCC_1997 PGGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIESNGAWE----PDQ
: * ... .
Mb1465|M.bovis_AF2122/97 YATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTP---EQ
Rv1430|M.tuberculosis_H37Rv YATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTP---EQ
MMAR_2235|M.marinum_M YPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHSLYYGLTP---DQ
MUL_2440|M.ulcerans_Agy99 YTTDVYTLEYDGFADFPRYPPNFVSDLNAIMGIYYVHTQYPTLTA---AQ
MLBr_01232|M.leprae_Br4923 YDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHTPSGFFNP---ED
MAV_1760|M.avium_104 YDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHTAVAFTNP---SM
Mvan_2068|M.vanbaalenii_PYR-1 YSVIDVAREYDPIADFPDNPFNLLALANALAAFYYVHLDYSDVDL---DD
Mflv_3374|M.gilvum_PYR-GCK YRIIDVSQEYDMASDFPDDPSNLLAMLNSTAGFFFTHQTYEPVDI---YD
TH_3724|M.thermoresistible__bu FDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYELLT---EN
MSMEG_6144|M.smegmatis_MC2_155 YETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYEDKVDGWDLS
MAB_4141|M.abscessus_ATCC_1997 FKTKVINTEYDTYGDFPAY-FNPLALANSIAAIQYAHPDAYYDRIDPAAL
: :* .:** * .: * . *
Mb1465|M.bovis_AF2122/97 VASG--IVLPVSSPDTNTTYILLPNEDLPLLQPLRG----IVPEPLLDLI
Rv1430|M.tuberculosis_H37Rv VASG--IVLPVSSPDTNTTYILLPNEDLPLLQPLRG----IVPEPLLDLI
MMAR_2235|M.marinum_M VAAG--VVLPVSSPDVNTTYILIPNEHLPLLQPLRG----IVPDSVLDGI
MUL_2440|M.ulcerans_Agy99 VATA--FTLPTEG-ATMTTYHMIPTENLPLLEPLRGV--PFIGNTLADLV
MLBr_01232|M.leprae_Br4923 VPPQN-IRTTVNSRGAKTTTYLIPVNHLPLTLPLRY---LGWSDALVDQI
MAV_1760|M.avium_104 VPPQN-IRTTINSRGAKDTTIMIPEKHLPLVMPLKY---IGIDENTLNKL
Mvan_2068|M.vanbaalenii_PYR-1 DANY-------VWTEGNTTYVFVPTEDLPLLQGLRD----LGLDWLADEW
Mflv_3374|M.gilvum_PYR-GCK EANY-------VWTEGHITYVFVPTRNLPLLQPLRW----FGLGFVADAL
TH_3724|M.thermoresistible__bu PDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRD---LGVPEEFVDAL
MSMEG_6144|M.smegmatis_MC2_155 TVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRD---LGFPESFVAAL
MAB_4141|M.abscessus_ATCC_1997 DDPDN--PNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAI
* :: ..*** *:
Mb1465|M.bovis_AF2122/97 EPDLRAIIELGYDR------TGYADVPTPAALFPVHIDP-----------
Rv1430|M.tuberculosis_H37Rv EPDLRAIIELGYDR------TGYADVPTPAALFPVHIDP-----------
MMAR_2235|M.marinum_M EPGLRDVVELGYDR------TGYADVPTPASLFPANVNPNVVAGAFVEGA
MUL_2440|M.ulcerans_Agy99 QPDLKVLVNLGYGDPNYGYSTGPANVPTPFGLFPDVAPATVFDALVAGTQ
MLBr_01232|M.leprae_Br4923 DAVLQPKIDAAYAY-------NDNPLNKPISVDPVNG-------------
MAV_1760|M.avium_104 DAILTPRVNAGYSR-------NDDPATAPVQVDPVHG-------------
Mvan_2068|M.vanbaalenii_PYR-1 EEPLREIIDEAYDR-----DYLEGVE--PQGEQSPVEES-----------
Mflv_3374|M.gilvum_PYR-GCK NAPLKEIVDRAYDR-----SYLPAQPGFPSTPDPEIEEP-----------
TH_3724|M.thermoresistible__bu EPYVRRIVDLGYDR------NTPYGEPAPVRVLPPLTPAPG---------
MSMEG_6144|M.smegmatis_MC2_155 EAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQTAVTEIDETPST
MAB_4141|M.abscessus_ATCC_1997 EPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHN
: : :: .*
Mb1465|M.bovis_AF2122/97 ------------------------------------------------IA
Rv1430|M.tuberculosis_H37Rv ------------------------------------------------IA
MMAR_2235|M.marinum_M VRG---IDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSAIA
MUL_2440|M.ulcerans_Agy99 QG------------------------------------ISDAAADIGAWQ
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mvan_2068|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3374|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 DG-------------------DIDETAVQSTTQRRTVANTAADRTAETAE
MAB_4141|M.abscessus_ATCC_1997 VENGLAGATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAPTPSVV
Mb1465|M.bovis_AF2122/97 VPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGY
Rv1430|M.tuberculosis_H37Rv VPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGY
MMAR_2235|M.marinum_M VPPQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQYGADLSAEAARH
MUL_2440|M.ulcerans_Agy99 LPSLPDISLSGISNALGSDPWSALSNATLPTLSVSTIENAIKGVQTATTD
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mvan_2068|M.vanbaalenii_PYR-1 -ADLVEIKSLSAVQDSTSEEATSDDVAGRDSSAEAESEAAADGGNSLDVL
Mflv_3374|M.gilvum_PYR-GCK -QEGSAISAATVQSAAARTTASGAASARAVEQAPVDVDVVDDAGDEIADD
TH_3724|M.thermoresistible__bu -----PATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRSTLKR
MSMEG_6144|M.smegmatis_MC2_155 VAEVTEDVDELAEQEEPVKEEATKDDEVTKVADEADKATPVKESTSVEKT
MAB_4141|M.abscessus_ATCC_1997 SLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTPP
Mb1465|M.bovis_AF2122/97 GAPAGVTNAIFIGQQVLPILVEGPGALVTADTH---YLVDAIQDLAAGDL
Rv1430|M.tuberculosis_H37Rv GAPAGVTNAIFIGQQVLPILVEGPGALVTADTH---YLVDAIQDLAAGDL
MMAR_2235|M.marinum_M GASSELLNAIYVGRQVLPILIEGPGVILTADTY---YSINAIKDLAAGNL
MUL_2440|M.ulcerans_Agy99 IANTISFDATTAYATLLPTADVVNAMVTTLPAYNLKLFLDGILQVLDGDP
MLBr_01232|M.leprae_Br4923 ---------------MDP----IAGIDAELR--------DSILNVFAQLR
MAV_1760|M.avium_104 ---------------FDPAEVTAPANQATFGGG-----ADPLSQIMAGAM
Mvan_2068|M.vanbaalenii_PYR-1 GDIDSSGTTAGDGPQLTPADVE-DPDVDVDSAGE---DEADHTDVDSAAE
Mflv_3374|M.gilvum_PYR-GCK DLGADLGADLGDDIGNDGTDVEVDVDVEVDVEKEPASDSDDATDAADAQG
TH_3724|M.thermoresistible__bu EKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVT----PDVTPDAPAGQP
MSMEG_6144|M.smegmatis_MC2_155 DQAVKPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKPKK
MAB_4141|M.abscessus_ATCC_1997 PTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVP
:
Mb1465|M.bovis_AF2122/97 SGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV--
Rv1430|M.tuberculosis_H37Rv SGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV--
MMAR_2235|M.marinum_M SGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP---
MUL_2440|M.ulcerans_Agy99 AGLIYALGAPIAADTALVTLLAGFNLYAYLYAFNKILPGVL-
MLBr_01232|M.leprae_Br4923 SILPPPPG----------------------------------
MAV_1760|M.avium_104 SVLSHGAGEADH------------------------------
Mvan_2068|M.vanbaalenii_PYR-1 SIDDAGAESADDANDDDSTVNSADQSTDSTSTDDS-------
Mflv_3374|M.gilvum_PYR-GCK DTESPGSGADSGEGDSDSGGGQARQSAKPGSSGSDE------
TH_3724|M.thermoresistible__bu EPAEPNESAAPPAAAEADDASE--------------------
MSMEG_6144|M.smegmatis_MC2_155 TRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA--
MAB_4141|M.abscessus_ATCC_1997 GLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA