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SDAREIFGGGVAVITGAGNGIGAGLARHAAALGMTVVLADIDEQAIGALSDELPGSFASGCDVRDPEALE MLAAQVYSDIGPVRLLINNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVKAFLPRMIAAGAPAWVWNL SSIGGVAAVPLQAPYIVSKHAVLALTECLRLEVELAGHGHFIHVQAVLPGAVKSNIFEAAGGVDASAAGT DVAAAEAQREAMLDIKAAAMDPVEAAEVVFEQSAQDVFYLLTQPDYVGSAMAERAGVLTSQVPPQLRTQR RFEPDRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2873 | - | - | 100% (288) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4479 | - | 1e-29 | 37.34% (241) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_1521 | - | 4e-27 | 41.54% (195) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 1e-28 | 35.29% (255) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_4561 | - | 1e-112 | 72.32% (289) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1245c | - | 1e-28 | 35.29% (255) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-29 | 34.90% (255) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0514 | - | 3e-27 | 36.23% (207) | oxidoreductase EphD |
| M. marinum M | MMAR_2600 | - | 7e-29 | 39.80% (196) | short-chain dehydrogenase |
| M. avium 104 | MAV_3031 | - | 1e-102 | 67.27% (275) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2876 | - | 1e-129 | 78.08% (292) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3042 | - | 1e-126 | 78.67% (286) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 6e-30 | 40.31% (196) | short-chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2873|M.vanbaalenii_PYR-1 -----MSDAREIFGGGVAVITGAGNGIGAGLARHAAALGMTVVLADIDEQ
TH_3042|M.thermoresistible__bu ------VDAHEVFGGGVAVITGAGHGVGAGLARYAASLGMTVVLADVDAA
MSMEG_2876|M.smegmatis_MC2_155 -----MSQARETFGGGVAVITGAGAGIGAGLARYAHRLGMTVVLADVDEA
Mflv_4561|M.gilvum_PYR-GCK ------MSARGTFAGGVAVITGAGAGIGAGLARYASSLGMTVVLVDIDAG
MAV_3031|M.avium_104 ------------------MITGAGSGLGAGLARYACGLGMTVVLADIDRD
Mb1277c|M.bovis_AF2122/97 ---------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTD
Rv1245c|M.tuberculosis_H37Rv ---------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTD
MLBr_01094|M.leprae_Br4923 ---------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGE
MMAR_2600|M.marinum_M MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDT
MUL_3160|M.ulcerans_Agy99 MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDT
MAB_0514|M.abscessus_ATCC_1997 -MRLLPAPKP-----GLVVVTGAGSGIGRAIAIQFAKGGAEVVASDVDLT
:**** *:* :* * :. *::
Mvan_2873|M.vanbaalenii_PYR-1 AIGALSDELPGS----FASGCDVRDPEALEMLAAQVYSDIGPVRLLINNA
TH_3042|M.thermoresistible__bu AIAALRGELPGS----VGQVCDVRDPDALEMLAARVYSEVGPVRLLVNNA
MSMEG_2876|M.smegmatis_MC2_155 AAAALRDELRADGGTAVAEKCDVRDPDAVADLADRTYRDLGPVRLLVNNA
Mflv_4561|M.gilvum_PYR-GCK AVAGLRAELEAAGGVAVDAMCDVRDPVAVQELADRVYRDVGPVRLLVNNA
MAV_3031|M.avium_104 AVAALRDELAAGGGAAHDAACDVRDPAAVQDLADRAY-DIGPVRLLVNNA
Mb1277c|M.bovis_AF2122/97 GLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNA
Rv1245c|M.tuberculosis_H37Rv GLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNA
MLBr_01094|M.leprae_Br4923 GLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNA
MMAR_2600|M.marinum_M AVADTAQTARGFGHDVITRRVDVSDPEQMTAFADATLGHFGGVDLLVNNA
MUL_3160|M.ulcerans_Agy99 AVADTAQTARGFGHDVITRRVDVSDPEQMTAFADATLGHFGGVDLLVNNA
MAB_0514|M.abscessus_ATCC_1997 TAQETAQIIHGKGHRAVAFQLDVTDPAAWERFAEQVRAEYGVPDVLVNNA
. ** : * . . * : ***
Mvan_2873|M.vanbaalenii_PYR-1 GVEQFGYLWDTPVANWNRVMDINVSGVFHGVKAFLPRMIAAGAPAWVWNL
TH_3042|M.thermoresistible__bu GIEQFGYLWDTPVPNWDRLVSVNVSGVFYGIRAFLPRMIDAGAPAWVWNL
MSMEG_2876|M.smegmatis_MC2_155 GVEQFGYLWDTPVANWNRVMDINVSGVFHGVRAFLPKMMAHGSPAWVWNL
Mflv_4561|M.gilvum_PYR-GCK GVEQFGYLWDTPVANWNRIMDINVDGVFHGVRAFLPKMIDAGTPAWVWNM
MAV_3031|M.avium_104 GIEQFGYLWDTPVVNWQRVMDVNVSGVFYGVRAFLPKMMAAGQQAWVWNI
Mb1277c|M.bovis_AF2122/97 GIAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASG-DGHVINI
Rv1245c|M.tuberculosis_H37Rv GIAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASG-DGHVINI
MLBr_01094|M.leprae_Br4923 GIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSG-DGHVINI
MMAR_2600|M.marinum_M GVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIESGRGGHVVNL
MUL_3160|M.ulcerans_Agy99 GVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIESGRGGHVVNL
MAB_0514|M.abscessus_ATCC_1997 GIMVGGRFFDLEQEHWEKQFRVNVFGVAYGGRVFGKQMAERGRGGQIVNI
*: * . . : . :: ** * ..* : * . : *:
Mvan_2873|M.vanbaalenii_PYR-1 SSIGGVAAVPLQAPYIVSKHAVLALTECLRLEVELAGHGHFIHVQAVLPG
TH_3042|M.thermoresistible__bu SSIGGVAAVPLQAPYIMSKHAVLALTECLRLEVELAGHADRITVQAVLPG
MSMEG_2876|M.smegmatis_MC2_155 SSIGGVAAVPLQAPYIISKHAVLALTECLRLEVQLAGHDDHVHVQAVLPG
Mflv_4561|M.gilvum_PYR-GCK SSIGGVAVVPLQAPYIVTKHAVLALTECLHLEVRHAGH-DHIHVQAVLPG
MAV_3031|M.avium_104 ASVGAVVAMPLQAPYIVSKHAVLSLTECLHLEVQATGHDDHVHVQAVLPG
Mb1277c|M.bovis_AF2122/97 SSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALAGH--PVKVTTVHPG
Rv1245c|M.tuberculosis_H37Rv SSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALAGH--PVKVTTVHPG
MLBr_01094|M.leprae_Br4923 SSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGR--PVNVTTVYPG
MMAR_2600|M.marinum_M SSAAGLLANSALSAYSATKFAVLGLSEALRIELEPHR----IGVTAICPG
MUL_3160|M.ulcerans_Agy99 SSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHR----IGVTAICPG
MAB_0514|M.abscessus_ATCC_1997 ASAGAITPTPLFPAYSASKAAVKMLSECMRMELGPKG----IGVSAVCPG
:* .: . ..* :* ** ::*.:: *: : * :: **
Mvan_2873|M.vanbaalenii_PYR-1 AVKSNIFEAAGGVDASAAGTDVAAAEAQREAMLDIK-----AAAMDPVEA
TH_3042|M.thermoresistible__bu AVKSNIFEAAGGVDD----GDVAAAEAQRAAMLDIK-----AAAMDPVEA
MSMEG_2876|M.smegmatis_MC2_155 AVKSNIFEAAGGVDSGQDGADVNAAESQREAMLDIK-----AAAMDPIDA
Mflv_4561|M.gilvum_PYR-GCK AVVSNIFESARGVDDS-DSEAVTAAESQRAAMLDIK-----AAAMDPVAA
MAV_3031|M.avium_104 PVRSNIFESAGGVDPD-AATDAAAAEAHRSAMLGIK-----AASMDALEA
Mb1277c|M.bovis_AF2122/97 GVKTAIARNATAAEG---LDQAELAETFDKRVAHLS----------PQRA
Rv1245c|M.tuberculosis_H37Rv GVKTAIARNATAAEG---LDQAELAETFDKRVAHLS----------PQRA
MLBr_01094|M.leprae_Br4923 GIKTAIARNATAAEG---LDVSKIASRFDTWVAHTS----------PQHA
MMAR_2600|M.marinum_M VINTAITKASPIRG---AGDTEGRRQRLTVTYQRRG--------YTPARA
MUL_3160|M.ulcerans_Agy99 VINTAITKASPIRG---AGDTEGRRQRLTVTYQRRG--------YTPARA
MAB_0514|M.abscessus_ATCC_1997 FINTNIGVNATVAGLDVRDDVRERANNMMRAFQSSAPMRVLDQLIGPPQV
: : * : . . .
Mvan_2873|M.vanbaalenii_PYR-1 AEVVFEQSAQDVFYLLTQPDYVGSAMAERAGVL-------TSQVPPQLRT
TH_3042|M.thermoresistible__bu ARVVFEQAAAGEFYLLTQPEYVGGAMAERAAVL-------TERRAPVLRT
MSMEG_2876|M.smegmatis_MC2_155 AEAIFEQSARGAFYLLTQPEYVGSAMAERAQVL-------ISQVPPQLRT
Mflv_4561|M.gilvum_PYR-GCK AEVVFDQAAAGEFYLLTQPGYVSSAMTERARVL-------STRQAPQLRT
MAV_3031|M.avium_104 AEMIFRQSTEGHFYLHTHPESVGAAMRERAKVL-------AAQQAPRLRT
Mb1277c|M.bovis_AF2122/97 AQIILTGVAKNKARVLVGVDAKVLDLVVRLTG-------SGYQRIFPIIT
Rv1245c|M.tuberculosis_H37Rv AQIILTGVAKNKARVLVGVDAKVLDLVVRLTG-------SGYQRIFPIIT
MLBr_01094|M.leprae_Br4923 ARIILKAVRKKKARVLVGPDAKVANVVVRFSGG------AGYQRLFAQVA
MMAR_2600|M.marinum_M ARNILRAVERNKAVAPVAAEAHVMYVLSRIMP--------PLARWVSAQM
MUL_3160|M.ulcerans_Agy99 ARNILRAVERNKAVAPVAAEAHVMYVLSRIMP--------PLARWVSAQM
MAB_0514|M.abscessus_ATCC_1997 ARAAVRAARYNFAVAPVRPEAWLGYFLSRLLPGLNRHFMYPIPYWLGLDI
*. . . . *
Mvan_2873|M.vanbaalenii_PYR-1 QRRFEPDRH----------------------
TH_3042|M.thermoresistible__bu EQRFDPARH----------------------
MSMEG_2876|M.smegmatis_MC2_155 ERRFDPAKH----------------------
Mflv_4561|M.gilvum_PYR-GCK ERRFDPAKH----------------------
MAV_3031|M.avium_104 ETRFDSAPD----------------------
Mb1277c|M.bovis_AF2122/97 GRLIPRPR-----------------------
Rv1245c|M.tuberculosis_H37Rv GRLIPRPR-----------------------
MLBr_01094|M.leprae_Br4923 SRLILNQR-----------------------
MMAR_2600|M.marinum_M AKAAK--------------------------
MUL_3160|M.ulcerans_Agy99 AKAAK--------------------------
MAB_0514|M.abscessus_ATCC_1997 DTLIPRLQRLIDNVAERTPTPRLTETEQSPV