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GLFGAKRTHRADAVITGAGSGIGAAFAVELARRGGRVVCSDVSVEAARGTADAIIADGGRALPAQCDVTD IDAMYRLAGEAQTWFDGPPTLVINNAGVGAGGAFIGETELADWKWVLDINLWGPIHGCHVFAPILREAGR PAGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAAELAGTGINVTVLCPTFVKTNIVESGRISTGTS QLAERLMRWTGFPAARVARSALDTLDRGGLYCMPQPEARIGWGVKRFTPTVFTRAAGIATRITT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1521 | - | - | 100% (275) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 2e-28 | 35.25% (261) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2873 | - | 4e-27 | 41.54% (195) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 2e-33 | 40.40% (198) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4610 | - | 1e-82 | 58.11% (265) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0851c | - | 8e-34 | 40.40% (198) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 7e-38 | 36.12% (263) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4478c | - | 1e-85 | 60.37% (270) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3700 | - | 1e-104 | 69.37% (271) | short-chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_1797 | - | 1e-101 | 66.42% (274) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 9e-37 | 37.93% (261) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-36 | 36.64% (262) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3643 | - | 1e-104 | 69.37% (271) | short-chain membrane-associated dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR----RGAARRLQA
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH---FVRVPV
MSMEG_4280|M.smegmatis_MC2_155 ID--TPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH---YVQVPV
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4478c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3700|M.marinum_M ----------MLGPLDKL-LGKSRKTSHDALAVVTGAGSGIGAAFALELG
MUL_3643|M.ulcerans_Agy99 ----------MLGPLDKL-LGKSRKTSHDALAVVTGAGSGIGAAFALELG
MAV_1797|M.avium_104 -------------MLDRL-LHRS-KTSRGALAVVTGAGSGIGAAFALELG
Mvan_1521|M.vanbaalenii_PYR-1 -----------------M-GLFGAKRTHRADAVITGAGSGIGAAFAVELA
Mflv_4610|M.gilvum_PYR-GCK --------------MDILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELA
MAB_4478c|M.abscessus_ATCC_199 -------------MVSLLGFGRGERRTRKVDAVVTGAASGIGRAFAVELA
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
Mb0874c|M.bovis_AF2122/97 -----------------------MDGFPGRGAVITGGASGIGLATGTEFA
Rv0851c|M.tuberculosis_H37Rv -----------------------MDGFPGRGAVITGGASGIGLATGTEFA
. :**...*** . :.
MMAR_3700|M.marinum_M RRGSAVVCSDIDEVAAQNTVAALTEAGARAISIDCDVSRIEDVTALAERS
MUL_3643|M.ulcerans_Agy99 RRGSAVVCSDIDEVAAQNTVAALTEAGARAISIGCDVSRIEDVTALAERS
MAV_1797|M.avium_104 KRGGTVVCSDIDQAAAQRTADAITEHGAKALATRCDVSQFGVVQALAEQS
Mvan_1521|M.vanbaalenii_PYR-1 RRGGRVVCSDVSVEAARGTADAIIADGGRALPAQCDVTDIDAMYRLAGEA
Mflv_4610|M.gilvum_PYR-GCK RRGGRVVCADIDPVRAKETVGLVVQAGGEGLDIACDVTDEEQVRELADSA
MAB_4478c|M.abscessus_ATCC_199 RRGGRVVCADVDLPGAKETAALIGER---AIEAACDVSVFDEVEALADTA
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
Mb0874c|M.bovis_AF2122/97 RRGARVVLGDVDKPGLRQAVNHLRAEGFDVHGVMCDVRHREEVTHLADEA
Rv0851c|M.tuberculosis_H37Rv RRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEA
: *. :: .*:. : :. : ** : :.
MMAR_3700|M.marinum_M QAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVF
MUL_3643|M.ulcerans_Agy99 QAWFDGPPTLVINNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVF
MAV_1797|M.avium_104 QSWFGAPPTLVINNAGVGAGGAAIGDAPLDDWQWTLGINLWGPIHGCHVF
Mvan_1521|M.vanbaalenii_PYR-1 QTWFDGPPTLVINNAGVGAGGAFIGETELADWKWVLDINLWGPIHGCHVF
Mflv_4610|M.gilvum_PYR-GCK EKWFGAAASLVINNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIF
MAB_4478c|M.abscessus_ATCC_199 EEWFGKPSDLVINNAGIGAGGQVVGAAPLADWQKTLGVNLWGVIHGSHVF
MLBr_00862|M.leprae_Br4923 SAKHG-VPDIVVNNAGIGQAGRFL-DTPPEEFDRVLAVNLGGVVNCCRAF
TH_4323|M.thermoresistible__bu CARHG-VPDIVVNNAGIGHAGRFL-DTPRDQWDRVLEVNLGGVVNGCRAF
MSMEG_4280|M.smegmatis_MC2_155 CATHG-VPDIVVNNAGIGHAGNFL-DTPADQYERVLEVNFGGVVNCCRAF
Mb0874c|M.bovis_AF2122/97 FRLLG-HFDVVFSNAGIVVG-GPIVEMTHDDWRWVIDVDLWGSIHTVEAF
Rv0851c|M.tuberculosis_H37Rv FRLLG-HVDVVFSNAGIVVG-GPIVEMTHDDWRWVIDVDLWGSIHTVEAF
. :*..***: . : :: .: ::: * : . *
MMAR_3700|M.marinum_M TPILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
MUL_3643|M.ulcerans_Agy99 TPILREAGRAVGPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
MAV_1797|M.avium_104 TPILRDAAPSAAPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAA
Mvan_1521|M.vanbaalenii_PYR-1 APILREAGR---PAGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAA
Mflv_4610|M.gilvum_PYR-GCK VPRLRAKGS----GGIINVASAASFGAAPRMGAYNVSKAGVLSLSETLAA
MAB_4478c|M.abscessus_ATCC_199 APRLRALGR----GGIINVASAASFAAAPRMGAYNVSKAGVLALSETLAA
MLBr_00862|M.leprae_Br4923 GQRLVERGTG---GHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
TH_4323|M.thermoresistible__bu APRLVERGTG---GHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRA
MSMEG_4280|M.smegmatis_MC2_155 GRRLVEQGTG---GHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRA
Mb0874c|M.bovis_AF2122/97 LPRLLEQGTG---GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAR
Rv0851c|M.tuberculosis_H37Rv LPRLLEQGTG---GHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAR
* . :: :* *. . : ** .:* .. ::: *
MMAR_3700|M.marinum_M ELSGTGINVTVLCPTFVKTNIVESGRISEQSSE---------VVTKLIRW
MUL_3643|M.ulcerans_Agy99 ELSGTGINVTVLCPTFVKTNIVESGRISEQSSE---------VVTKLIRW
MAV_1797|M.avium_104 ELSGTPVRVTVLCPTFVKTTILESGRISEESGE---------LAAKLMRW
Mvan_1521|M.vanbaalenii_PYR-1 ELAGTGINVTVLCPTFVKTNIVESGRISTGTSQ---------LAERLMRW
Mflv_4610|M.gilvum_PYR-GCK ELSGTGVAVTVLCPTFVKTNIVDNPGIEESAAK---------LATNLMKW
MAB_4478c|M.abscessus_ATCC_199 ELSGTGVAVTVLCPTFVKTSIVDSGIIEESAAR---------LAATAMKW
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
TH_4323|M.thermoresistible__bu ELDSAGIMLTTICPSTVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFAL
MSMEG_4280|M.smegmatis_MC2_155 ELAHAGIGVTTLCPGMIDTGIVDTTRFDVPAHKAGQVEARRAQVKKTFQA
Mb0874c|M.bovis_AF2122/97 EVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTG-SPGPLPLQD
Rv0851c|M.tuberculosis_H37Rv EVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTG-SPGPLPLQD
*: : ::.:** :.* :: . :
MMAR_3700|M.marinum_M TGFSPDKVARICLDANDRGDLYCMPQLD--AKIGWNIKRMAPGTYTRAAG
MUL_3643|M.ulcerans_Agy99 TGFSPDKVARICLDANDRGDLYCMPQLD--AKIGWNIKRMAPGTYTRAAG
MAV_1797|M.avium_104 TGFSADKVARICLDAHDRGDLYCMPQLD--AQIGWHIKRLAPQAYTRAAG
Mvan_1521|M.vanbaalenii_PYR-1 TGFPAARVARSALDTLDRGGLYCMPQPE--ARIGWGVKRFTPTVFTRAAG
Mflv_4610|M.gilvum_PYR-GCK TGVSAESVARKTLDANDRGQLHVLPQVD--AKILWLFKRAVPATYTRALG
MAB_4478c|M.abscessus_ATCC_199 TGVSADSVARGCLDAHDRGQLYVLPQFD--ARFMWQAKRLAPDTYTKALG
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPE--AYALYGISRVLPQVLRSTAR
TH_4323|M.thermoresistible__bu RRFGPDKAAKAIVSAVKQNKPIRPVMPE--AYFVYGVSRVLPQALRSTAR
MSMEG_4280|M.smegmatis_MC2_155 RRYGPEKVAKAVTSAVSRNQALRPVTPE--AYVAYGVSRLFPAALRRAAR
Mb0874c|M.bovis_AF2122/97 DNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAE
Rv0851c|M.tuberculosis_H37Rv DNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAE
* .: . * .* :
MMAR_3700|M.marinum_M LILRATMR---
MUL_3643|M.ulcerans_Agy99 LILRATMR---
MAV_1797|M.avium_104 LVSRINLP---
Mvan_1521|M.vanbaalenii_PYR-1 IATRITT----
Mflv_4610|M.gilvum_PYR-GCK LVERIAR----
MAB_4478c|M.abscessus_ATCC_199 IAERFSRQRGN
MLBr_00862|M.leprae_Br4923 IRVI-------
TH_4323|M.thermoresistible__bu GRVL-------
MSMEG_4280|M.smegmatis_MC2_155 SQVL-------
Mb0874c|M.bovis_AF2122/97 GWRH-------
Rv0851c|M.tuberculosis_H37Rv GWRH-------