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SQARETFGGGVAVITGAGAGIGAGLARYAHRLGMTVVLADVDEAAAAALRDELRADGGTAVAEKCDVRDP DAVADLADRTYRDLGPVRLLVNNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVRAFLPKMMAHGSPAW VWNLSSIGGVAAVPLQAPYIISKHAVLALTECLRLEVQLAGHDDHVHVQAVLPGAVKSNIFEAAGGVDSG QDGADVNAAESQREAMLDIKAAAMDPIDAAEAIFEQSARGAFYLLTQPEYVGSAMAERAQVLISQVPPQL RTERRFDPAKH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2876 | - | - | 100% (292) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_5053 | - | 9e-30 | 35.69% (255) | short chain alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 2e-26 | 29.62% (260) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 2e-31 | 32.38% (244) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4561 | - | 1e-124 | 77.51% (289) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2214c | ephD | 2e-31 | 32.38% (244) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-31 | 35.29% (255) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4022c | - | 2e-29 | 37.79% (217) | oxidoreductase |
| M. marinum M | MMAR_3259 | ephD | 5e-31 | 32.06% (287) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_3031 | - | 1e-111 | 72.56% (277) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3042 | - | 1e-120 | 74.74% (289) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 1e-31 | 39.29% (196) | short-chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2873 | - | 1e-129 | 78.08% (292) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 MPATQQMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWDGVV
Rv2214c|M.tuberculosis_H37Rv MPATQQMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWDGVV
MMAR_3259|M.marinum_M MSATRQAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWDGVV
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 PLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEP
Rv2214c|M.tuberculosis_H37Rv PLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEP
MMAR_3259|M.marinum_M PRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSPGQP
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 VHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRR
Rv2214c|M.tuberculosis_H37Rv VHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRR
MMAR_3259|M.marinum_M VHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGGLRQ
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 PWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDI
Rv2214c|M.tuberculosis_H37Rv PWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDI
MMAR_3259|M.marinum_M PWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMVDNL
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 PVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIV
Rv2214c|M.tuberculosis_H37Rv PVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIV
MMAR_3259|M.marinum_M PLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQLIV
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 NSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFAD
Rv2214c|M.tuberculosis_H37Rv NSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFAD
MMAR_3259|M.marinum_M NTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFAD
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
TH_3042|M.thermoresistible__bu ----------------VDAHEVFGGGVAVITGAGHGVGAGLARYAASLGM
Mvan_2873|M.vanbaalenii_PYR-1 ---------------MSDAREIFGGGVAVITGAGNGIGAGLARHAAALGM
MSMEG_2876|M.smegmatis_MC2_155 ---------------MSQARETFGGGVAVITGAGAGIGAGLARYAHRLGM
Mflv_4561|M.gilvum_PYR-GCK ----------------MSARGTFAGGVAVITGAGAGIGAGLARYASSLGM
MAV_3031|M.avium_104 ----------------------------MITGAGSGLGAGLARYACGLGM
Mb2237c|M.bovis_AF2122/97 LADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAREGA
Rv2214c|M.tuberculosis_H37Rv LADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAREGA
MMAR_3259|M.marinum_M LVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAREGA
MUL_3160|M.ulcerans_Agy99 ----------MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGA
MAB_4022c|M.abscessus_ATCC_199 ----------MVKLNQLQP------QLVVVTGAGSGIGRATAIRFAKRGA
MLBr_01094|M.leprae_Br4923 -------------------MEGFAGKVAVVTGAGSGIGQALAIELARSGA
:**** *:* * *
TH_3042|M.thermoresistible__bu TVVLADVDAAAIAALRGELPGS----VGQVCDVRDPDALEMLAARVYSEV
Mvan_2873|M.vanbaalenii_PYR-1 TVVLADIDEQAIGALSDELPGS----FASGCDVRDPEALEMLAAQVYSDI
MSMEG_2876|M.smegmatis_MC2_155 TVVLADVDEAAAAALRDELRADGGTAVAEKCDVRDPDAVADLADRTYRDL
Mflv_4561|M.gilvum_PYR-GCK TVVLVDIDAGAVAGLRAELEAAGGVAVDAMCDVRDPVAVQELADRVYRDV
MAV_3031|M.avium_104 TVVLADIDRDAVAALRDELAAGGGAAHDAACDVRDPAAVQDLADRAY-DI
Mb2237c|M.bovis_AF2122/97 EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEH
Rv2214c|M.tuberculosis_H37Rv EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEH
MMAR_3259|M.marinum_M EVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVSATH
MUL_3160|M.ulcerans_Agy99 DLALCDINDTAVADTAQTARGFGHDVITRRVDVSDPEQMTAFADATLGHF
MAB_4022c|M.abscessus_ATCC_199 HVVVSDMDLDSAHATTAMIQADGNTASAVQLDVTDPDQWETFARDVLADH
MLBr_01094|M.leprae_Br4923 KLAISDVDGEGLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENF
:.: *:: . ** : * .
TH_3042|M.thermoresistible__bu GPVRLLVNNAGIEQFGYLWDTPVPNWDRLVSVNVSGVFYGIRAFLPRMID
Mvan_2873|M.vanbaalenii_PYR-1 GPVRLLINNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVKAFLPRMIA
MSMEG_2876|M.smegmatis_MC2_155 GPVRLLVNNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVRAFLPKMMA
Mflv_4561|M.gilvum_PYR-GCK GPVRLLVNNAGVEQFGYLWDTPVANWNRIMDINVDGVFHGVRAFLPKMID
MAV_3031|M.avium_104 GPVRLLVNNAGIEQFGYLWDTPVVNWQRVMDVNVSGVFYGVRAFLPKMMA
Mb2237c|M.bovis_AF2122/97 GVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVE
Rv2214c|M.tuberculosis_H37Rv GVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVE
MMAR_3259|M.marinum_M GLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQRLVE
MUL_3160|M.ulcerans_Agy99 GGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIE
MAB_4022c|M.abscessus_ATCC_199 GVADVLVNNAGIALGGPFLKLTPADWDRLLSVNLMGVVHGCRVFGEQMVE
MLBr_01094|M.leprae_Br4923 GKVNQIYNNAGIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLIS
* : ****: * . : : :: :: **. * ..* ::
TH_3042|M.thermoresistible__bu AGAPAWVWNLSSIGGVAAVPLQAPYIMSKHAVLALTECLRLEVELAGHAD
Mvan_2873|M.vanbaalenii_PYR-1 AGAPAWVWNLSSIGGVAAVPLQAPYIVSKHAVLALTECLRLEVELAGHGH
MSMEG_2876|M.smegmatis_MC2_155 HGSPAWVWNLSSIGGVAAVPLQAPYIISKHAVLALTECLRLEVQLAGHDD
Mflv_4561|M.gilvum_PYR-GCK AGTPAWVWNMSSIGGVAVVPLQAPYIVTKHAVLALTECLHLEVRHAGH-D
MAV_3031|M.avium_104 AGQQAWVWNIASVGAVVAMPLQAPYIVSKHAVLSLTECLHLEVQATGHDD
Mb2237c|M.bovis_AF2122/97 RGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAG---
Rv2214c|M.tuberculosis_H37Rv RGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAG---
MMAR_3259|M.marinum_M RGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAAD---
MUL_3160|M.ulcerans_Agy99 SGRGGHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHR---
MAB_4022c|M.abscessus_ATCC_199 RGSG-HIVNIASAAAFTPTAVMAPYSVSKAGVKMLTECLRLELGPKG---
MLBr_01094|M.leprae_Br4923 SGDG-HVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGR--
* : *::* . :.* :* .. :::.*: *:
TH_3042|M.thermoresistible__bu RITVQAVLPGAVKSNIF--EAAGGVDD----GDVAAAEAQRAAMLDIKAA
Mvan_2873|M.vanbaalenii_PYR-1 FIHVQAVLPGAVKSNIF--EAAGGVDASAAGTDVAAAEAQREAMLDIKAA
MSMEG_2876|M.smegmatis_MC2_155 HVHVQAVLPGAVKSNIF--EAAGGVDSGQDGADVNAAESQREAMLDIKAA
Mflv_4561|M.gilvum_PYR-GCK HIHVQAVLPGAVVSNIF--ESARGVDDS-DSEAVTAAESQRAAMLDIKAA
MAV_3031|M.avium_104 HVHVQAVLPGPVRSNIF--ESAGGVDPD-AATDAAAAEAHRSAMLGIKAA
Mb2237c|M.bovis_AF2122/97 -VGLTTICPGVIDTNI---VATTGFHAP-GTDEEKIDGRRGQIDKMFALR
Rv2214c|M.tuberculosis_H37Rv -VGLTTICPGVIDTNI---VATTGFHAP-GTDEEKIDGRRGQIDKMFALR
MMAR_3259|M.marinum_M -VGLTTICPGVINTNI---VNTTRFDAPPGKGGDQVDGRRGQIDKMFALR
MUL_3160|M.ulcerans_Agy99 -IGVTAICPGVINTAI---TKAS----P-IRGAGDTEGRRQRLTVTYQRR
MAB_4022c|M.abscessus_ATCC_199 -VGVSAICPGFINTNIGLNGITVGVDQEMVQRGKEIMRRAQEFAAHLPFS
MLBr_01094|M.leprae_Br4923 PVNVTTVYPGGIKTAIAR--------NATAAEGLDVSKIASRFDTWVAHT
: : :: ** : : *
TH_3042|M.thermoresistible__bu AMDPVEAARVVFEQAAAGEFYLLTQPEYVGGAMAERAAVLTERRAPVLRT
Mvan_2873|M.vanbaalenii_PYR-1 AMDPVEAAEVVFEQSAQDVFYLLTQPDYVGSAMAERAGVLTSQVPPQLRT
MSMEG_2876|M.smegmatis_MC2_155 AMDPIDAAEAIFEQSARGAFYLLTQPEYVGSAMAERAQVLISQVPPQLRT
Mflv_4561|M.gilvum_PYR-GCK AMDPVAAAEVVFDQAAAGEFYLLTQPGYVSSAMTERARVLSTRQAPQLRT
MAV_3031|M.avium_104 SMDALEAAEMIFRQSTEGHFYLHTHPESVGAAMRERAKVLAAQQAPRLRT
Mb2237c|M.bovis_AF2122/97 SYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRV
Rv2214c|M.tuberculosis_H37Rv SYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRV
MMAR_3259|M.marinum_M SYGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRV
MUL_3160|M.ulcerans_Agy99 GYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPPLARWVSAQMA
MAB_4022c|M.abscessus_ATCC_199 PMSPDLVARAVTRAVRYDLAVVPVRTEAWLGYVLGRVAPGINRRTTQAFS
MLBr_01094|M.leprae_Br4923 --SPQHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQV
. .* : . . *
TH_3042|M.thermoresistible__bu EQRFDPARH-----------------------------
Mvan_2873|M.vanbaalenii_PYR-1 QRRFEPDRH-----------------------------
MSMEG_2876|M.smegmatis_MC2_155 ERRFDPAKH-----------------------------
Mflv_4561|M.gilvum_PYR-GCK ERRFDPAKH-----------------------------
MAV_3031|M.avium_104 ETRFDSAPD-----------------------------
Mb2237c|M.bovis_AF2122/97 I-------------------------------------
Rv2214c|M.tuberculosis_H37Rv I-------------------------------------
MMAR_3259|M.marinum_M I-------------------------------------
MUL_3160|M.ulcerans_Agy99 KAAK----------------------------------
MAB_4022c|M.abscessus_ATCC_199 IERAERWGAWALGKLDDLNLLSRQGGVEEDRKPTAARR
MLBr_01094|M.leprae_Br4923 ASRLILNQR-----------------------------